Apply confidence score threshhold  0.10 0.16 0.25 0.38 0.50 0.66 0.75 0.83 0.90 0.95 0.97 0.98 0.99  to search at network distance  0 1 2 3  steps (genes) from the query.

?      Reduce too large sub-networks by   selecting 10 most confident selecting 20 most confident selecting 30 most confident selecting 50 most confident selecting 100 most confident selecting 150 most confident selecting 200 most confident considering all  links at each expansion step and 
prioritizing close neighbors (1) treating all links equally - may produce isolated islets (2) applying ARACNE algorithm as is (3) applying ARACNE in absence of physical interactions (4)    Retain at least 5 links per query gene