Found 1 of 1 query genes

Network information:

Filter Results:

Evidence Source:
Filter by Tissue:

Select multiple tissues by holding down shift or ctrl.
Filter by Pathway:

Network appearance:

Label Type:
Node Size:
Charge:
Link distance:
Min confidence:

Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000196735
3. major histocompatibilit…
- 2. CD74
  3. CD74 molecule
  4. 1.000
  5. PPI
- 2. HLA-DRB1
  3. major histocompatibilit…
  4. 0.999
  5. PPI
- 2. HLA-DRB5
  3. major histocompatibilit…
  4. 0.996
  5. Metabolic
- 2. HLA-DPB1
  3. major histocompatibilit…
  4. 0.989
  5. Metabolic
- 2. HLA-B
  3. major histocompatibilit…
  4. 0.984
  5. Metabolic
- 2. SLC38A9
  3. solute carrier family 3…
  4. 0.984
  5. PPI
- 2. HLA-DMA
  3. major histocompatibilit…
  4. 0.977
  5. Metabolic
- 2. HLA-DMB
  3. major histocompatibilit…
  4. 0.976
  5. Metabolic
- 2. B2M
  3. beta-2-microglobulin
  4. 0.969
  5. Complex
- 2. HLA-C
  3. major histocompatibilit…
  4. 0.945
  5. Metabolic
- 2. HLA-DQB1
  3. major histocompatibilit…
  4. 0.943
  5. Metabolic
- 2. PLD4
  3. phospholipase D family …
  4. 0.940
  5. PPI
- 2. CYBB
  3. cytochrome b-245 beta c…
  4. 0.939
  5. Metabolic
- 2. HLA-DQB2
  3. major histocompatibilit…
  4. 0.929
  5. Metabolic
- 2. FCER1G
  3. Fc fragment of IgE rece…
  4. 0.917
  5. PPI
- 2. ITGB2
  3. integrin subunit beta 2
  4. 0.914
  5. Metabolic
- 2. HLA-A
  3. major histocompatibilit…
  4. 0.904
  5. Complex
- 2. HLA-E
  3. major histocompatibilit…
  4. 0.888
  5. Complex
- 2. HLA-F
  3. major histocompatibilit…
  4. 0.876
  5. Complex
- 2. CD14
  3. CD14 molecule
  4. 0.837
  5. Metabolic
- 2. CORO1A
  3. coronin 1A
  4. 0.827
  5. Complex
- 2. GIMAP5
  3. GTPase, IMAP family mem…
  4. 0.811
  5. Metabolic
- 2. ENSG00000250264
  3. novel protein, TAP2-HLA…
  4. 0.802
  5. PPI
- 2. TAP2
  3. transporter 2, ATP bind…
  4. 0.779
  5. Metabolic
- 2. CD68
  3. CD68 molecule
  4. 0.772
  5. Complex
- 2. TMBIM1
  3. transmembrane BAX inhib…
  4. 0.765
  5. Metabolic
- 2. SLC11A1
  3. solute carrier family 1…
  4. 0.757
  5. PPI
- 2. HLA-G
  3. major histocompatibilit…
  4. 0.753
  5. Complex
- 2. ATP6V0A2
  3. ATPase H+ transporting …
  4. 0.749
  5. PPI
- 2. RAC2
  3. Rac family small GTPase…
  4. 0.747
  5. Metabolic

Subnetwork gene interactions

ENSG00000196735

major histocompatibility complex, class II, DQ alpha 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000196735

UniProt

NCBI

3117

HLA-A

major histocompatibility complex, class I, A

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000206503

UniProt

NCBI

3105

FCER1G

Fc fragment of IgE receptor Ig

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000158869

UniProt

NCBI

2207

CD74

CD74 molecule

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000019582

UniProt

NCBI

B2M

beta-2-microglobulin

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000166710

UniProt

NCBI

HLA-DRB1

major histocompatibility complex, class II, DR beta 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000196126

UniProt

P01911

NCBI

3123

HLA-DPB1

major histocompatibility complex, class II, DP beta 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000223865

