Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000272886
3. decapping mRNA 1A
- 2. EDC4
  3. enhancer of mRNA decapp…
  4. 1.000
  5. PPI
- 2. EDC3
  3. enhancer of mRNA decapp…
  4. 1.000
  5. PPI
- 2. DDX6
  3. DEAD-box helicase 6
  4. 1.000
  5. PPI
- 2. DCP2
  3. decapping mRNA 2
  4. 1.000
  5. PPI
- 2. PNRC2
  3. proline rich nuclear re…
  4. 1.000
  5. PPI
- 2. UPF1
  3. UPF1 RNA helicase and A…
  4. 1.000
  5. PPI
- 2. DCP1B
  3. decapping mRNA 1B
  4. 0.998
  5. PPI
- 2. PATL1
  3. PAT1 homolog 1, process…
  4. 0.998
  5. PPI
- 2. PRPF3
  3. pre-mRNA processing fac…
  4. 0.990
  5. Complex
- 2. XRN1
  3. 5'-3' exoribonuclease 1
  4. 0.990
  5. PPI
- 2. PRPF4
  3. pre-mRNA processing fac…
  4. 0.989
  5. Complex
- 2. TNRC6A
  3. trinucleotide repeat co…
  4. 0.987
  5. PPI
- 2. STAM2
  3. signal transducing adap…
  4. 0.987
  5. PPI
- 2. LSM6
  3. LSM6 homolog, U6 small …
  4. 0.984
  5. Complex
- 2. ADSL
  3. adenylosuccinate lyase
  4. 0.984
  5. Complex
- 2. UPF2
  3. UPF2 regulator of nonse…
  4. 0.983
  5. PPI
- 2. LSM2
  3. LSM2 homolog, U6 small …
  4. 0.981
  5. Complex
- 2. PRPF40A
  3. pre-mRNA processing fac…
  4. 0.978
  5. Complex
- 2. EIF4E2
  3. eukaryotic translation …
  4. 0.974
  5. Complex
- 2. PPIH
  3. peptidylprolyl isomeras…
  4. 0.973
  5. Complex
- 2. PPM1A
  3. protein phosphatase, Mg…
  4. 0.971
  5. Complex
- 2. LSM4
  3. LSM4 homolog, U6 small …
  4. 0.969
  5. Complex
- 2. UPF3A
  3. UPF3A regulator of nons…
  4. 0.961
  5. PPI
- 2. TTF2
  3. transcription terminati…
  4. 0.959
  5. PPI
- 2. PRPF31
  3. pre-mRNA processing fac…
  4. 0.957
  5. Complex
- 2. SMAD4
  3. SMAD family member 4
  4. 0.935
  5. PPI
- 2. EIF2B4
  3. eukaryotic translation …
  4. 0.928
  5. PPI
- 2. BAG4
  3. BAG cochaperone 4
  4. 0.924
  5. PPI
- 2. MAP2K1
  3. mitogen-activated prote…
  4. 0.919
  5. PPI
- 2. TRMT6
  3. tRNA methyltransferase 6
  4. 0.915
  5. PPI

