Found 1 of 1 query genes

Network information:

Filter Results:

Evidence Source:
Filter by Tissue:

Select multiple tissues by holding down shift or ctrl.
Filter by Pathway:
Show directions:

Select to show directions of links inferred from transcriptionfactor-gene bindings

Hoover over the directed link to see the llr of that interaction

Network appearance:

Label Type:
Node Size:
Charge:
Link distance:
Min confidence:

Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000186480
3. insulin induced gene 1
- 2. HMGCR
  3. 3-hydroxy-3-methylgluta…
  4. 1.000
  5. PPI
- 2. SREBF2
  3. sterol regulatory eleme…
  4. 1.000
  5. PPI
- 2. VCP
  3. valosin containing prot…
  4. 0.998
  5. PPI
- 2. FAF2
  3. Fas associated factor f…
  4. 0.997
  5. PPI
- 2. VAPA
  3. VAMP associated protein…
  4. 0.992
  5. PPI
- 2. VAPB
  3. VAMP associated protein…
  4. 0.983
  5. PPI
- 2. ELOVL5
  3. ELOVL fatty acid elonga…
  4. 0.979
  5. Metabolic
- 2. POR
  3. cytochrome p450 oxidore…
  4. 0.979
  5. PPI
- 2. RNF145
  3. ring finger protein 145
  4. 0.974
  5. PPI
- 2. RNF139
  3. ring finger protein 139
  4. 0.955
  5. PPI
- 2. TM7SF2
  3. transmembrane 7 superfa…
  4. 0.954
  5. Metabolic
- 2. MSMO1
  3. methylsterol monooxygen…
  4. 0.936
  5. Metabolic
- 2. CYP51A1
  3. cytochrome P450 family …
  4. 0.930
  5. Metabolic
- 2. SC5D
  3. sterol-C5-desaturase
  4. 0.923
  5. Metabolic
- 2. ERLIN1
  3. ER lipid raft associate…
  4. 0.922
  5. PPI
- 2. DHCR7
  3. 7-dehydrocholesterol re…
  4. 0.906
  5. Metabolic
- 2. TECR
  3. trans-2,3-enoyl-CoA red…
  4. 0.904
  5. Metabolic
- 2. SQLE
  3. squalene epoxidase
  4. 0.902
  5. Metabolic
- 2. SCD
  3. stearoyl-CoA desaturase
  4. 0.897
  5. Metabolic
- 2. PSMC3
  3. proteasome 26S subunit,…
  4. 0.897
  5. PPI
- 2. NSDHL
  3. NAD(P) dependent steroi…
  4. 0.892
  5. Metabolic
- 2. FDFT1
  3. farnesyl-diphosphate fa…
  4. 0.890
  5. Metabolic
- 2. FADS1
  3. fatty acid desaturase 1
  4. 0.881
  5. Metabolic
- 2. DHCR24
  3. 24-dehydrocholesterol r…
  4. 0.818
  5. Metabolic
- 2. HSD17B12
  3. hydroxysteroid 17-beta …
  4. 0.747
  5. Metabolic
- 2. HSPA5
  3. heat shock protein fami…
  4. 0.709
  5. Metabolic
- 2. CANX
  3. calnexin
  4. 0.700
  5. Metabolic
- 2. PDIA3
  3. protein disulfide isome…
  4. 0.663
  5. Metabolic
- 2. CERS2
  3. ceramide synthase 2
  4. 0.650
  5. Metabolic
- 2. FADS2
  3. fatty acid desaturase 2
  4. 0.632
  5. Metabolic

Subnetwork gene interactions

ENSG00000186480

insulin induced gene 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000186480

UniProt

NCBI

3638

FADS1

fatty acid desaturase 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000149485

