Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000179163
3. alpha-L-fucosidase 1
- 2. CTSB
  3. cathepsin B
  4. 0.981
  5. Metabolic
- 2. PRDX4
  3. peroxiredoxin 4
  4. 0.978
  5. Metabolic
- 2. PLD3
  3. phospholipase D family …
  4. 0.977
  5. Metabolic
- 2. PPT1
  3. palmitoyl-protein thioe…
  4. 0.972
  5. Metabolic
- 2. DPP7
  3. dipeptidyl peptidase 7
  4. 0.966
  5. Metabolic
- 2. CUL3
  3. cullin 3
  4. 0.962
  5. PPI
- 2. NIT2
  3. nitrilase family member…
  4. 0.957
  5. Metabolic
- 2. APP
  3. amyloid beta precursor …
  4. 0.957
  5. PPI
- 2. IFI30
  3. IFI30 lysosomal thiol r…
  4. 0.954
  5. Metabolic
- 2. HEXA
  3. hexosaminidase subunit …
  4. 0.948
  5. Metabolic
- 2. DNAJC3
  3. DnaJ heat shock protein…
  4. 0.948
  5. Metabolic
- 2. GLB1
  3. galactosidase beta 1
  4. 0.944
  5. Metabolic
- 2. CAT
  3. catalase
  4. 0.936
  5. Metabolic
- 2. PDIA5
  3. protein disulfide isome…
  4. 0.930
  5. PPI
- 2. SDF4
  3. stromal cell derived fa…
  4. 0.922
  5. Metabolic
- 2. GPI
  3. glucose-6-phosphate iso…
  4. 0.907
  5. Metabolic
- 2. AGA
  3. aspartylglucosaminidase
  4. 0.906
  5. Metabolic
- 2. IDH1
  3. isocitrate dehydrogenas…
  4. 0.906
  5. Metabolic
- 2. HEXB
  3. hexosaminidase subunit …
  4. 0.894
  5. Metabolic
- 2. SUMF1
  3. sulfatase modifying fac…
  4. 0.890
  5. PPI
- 2. DERA
  3. deoxyribose-phosphate a…
  4. 0.886
  5. Metabolic
- 2. EEF1A1
  3. eukaryotic translation …
  4. 0.883
  5. Complex
- 2. CD53
  3. CD53 molecule
  4. 0.880
  5. Metabolic
- 2. SOD1
  3. superoxide dismutase 1
  4. 0.880
  5. Metabolic
- 2. VCP
  3. valosin containing prot…
  4. 0.879
  5. Metabolic
- 2. LMAN2
  3. lectin, mannose binding…
  4. 0.877
  5. Metabolic
- 2. PSMB1
  3. proteasome 20S subunit …
  4. 0.876
  5. Metabolic
- 2. QPCT
  3. glutaminyl-peptide cycl…
  4. 0.872
  5. Metabolic
- 2. ASAH1
  3. N-acylsphingosine amido…
  4. 0.872
  5. Metabolic
- 2. CTSD
  3. cathepsin D
  4. 0.870
  5. Metabolic