Subnetwork gene interactions

ENSG00000272886

decapping mRNA 1A

FunCoup

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Ensembl

ENSG00000272886

UniProt

NCBI

55802

ADSL

adenylosuccinate lyase

FunCoup

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Ensembl

ENSG00000239900

UniProt

NCBI

LSM2

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

FunCoup

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Ensembl

ENSG00000204392

UniProt

Q9Y333

NCBI

57819

MAP2K1

mitogen-activated protein kinase kinase 1

FunCoup

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Ensembl

ENSG00000169032

UniProt

NCBI

5604

DDX6

DEAD-box helicase 6

FunCoup

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Ensembl

ENSG00000110367

UniProt

NCBI

1656

PRPF40A

pre-mRNA processing factor 40 homolog A

FunCoup

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Ensembl

ENSG00000196504

UniProt

NCBI

55660

LSM4

LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated

FunCoup

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Ensembl

ENSG00000130520

UniProt

NCBI

25804

PRPF4

pre-mRNA processing factor 4

FunCoup

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Ensembl

ENSG00000136875

UniProt

O43172

NCBI

9128

PATL1

PAT1 homolog 1, processing body mRNA decay factor

FunCoup

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Ensembl

ENSG00000166889

UniProt

Q86TB9

NCBI

219988

UPF3A

UPF3A regulator of nonsense mediated mRNA decay

FunCoup

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Ensembl

ENSG00000169062

UniProt

NCBI

65110

UPF1

UPF1 RNA helicase and ATPase

FunCoup

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Ensembl

ENSG00000005007

UniProt

Q92900

NCBI

5976

EDC4

enhancer of mRNA decapping 4

FunCoup

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Ensembl

ENSG00000038358

UniProt

NCBI

23644

PRPF31

pre-mRNA processing factor 31

FunCoup

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Ensembl

ENSG00000105618

UniProt

NCBI

26121

EIF4E2

eukaryotic translation initiation factor 4E family member 2

FunCoup

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Ensembl

ENSG00000135930

UniProt

NCBI

9470

UPF2

UPF2 regulator of nonsense mediated mRNA decay

FunCoup

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Ensembl

ENSG00000151461

UniProt

Q9HAU5

NCBI

26019

XRN1

5'-3' exoribonuclease 1

FunCoup

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Ensembl

ENSG00000114127

UniProt

NCBI

54464

PPM1A

protein phosphatase, Mg2+/Mn2+ dependent 1A

FunCoup

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Ensembl

ENSG00000100614

UniProt

NCBI

5494

DCP1B

decapping mRNA 1B

FunCoup

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Ensembl

ENSG00000151065

UniProt

NCBI

196513

BAG4

BAG cochaperone 4

FunCoup

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Ensembl

ENSG00000156735

UniProt

NCBI

9530

TRMT6

tRNA methyltransferase 6

FunCoup

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Ensembl

ENSG00000089195

UniProt

Q9UJA5

NCBI

51605

EDC3

enhancer of mRNA decapping 3

FunCoup

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Ensembl

ENSG00000179151

UniProt

NCBI

80153

PRPF3

pre-mRNA processing factor 3

FunCoup

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Ensembl

ENSG00000117360

UniProt

O43395

NCBI

9129

LSM6

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

FunCoup

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Ensembl

ENSG00000164167

UniProt

P62312

NCBI

11157

TNRC6A

trinucleotide repeat containing adaptor 6A

FunCoup

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Ensembl

ENSG00000090905

UniProt

NCBI

27327

DCP2

decapping mRNA 2

FunCoup

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Ensembl

ENSG00000172795

UniProt

NCBI

167227

STAM2

signal transducing adaptor molecule 2

FunCoup

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Ensembl

ENSG00000115145

UniProt

O75886

NCBI

10254

PPIH

peptidylprolyl isomerase H

FunCoup

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Ensembl

ENSG00000171960

UniProt

NCBI

10465

PNRC2

proline rich nuclear receptor coactivator 2

FunCoup

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Ensembl

ENSG00000189266

UniProt

NCBI

55629

TTF2

transcription termination factor 2

FunCoup

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Ensembl

ENSG00000116830

UniProt

NCBI

8458

EIF2B4

eukaryotic translation initiation factor 2B subunit delta

FunCoup

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Ensembl

ENSG00000115211

UniProt

NCBI

8890

SMAD4

SMAD family member 4

FunCoup

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Ensembl

ENSG00000141646

UniProt

NCBI

4089

Query genes

		Identifier	Description
30	ENSG00000272886	ENSG00000272886	decapping mRNA 1A
		UniProt	A0A087WT55 A0A087WVE6 A0A087WXD0 Q9NPI6
		NCBI	55802
		KEGG metabolic	RNA degradation

