Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000254087
3. LYN proto-oncogene, Src…
- 2. PTPN6
  3. protein tyrosine phosph…
  4. 1.000
  5. PPI
- 2. PLCG2
  3. phospholipase C gamma 2
  4. 1.000
  5. PPI
- 2. BTK
  3. Bruton tyrosine kinase
  4. 1.000
  5. PPI
- 2. CSK
  3. C-terminal Src kinase
  4. 1.000
  5. PPI
- 2. PTPRC
  3. protein tyrosine phosph…
  4. 1.000
  5. PPI
- 2. HCLS1
  3. hematopoietic cell-spec…
  4. 1.000
  5. PPI
- 2. CBL
  3. Cbl proto-oncogene
  4. 1.000
  5. PPI
- 2. ITGB2
  3. integrin subunit beta 2
  4. 1.000
  5. PPI
- 2. CD14
  3. CD14 molecule
  4. 1.000
  5. PPI
- 2. SKAP2
  3. src kinase associated p…
  4. 1.000
  5. PPI
- 2. SYK
  3. spleen associated tyros…
  4. 1.000
  5. PPI
- 2. LCK
  3. LCK proto-oncogene, Src…
  4. 1.000
  5. PPI
- 2. INPP5D
  3. inositol polyphosphate-…
  4. 1.000
  5. PPI
- 2. PIK3R1
  3. phosphoinositide-3-kina…
  4. 1.000
  5. PPI
- 2. CSF2RB
  3. colony stimulating fact…
  4. 1.000
  5. PPI
- 2. ITGB1
  3. integrin subunit beta 1
  4. 1.000
  5. PPI
- 2. CD37
  3. CD37 molecule
  4. 1.000
  5. PPI
- 2. TEC
  3. tec protein tyrosine ki…
  4. 1.000
  5. PPI
- 2. STAT3
  3. signal transducer and a…
  4. 1.000
  5. PPI
- 2. LCP2
  3. lymphocyte cytosolic pr…
  4. 1.000
  5. PPI
- 2. PTK2B
  3. protein tyrosine kinase…
  4. 1.000
  5. PPI
- 2. TRIP10
  3. thyroid hormone recepto…
  4. 1.000
  5. PPI
- 2. CSF1R
  3. colony stimulating fact…
  4. 0.999
  5. PPI
- 2. GRB2
  3. growth factor receptor …
  4. 0.999
  5. PPI
- 2. CRK
  3. CRK proto-oncogene, ada…
  4. 0.999
  5. PPI
- 2. CD36
  3. CD36 molecule
  4. 0.999
  5. PPI
- 2. FYN
  3. FYN proto-oncogene, Src…
  4. 0.999
  5. PPI
- 2. SRC
  3. SRC proto-oncogene, non…
  4. 0.999
  5. PPI
- 2. ITGA4
  3. integrin subunit alpha 4
  4. 0.999
  5. PPI
- 2. DOK1
  3. docking protein 1
  4. 0.999
  5. PPI