UniProt

NCBI

3992

HSD17B12

hydroxysteroid 17-beta dehydrogenase 12

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000149084

UniProt

NCBI

51144

POR

cytochrome p450 oxidoreductase

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000127948

UniProt

NCBI

5447

DHCR24

24-dehydrocholesterol reductase

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000116133

UniProt

NCBI

1718

SC5D

sterol-C5-desaturase

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000109929

UniProt

NCBI

6309

FADS2

fatty acid desaturase 2

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000134824

UniProt

NCBI

9415

FAF2

Fas associated factor family member 2

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000113194

UniProt

NCBI

23197

CYP51A1

cytochrome P450 family 51 subfamily A member 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000001630

UniProt

NCBI

1595

FDFT1

farnesyl-diphosphate farnesyltransferase 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000079459

UniProt

NCBI

2222

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000113161

UniProt

NCBI

3156

TECR

trans-2,3-enoyl-CoA reductase

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000099797

UniProt

NCBI

9524

VCP

valosin containing protein

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000165280

UniProt

NCBI

7415

PDIA3

protein disulfide isomerase family A member 3

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000167004

UniProt

NCBI

2923

TM7SF2

transmembrane 7 superfamily member 2

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000149809

UniProt

NCBI

7108

SCD

stearoyl-CoA desaturase

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000099194

UniProt

O00767

NCBI

6319

NSDHL

NAD(P) dependent steroid dehydrogenase-like

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000147383

UniProt

NCBI

50814

SREBF2

sterol regulatory element binding transcription factor 2

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000198911

UniProt

NCBI

6721

MSMO1

methylsterol monooxygenase 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000052802

UniProt

NCBI

6307

CANX

calnexin

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000127022

UniProt

NCBI

VAPB

VAMP associated protein B and C

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000124164

UniProt

NCBI

9217

HSPA5

heat shock protein family A (Hsp70) member 5

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000044574

UniProt

P11021

NCBI

3309

DHCR7

7-dehydrocholesterol reductase

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000172893

UniProt

NCBI

1717

RNF139

ring finger protein 139

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000170881

UniProt

NCBI

11236

ELOVL5

ELOVL fatty acid elongase 5

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000012660

UniProt

NCBI

60481

CERS2

ceramide synthase 2

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000143418

UniProt

NCBI

29956

SQLE

squalene epoxidase

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000104549

UniProt

NCBI

6713

PSMC3

proteasome 26S subunit, ATPase 3

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000165916

UniProt

NCBI

5702

RNF145

ring finger protein 145

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000145860

UniProt

Q96MT1

NCBI

153830

VAPA

VAMP associated protein A

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000101558

UniProt

NCBI

9218

ERLIN1

ER lipid raft associated 1

FunCoup

Use as query
Use pair as query
Add to current query

Ensembl

ENSG00000107566

UniProt

NCBI

10613

Query genes

		Identifier	Description
30	ENSG00000186480	ENSG00000186480	insulin induced gene 1
		UniProt	C9JSG8 F5H6P3 H7C5L3 O15503
		NCBI	3638