UniProt

NCBI

3115

CORO1A

coronin 1A

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000102879

UniProt

NCBI

11151

HLA-DMA

major histocompatibility complex, class II, DM alpha

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000204257

UniProt

NCBI

HLA-C

major histocompatibility complex, class I, C

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000204525

UniProt

NCBI

3107

HLA-DMB

major histocompatibility complex, class II, DM beta

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000242574

UniProt

NCBI

3109

GIMAP5

GTPase, IMAP family member 5

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000196329

UniProt

Q96F15

NCBI

55340

CD68

CD68 molecule

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000129226

UniProt

NCBI

ITGB2

integrin subunit beta 2

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000160255

UniProt

NCBI

3689

CYBB

cytochrome b-245 beta chain

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000165168

UniProt

P04839

NCBI

1536

CD14

CD14 molecule

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000170458

UniProt

NCBI

PLD4

phospholipase D family member 4

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000166428

UniProt

NCBI

122618

HLA-F

major histocompatibility complex, class I, F

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000204642

UniProt

NCBI

3134

HLA-E

major histocompatibility complex, class I, E

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000204592

UniProt

P13747

NCBI

3133

RAC2

Rac family small GTPase 2

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000128340

UniProt

NCBI

5880

ENSG00000250264

novel protein, TAP2-HLA-DOB readthrough

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000250264

UniProt

E7ENX8

NCBI

HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000179344

UniProt

NCBI

3119

TAP2

transporter 2, ATP binding cassette subfamily B member

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000204267

UniProt

NCBI

6891

SLC38A9

solute carrier family 38 member 9

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000177058

UniProt

NCBI

153129

ATP6V0A2

ATPase H+ transporting V0 subunit a2

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000185344

UniProt

NCBI

23545

HLA-B

major histocompatibility complex, class I, B

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000234745

UniProt

NCBI

3106

SLC11A1

solute carrier family 11 member 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000018280

UniProt

NCBI

6556

HLA-DRB5

major histocompatibility complex, class II, DR beta 5

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000198502

UniProt

Q30154

NCBI

3127

HLA-DQB2

major histocompatibility complex, class II, DQ beta 2

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000232629

UniProt

NCBI

3120

HLA-G

major histocompatibility complex, class I, G

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000204632

UniProt

NCBI

3135

TMBIM1

transmembrane BAX inhibitor motif containing 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000135926

UniProt

NCBI

64114

Query genes

		Identifier	Description
30	ENSG00000196735	ENSG00000196735	major histocompatibility complex, class II, DQ alpha 1
		UniProt	E9PI37 E9PMV2 F6UB03 P01909
		NCBI	3117
		KEGG signaling	Antigen processing and presentation Hematopoietic cell lineage Intestinal immune network for IgA production Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome

