Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000077522
3. actinin alpha 2
- 2. LDB3
  3. LIM domain binding 3
  4. 1.000
  5. PPI
- 2. CSRP3
  3. cysteine and glycine ri…
  4. 1.000
  5. PPI
- 2. PDLIM1
  3. PDZ and LIM domain 1
  4. 1.000
  5. PPI
- 2. MYOZ2
  3. myozenin 2
  4. 1.000
  5. PPI
- 2. PDLIM3
  3. PDZ and LIM domain 3
  4. 0.999
  5. PPI
- 2. TTN
  3. titin
  4. 0.999
  5. PPI
- 2. ACTN3
  3. actinin alpha 3 (gene/p…
  4. 0.998
  5. PPI
- 2. MYOT
  3. myotilin
  4. 0.996
  5. PPI
- 2. NRAP
  3. nebulin related anchori…
  4. 0.996
  5. PPI
- 2. PDLIM5
  3. PDZ and LIM domain 5
  4. 0.996
  5. PPI
- 2. TCAP
  3. titin-cap
  4. 0.994
  5. PPI
- 2. KCNA5
  3. potassium voltage-gated…
  4. 0.994
  5. PPI
- 2. MYOM2
  3. myomesin 2
  4. 0.992
  5. PPI
- 2. DYSF
  3. dysferlin
  4. 0.989
  5. PPI
- 2. ATP5MC1
  3. ATP synthase membrane s…
  4. 0.989
  5. PPI
- 2. PRKAR2B
  3. protein kinase cAMP-dep…
  4. 0.988
  5. PPI
- 2. ZYX
  3. zyxin
  4. 0.987
  5. PPI
- 2. TPM1
  3. tropomyosin 1
  4. 0.972
  5. PPI
- 2. SYNPO2
  3. synaptopodin 2
  4. 0.965
  5. PPI
- 2. CACNA1D
  3. calcium voltage-gated c…
  4. 0.958
  5. PPI
- 2. RPL35
  3. ribosomal protein L35
  4. 0.957
  5. PPI
- 2. FLNC
  3. filamin C
  4. 0.948
  5. PPI
- 2. DLG3
  3. discs large MAGUK scaff…
  4. 0.941
  5. PPI
- 2. ENO1
  3. enolase 1
  4. 0.941
  5. Metabolic
- 2. KCNA4
  3. potassium voltage-gated…
  4. 0.938
  5. PPI
- 2. MYOZ1
  3. myozenin 1
  4. 0.938
  5. PPI
- 2. RGP1
  3. RGP1 homolog, RAB6A GEF…
  4. 0.924
  5. PPI
- 2. CAPN1
  3. calpain 1
  4. 0.924
  5. PPI
- 2. PLS1
  3. plastin 1
  4. 0.922
  5. Metabolic
- 2. RACK1
  3. receptor for activated …
  4. 0.920
  5. PPI

Subnetwork gene interactions

ENSG00000077522

actinin alpha 2

FunCoup

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Ensembl

ENSG00000077522

UniProt

NCBI

CSRP3

cysteine and glycine rich protein 3

FunCoup

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Ensembl

ENSG00000129170

UniProt

NCBI

8048

MYOM2

myomesin 2

FunCoup

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Ensembl

ENSG00000036448

UniProt

NCBI

9172

FLNC

filamin C

FunCoup

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Ensembl

ENSG00000128591

UniProt

Q14315

NCBI

2318

MYOZ1

myozenin 1

FunCoup

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Ensembl

ENSG00000177791

UniProt

Q9NP98

NCBI

58529

CACNA1D

calcium voltage-gated channel subunit alpha1 D

FunCoup

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Ensembl

ENSG00000157388

UniProt

NCBI

TTN

titin

FunCoup

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Ensembl

ENSG00000155657

UniProt

NCBI

7273

ENO1

enolase 1

FunCoup

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Ensembl

ENSG00000074800

UniProt

NCBI

2023

PDLIM1

PDZ and LIM domain 1

FunCoup

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Ensembl

ENSG00000107438

UniProt

O00151

NCBI

9124

NRAP

nebulin related anchoring protein

FunCoup

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Ensembl

ENSG00000197893

UniProt

NCBI

4892

PDLIM3

PDZ and LIM domain 3

FunCoup

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Ensembl

ENSG00000154553

UniProt

NCBI

27295

TCAP

titin-cap

FunCoup

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Ensembl

ENSG00000173991

UniProt

NCBI

8557

DYSF

dysferlin

FunCoup

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Ensembl

ENSG00000135636

UniProt

O75923

NCBI

8291

RACK1

receptor for activated C kinase 1

FunCoup

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Ensembl

ENSG00000204628

UniProt

NCBI

10399

RPL35

ribosomal protein L35

FunCoup

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Ensembl

ENSG00000136942

UniProt

NCBI

11224

KCNA5

potassium voltage-gated channel subfamily A member 5

FunCoup

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Ensembl

ENSG00000130037

UniProt

P22460

NCBI

3741

TPM1

tropomyosin 1

FunCoup

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Ensembl

ENSG00000140416

UniProt

NCBI

7168

PDLIM5

PDZ and LIM domain 5

FunCoup

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Ensembl

ENSG00000163110

UniProt

NCBI

10611

ATP5MC1

ATP synthase membrane subunit c locus 1

FunCoup

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Ensembl

ENSG00000159199

UniProt

NCBI

PLS1

plastin 1

FunCoup

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Ensembl

ENSG00000120756

UniProt

NCBI

5357

PRKAR2B

protein kinase cAMP-dependent type II regulatory subunit beta

FunCoup

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Ensembl

ENSG00000005249

UniProt

P31323

NCBI

5577

ACTN3

actinin alpha 3 (gene/pseudogene)

