Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000198648
3. serine/threonine kinase…
- 2. MAPK14
  3. mitogen-activated prote…
  4. 0.999
  5. PPI
- 2. PIK3C2A
  3. phosphatidylinositol-4-…
  4. 0.994
  5. Complex
- 2. SLC12A2
  3. solute carrier family 1…
  4. 0.989
  5. PPI
- 2. CLTC
  3. clathrin heavy chain
  4. 0.964
  5. Complex
- 2. HSPH1
  3. heat shock protein fami…
  4. 0.961
  5. PPI
- 2. KLC2
  3. kinesin light chain 2
  4. 0.958
  5. PPI
- 2. FUBP3
  3. far upstream element bi…
  4. 0.934
  5. Complex
- 2. CLTB
  3. clathrin light chain B
  4. 0.930
  5. Complex
- 2. UBE2V2
  3. ubiquitin conjugating e…
  4. 0.928
  5. Complex
- 2. CLTA
  3. clathrin light chain A
  4. 0.888
  5. Complex
- 2. AP2A1
  3. adaptor related protein…
  4. 0.873
  5. Complex
- 2. PPP5C
  3. protein phosphatase 5 c…
  4. 0.832
  5. Metabolic
- 2. RHOA
  3. ras homolog family memb…
  4. 0.760
  5. PPI
- 2. CAB39
  3. calcium binding protein…
  4. 0.751
  5. Complex
- 2. MIGA1
  3. mitoguardin 1
  4. 0.719
  5. Complex
- 2. CYFIP1
  3. cytoplasmic FMR1 intera…
  4. 0.702
  5. Complex
- 2. SEC16A
  3. SEC16 homolog A, endopl…
  4. 0.645
  5. Complex
- 2. RELL2
  3. RELT like 2
  4. 0.639
  5. PPI
- 2. GSN
  3. gelsolin
  4. 0.627
  5. PPI
- 2. PRKACB
  3. protein kinase cAMP-act…
  4. 0.594
  5. Metabolic
- 2. MRRF
  3. mitochondrial ribosome …
  4. 0.563
  5. Complex
- 2. TOMM22
  3. translocase of outer mi…
  4. 0.540
  5. Complex
- 2. RAB7A
  3. RAB7A, member RAS oncog…
  4. 0.516
  5. Metabolic
- 2. HSP90AB1
  3. heat shock protein 90 a…
  4. 0.492
  5. Metabolic
- 2. SRPK1
  3. SRSF protein kinase 1
  4. 0.492
  5. Metabolic
- 2. ARX
  3. aristaless related home…
  4. 0.432
  5. PPI
- 2. DNAJC7
  3. DnaJ heat shock protein…
  4. 0.431
  5. Metabolic
- 2. USP13
  3. ubiquitin specific pept…
  4. 0.427
  5. Metabolic
- 2. HECTD1
  3. HECT domain E3 ubiquiti…
  4. 0.418
  5. Metabolic
- 2. GSK3B
  3. glycogen synthase kinas…
  4. 0.409
  5. Metabolic