Subnetwork gene interactions

ENSG00000254087

LYN proto-oncogene, Src family tyrosine kinase

FunCoup

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Ensembl

ENSG00000254087

UniProt

NCBI

4067

PLCG2

phospholipase C gamma 2

FunCoup

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Ensembl

ENSG00000197943

UniProt

NCBI

5336

INPP5D

inositol polyphosphate-5-phosphatase D

FunCoup

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Ensembl

ENSG00000168918

UniProt

NCBI

3635

ITGB2

integrin subunit beta 2

FunCoup

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Ensembl

ENSG00000160255

UniProt

NCBI

3689

CSK

C-terminal Src kinase

FunCoup

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Ensembl

ENSG00000103653

UniProt

NCBI

1445

HCLS1

hematopoietic cell-specific Lyn substrate 1

FunCoup

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Ensembl

ENSG00000180353

UniProt

NCBI

3059

PTPN6

protein tyrosine phosphatase non-receptor type 6

FunCoup

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Ensembl

ENSG00000111679

UniProt

NCBI

5777

CRK

CRK proto-oncogene, adaptor protein

FunCoup

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Ensembl

ENSG00000167193

UniProt

NCBI

1398

CBL

Cbl proto-oncogene

FunCoup

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Ensembl

ENSG00000110395

UniProt

NCBI

LCK

LCK proto-oncogene, Src family tyrosine kinase

FunCoup

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Ensembl

ENSG00000182866

UniProt

NCBI

3932

LCP2

lymphocyte cytosolic protein 2

FunCoup

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Ensembl

ENSG00000043462

UniProt

NCBI

3937

GRB2

growth factor receptor bound protein 2

FunCoup

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Ensembl

ENSG00000177885

UniProt

NCBI

2885

BTK

Bruton tyrosine kinase

FunCoup

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Ensembl

ENSG00000010671

UniProt

NCBI

PTK2B

protein tyrosine kinase 2 beta

FunCoup

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Ensembl

ENSG00000120899

UniProt

NCBI

2185

STAT3

signal transducer and activator of transcription 3

FunCoup

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Ensembl

ENSG00000168610

UniProt

NCBI

6774

PTPRC

protein tyrosine phosphatase receptor type C

FunCoup

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Ensembl

ENSG00000081237

UniProt

NCBI

5788

SRC

SRC proto-oncogene, non-receptor tyrosine kinase

FunCoup

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Ensembl

ENSG00000197122

UniProt

P12931

NCBI

6714

CSF1R

colony stimulating factor 1 receptor

FunCoup

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Ensembl

ENSG00000182578

UniProt

NCBI

1436

SKAP2

src kinase associated phosphoprotein 2

FunCoup

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Ensembl

ENSG00000005020

UniProt

NCBI

8935

TRIP10

thyroid hormone receptor interactor 10

FunCoup

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Ensembl

ENSG00000125733

UniProt

NCBI

9322

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

FunCoup

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Ensembl

ENSG00000145675

UniProt

NCBI

5295

FYN

FYN proto-oncogene, Src family tyrosine kinase

FunCoup

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Ensembl

ENSG00000010810

UniProt

NCBI

2534

SYK

spleen associated tyrosine kinase

FunCoup

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Ensembl

ENSG00000165025

UniProt

P43405

NCBI

6850

CSF2RB

colony stimulating factor 2 receptor subunit beta

FunCoup

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Ensembl

ENSG00000100368

UniProt

NCBI

1439

ITGB1

integrin subunit beta 1

FunCoup

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Ensembl

ENSG00000150093

UniProt

NCBI

3688

ITGA4

integrin subunit alpha 4

FunCoup

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Ensembl

ENSG00000115232

UniProt

NCBI

3676

DOK1

docking protein 1

FunCoup

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Ensembl

ENSG00000115325

UniProt

NCBI

1796

CD37

CD37 molecule

FunCoup

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Ensembl

ENSG00000104894

UniProt

NCBI

CD36

CD36 molecule

FunCoup

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Ensembl

ENSG00000135218

UniProt

NCBI

CD14

CD14 molecule

FunCoup

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Ensembl

ENSG00000170458

UniProt

NCBI

TEC

tec protein tyrosine kinase

FunCoup

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Ensembl

ENSG00000135605

UniProt

NCBI

7006

Query genes

		Identifier	Description
30	ENSG00000254087	ENSG00000254087	LYN proto-oncogene, Src family tyrosine kinase
		UniProt	E5RJ37 P07948
		NCBI	4067
		KEGG signaling	Fc gamma R-mediated phagocytosis Long-term depression Fc epsilon RI signaling pathway B cell receptor signaling pathway NF-kappa B signaling pathway Chemokine signaling pathway