Subnetwork gene interactions

ENSG00000179163

alpha-L-fucosidase 1

FunCoup

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Ensembl

ENSG00000179163

UniProt

P04066

NCBI

2517

PPT1

palmitoyl-protein thioesterase 1

FunCoup

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Ensembl

ENSG00000131238

UniProt

NCBI

5538

IDH1

isocitrate dehydrogenase (NADP(+)) 1

FunCoup

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Ensembl

ENSG00000138413

UniProt

NCBI

3417

EEF1A1

eukaryotic translation elongation factor 1 alpha 1

FunCoup

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Ensembl

ENSG00000156508

UniProt

NCBI

1915

DERA

deoxyribose-phosphate aldolase

FunCoup

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Ensembl

ENSG00000023697

UniProt

NCBI

51071

PSMB1

proteasome 20S subunit beta 1

FunCoup

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Ensembl

ENSG00000008018

UniProt

P20618

NCBI

5689

GPI

glucose-6-phosphate isomerase

FunCoup

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Ensembl

ENSG00000105220

UniProt

NCBI

2821

VCP

valosin containing protein

FunCoup

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Ensembl

ENSG00000165280

UniProt

NCBI

7415

DPP7

dipeptidyl peptidase 7

FunCoup

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Ensembl

ENSG00000176978

UniProt

NCBI

29952

HEXA

hexosaminidase subunit alpha

FunCoup

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Ensembl

ENSG00000213614

UniProt

NCBI

3073

CTSD

cathepsin D

FunCoup

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Ensembl

ENSG00000117984

UniProt

NCBI

1509

QPCT

glutaminyl-peptide cyclotransferase

FunCoup

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Ensembl

ENSG00000115828

UniProt

NCBI

25797

PLD3

phospholipase D family member 3

FunCoup

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Ensembl

ENSG00000105223

UniProt

NCBI

23646

GLB1

galactosidase beta 1

FunCoup

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Ensembl

ENSG00000170266

UniProt

NCBI

2720

PRDX4

peroxiredoxin 4

FunCoup

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Ensembl

ENSG00000123131

UniProt

NCBI

10549

CAT

catalase

FunCoup

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Ensembl

ENSG00000121691

UniProt

NCBI

CTSB

cathepsin B

FunCoup

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Ensembl

ENSG00000164733

UniProt

NCBI

1508

SDF4

stromal cell derived factor 4

FunCoup

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Ensembl

ENSG00000078808

UniProt

NCBI

51150

LMAN2

lectin, mannose binding 2

FunCoup

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Ensembl

ENSG00000169223

UniProt

NCBI

10960

IFI30

IFI30 lysosomal thiol reductase

FunCoup

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Ensembl

ENSG00000216490

UniProt

NCBI

10437

AGA

aspartylglucosaminidase

FunCoup

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Ensembl

ENSG00000038002

UniProt

NCBI

HEXB

hexosaminidase subunit beta

FunCoup

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Ensembl

ENSG00000049860

UniProt

NCBI

3074

DNAJC3

DnaJ heat shock protein family (Hsp40) member C3

FunCoup

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Ensembl

ENSG00000102580

UniProt

NCBI

5611

SOD1

superoxide dismutase 1

FunCoup

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Ensembl

ENSG00000142168

UniProt

NCBI

6647

ASAH1

N-acylsphingosine amidohydrolase 1

FunCoup

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Ensembl

ENSG00000104763

UniProt

NCBI

SUMF1

sulfatase modifying factor 1

FunCoup

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Ensembl

ENSG00000144455

UniProt

NCBI

285362

CD53

CD53 molecule

FunCoup

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Ensembl

ENSG00000143119

UniProt

P19397

NCBI

CUL3

cullin 3

FunCoup

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Ensembl

ENSG00000036257

UniProt

NCBI

8452

NIT2

nitrilase family member 2

FunCoup

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Ensembl

ENSG00000114021

UniProt

NCBI

56954

APP

amyloid beta precursor protein

FunCoup

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Ensembl

ENSG00000142192

UniProt

NCBI

PDIA5

protein disulfide isomerase family A member 5

FunCoup

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Ensembl

ENSG00000065485

UniProt

NCBI

10954

Query genes

		Identifier	Description
30	ENSG00000179163	ENSG00000179163	alpha-L-fucosidase 1
		UniProt	P04066
		NCBI	2517
		KEGG metabolic	Other glycan degradation Lysosome