FunCoup

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Ensembl

ENSG00000248746

UniProt

NCBI

SYNPO2

synaptopodin 2

FunCoup

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Ensembl

ENSG00000172403

UniProt

NCBI

171024

RGP1

RGP1 homolog, RAB6A GEF complex partner 1

FunCoup

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Ensembl

ENSG00000107185

UniProt

Q92546

NCBI

9827

KCNA4

potassium voltage-gated channel subfamily A member 4

FunCoup

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Ensembl

ENSG00000182255

UniProt

P22459

NCBI

3739

DLG3

discs large MAGUK scaffold protein 3

FunCoup

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Ensembl

ENSG00000082458

UniProt

NCBI

1741

LDB3

LIM domain binding 3

FunCoup

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Ensembl

ENSG00000122367

UniProt

NCBI

11155

MYOZ2

myozenin 2

FunCoup

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Ensembl

ENSG00000172399

UniProt

Q9NPC6

NCBI

51778

CAPN1

calpain 1

FunCoup

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Ensembl

ENSG00000014216

UniProt

NCBI

ZYX

zyxin

FunCoup

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Ensembl

ENSG00000159840

UniProt

NCBI

7791

MYOT

myotilin

FunCoup

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Ensembl

ENSG00000120729

UniProt

NCBI

9499

Query genes

		Identifier	Description
30	ENSG00000077522	ENSG00000077522	actinin alpha 2
		UniProt	A0A494C031 A0A494C033 A0A494C060 A0A494C0Q3 A0A494C166 A0A494C1A0 F6THM6 P35609
		NCBI	88