Subnetwork genes

		Identifier	Description
15	PLCG2	ENSG00000197943	phospholipase C gamma 2
		UniProt	A0A0A0MRF9 H3BMT7 H3BPZ3 H3BQV5 P16885
		NCBI	5336
		KEGG signaling	Thyroid hormone signaling pathway Leukocyte transendothelial migration NF-kappa B signaling pathway Calcium signaling pathway VEGF signaling pathway Phospholipase D signaling pathway Phosphatidylinositol signaling system Neurotrophin signaling pathway Fc gamma R-mediated phagocytosis Fc epsilon RI signaling pathway Ras signaling pathway B cell receptor signaling pathway Natural killer cell mediated cytotoxicity ErbB signaling pathway HIF-1 signaling pathway C-type lectin receptor signaling pathway
		KEGG metabolic	Inositol phosphate metabolism
15	INPP5D	ENSG00000168918	inositol polyphosphate-5-phosphatase D
		UniProt	H0Y5Q9 H7C403 Q92835 R4GMN8
		NCBI	3635
		KEGG signaling	Fc gamma R-mediated phagocytosis Fc epsilon RI signaling pathway B cell receptor signaling pathway Phosphatidylinositol signaling system
		KEGG metabolic	Inositol phosphate metabolism
19	ITGB2	ENSG00000160255	integrin subunit beta 2
		UniProt	A0A494C0X7 A8MVG7 D3DSM0 E5RFI0 E5RGK9 E5RHE6 E5RHT0 E5RIE4 E5RIG7 E5RK25 E5RK54 E7EVZ9 J3KNI6 P05107
		NCBI	3689
		KEGG signaling	Complement and coagulation cascades Rap1 signaling pathway Natural killer cell mediated cytotoxicity Leukocyte transendothelial migration Hippo signaling pathway Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome
19	CSK	ENSG00000103653	C-terminal Src kinase
		UniProt	H3BN15 H3BU69 H3BUM9 P41240
		NCBI	1445
8	HCLS1	ENSG00000180353	hematopoietic cell-specific Lyn substrate 1
		UniProt	E7EVW7 F8WDD5 F8WEZ6 P14317
		NCBI	3059
		KEGG signaling	Tight junction
20	PTPN6	ENSG00000111679	protein tyrosine phosphatase non-receptor type 6
		UniProt	F5GXD4 F5GY79 F5H0N8 F5H1V7 F5H1Z8 F5H4Z1 F5H5H9 P29350 U3KQS1
		NCBI	5777
		KEGG signaling	Adherens junction JAK-STAT signaling pathway B cell receptor signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway
9	CRK	ENSG00000167193	CRK proto-oncogene, adaptor protein
		UniProt	I3L297 P46108
		NCBI	1398
		KEGG signaling	Neurotrophin signaling pathway Fc gamma R-mediated phagocytosis Rap1 signaling pathway Focal adhesion ErbB signaling pathway MAPK signaling pathway Chemokine signaling pathway Insulin signaling pathway
16	CBL	ENSG00000110395	Cbl proto-oncogene
		UniProt	A0A0U1RQX8 A0A0U1RR39 A0A0U1RRJ5 A0A1B0GW38 P22681
		NCBI	867
		KEGG signaling	ErbB signaling pathway Insulin signaling pathway
		KEGG metabolic	Endocytosis Ubiquitin mediated proteolysis
16	LCK	ENSG00000182866	LCK proto-oncogene, Src family tyrosine kinase
		UniProt	E9PAP0 E9PI33 E9PJ92 E9PKQ8 E9PQ10 F8W6B9 P06239 Q573B4
		NCBI	3932
		KEGG signaling	Natural killer cell mediated cytotoxicity T cell receptor signaling pathway NF-kappa B signaling pathway
14	LCP2	ENSG00000043462	lymphocyte cytosolic protein 2
		UniProt	A0A0D9SGG1 E5RKA2 E7ESF6 Q13094
		NCBI	3937
		KEGG signaling	Rap1 signaling pathway Fc epsilon RI signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway
23	GRB2	ENSG00000177885	growth factor receptor bound protein 2
		UniProt	J3KT38 J3QLF6 J3QRL5 P62993
		NCBI	2885