Subnetwork genes

		Identifier	Description
25	PPT1	ENSG00000131238	palmitoyl-protein thioesterase 1
		UniProt	A0A286YEP3 A0A286YF39 A0A286YFE3 A0A286YFF7 A0A286YFL6 A0A286YFL8 A0A2C9F2P4 E9PIA8 E9PK48 E9PMG2 E9PP28 E9PSE5 P50897 Q5T0S4
		NCBI	5538
		KEGG metabolic	Lysosome Fatty acid elongation Fatty acid metabolism
25	IDH1	ENSG00000138413	isocitrate dehydrogenase (NADP(+)) 1
		UniProt	C9J4N6 C9JJE5 C9JLU6 O75874
		NCBI	3417
		KEGG metabolic	Peroxisome Glutathione metabolism Citrate cycle (TCA cycle) Biosynthesis of amino acids Carbon metabolism 2-Oxocarboxylic acid metabolism
25	EEF1A1	ENSG00000156508	eukaryotic translation elongation factor 1 alpha 1
		UniProt	A0A087WV01 A0A087WVQ9 A6PW80 P68104 Q5JR01
		NCBI	1915
		KEGG metabolic	RNA transport
20	DERA	ENSG00000023697	deoxyribose-phosphate aldolase
		UniProt	E9PJ44 E9PJB9 E9PMH9 E9PML7 E9PPK3 E9PPM8 G3V158 Q9Y315
		NCBI	51071
		KEGG metabolic	Pentose phosphate pathway
25	PSMB1	ENSG00000008018	proteasome 20S subunit beta 1
		UniProt	P20618
		NCBI	5689
		KEGG metabolic	Proteasome
25	GPI	ENSG00000105220	glucose-6-phosphate isomerase
		UniProt	A0A0G2JLI6 A0A2R8Y6C7 A0A2R8YF08 A0A2U3TZU2 K7EIL4 K7ELR7 K7ENA0 K7EP41 K7EPY4 K7EQ48 K7ERC6 K7ERK8 P06744
		NCBI	2821
		KEGG metabolic	Starch and sucrose metabolism Pentose phosphate pathway Glycolysis / Gluconeogenesis Carbon metabolism Amino sugar and nucleotide sugar metabolism
25	VCP	ENSG00000165280	valosin containing protein
		UniProt	C9IZA5 C9JUP7 P55072
		NCBI	7415
		KEGG metabolic	Protein processing in endoplasmic reticulum
24	DPP7	ENSG00000176978	dipeptidyl peptidase 7
		UniProt	Q9UHL4 R4GMR2 R4GMU5 R4GMV4 R4GN05 R4GNE8
		NCBI	29952
24	HEXA	ENSG00000213614	hexosaminidase subunit alpha
		UniProt	A0A087WTY2 H3BP20 H3BQ04 H3BRP6 H3BS10 H3BT62 H3BTD4 H3BU85 H3BVH8 P06865
		NCBI	3073
		KEGG metabolic	Other glycan degradation Various types of N-glycan biosynthesis Glycosphingolipid biosynthesis - globo and isoglobo series Glycosphingolipid biosynthesis - ganglio series Lysosome Glycosaminoglycan degradation Amino sugar and nucleotide sugar metabolism
26	CTSD	ENSG00000117984	cathepsin D
		UniProt	A0A1B0GV01 A0A1B0GV23 A0A1B0GVD5 A0A1B0GVP3 A0A1B0GW44 A0A1B0GWE8 C9JH19 F8W787 F8WD96 H7C1V0 P07339
		NCBI	1509
		KEGG signaling	Apoptosis Estrogen signaling pathway Sphingolipid signaling pathway
		KEGG metabolic	Lysosome Autophagy - animal
19	QPCT	ENSG00000115828	glutaminyl-peptide cyclotransferase
		UniProt	A0A3B3IUD5 B5MCZ9 C9JS14 Q16769
		NCBI	25797
20	PLD3	ENSG00000105223	phospholipase D family member 3
		UniProt	A0A0A0MS28 E2QRG1 M0QX50 M0QX99 M0QY94 M0QYJ4 M0QZK2 M0R1F7 M0R2E7 M0R2W7 M0R3G9 Q8IV08
		NCBI	23646
		KEGG metabolic	Ether lipid metabolism Glycerophospholipid metabolism
22	GLB1	ENSG00000170266	galactosidase beta 1
		UniProt	C9J4G9 C9J539 C9JF15 C9JWX1 E7EQ29 F8WEN1 F8WF40 P16278
		NCBI	2720
		KEGG metabolic	Other glycan degradation Sphingolipid metabolism Glycosphingolipid biosynthesis - ganglio series Lysosome Galactose metabolism Glycosaminoglycan degradation
27	PRDX4	ENSG00000123131	peroxiredoxin 4
		UniProt	A6NG45 A6NJJ0 H7C3T4 Q13162
		NCBI	10549
23	CAT	ENSG00000121691	catalase
		UniProt	A0A3B3ITJ0 P04040
		NCBI	847
		KEGG signaling	FoxO signaling pathway
		KEGG metabolic	Peroxisome Tryptophan metabolism Carbon metabolism Glyoxylate and dicarboxylate metabolism
28	CTSB	ENSG00000164733	cathepsin B
