Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000196139
3. aldo-keto reductase fam…
- 2. AKR1C1
  3. aldo-keto reductase fam…
  4. 1.000
  5. Complex
- 2. AKR1C4
  3. aldo-keto reductase fam…
  4. 1.000
  5. Complex
- 2. DARS1
  3. aspartyl-tRNA synthetas…
  4. 0.996
  5. Complex
- 2. SOD1
  3. superoxide dismutase 1
  4. 0.988
  5. Metabolic
- 2. ALDH2
  3. aldehyde dehydrogenase …
  4. 0.978
  5. Metabolic
- 2. ENO1
  3. enolase 1
  4. 0.978
  5. Metabolic
- 2. GPI
  3. glucose-6-phosphate iso…
  4. 0.974
  5. Metabolic
- 2. YWHAE
  3. tyrosine 3-monooxygenas…
  4. 0.971
  5. Metabolic
- 2. AHCY
  3. adenosylhomocysteinase
  4. 0.969
  5. Metabolic
- 2. CS
  3. citrate synthase
  4. 0.966
  5. Metabolic
- 2. GAPDH
  3. glyceraldehyde-3-phosph…
  4. 0.956
  5. Metabolic
- 2. GRHPR
  3. glyoxylate and hydroxyp…
  4. 0.954
  5. Metabolic
- 2. NIT2
  3. nitrilase family member…
  4. 0.944
  5. Metabolic
- 2. AKR1A1
  3. aldo-keto reductase fam…
  4. 0.943
  5. Complex
- 2. VCP
  3. valosin containing prot…
  4. 0.939
  5. Metabolic
- 2. ALDH1A1
  3. aldehyde dehydrogenase …
  4. 0.936
  5. Metabolic
- 2. ALDH18A1
  3. aldehyde dehydrogenase …
  4. 0.933
  5. Metabolic
- 2. PGD
  3. phosphogluconate dehydr…
  4. 0.931
  5. Metabolic
- 2. UGP2
  3. UDP-glucose pyrophospho…
  4. 0.928
  5. Metabolic
- 2. PSMD2
  3. proteasome 26S subunit,…
  4. 0.920
  5. Metabolic
- 2. IARS1
  3. isoleucyl-tRNA syntheta…
  4. 0.918
  5. Metabolic
- 2. AKR1B1
  3. aldo-keto reductase fam…
  4. 0.903
  5. Metabolic
- 2. PYGL
  3. glycogen phosphorylase L
  4. 0.901
  5. Metabolic
- 2. ADH5
  3. alcohol dehydrogenase 5…
  4. 0.895
  5. Metabolic
- 2. HSPD1
  3. heat shock protein fami…
  4. 0.888
  5. Metabolic
- 2. PKM
  3. pyruvate kinase M1/2
  4. 0.888
  5. Metabolic
- 2. G6PD
  3. glucose-6-phosphate deh…
  4. 0.888
  5. Metabolic
- 2. MIF
  3. macrophage migration in…
  4. 0.880
  5. Metabolic
- 2. ALDH1A3
  3. aldehyde dehydrogenase …
  4. 0.878
  5. Metabolic
- 2. ACAT1
  3. acetyl-CoA acetyltransf…
  4. 0.876
  5. Metabolic