		KEGG signaling	MAPK signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway mTOR signaling pathway Phospholipase D signaling pathway Neurotrophin signaling pathway Fc epsilon RI signaling pathway Focal adhesion Ras signaling pathway JAK-STAT signaling pathway FoxO signaling pathway B cell receptor signaling pathway Natural killer cell mediated cytotoxicity ErbB signaling pathway Gap junction T cell receptor signaling pathway Prolactin signaling pathway Estrogen signaling pathway Relaxin signaling pathway GnRH signaling pathway Insulin signaling pathway
14	BTK	ENSG00000010671	Bruton tyrosine kinase
		UniProt	Q06187 Q5JY90 U3NG26
		NCBI	695
		KEGG signaling	Fc epsilon RI signaling pathway B cell receptor signaling pathway NF-kappa B signaling pathway
14	PTK2B	ENSG00000120899	protein tyrosine kinase 2 beta
		UniProt	C9JHV9 E5RHL2 E5RJ77 E5RK84 H0YB74 Q14289
		NCBI	2185
		KEGG signaling	Natural killer cell mediated cytotoxicity Leukocyte transendothelial migration Calcium signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway GnRH signaling pathway
7	STAT3	ENSG00000168610	signal transducer and activator of transcription 3
		UniProt	G8JLH9 K7EP08 P40763
		NCBI	6774
		KEGG signaling	Adipocytokine signaling pathway JAK-STAT signaling pathway FoxO signaling pathway HIF-1 signaling pathway Prolactin signaling pathway Chemokine signaling pathway
17	PTPRC	ENSG00000081237	protein tyrosine phosphatase receptor type C
		UniProt	A0A075B788 A0A2R8Y5B1 A0A2R8YE81 E9PKH0 M3ZCP1 M9MMK8 M9MMK9 M9MML3 M9MML4 P08575
		NCBI	5788
		KEGG signaling	Fc gamma R-mediated phagocytosis T cell receptor signaling pathway Cell adhesion molecules (CAMs)
15	SRC	ENSG00000197122	SRC proto-oncogene, non-receptor tyrosine kinase
		UniProt	P12931
		NCBI	6714
		KEGG signaling	Thyroid hormone signaling pathway Chemokine signaling pathway VEGF signaling pathway Rap1 signaling pathway Focal adhesion Adherens junction Tight junction Gap junction ErbB signaling pathway Prolactin signaling pathway Relaxin signaling pathway Estrogen signaling pathway GABAergic synapse GnRH signaling pathway C-type lectin receptor signaling pathway Oxytocin signaling pathway
		KEGG metabolic	Endocytosis
10	CSF1R	ENSG00000182578	colony stimulating factor 1 receptor
		UniProt	D6RGW1 E9PEK4 H0YAL5 P07333
		NCBI	1436
		KEGG signaling	Rap1 signaling pathway Ras signaling pathway Hematopoietic cell lineage MAPK signaling pathway PI3K-Akt signaling pathway Viral protein interaction with cytokine and cytokine receptor Cytokine-cytokine receptor interaction
7	SKAP2	ENSG00000005020	src kinase associated phosphoprotein 2
		UniProt	C9JQ17 O75563
		NCBI	8935
6	TRIP10	ENSG00000125733	thyroid hormone receptor interactor 10
		UniProt	M0R070 M0R0F9 M0R2H7 Q15642 W4VSQ9
		NCBI	9322
		KEGG signaling	Insulin signaling pathway
16	PIK3R1	ENSG00000145675	phosphoinositide-3-kinase regulatory subunit 1
		UniProt	E5RGI8 E5RHI0 E5RJY0 E5RK66 H0YB27 H0YBC2 P27986
		NCBI	5295
		KEGG signaling	Thyroid hormone signaling pathway Chemokine signaling pathway Neurotrophin signaling pathway Fc gamma R-mediated phagocytosis Toll-like receptor signaling pathway Fc epsilon RI signaling pathway FoxO signaling pathway cAMP signaling pathway B cell receptor signaling pathway HIF-1 signaling pathway T cell receptor signaling pathway Relaxin signaling pathway Cholinergic synapse C-type lectin receptor signaling pathway TNF signaling pathway Leukocyte transendothelial migration AMPK signaling pathway PI3K-Akt signaling pathway mTOR signaling pathway VEGF signaling pathway Phospholipase D signaling pathway Sphingolipid signaling pathway Phosphatidylinositol signaling system Focal adhesion Rap1 signaling pathway JAK-STAT signaling pathway Ras signaling pathway Natural killer cell mediated cytotoxicity ErbB signaling pathway Apoptosis Prolactin signaling pathway Estrogen signaling pathway Progesterone-mediated oocyte maturation Insulin signaling pathway