		UniProt	E9PCB3 E9PHZ5 E9PID0 E9PIS1 E9PJ67 E9PKQ7 E9PKX0 E9PL32 E9PLY3 E9PNL5 E9PQM1 E9PR00 E9PR54 E9PS78 E9PSG5 P07858 R4GMQ5
		NCBI	1508
		KEGG signaling	Antigen processing and presentation NOD-like receptor signaling pathway Apoptosis
		KEGG metabolic	Lysosome Autophagy - animal
20	SDF4	ENSG00000078808	stromal cell derived factor 4
		UniProt	A0A5F9UJX7 A0A5F9UP49 G3V1E2 H0Y3T6 Q9BRK5
		NCBI	51150
25	LMAN2	ENSG00000169223	lectin, mannose binding 2
		UniProt	D6RBH1 D6RBV2 D6RDX1 D6RIU4 Q12907
		NCBI	10960
		KEGG metabolic	Protein processing in endoplasmic reticulum
20	IFI30	ENSG00000216490	IFI30 lysosomal thiol reductase
		UniProt	M0QZG3 P13284
		NCBI	10437
		KEGG signaling	Antigen processing and presentation
20	AGA	ENSG00000038002	aspartylglucosaminidase
		UniProt	H0Y8L9 H0Y9C7 P20933
		NCBI	175
		KEGG metabolic	Other glycan degradation Lysosome
24	HEXB	ENSG00000049860	hexosaminidase subunit beta
		UniProt	D6REQ8 H0Y9B6 H0Y9M3 H0YA83 P07686 Q5URX0
		NCBI	3074
		KEGG metabolic	Other glycan degradation Various types of N-glycan biosynthesis Glycosphingolipid biosynthesis - globo and isoglobo series Glycosphingolipid biosynthesis - ganglio series Lysosome Glycosaminoglycan degradation Amino sugar and nucleotide sugar metabolism
28	DNAJC3	ENSG00000102580	DnaJ heat shock protein family (Hsp40) member C3
		UniProt	Q13217 X6R9L0
		NCBI	5611
		KEGG metabolic	Protein processing in endoplasmic reticulum
24	SOD1	ENSG00000142168	superoxide dismutase 1
		UniProt	H7BYH4 P00441
		NCBI	6647
		KEGG metabolic	Peroxisome
24	ASAH1	ENSG00000104763	N-acylsphingosine amidohydrolase 1
		UniProt	A0A1B0GTA6 A0A1B0GTD4 A0A1B0GTM3 A0A1B0GTP7 A0A1B0GTQ7 A0A1B0GTX9 A0A1B0GTZ5 A0A1B0GU06 A0A1B0GU62 A0A1B0GU70 A0A1B0GUA4 A0A1B0GUB3 A0A1B0GUE3 A0A1B0GUG1 A0A1B0GUH5 A0A1B0GUJ2 A0A1B0GUJ3 A0A1B0GUP1 A0A1B0GUQ5 A0A1B0GUW4 A0A1B0GV06 A0A1B0GV88 A0A1B0GV95 A0A1B0GVA3 A0A1B0GVA8 A0A1B0GVC9 A0A1B0GVE7 A0A1B0GVG2 A0A1B0GVJ1 A0A1B0GVL2 A0A1B0GVY5 A0A1B0GW30 A0A1B0GW48 A0A1B0GW66 A0A1B0GW68 A0A1B0GWC9 E7EMM4 Q13510
		NCBI	427
		KEGG signaling	Sphingolipid signaling pathway
		KEGG metabolic	Sphingolipid metabolism Lysosome
3	SUMF1	ENSG00000144455	sulfatase modifying factor 1
		UniProt	E9PF05 F5GXA0 Q8NBK3
		NCBI	285362
		KEGG metabolic	Lysosome
5	CD53	ENSG00000143119	CD53 molecule
		UniProt	P19397
		NCBI	963
11	CUL3	ENSG00000036257	cullin 3
		UniProt	A0A087WTG3 A0A087X1R9 H7C1J0 H7C1L6 H7C399 Q13618
		NCBI	8452
		KEGG signaling	Hedgehog signaling pathway
		KEGG metabolic	Ubiquitin mediated proteolysis
24	NIT2	ENSG00000114021	nitrilase family member 2
		UniProt	F8WF58 F8WF70 H7C579 Q9NQR4
		NCBI	56954
		KEGG metabolic	Alanine, aspartate and glutamate metabolism
10	APP	ENSG00000142192	amyloid beta precursor protein
		UniProt	A0A0A0MRG2 E9PG40 H7C0V9 H7C2L2 P05067
		NCBI	351
		KEGG signaling	Serotonergic synapse
7	PDIA5	ENSG00000065485	protein disulfide isomerase family A member 5
		UniProt	C9JY10 H7C4F9 Q14554
		NCBI	10954

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	292.57 KB
	H.sapiens_subnetwork.tsv	58.97 KB

Species:

Network information:

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Network appearance:

ENSG00000179163

PPT1

IDH1

EEF1A1

DERA

PSMB1

GPI

VCP

DPP7

HEXA

CTSD

QPCT

PLD3

GLB1

PRDX4

CAT

CTSB

SDF4

LMAN2

IFI30

AGA

HEXB

DNAJC3

SOD1

ASAH1

SUMF1

CD53

CUL3

NIT2

APP

PDIA5

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