Subnetwork genes

		Identifier	Description
19	FADS1	ENSG00000149485	fatty acid desaturase 1
		UniProt	A0A0A0MR51 C9J425 C9JJB3 F5GWE3 F5GYH4 F5H0Y2 F5H1Q7 F5H2H3 F5H2R9 F5H3P6 F5H3U5 F5H5X5 F5H852 F5H8G5 H0YB97 H7C2V0 O60427
		NCBI	3992
		KEGG metabolic	Biosynthesis of unsaturated fatty acids Fatty acid metabolism
25	HSD17B12	ENSG00000149084	hydroxysteroid 17-beta dehydrogenase 12
		UniProt	A0A1B0GU83 A0A1B0GV93 A0A1B0GVY6 A0A1B0GW27 A0A1B0GW85 E9PI21 Q53GQ0
		NCBI	51144
		KEGG metabolic	Biosynthesis of unsaturated fatty acids Steroid hormone biosynthesis Fatty acid elongation Fatty acid metabolism
21	POR	ENSG00000127948	cytochrome p450 oxidoreductase
		UniProt	C9JDE2 C9JQ78 C9JU80 E7EMD0 E7EWU0 H0Y4R2 P16435
		NCBI	5447
21	DHCR24	ENSG00000116133	24-dehydrocholesterol reductase
		UniProt	A0A0A0MTI1 A0A3B3IRV7 A0A3B3ISR5 A0A3B3IT58 A0A3B3ITT9 Q15392
		NCBI	1718
		KEGG metabolic	Steroid biosynthesis
20	SC5D	ENSG00000109929	sterol-C5-desaturase
		UniProt	E9PPW5 E9PQ91 O75845
		NCBI	6309
		KEGG metabolic	Steroid biosynthesis
20	FADS2	ENSG00000134824	fatty acid desaturase 2
		UniProt	E5RGD8 E5RGZ5 E5RHL3 F5GZ92 F5GZU2 F5H622 O95864
		NCBI	9415
		KEGG signaling	PPAR signaling pathway
		KEGG metabolic	Biosynthesis of unsaturated fatty acids alpha-Linolenic acid metabolism Fatty acid metabolism
15	FAF2	ENSG00000113194	Fas associated factor family member 2
		UniProt	D6RBG6 Q96CS3
		NCBI	23197
23	CYP51A1	ENSG00000001630	cytochrome P450 family 51 subfamily A member 1
		UniProt	A0A0C4DFL7 H7C0D0 Q16850
		NCBI	1595
		KEGG metabolic	Steroid biosynthesis
25	FDFT1	ENSG00000079459	farnesyl-diphosphate farnesyltransferase 1
		UniProt	A0A1W2PQ47 E9PJG4 E9PNJ2 E9PNM1 E9PQ90 E9PS69 E9PSH1 P37268
		NCBI	2222
		KEGG metabolic	Steroid biosynthesis
23	HMGCR	ENSG00000113161	3-hydroxy-3-methylglutaryl-CoA reductase
		UniProt	C9JKX7 D6RIW0 H0Y8F6 H0Y8K6 P04035
		NCBI	3156
		KEGG signaling	AMPK signaling pathway
		KEGG metabolic	Terpenoid backbone biosynthesis
27	TECR	ENSG00000099797	trans-2,3-enoyl-CoA reductase
		UniProt	M0R2E5 M0R2N5 M0R329 M0R3C3 Q9NZ01
		NCBI	9524
		KEGG metabolic	Biosynthesis of unsaturated fatty acids Fatty acid elongation Fatty acid metabolism
20	VCP	ENSG00000165280	valosin containing protein
		UniProt	C9IZA5 C9JUP7 P55072
		NCBI	7415
		KEGG metabolic	Protein processing in endoplasmic reticulum
23	PDIA3	ENSG00000167004	protein disulfide isomerase family A member 3
		UniProt	F8WBS6 F8WBW5 H7BZJ3 P30101
		NCBI	2923
		KEGG signaling	Antigen processing and presentation
		KEGG metabolic	Protein processing in endoplasmic reticulum
20	TM7SF2	ENSG00000149809	transmembrane 7 superfamily member 2
		UniProt	E9PK81 E9PLI3 E9PLL1 E9PLS9 E9PP79 E9PQ50 E9PQZ7 E9PRQ1 E9PS09 E9PS18 H0YCI8 H0YDY5 H0YEN6 O76062
		NCBI	7108
		KEGG metabolic	Steroid biosynthesis
24	SCD	ENSG00000099194	stearoyl-CoA desaturase
		UniProt	O00767
		NCBI	6319
		KEGG signaling	AMPK signaling pathway PPAR signaling pathway