Subnetwork gene interactions

ENSG00000196139

aldo-keto reductase family 1 member C3

FunCoup

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Ensembl

ENSG00000196139

UniProt

NCBI

8644

GPI

glucose-6-phosphate isomerase

FunCoup

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Ensembl

ENSG00000105220

UniProt

NCBI

2821

YWHAE

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

FunCoup

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Ensembl

ENSG00000108953

UniProt

NCBI

7531

ADH5

alcohol dehydrogenase 5 (class III), chi polypeptide

FunCoup

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Ensembl

ENSG00000197894

UniProt

NCBI

NIT2

nitrilase family member 2

FunCoup

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Ensembl

ENSG00000114021

UniProt

NCBI

56954

PKM

pyruvate kinase M1/2

FunCoup

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Ensembl

ENSG00000067225

UniProt

NCBI

5315

PYGL

glycogen phosphorylase L

FunCoup

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Ensembl

ENSG00000100504

UniProt

NCBI

5836

VCP

valosin containing protein

FunCoup

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Ensembl

ENSG00000165280

UniProt

NCBI

7415

AKR1A1

aldo-keto reductase family 1 member A1

FunCoup

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Ensembl

ENSG00000117448

UniProt

NCBI

10327

GRHPR

glyoxylate and hydroxypyruvate reductase

FunCoup

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Ensembl

ENSG00000137106

UniProt

NCBI

9380

UGP2

UDP-glucose pyrophosphorylase 2

FunCoup

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Ensembl

ENSG00000169764

UniProt

NCBI

7360

IARS1

isoleucyl-tRNA synthetase 1

FunCoup

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Ensembl

ENSG00000196305

UniProt

NCBI

3376

ACAT1

acetyl-CoA acetyltransferase 1

FunCoup

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Ensembl

ENSG00000075239

UniProt

NCBI

SOD1

superoxide dismutase 1

FunCoup

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Ensembl

ENSG00000142168

UniProt

NCBI

6647

PGD

phosphogluconate dehydrogenase

FunCoup

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Ensembl

ENSG00000142657

UniProt

NCBI

5226

CS

citrate synthase

FunCoup

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Ensembl

ENSG00000062485

UniProt

NCBI

1431

PSMD2

proteasome 26S subunit, non-ATPase 2

FunCoup

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Ensembl

ENSG00000175166

UniProt

NCBI

5708

HSPD1

heat shock protein family D (Hsp60) member 1

FunCoup

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Ensembl

ENSG00000144381

UniProt

NCBI

3329

AKR1C1

aldo-keto reductase family 1 member C1

FunCoup

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Ensembl

ENSG00000187134

UniProt

NCBI

1645

ALDH1A3

aldehyde dehydrogenase 1 family member A3

FunCoup

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Ensembl

ENSG00000184254

UniProt

NCBI

ALDH2

aldehyde dehydrogenase 2 family member

FunCoup

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Ensembl

ENSG00000111275

UniProt

NCBI

GAPDH

glyceraldehyde-3-phosphate dehydrogenase

FunCoup

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Ensembl

ENSG00000111640

UniProt

NCBI

2597

G6PD

glucose-6-phosphate dehydrogenase

FunCoup

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Ensembl

ENSG00000160211

UniProt

NCBI

2539

ALDH1A1

aldehyde dehydrogenase 1 family member A1

FunCoup

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Ensembl

ENSG00000165092

UniProt

NCBI

ENO1

enolase 1

FunCoup

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Ensembl

ENSG00000074800

UniProt

NCBI

2023

DARS1

aspartyl-tRNA synthetase 1

FunCoup

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Ensembl

ENSG00000115866

UniProt

NCBI

1615

AKR1C4

aldo-keto reductase family 1 member C4

FunCoup

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Ensembl

ENSG00000198610

UniProt

P17516

NCBI

1109

AHCY

adenosylhomocysteinase

FunCoup

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Ensembl

ENSG00000101444

UniProt

P23526

NCBI

MIF

macrophage migration inhibitory factor

FunCoup

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Ensembl

ENSG00000240972

UniProt

P14174

NCBI

4282

AKR1B1

aldo-keto reductase family 1 member B

FunCoup

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Ensembl

ENSG00000085662

UniProt

NCBI

ALDH18A1

aldehyde dehydrogenase 18 family member A1

FunCoup

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Ensembl

ENSG00000059573

UniProt

P54886

NCBI

5832

Query genes

		Identifier	Description
30	ENSG00000196139	ENSG00000196139	aldo-keto reductase family 1 member C3
		UniProt	A0A0A0MSS8 P42330 S4R3D5 S4R3Z2
		NCBI	8644
		KEGG metabolic	Steroid hormone biosynthesis Arachidonic acid metabolism Folate biosynthesis