Subnetwork genes

		Identifier	Description
5	CSRP3	ENSG00000129170	cysteine and glycine rich protein 3
		UniProt	A0A3B3IRI5 A0A3B3ISZ2 A0A3B3IT61 P50461
		NCBI	8048
2	MYOM2	ENSG00000036448	myomesin 2
		UniProt	E7EWH9 P54296
		NCBI	9172
8	FLNC	ENSG00000128591	filamin C
		UniProt	Q14315
		NCBI	2318
		KEGG signaling	Focal adhesion MAPK signaling pathway
3	MYOZ1	ENSG00000177791	myozenin 1
		UniProt	Q9NP98
		NCBI	58529
2	CACNA1D	ENSG00000157388	calcium voltage-gated channel subunit alpha1 D
		UniProt	A0A1B0GTN0 A0A1B0GTP8 A0A1B0GU49 A0A1B0GUB6 A0A1B0GUH2 A0A1B0GUN6 A0A1B0GVI2 A0A1B0GW98 A0A1B0GWE1 A0A1B0GWF7 A0A1W2PQ56 A0A5F9Z6M3 H7C4S8 Q01668 Q59GD8
		NCBI	776
		KEGG signaling	MAPK signaling pathway Calcium signaling pathway Adrenergic signaling in cardiomyocytes Cardiac muscle contraction Vascular smooth muscle contraction Tight junction cAMP signaling pathway cGMP-PKG signaling pathway Dopaminergic synapse GABAergic synapse Serotonergic synapse GnRH signaling pathway Cholinergic synapse Glutamatergic synapse Retrograde endocannabinoid signaling Oxytocin signaling pathway
		KEGG metabolic	Carbohydrate digestion and absorption
4	TTN	ENSG00000155657	titin
		UniProt	A0A0A0MRA3 A0A0A0MTS7 A0A0C4DG59 A0A0U1RRH3 A0A1B0GXE3 C9JQJ2 H0Y4J7 H7C0U7 H7C195 H7C1P9 Q8WZ42
		NCBI	7273
14	ENO1	ENSG00000074800	enolase 1
		UniProt	A0A2R8Y6G6 A0A2R8Y6I8 A0A2R8Y798 A0A2R8Y879 A0A2R8YEG5 A0A2R8YEM5 K7EM90 K7ERS8 P06733
		NCBI	2023
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	RNA degradation Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
9	PDLIM1	ENSG00000107438	PDZ and LIM domain 1
		UniProt	O00151
		NCBI	9124
3	NRAP	ENSG00000197893	nebulin related anchoring protein
		UniProt	A0A0A0MRM2 Q86VF7
		NCBI	4892
6	PDLIM3	ENSG00000154553	PDZ and LIM domain 3
		UniProt	A0A087WYF8 A0A2R8Y6L7 A0A2U3TZH4 D6RAF1 Q53GG5
		NCBI	27295
6	TCAP	ENSG00000173991	titin-cap
		UniProt	J3KT40 O15273
		NCBI	8557
2	DYSF	ENSG00000135636	dysferlin
		UniProt	O75923
		NCBI	8291
10	RACK1	ENSG00000204628	receptor for activated C kinase 1
		UniProt	D6R909 D6R9L0 D6R9Z1 D6RAC2 D6RAU2 D6RBD0 D6RDI0 D6REE5 D6RF23 D6RFX4 D6RFZ9 D6RGK8 D6RHH4 D6RHJ5 E9PD14 H0Y8R5 H0Y8W2 H0Y9P0 H0YAF8 H0YAM7 J3KPE3 P63244
		NCBI	10399
6	RPL35	ENSG00000136942	ribosomal protein L35
		UniProt	F2Z388 P42766
		NCBI	11224
		KEGG metabolic	Ribosome
2	KCNA5	ENSG00000130037	potassium voltage-gated channel subfamily A member 5
		UniProt	P22460
		NCBI	3741
10	TPM1	ENSG00000140416	tropomyosin 1
		UniProt	A0A087WTJ7 A0A0S2Z4G6 A0A494BZZ2 A0A494C0I0 A0A494C0V8 B7Z596 F5H7S3 H0YK48 H0YKJ4 H0YKP3 H0YKX5 H0YL42 H0YL80 H0YLS7 H0YN06 H7BYY1 P09493 Q6ZN40
		NCBI	7168
		KEGG signaling	Adrenergic signaling in cardiomyocytes Cardiac muscle contraction
5	PDLIM5	ENSG00000163110	PDZ and LIM domain 5
		UniProt	A0A0A0MSP3 A0A0D9SFR4 A0A0D9SFW3 D6RAA1 D6RGG6 H0Y8Y3 H0Y929 H0YBI4 Q96HC4
		NCBI	10611
4	ATP5MC1	ENSG00000159199	ATP synthase membrane subunit c locus 1
		UniProt	D6R9H7 E7EPU7 E7EQ97 I3L0Y5 P05496
		NCBI	516
		KEGG metabolic	Oxidative phosphorylation
3	PLS1	ENSG00000120756	plastin 1
		UniProt	C9J0F3 C9J359 C9JAM3 C9JAM8 C9JU08 C9JVY2 C9JYI1 Q14651
		NCBI	5357
7	PRKAR2B	ENSG00000005249	protein kinase cAMP-dependent type II regulatory subunit beta
		UniProt	P31323
		NCBI	5577
		KEGG signaling	Insulin signaling pathway
7	ACTN3	ENSG00000248746	actinin alpha 3 (gene/pseudogene)
		UniProt	A0A087WSZ2 D6RH00 Q08043
		NCBI	89
2	SYNPO2	ENSG00000172403	synaptopodin 2
		UniProt	B4E258 H0Y9Y3 Q9UMS6
		NCBI	171024
2	RGP1	ENSG00000107185	RGP1 homolog, RAB6A GEF complex partner 1
		UniProt	Q92546
		NCBI	9827
3	KCNA4	ENSG00000182255	potassium voltage-gated channel subfamily A member 4
		UniProt	P22459
		NCBI	3739
3	DLG3	ENSG00000082458	discs large MAGUK scaffold protein 3
		UniProt	Q5JUW8 Q92796
		NCBI	1741
		KEGG signaling	Tight junction Hippo signaling pathway
3	LDB3	ENSG00000122367	LIM domain binding 3
		UniProt	A0A096LPD7 A0A0C4DGG7 O75112
		NCBI	11155
3	MYOZ2	ENSG00000172399	myozenin 2
		UniProt	Q9NPC6
		NCBI	51778
5	CAPN1	ENSG00000014216	calpain 1
		UniProt	E9PIA9 E9PJA6 E9PJJ3 E9PL37 E9PLC9 E9PLX0 E9PMC6 E9PQB3 E9PRM1 E9PSA6 P07384
		NCBI	823
		KEGG signaling	Apoptosis
		KEGG metabolic	Protein processing in endoplasmic reticulum
5	ZYX	ENSG00000159840	zyxin
		UniProt	C9IZ41 C9JJK5 H0Y2Y8 H7C3D3 H7C3R3 Q15942
		NCBI	7791
		KEGG signaling	Focal adhesion
2	MYOT	ENSG00000120729	myotilin
		UniProt	A0A0C4DFM5 B4DT68 Q9UBF9
		NCBI	9499

Enrichment analysis

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	jSquid_subnetworks.xml	202.86 KB
	H.sapiens_subnetwork.tsv	15.09 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000077522

CSRP3

MYOM2

FLNC

MYOZ1

CACNA1D

TTN

ENO1

PDLIM1

NRAP

PDLIM3

TCAP

DYSF

RACK1

RPL35

KCNA5

TPM1

PDLIM5

ATP5MC1

PLS1

PRKAR2B

ACTN3

SYNPO2

RGP1

KCNA4

DLG3

LDB3

MYOZ2

CAPN1

ZYX

MYOT

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