		KEGG metabolic	Biosynthesis of unsaturated fatty acids Fatty acid metabolism
21	NSDHL	ENSG00000147383	NAD(P) dependent steroid dehydrogenase-like
		UniProt	C9JDR0 Q15738
		NCBI	50814
		KEGG metabolic	Steroid biosynthesis
16	SREBF2	ENSG00000198911	sterol regulatory element binding transcription factor 2
		UniProt	A0A087X1T2 G3V0I8 H0Y7E5 Q12772
		NCBI	6721
21	MSMO1	ENSG00000052802	methylsterol monooxygenase 1
		UniProt	D6R952 D6RDP9 D6REA2 Q15800
		NCBI	6307
		KEGG metabolic	Steroid biosynthesis
24	CANX	ENSG00000127022	calnexin
		UniProt	D6RAQ8 D6RAU8 D6RB85 D6RD16 D6RDP7 D6RFL1 D6RFW4 D6RG29 D6RGY2 D6RHJ3 H0Y9H1 H0Y9Q7 P27824
		NCBI	821
		KEGG signaling	Antigen processing and presentation
		KEGG metabolic	Phagosome Protein processing in endoplasmic reticulum
12	VAPB	ENSG00000124164	VAMP associated protein B and C
		UniProt	E5RK64 O95292
		NCBI	9217
26	HSPA5	ENSG00000044574	heat shock protein family A (Hsp70) member 5
		UniProt	P11021
		NCBI	3309
		KEGG signaling	Antigen processing and presentation
		KEGG metabolic	Protein export Protein processing in endoplasmic reticulum
22	DHCR7	ENSG00000172893	7-dehydrocholesterol reductase
		UniProt	E9PIP9 E9PJ54 E9PLZ2 E9PM00 E9PQ71 E9PRL8 H0YCS7 H0YE57 H0YEJ5 Q9UBM7
		NCBI	1717
		KEGG metabolic	Steroid biosynthesis
4	RNF139	ENSG00000170881	ring finger protein 139
		UniProt	E5RH85 Q8WU17
		NCBI	11236
21	ELOVL5	ENSG00000012660	ELOVL fatty acid elongase 5
		UniProt	A0A0A0MTI6 Q9NYP7
		NCBI	60481
		KEGG metabolic	Biosynthesis of unsaturated fatty acids Fatty acid elongation Fatty acid metabolism
16	CERS2	ENSG00000143418	ceramide synthase 2
		UniProt	H0YKH6 H0YLQ6 H0YNU7 Q5SZE1 Q5SZE2 Q5SZE3 Q5SZE4 Q96G23
		NCBI	29956
		KEGG signaling	Sphingolipid signaling pathway
		KEGG metabolic	Sphingolipid metabolism
24	SQLE	ENSG00000104549	squalene epoxidase
		UniProt	E5RJH9 E7EVQ6 H0YBN7 Q14534
		NCBI	6713
		KEGG metabolic	Steroid biosynthesis
10	PSMC3	ENSG00000165916	proteasome 26S subunit, ATPase 3
		UniProt	E9PKD5 E9PLG2 E9PM69 E9PMD8 E9PMW0 E9PN50 E9PS45 P17980 R4GNH3
		NCBI	5702
		KEGG metabolic	Proteasome
1	RNF145	ENSG00000145860	ring finger protein 145
		UniProt	Q96MT1
		NCBI	153830
16	VAPA	ENSG00000101558	VAMP associated protein A
		UniProt	J3QKM9 Q9P0L0
		NCBI	9218
10	ERLIN1	ENSG00000107566	ER lipid raft associated 1
		UniProt	B0QZ43 O75477
		NCBI	10613

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

To use PathwAX, first use the button below to copy the subnetwork genes and then paste them in PathwAX

Copied subnetwork genes to clipboard

Use as query
Add to current query

	jSquid_subnetworks.xml	293.33 KB
	H.sapiens_subnetwork.tsv	52.89 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000186480

FADS1

HSD17B12

POR

DHCR24

SC5D

FADS2

FAF2

CYP51A1

FDFT1

HMGCR

TECR

VCP

PDIA3

TM7SF2

SCD

NSDHL

SREBF2

MSMO1

CANX

VAPB

HSPA5

DHCR7

RNF139

ELOVL5

CERS2

SQLE

PSMC3

RNF145

VAPA

ERLIN1

JavaScript is required.