Subnetwork genes

		Identifier	Description
30	GPI	ENSG00000105220	glucose-6-phosphate isomerase
		UniProt	A0A0G2JLI6 A0A2R8Y6C7 A0A2R8YF08 A0A2U3TZU2 K7EIL4 K7ELR7 K7ENA0 K7EP41 K7EPY4 K7EQ48 K7ERC6 K7ERK8 P06744
		NCBI	2821
		KEGG metabolic	Starch and sucrose metabolism Pentose phosphate pathway Glycolysis / Gluconeogenesis Carbon metabolism Amino sugar and nucleotide sugar metabolism
29	YWHAE	ENSG00000108953	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
		UniProt	B4DJF2 I3L0W5 I3L3T1 K7EIT4 K7EM20 P62258
		NCBI	7531
		KEGG signaling	Neurotrophin signaling pathway NOD-like receptor signaling pathway Oocyte meiosis Cell cycle PI3K-Akt signaling pathway Hippo signaling pathway
29	ADH5	ENSG00000197894	alcohol dehydrogenase 5 (class III), chi polypeptide
		UniProt	D6R9G2 D6RAY0 D6RFE4 H0YAG8 P11766
		NCBI	128
		KEGG metabolic	Retinol metabolism Fatty acid degradation Glycolysis / Gluconeogenesis Tyrosine metabolism Carbon metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450
28	NIT2	ENSG00000114021	nitrilase family member 2
		UniProt	F8WF58 F8WF70 H7C579 Q9NQR4
		NCBI	56954
		KEGG metabolic	Alanine, aspartate and glutamate metabolism
29	PKM	ENSG00000067225	pyruvate kinase M1/2
		UniProt	B4DNK4 H3BN34 H3BQ34 H3BQZ3 H3BR70 H3BT25 H3BTJ2 H3BTN5 H3BU13 H3BUW1 P14618
		NCBI	5315
		KEGG signaling	Glucagon signaling pathway
		KEGG metabolic	Pyruvate metabolism Glycolysis / Gluconeogenesis Purine metabolism Biosynthesis of amino acids Carbon metabolism
29	PYGL	ENSG00000100504	glycogen phosphorylase L
		UniProt	E9PK47 P06737
		NCBI	5836
		KEGG signaling	Glucagon signaling pathway Insulin signaling pathway
		KEGG metabolic	Starch and sucrose metabolism
30	VCP	ENSG00000165280	valosin containing protein
		UniProt	C9IZA5 C9JUP7 P55072
		NCBI	7415
		KEGG metabolic	Protein processing in endoplasmic reticulum
30	AKR1A1	ENSG00000117448	aldo-keto reductase family 1 member A1
		UniProt	P14550 Q5T621 V9GYG2 V9GYP9
		NCBI	10327
		KEGG metabolic	Pentose and glucuronate interconversions Glycolysis / Gluconeogenesis Glycerolipid metabolism
29	GRHPR	ENSG00000137106	glyoxylate and hydroxypyruvate reductase
		UniProt	Q9UBQ7 U3KQ56
		NCBI	9380
		KEGG metabolic	Pyruvate metabolism Glycine, serine and threonine metabolism Glyoxylate and dicarboxylate metabolism
28	UGP2	ENSG00000169764	UDP-glucose pyrophosphorylase 2
		UniProt	A0A087WYS1 C9J3M0 C9J6Q0 C9JNZ1 C9JQU9 C9JTZ5 C9JUW1 C9JVG3 C9JWG0 E7EUC7 F2Z3H1 F2Z3P4 F8WC70 F8WDA2 H7C500 Q16851
		NCBI	7360
		KEGG metabolic	Starch and sucrose metabolism Galactose metabolism Pentose and glucuronate interconversions Amino sugar and nucleotide sugar metabolism
29	IARS1	ENSG00000196305	isoleucyl-tRNA synthetase 1
		UniProt	A0A0A0MSX9 J3KR24 P41252 Q5TCC6 Q5TCC9 Q5TCD1
		NCBI	3376
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
29	ACAT1	ENSG00000075239	acetyl-CoA acetyltransferase 1
		UniProt	A0A5F9ZHD4 A0A5F9ZHH9 A0A5F9ZHJ0 A0A5F9ZHJ7 A0A5F9ZHL1 A0A5F9ZHL7 A0A5F9ZI66 E9PRQ6 H0YEL7 P24752
		NCBI	38
		KEGG metabolic	Synthesis and degradation of ketone bodies Tryptophan metabolism Valine, leucine and isoleucine degradation Fatty acid degradation Fat digestion and absorption Pyruvate metabolism Terpenoid backbone biosynthesis Carbon metabolism Butanoate metabolism Glyoxylate and dicarboxylate metabolism Propanoate metabolism Lysine degradation Fatty acid metabolism
29	SOD1	ENSG00000142168	superoxide dismutase 1
		UniProt	H7BYH4 P00441
		NCBI	6647
		KEGG metabolic	Peroxisome
29	PGD	ENSG00000142657	phosphogluconate dehydrogenase
		UniProt	K7EJT3 K7ELN9 K7EM49 K7EMN2 K7EPF6 P52209
		NCBI	5226
		KEGG metabolic	Pentose phosphate pathway Glutathione metabolism Carbon metabolism
30	CS	ENSG00000062485	citrate synthase