Subnetwork gene interactions

ENSG00000198648

serine/threonine kinase 39

FunCoup

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Ensembl

ENSG00000198648

UniProt

Q9UEW8

NCBI

27347

PRKACB

protein kinase cAMP-activated catalytic subunit beta

FunCoup

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Ensembl

ENSG00000142875

UniProt

NCBI

5567

HSP90AB1

heat shock protein 90 alpha family class B member 1

FunCoup

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Ensembl

ENSG00000096384

UniProt

P08238

NCBI

3326

MAPK14

mitogen-activated protein kinase 14

FunCoup

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Ensembl

ENSG00000112062

UniProt

NCBI

1432

PIK3C2A

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

FunCoup

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Ensembl

ENSG00000011405

UniProt

NCBI

5286

SRPK1

SRSF protein kinase 1

FunCoup

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Ensembl

ENSG00000096063

UniProt

NCBI

6732

SLC12A2

solute carrier family 12 member 2

FunCoup

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Ensembl

ENSG00000064651

UniProt

NCBI

6558

CLTA

clathrin light chain A

FunCoup

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Ensembl

ENSG00000122705

UniProt

NCBI

1211

TOMM22

translocase of outer mitochondrial membrane 22

FunCoup

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Ensembl

ENSG00000100216

UniProt

Q9NS69

NCBI

56993

CYFIP1

cytoplasmic FMR1 interacting protein 1

FunCoup

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Ensembl

ENSG00000273749

UniProt

NCBI

23191

CLTB

clathrin light chain B

FunCoup

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Ensembl

ENSG00000175416

UniProt

NCBI

1212

UBE2V2

ubiquitin conjugating enzyme E2 V2

FunCoup

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Ensembl

ENSG00000169139

UniProt

NCBI

7336

GSN

gelsolin

FunCoup

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Ensembl

ENSG00000148180

UniProt

NCBI

2934

RAB7A

RAB7A, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000075785

UniProt

NCBI

7879

RHOA

ras homolog family member A

FunCoup

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Ensembl

ENSG00000067560

UniProt

NCBI

USP13

ubiquitin specific peptidase 13

FunCoup

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Ensembl

ENSG00000058056

UniProt

NCBI

8975

AP2A1

adaptor related protein complex 2 subunit alpha 1

FunCoup

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Ensembl

ENSG00000196961

UniProt

NCBI

CAB39

calcium binding protein 39

FunCoup

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Ensembl

ENSG00000135932

UniProt

NCBI

51719

DNAJC7

DnaJ heat shock protein family (Hsp40) member C7

FunCoup

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Ensembl

ENSG00000168259

UniProt

NCBI

7266

GSK3B

glycogen synthase kinase 3 beta

FunCoup

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Ensembl

ENSG00000082701

UniProt

NCBI

2932

ARX

aristaless related homeobox

FunCoup

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Ensembl

ENSG00000004848

UniProt

NCBI

170302

KLC2

kinesin light chain 2

FunCoup

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Ensembl

ENSG00000174996

UniProt

NCBI

64837

MIGA1

mitoguardin 1

FunCoup

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Ensembl

ENSG00000180488

UniProt

NCBI

374986

MRRF

mitochondrial ribosome recycling factor

FunCoup

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Ensembl

ENSG00000148187

UniProt

NCBI

92399

HSPH1

heat shock protein family H (Hsp110) member 1

FunCoup

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Ensembl

ENSG00000120694

UniProt

NCBI

10808

CLTC

clathrin heavy chain

FunCoup

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Ensembl

ENSG00000141367

UniProt

NCBI

1213

FUBP3

far upstream element binding protein 3

FunCoup

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Ensembl

ENSG00000107164

UniProt

NCBI

8939

PPP5C

protein phosphatase 5 catalytic subunit

FunCoup

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Ensembl

ENSG00000011485

UniProt

NCBI

5536

RELL2

RELT like 2

FunCoup

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Ensembl

ENSG00000164620

UniProt

NCBI

285613

SEC16A

SEC16 homolog A, endoplasmic reticulum export factor

FunCoup

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Ensembl

ENSG00000148396

UniProt

NCBI

9919

HECTD1

HECT domain E3 ubiquitin protein ligase 1

FunCoup

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Ensembl

ENSG00000092148

UniProt

NCBI

25831

Query genes

		Identifier	Description
30	ENSG00000198648	ENSG00000198648	serine/threonine kinase 39
		UniProt	Q9UEW8
		NCBI	27347