Subnetwork genes

		Identifier	Description
21	HLA-A	ENSG00000206503	major histocompatibility complex, class I, A
		UniProt	A0A1W2PS24 P04439 Q5SRN5 Q5SRN7
		NCBI	3105
		KEGG signaling	Antigen processing and presentation Natural killer cell mediated cytotoxicity Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome Endocytosis
23	FCER1G	ENSG00000158869	Fc fragment of IgE receptor Ig
		UniProt	A6NCQ8 P30273
		NCBI	2207
		KEGG signaling	Fc epsilon RI signaling pathway Natural killer cell mediated cytotoxicity Phospholipase D signaling pathway Sphingolipid signaling pathway C-type lectin receptor signaling pathway
28	CD74	ENSG00000019582	CD74 molecule
		UniProt	E7EQJ3 E7ER71 E7ESL3 H0YBZ2 H0YBZ8 P04233
		NCBI	972
		KEGG signaling	Antigen processing and presentation
27	B2M	ENSG00000166710	beta-2-microglobulin
		UniProt	F5H6I0 H0YLF3 J3KNU0 P61769 Q16446
		NCBI	567
		KEGG signaling	Antigen processing and presentation
26	HLA-DRB1	ENSG00000196126	major histocompatibility complex, class II, DR beta 1
		UniProt	P01911
		NCBI	3123
19	HLA-DPB1	ENSG00000223865	major histocompatibility complex, class II, DP beta 1
		UniProt	H0Y5P2 H0Y7G7 P04440
		NCBI	3115
		KEGG signaling	Antigen processing and presentation Hematopoietic cell lineage Intestinal immune network for IgA production Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome
25	CORO1A	ENSG00000102879	coronin 1A
		UniProt	H3BNA2 H3BRJ0 H3BRY3 H3BSL1 H3BTU6 H3BU76 P31146
		NCBI	11151
		KEGG metabolic	Phagosome
27	HLA-DMA	ENSG00000204257	major histocompatibility complex, class II, DM alpha
		UniProt	A2AAT8 F6S093 H0Y732 P28067 Q5SP00
26	HLA-C	ENSG00000204525	major histocompatibility complex, class I, C
		UniProt	A0A140T9E1 A0A1W2PRU9 A2AEA2 F8W9Z8 P10321
		NCBI	3107
		KEGG signaling	Antigen processing and presentation Natural killer cell mediated cytotoxicity Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome Endocytosis
25	HLA-DMB	ENSG00000242574	major histocompatibility complex, class II, DM beta
		UniProt	H0Y4B8 H0Y7A2 P28068
		NCBI	3109
		KEGG signaling	Antigen processing and presentation Hematopoietic cell lineage Intestinal immune network for IgA production Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome
15	GIMAP5	ENSG00000196329	GTPase, IMAP family member 5
		UniProt	Q96F15
		NCBI	55340
17	CD68	ENSG00000129226	CD68 molecule
		UniProt	J3KRX0 J3KT24 P34810
		NCBI	968
		KEGG metabolic	Lysosome
23	ITGB2	ENSG00000160255	integrin subunit beta 2
		UniProt	A0A494C0X7 A8MVG7 D3DSM0 E5RFI0 E5RGK9 E5RHE6 E5RHT0 E5RIE4 E5RIG7 E5RK25 E5RK54 E7EVZ9 J3KNI6 P05107
		NCBI	3689
		KEGG signaling	Complement and coagulation cascades Rap1 signaling pathway Natural killer cell mediated cytotoxicity Leukocyte transendothelial migration Hippo signaling pathway Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome
22	CYBB	ENSG00000165168	cytochrome b-245 beta chain
		UniProt	P04839
		NCBI	1536
		KEGG signaling	NOD-like receptor signaling pathway HIF-1 signaling pathway Leukocyte transendothelial migration
		KEGG metabolic	Phagosome
17	CD14	ENSG00000170458	CD14 molecule
		UniProt	D6RD81 D6RFL4 E7EVL5 P08571
		NCBI	929
		KEGG signaling	Toll-like receptor signaling pathway Hematopoietic cell lineage MAPK signaling pathway NF-kappa B signaling pathway
		KEGG metabolic	Phagosome
18	PLD4	ENSG00000166428	phospholipase D family member 4
		UniProt	A0A3B3IT68 F5H2B5 G3V3J8 G3V472 Q96BZ4
		NCBI	122618
		KEGG metabolic	Ether lipid metabolism Glycerophospholipid metabolism
24	HLA-F	ENSG00000204642	major histocompatibility complex, class I, F
		UniProt	A0A0D9SF55 A0A0D9SFW8 H0Y4J4 P30511
		NCBI	3134
		KEGG signaling	Antigen processing and presentation Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome Endocytosis