Subnetwork genes

		Identifier	Description
12	ADSL	ENSG00000239900	adenylosuccinate lyase
		UniProt	A0A096LNT0 A0A096LNY4 A0A096LNY5 A0A096LNY6 A0A096LP72 A0A096LP76 A0A096LP92 A0A096LPA2 A0A0A6YY92 A0A1B0GTG9 A0A1B0GTJ7 A0A1B0GWF8 A0A1B0GWJ0 B4DEP1 P30566 V9GY96
		NCBI	158
		KEGG metabolic	Alanine, aspartate and glutamate metabolism Purine metabolism
19	LSM2	ENSG00000204392	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
		UniProt	Q9Y333
		NCBI	57819
		KEGG metabolic	RNA degradation Spliceosome
9	MAP2K1	ENSG00000169032	mitogen-activated protein kinase kinase 1
		UniProt	H3BRW9 Q02750
		NCBI	5604
		KEGG signaling	Thyroid hormone signaling pathway Chemokine signaling pathway Neurotrophin signaling pathway Fc gamma R-mediated phagocytosis Long-term potentiation Toll-like receptor signaling pathway Fc epsilon RI signaling pathway B cell receptor signaling pathway cAMP signaling pathway FoxO signaling pathway Gap junction HIF-1 signaling pathway cGMP-PKG signaling pathway T cell receptor signaling pathway Relaxin signaling pathway Serotonergic synapse Cholinergic synapse TNF signaling pathway Oxytocin signaling pathway MAPK signaling pathway Apelin signaling pathway PI3K-Akt signaling pathway mTOR signaling pathway VEGF signaling pathway Vascular smooth muscle contraction Phospholipase D signaling pathway Sphingolipid signaling pathway Long-term depression Rap1 signaling pathway Focal adhesion Oocyte meiosis Ras signaling pathway ErbB signaling pathway Natural killer cell mediated cytotoxicity Apoptosis Prolactin signaling pathway Melanogenesis Estrogen signaling pathway Progesterone-mediated oocyte maturation GnRH signaling pathway Insulin signaling pathway
		KEGG metabolic	Autophagy - animal
20	DDX6	ENSG00000110367	DEAD-box helicase 6
		UniProt	P26196 Q8IV96
		NCBI	1656
		KEGG metabolic	RNA degradation
19	PRPF40A	ENSG00000196504	pre-mRNA processing factor 40 homolog A
		UniProt	A0A3F2YNY6 F5H578 H0YG38 H7BXZ7 H7C2N3 O75400
		NCBI	55660
		KEGG metabolic	Spliceosome
19	LSM4	ENSG00000130520	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
		UniProt	M0QXB0 Q9Y4Z0 U3KQK1 V9GZ56
		NCBI	25804
		KEGG metabolic	RNA degradation Spliceosome
16	PRPF4	ENSG00000136875	pre-mRNA processing factor 4
		UniProt	O43172
		NCBI	9128
		KEGG metabolic	Spliceosome
18	PATL1	ENSG00000166889	PAT1 homolog 1, processing body mRNA decay factor
		UniProt	Q86TB9
		NCBI	219988
		KEGG metabolic	RNA degradation
7	UPF3A	ENSG00000169062	UPF3A regulator of nonsense mediated mRNA decay
		UniProt	A0A087WZ33 Q9H1J1
		NCBI	65110
		KEGG metabolic	RNA transport mRNA surveillance pathway
18	UPF1	ENSG00000005007	UPF1 RNA helicase and ATPase
		UniProt	Q92900
		NCBI	5976
		KEGG metabolic	RNA transport mRNA surveillance pathway
19	EDC4	ENSG00000038358	enhancer of mRNA decapping 4
		UniProt	I3L0V0 I3L2F4 I3L3M2 Q6P2E9
		NCBI	23644
		KEGG metabolic	RNA degradation
19	PRPF31	ENSG00000105618	pre-mRNA processing factor 31
		UniProt	E7EN72 E7ESX0 E7EU94 E7EVX8 Q8WWY3
		NCBI	26121
		KEGG metabolic	Spliceosome
11	EIF4E2	ENSG00000135930	eukaryotic translation initiation factor 4E family member 2
		UniProt	B4E1E4 B8ZZ50 B8ZZL3 B9A023 B9A044 C9JEL3 H7BZH2 O60573
		NCBI	9470