Subnetwork genes

		Identifier	Description
7	PRKACB	ENSG00000142875	protein kinase cAMP-activated catalytic subunit beta
		UniProt	A0A087WVC4 A0A0A0MS54 B1APF7 B1APF8 B1APF9 B1APG0 B1APG1 B1APG2 B1APG3 P22694
		NCBI	5567
		KEGG signaling	Thyroid hormone signaling pathway Hedgehog signaling pathway Calcium signaling pathway Adrenergic signaling in cardiomyocytes Chemokine signaling pathway Taste transduction Long-term potentiation Olfactory transduction cAMP signaling pathway Gap junction Dopaminergic synapse Relaxin signaling pathway GABAergic synapse Serotonergic synapse Cholinergic synapse Glutamatergic synapse Glucagon signaling pathway Oxytocin signaling pathway Retrograde endocannabinoid signaling MAPK signaling pathway Apelin signaling pathway Vascular smooth muscle contraction Oocyte meiosis Ras signaling pathway Tight junction Wnt signaling pathway Melanogenesis Estrogen signaling pathway Progesterone-mediated oocyte maturation GnRH signaling pathway Insulin signaling pathway
		KEGG metabolic	Autophagy - animal
17	HSP90AB1	ENSG00000096384	heat shock protein 90 alpha family class B member 1
		UniProt	P08238
		NCBI	3326
		KEGG signaling	Antigen processing and presentation NOD-like receptor signaling pathway PI3K-Akt signaling pathway Estrogen signaling pathway Progesterone-mediated oocyte maturation IL-17 signaling pathway
		KEGG metabolic	Protein processing in endoplasmic reticulum
10	MAPK14	ENSG00000112062	mitogen-activated protein kinase 14
		UniProt	B4E0K5 B5TY33 E7EX54 H7C4E2 Q16539
		NCBI	1432
		KEGG signaling	MAPK signaling pathway Leukocyte transendothelial migration Adrenergic signaling in cardiomyocytes VEGF signaling pathway Sphingolipid signaling pathway Neurotrophin signaling pathway RIG-I-like receptor signaling pathway NOD-like receptor signaling pathway Fc epsilon RI signaling pathway Oocyte meiosis Rap1 signaling pathway Toll-like receptor signaling pathway FoxO signaling pathway T cell receptor signaling pathway Prolactin signaling pathway Dopaminergic synapse Relaxin signaling pathway Progesterone-mediated oocyte maturation GnRH signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway IL-17 signaling pathway Retrograde endocannabinoid signaling
12	PIK3C2A	ENSG00000011405	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
		UniProt	A0A0C4DGF9 E9PPP3 O00443
		NCBI	5286
		KEGG signaling	Phosphatidylinositol signaling system
		KEGG metabolic	Inositol phosphate metabolism
13	SRPK1	ENSG00000096063	SRSF protein kinase 1
		UniProt	D6RB98 D6RBF8 D6RBM8 D6RDZ3 H0Y932 H3BLV9 Q96SB4
		NCBI	6732
5	SLC12A2	ENSG00000064651	solute carrier family 12 member 2
		UniProt	G3XAL9 P55011
		NCBI	6558
15	CLTA	ENSG00000122705	clathrin light chain A
		UniProt	C9J8P9 F8WF69 P09496 S4R3F6
		NCBI	1211
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Endocytosis Lysosome
6	TOMM22	ENSG00000100216	translocase of outer mitochondrial membrane 22
		UniProt	Q9NS69
		NCBI	56993
15	CYFIP1	ENSG00000273749	cytoplasmic FMR1 interacting protein 1
		UniProt	A0A087WU52 A0A087WVZ5 A0A087WWL1 A0A087WWY5 A0A087WZ89 H0YL50 Q7L576
		NCBI	23191
		KEGG metabolic	RNA transport
15	CLTB	ENSG00000175416	clathrin light chain B
		UniProt	B4DTF9 D6RJD1 H0Y9Q6 P09497
		NCBI	1212
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Endocytosis Lysosome
13	UBE2V2	ENSG00000169139	ubiquitin conjugating enzyme E2 V2
		UniProt	E5RIF1 G3V113 H0YBP9 H0YBX6 Q15819
		NCBI	7336
4	GSN	ENSG00000148180	gelsolin
		UniProt	A0A0A0MS51 A0A0A0MT01 A0A0U1RQL8 P06396 Q5T0H8 Q5T0I0
		NCBI	2934
		KEGG signaling	Fc gamma R-mediated phagocytosis
17	RAB7A	ENSG00000075785	RAB7A, member RAS oncogene family
		UniProt	C9IZZ0 C9J4S4 C9J4V0 C9J592 C9J7D1 C9J8S3 P51149
		NCBI	7879
		KEGG metabolic	Phagosome Endocytosis Autophagy - animal