22	HLA-E	ENSG00000204592	major histocompatibility complex, class I, E
		UniProt	P13747
		NCBI	3133
		KEGG signaling	Antigen processing and presentation Natural killer cell mediated cytotoxicity Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome Endocytosis
24	RAC2	ENSG00000128340	Rac family small GTPase 2
		UniProt	B1AH77 B1AH78 B1AH79 B1AH80 P15153
		NCBI	5880
		KEGG signaling	Leukocyte transendothelial migration MAPK signaling pathway VEGF signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Fc gamma R-mediated phagocytosis Fc epsilon RI signaling pathway Focal adhesion Rap1 signaling pathway Adherens junction Ras signaling pathway cAMP signaling pathway Wnt signaling pathway B cell receptor signaling pathway Natural killer cell mediated cytotoxicity
14	ENSG00000250264	ENSG00000250264	novel protein, TAP2-HLA-DOB readthrough
		UniProt	E7ENX8
16	HLA-DQB1	ENSG00000179344	major histocompatibility complex, class II, DQ beta 1
		UniProt	A2AAY8 A2AAZ0 E9PIB1 Q5SU54 Q5Y7D6
		NCBI	3119
18	TAP2	ENSG00000204267	transporter 2, ATP binding cassette subfamily B member
		UniProt	A0A087WYD6 Q03519
		NCBI	6891
		KEGG signaling	Antigen processing and presentation
		KEGG metabolic	Phagosome ABC transporters
3	SLC38A9	ENSG00000177058	solute carrier family 38 member 9
		UniProt	B3KVK8 D6R9Q7 D6R9X0 D6RBB9 D6RDH2 D6RE72 D6RER8 D6RG31 D6RHF5 D6RHW0 D6RIW7 E7ESU6 Q8NBW4
		NCBI	153129
		KEGG signaling	mTOR signaling pathway
3	ATP6V0A2	ENSG00000185344	ATPase H+ transporting V0 subunit a2
		UniProt	F5GX48 F5H5F3 F5H847 Q8TBM3 Q9Y487
		NCBI	23545
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Oxidative phosphorylation Phagosome Lysosome
27	HLA-B	ENSG00000234745	major histocompatibility complex, class I, B
		UniProt	A0A1W2PP29 A0A1W2PPR8 A0A1W2PQE2 F6U0H7 P01889
		NCBI	3106
		KEGG signaling	Antigen processing and presentation Natural killer cell mediated cytotoxicity Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome Endocytosis
22	SLC11A1	ENSG00000018280	solute carrier family 11 member 1
		UniProt	A0A087X181 A0A087X2D6 A0A0A0MTL3 P49279 Q9HBK0
		NCBI	6556
		KEGG metabolic	Lysosome
26	HLA-DRB5	ENSG00000198502	major histocompatibility complex, class II, DR beta 5
		UniProt	Q30154
		NCBI	3127
		KEGG signaling	Antigen processing and presentation Hematopoietic cell lineage Intestinal immune network for IgA production Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome
22	HLA-DQB2	ENSG00000232629	major histocompatibility complex, class II, DQ beta 2
		UniProt	A2ADX3 H0Y7Y7 P05538 Q5SR05
		NCBI	3120
19	HLA-G	ENSG00000204632	major histocompatibility complex, class I, G
		UniProt	P17693 Q31611 Q5RJ85
		NCBI	3135
		KEGG signaling	Antigen processing and presentation Natural killer cell mediated cytotoxicity Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome Endocytosis
15	TMBIM1	ENSG00000135926	transmembrane BAX inhibitor motif containing 1
		UniProt	A0A1D5RMQ2 B3KSM0 B4DUD2 C9IYT2 C9IZ27 C9JAK9 C9JAP5 C9JDV0 C9JEN3 C9JI44 C9JM62 C9JN47 C9JW19 C9JWV9 F8WDY4 Q969X1
		NCBI	64114

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

To use PathwAX, first use the button below to copy the subnetwork genes and then paste them in PathwAX

Copied subnetwork genes to clipboard

Use as query
Add to current query

	jSquid_subnetworks.xml	256.09 KB
	H.sapiens_subnetwork.tsv	49.26 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000196735

HLA-A

FCER1G

CD74

B2M

HLA-DRB1

HLA-DPB1

CORO1A

HLA-DMA

HLA-C

HLA-DMB

GIMAP5

CD68

ITGB2

CYBB

CD14

PLD4

HLA-F

HLA-E

RAC2

ENSG00000250264

HLA-DQB1

TAP2

SLC38A9

ATP6V0A2

HLA-B

SLC11A1

HLA-DRB5

HLA-DQB2

HLA-G

TMBIM1

JavaScript is required.