		KEGG metabolic	Carbohydrate digestion and absorption Autophagy - animal
21	FYN	ENSG00000010810	FYN proto-oncogene, Src family tyrosine kinase
		UniProt	E5RFM0 E5RFM4 E5RFM6 E5RFS5 E5RGM6 E5RGT0 E5RH71 E5RHF7 E5RHX7 E5RI25 E5RIX5 E5RJX7 E5RK23 P06241
		NCBI	2534
		KEGG signaling	Focal adhesion Fc epsilon RI signaling pathway Adherens junction Natural killer cell mediated cytotoxicity T cell receptor signaling pathway Phospholipase D signaling pathway Cholinergic synapse Sphingolipid signaling pathway
13	SYK	ENSG00000165025	spleen associated tyrosine kinase
		UniProt	P43405
		NCBI	6850
		KEGG signaling	Fc gamma R-mediated phagocytosis Fc epsilon RI signaling pathway B cell receptor signaling pathway Natural killer cell mediated cytotoxicity NF-kappa B signaling pathway PI3K-Akt signaling pathway Phospholipase D signaling pathway C-type lectin receptor signaling pathway
4	CSF2RB	ENSG00000100368	colony stimulating factor 2 receptor subunit beta
		UniProt	B0QY07 P32927 Q6NSJ8
		NCBI	1439
		KEGG signaling	JAK-STAT signaling pathway Apoptosis Cytokine-cytokine receptor interaction
9	ITGB1	ENSG00000150093	integrin subunit beta 1
		UniProt	C9JJP8 C9JNE0 C9JPK5 E7EQW5 E7ERX5 E7EUI6 E9PLR6 E9PQJ2 H7C4K3 H7C4N8 P05556 Q5T3E4 Q5T3E5 Q5T3E6
		NCBI	3688
		KEGG signaling	ECM-receptor interaction Focal adhesion Rap1 signaling pathway Tight junction Leukocyte transendothelial migration PI3K-Akt signaling pathway Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome
3	ITGA4	ENSG00000115232	integrin subunit alpha 4
		UniProt	E7EP60 P13612
		NCBI	3676
		KEGG signaling	ECM-receptor interaction Focal adhesion Hematopoietic cell lineage Intestinal immune network for IgA production Leukocyte transendothelial migration PI3K-Akt signaling pathway Cell adhesion molecules (CAMs)
6	DOK1	ENSG00000115325	docking protein 1
		UniProt	H7C093 Q99704
		NCBI	1796
6	CD37	ENSG00000104894	CD37 molecule
		UniProt	B7ZAN3 M0QZ33 M0QZP6 M0R083 M0R1J1 P11049 Q96LM7
		NCBI	951
		KEGG signaling	Hematopoietic cell lineage
3	CD36	ENSG00000135218	CD36 molecule
		UniProt	E7ERZ9 E7EU05 E7EVU1 E7EWI4 E7EX47 E9PC45 E9PJX8 E9PLT1 H0YEE7 P16671
		NCBI	948
		KEGG signaling	Adipocytokine signaling pathway ECM-receptor interaction Hematopoietic cell lineage AMPK signaling pathway PPAR signaling pathway
		KEGG metabolic	Fat digestion and absorption Phagosome
5	CD14	ENSG00000170458	CD14 molecule
		UniProt	D6RD81 D6RFL4 E7EVL5 P08571
		NCBI	929
		KEGG signaling	Toll-like receptor signaling pathway Hematopoietic cell lineage MAPK signaling pathway NF-kappa B signaling pathway
		KEGG metabolic	Phagosome
4	TEC	ENSG00000135605	tec protein tyrosine kinase
		UniProt	D6RB05 D6RB75 P42680
		NCBI	7006
		KEGG signaling	T cell receptor signaling pathway

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	272.31 KB
	H.sapiens_subnetwork.tsv	30.03 KB

Species:

Network information:

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Network appearance:

ENSG00000254087

PLCG2

INPP5D

ITGB2

CSK

HCLS1

PTPN6

CRK

CBL

LCK

LCP2

GRB2

BTK

PTK2B

STAT3

PTPRC

SRC

CSF1R

SKAP2

TRIP10

PIK3R1

FYN

SYK

CSF2RB

ITGB1

ITGA4

DOK1

CD37

CD36

CD14

TEC

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