		UniProt	A0A0C4DGI3 B4DJV2 F8VPA1 F8VPF9 F8VR34 F8VRI6 F8VRP1 F8VTT8 F8VU34 F8VVY4 F8VWQ5 F8VX07 F8VX68 F8VZK9 F8W0J2 F8W1S4 F8W4S1 F8W642 H0YH82 H0YIC4 O75390
		NCBI	1431
		KEGG metabolic	Biosynthesis of amino acids Citrate cycle (TCA cycle) Carbon metabolism 2-Oxocarboxylic acid metabolism Glyoxylate and dicarboxylate metabolism
28	PSMD2	ENSG00000175166	proteasome 26S subunit, non-ATPase 2
		UniProt	C9JPC0 F8WBS8 H7C1H2 H7C2Q3 Q13200
		NCBI	5708
		KEGG metabolic	Proteasome
30	HSPD1	ENSG00000144381	heat shock protein family D (Hsp60) member 1
		UniProt	C9J0S9 C9JCQ4 C9JL19 C9JL25 E7ESH4 E7EXB4 F8WBB1 P10809
		NCBI	3329
		KEGG metabolic	RNA degradation
30	AKR1C1	ENSG00000187134	aldo-keto reductase family 1 member C1
		UniProt	A6NHU4 H0Y804 Q04828
		NCBI	1645
		KEGG metabolic	Steroid hormone biosynthesis Metabolism of xenobiotics by cytochrome P450
27	ALDH1A3	ENSG00000184254	aldehyde dehydrogenase 1 family member A3
		UniProt	H0Y2X5 H0YKF9 H0YLT1 H0YNQ3 P47895
		NCBI	220
		KEGG metabolic	Phenylalanine metabolism Glycolysis / Gluconeogenesis Histidine metabolism Tyrosine metabolism Metabolism of xenobiotics by cytochrome P450 beta-Alanine metabolism Drug metabolism - cytochrome P450
29	ALDH2	ENSG00000111275	aldehyde dehydrogenase 2 family member
		UniProt	F8VSB0 P05091 S4R3S4
		NCBI	217
		KEGG metabolic	Pyruvate metabolism Tryptophan metabolism Fatty acid degradation Valine, leucine and isoleucine degradation Histidine metabolism Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Arginine and proline metabolism Glycerolipid metabolism beta-Alanine metabolism Lysine degradation
29	GAPDH	ENSG00000111640	glyceraldehyde-3-phosphate dehydrogenase
		UniProt	E7EUT5 P04406
		NCBI	2597
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
29	G6PD	ENSG00000160211	glucose-6-phosphate dehydrogenase
		UniProt	E7EM57 E7EUI8 E9PD92 P11413
		NCBI	2539
		KEGG metabolic	Pentose phosphate pathway Glutathione metabolism Carbon metabolism
29	ALDH1A1	ENSG00000165092	aldehyde dehydrogenase 1 family member A1
		UniProt	P00352 Q5SYQ7 Q5SYQ8 Q5SYQ9
		NCBI	216
		KEGG metabolic	Retinol metabolism
29	ENO1	ENSG00000074800	enolase 1
		UniProt	A0A2R8Y6G6 A0A2R8Y6I8 A0A2R8Y798 A0A2R8Y879 A0A2R8YEG5 A0A2R8YEM5 K7EM90 K7ERS8 P06733
		NCBI	2023
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	RNA degradation Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
30	DARS1	ENSG00000115866	aspartyl-tRNA synthetase 1
		UniProt	C9J7S3 C9JLC1 C9JQM9 H7BZ35 H7C278 P14868
		NCBI	1615
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
26	AKR1C4	ENSG00000198610	aldo-keto reductase family 1 member C4
		UniProt	P17516
		NCBI	1109
		KEGG metabolic	Steroid hormone biosynthesis Primary bile acid biosynthesis
29	AHCY	ENSG00000101444	adenosylhomocysteinase
		UniProt	P23526
		NCBI	191
		KEGG metabolic	Cysteine and methionine metabolism
26	MIF	ENSG00000240972	macrophage migration inhibitory factor
		UniProt	P14174
		NCBI	4282
		KEGG metabolic	Phenylalanine metabolism Tyrosine metabolism
30	AKR1B1	ENSG00000085662	aldo-keto reductase family 1 member B
		UniProt	E9PCX2 E9PEF9 P15121
		NCBI	231
		KEGG metabolic	Galactose metabolism Fructose and mannose metabolism Pentose and glucuronate interconversions Folate biosynthesis Glycerolipid metabolism
12	ALDH18A1	ENSG00000059573	aldehyde dehydrogenase 18 family member A1
		UniProt	P54886
		NCBI	5832
		KEGG metabolic	Biosynthesis of amino acids Arginine and proline metabolism

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	319.80 KB
	H.sapiens_subnetwork.tsv	86.94 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000196139

GPI

YWHAE

ADH5

NIT2

PKM

PYGL

VCP

AKR1A1

GRHPR

UGP2

IARS1

ACAT1

SOD1

PGD

CS

PSMD2

HSPD1

AKR1C1

ALDH1A3

ALDH2

GAPDH

G6PD

ALDH1A1

ENO1

DARS1

AKR1C4

AHCY

MIF

AKR1B1

ALDH18A1

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