13	RHOA	ENSG00000067560	ras homolog family member A
		UniProt	C9JNR4 C9JRM1 C9JX21 P61586
		NCBI	387
		KEGG signaling	Leukocyte transendothelial migration TGF-beta signaling pathway mTOR signaling pathway Chemokine signaling pathway Vascular smooth muscle contraction Phospholipase D signaling pathway Sphingolipid signaling pathway Neurotrophin signaling pathway NOD-like receptor signaling pathway Focal adhesion Rap1 signaling pathway Ras signaling pathway Adherens junction Tight junction Wnt signaling pathway cAMP signaling pathway T cell receptor signaling pathway cGMP-PKG signaling pathway C-type lectin receptor signaling pathway Oxytocin signaling pathway
		KEGG metabolic	Endocytosis
6	USP13	ENSG00000058056	ubiquitin specific peptidase 13
		UniProt	H7C502 H7C5J3 Q92995
		NCBI	8975
13	AP2A1	ENSG00000196961	adaptor related protein complex 2 subunit alpha 1
		UniProt	M0R2D9 O95782
		NCBI	160
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Endocytosis
8	CAB39	ENSG00000135932	calcium binding protein 39
		UniProt	A0A087X0K1 Q9Y376
		NCBI	51719
		KEGG signaling	AMPK signaling pathway mTOR signaling pathway
10	DNAJC7	ENSG00000168259	DnaJ heat shock protein family (Hsp40) member C7
		UniProt	K7EIH8 K7EJ24 K7EJE9 K7EJL5 K7EJV7 K7EK03 K7ELJ8 K7EN19 K7ENB7 K7EPP7 K7EQ73 K7ER44 K7ESP1 Q99615
		NCBI	7266
14	GSK3B	ENSG00000082701	glycogen synthase kinase 3 beta
		UniProt	A0A3B3ITW1 P49841
		NCBI	2932
		KEGG signaling	Thyroid hormone signaling pathway Hedgehog signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway mTOR signaling pathway Hippo signaling pathway Neurotrophin signaling pathway Focal adhesion Wnt signaling pathway B cell receptor signaling pathway ErbB signaling pathway Cell cycle T cell receptor signaling pathway Prolactin signaling pathway Melanogenesis Dopaminergic synapse IL-17 signaling pathway Insulin signaling pathway
5	ARX	ENSG00000004848	aristaless related homeobox
		UniProt	A0A1B0GUI3 Q96QS3
		NCBI	170302
13	KLC2	ENSG00000174996	kinesin light chain 2
		UniProt	A8MX29 A8MZ87 C9JHT2 E9PI24 E9PM83 E9PP09 E9PQ02 Q9H0B6
		NCBI	64837
10	MIGA1	ENSG00000180488	mitoguardin 1
		UniProt	A0A2R8YDC7 A0A2R8YE40 A0A2R8YF99 A0A2R8YFQ8 A0A2R8YGK2 F8W7S1 Q8NAN2
		NCBI	374986
12	MRRF	ENSG00000148187	mitochondrial ribosome recycling factor
		UniProt	Q96E11 X6RDS5
		NCBI	92399
14	HSPH1	ENSG00000120694	heat shock protein family H (Hsp110) member 1
		UniProt	A0A0A0MSM0 Q5TBM3 Q92598 R4GN69
		NCBI	10808
		KEGG metabolic	Protein processing in endoplasmic reticulum
26	CLTC	ENSG00000141367	clathrin heavy chain
		UniProt	A0A087WVQ6 J3KRF5 J3KS13 J3KSQ2 J3KTN1 J3QL20 K7EJJ5 Q00610
		NCBI	1213
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Endocytosis Lysosome
6	FUBP3	ENSG00000107164	far upstream element binding protein 3
		UniProt	A0A494C1K6 Q96I24
		NCBI	8939
11	PPP5C	ENSG00000011485	protein phosphatase 5 catalytic subunit
		UniProt	A8MU39 H0YDU8 P53041
		NCBI	5536
		KEGG signaling	MAPK signaling pathway
1	RELL2	ENSG00000164620	RELT like 2
		UniProt	E5RFS6 E5RHA7 Q8NC24
		NCBI	285613
15	SEC16A	ENSG00000148396	SEC16 homolog A, endoplasmic reticulum export factor
		UniProt	A0A0C4DH09 A0A3F2YNX0 A0A3F2YNZ0 F1T0I1 O15027 Q8N9G1 X6RGP5
		NCBI	9919
4	HECTD1	ENSG00000092148	HECT domain E3 ubiquitin protein ligase 1
		UniProt	A0A087WVU6 A0A087X2H1 G3V4V5 H0YJ72 H0YJD4 H0YJP0 H0YJV8 Q9ULT8
		NCBI	25831

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	277.29 KB
	H.sapiens_subnetwork.tsv	31.62 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000198648

PRKACB

HSP90AB1

MAPK14

PIK3C2A

SRPK1

SLC12A2

CLTA

TOMM22

CYFIP1

CLTB

UBE2V2

GSN

RAB7A

RHOA

USP13

AP2A1

CAB39

DNAJC7

GSK3B

ARX

KLC2

MIGA1

MRRF

HSPH1

CLTC

FUBP3

PPP5C

RELL2

SEC16A

HECTD1

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