		KEGG signaling	HIF-1 signaling pathway PI3K-Akt signaling pathway mTOR signaling pathway Insulin signaling pathway
		KEGG metabolic	RNA transport
11	UPF2	ENSG00000151461	UPF2 regulator of nonsense mediated mRNA decay
		UniProt	Q9HAU5
		NCBI	26019
6	XRN1	ENSG00000114127	5'-3' exoribonuclease 1
		UniProt	C9JCZ8 F8WDA0 H7C583 H7C5E4 Q8IZH2
		NCBI	54464
		KEGG metabolic	RNA degradation Ribosome biogenesis in eukaryotes
6	PPM1A	ENSG00000100614	protein phosphatase, Mg2+/Mn2+ dependent 1A
		UniProt	E9PJN3 E9PKB5 E9PL75 E9PNE1 E9PP44 P35813
		NCBI	5494
		KEGG signaling	MAPK signaling pathway
17	DCP1B	ENSG00000151065	decapping mRNA 1B
		UniProt	B4DVJ6 F5GZK9 F5H4R4 Q8IZD4
		NCBI	196513
		KEGG metabolic	RNA degradation
10	BAG4	ENSG00000156735	BAG cochaperone 4
		UniProt	H0YBT1 O95429
		NCBI	9530
		KEGG signaling	TNF signaling pathway
18	TRMT6	ENSG00000089195	tRNA methyltransferase 6
		UniProt	Q9UJA5
		NCBI	51605
21	EDC3	ENSG00000179151	enhancer of mRNA decapping 3
		UniProt	H3BMB8 H3BNJ7 H3BPN4 H3BPW9 H3BQ37 H3BQA1 H3BQP5 H3BSQ0 H3BTD6 H3BTF8 H3BTH0 H3BU87 Q96F86
		NCBI	80153
		KEGG metabolic	RNA degradation
19	PRPF3	ENSG00000117360	pre-mRNA processing factor 3
		UniProt	O43395
		NCBI	9129
		KEGG metabolic	Spliceosome
20	LSM6	ENSG00000164167	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
		UniProt	P62312
		NCBI	11157
		KEGG metabolic	RNA degradation Spliceosome
7	TNRC6A	ENSG00000090905	trinucleotide repeat containing adaptor 6A
		UniProt	H3BRT3 H3BTQ1 H7C269 I3L218 I3L3S5 Q8NDV7
		NCBI	27327
16	DCP2	ENSG00000172795	decapping mRNA 2
		UniProt	D6RCL0 H0Y9T5 Q8IU60
		NCBI	167227
		KEGG metabolic	RNA degradation
4	STAM2	ENSG00000115145	signal transducing adaptor molecule 2
		UniProt	O75886
		NCBI	10254
		KEGG signaling	JAK-STAT signaling pathway
		KEGG metabolic	Endocytosis
14	PPIH	ENSG00000171960	peptidylprolyl isomerase H
		UniProt	A6NM32 C9JAN8 C9JQD4 H0YEL5 O43447
		NCBI	10465
		KEGG metabolic	Spliceosome
3	PNRC2	ENSG00000189266	proline rich nuclear receptor coactivator 2
		UniProt	J3KS97 Q9NPJ4
		NCBI	55629
7	TTF2	ENSG00000116830	transcription termination factor 2
		UniProt	Q9UNY4 X6RI15
		NCBI	8458
4	EIF2B4	ENSG00000115211	eukaryotic translation initiation factor 2B subunit delta
		UniProt	A0A087WTA5 A0A087WW69 E7ERK9 F8W8L6 F8WEV6 H7C2L8 Q9UI10
		NCBI	8890
		KEGG metabolic	RNA transport
1	SMAD4	ENSG00000141646	SMAD family member 4
		UniProt	A0A087WUF3 K7EIJ2 K7EIU8 K7EL15 K7EL18 K7ELK2 K7ENG1 K7ENG8 K7ES96 Q13485
		NCBI	4089
		KEGG signaling	Adherens junction Wnt signaling pathway FoxO signaling pathway Cell cycle TGF-beta signaling pathway Apelin signaling pathway Hippo signaling pathway

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

To use PathwAX, first use the button below to copy the subnetwork genes and then paste them in PathwAX

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	jSquid_subnetworks.xml	297.69 KB
	H.sapiens_subnetwork.tsv	36.90 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000272886

ADSL

LSM2

MAP2K1

DDX6

PRPF40A

LSM4

PRPF4

PATL1

UPF3A

UPF1

EDC4

PRPF31

EIF4E2

UPF2

XRN1

PPM1A

DCP1B

BAG4

TRMT6

EDC3

PRPF3

LSM6

TNRC6A

DCP2

STAM2

PPIH

PNRC2

TTF2

EIF2B4

SMAD4

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