Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000177606
3. Jun proto-oncogene, AP-…
- 2. FOS
  3. Fos proto-oncogene, AP-…
  4. 1.000
  5. PPI
- 2. JUND
  3. JunD proto-oncogene, AP…
  4. 1.000
  5. PPI
- 2. FOSB
  3. FosB proto-oncogene, AP…
  4. 1.000
  5. PPI
- 2. ATF3
  3. activating transcriptio…
  4. 1.000
  5. PPI
- 2. ATF4
  3. activating transcriptio…
  4. 1.000
  5. PPI
- 2. JUNB
  3. JunB proto-oncogene, AP…
  4. 1.000
  5. PPI
- 2. DDIT3
  3. DNA damage inducible tr…
  4. 1.000
  5. PPI
- 2. NFATC2
  3. nuclear factor of activ…
  4. 0.999
  5. PPI
- 2. SMAD3
  3. SMAD family member 3
  4. 0.999
  5. PPI
- 2. CREB5
  3. cAMP responsive element…
  4. 0.998
  5. PPI
- 2. NFYA
  3. nuclear transcription f…
  4. 0.998
  5. PPI
- 2. TEAD1
  3. TEA domain transcriptio…
  4. 0.998
  5. PPI
- 2. TCF7L2
  3. transcription factor 7 …
  4. 0.998
  5. PPI
- 2. CTNNB1
  3. catenin beta 1
  4. 0.998
  5. PPI
- 2. GTF2B
  3. general transcription f…
  4. 0.997
  5. PPI
- 2. ETS2
  3. ETS proto-oncogene 2, t…
  4. 0.997
  5. PPI
- 2. ATF7
  3. activating transcriptio…
  4. 0.996
  5. PPI
- 2. ETS1
  3. ETS proto-oncogene 1, t…
  4. 0.993
  5. PPI
- 2. FOSL2
  3. FOS like 2, AP-1 transc…
  4. 0.993
  5. PPI
- 2. KLF5
  3. Kruppel like factor 5
  4. 0.993
  5. PPI
- 2. RELA
  3. RELA proto-oncogene, NF…
  4. 0.992
  5. PPI
- 2. SMAD4
  3. SMAD family member 4
  4. 0.992
  5. PPI
- 2. KAT7
  3. lysine acetyltransferas…
  4. 0.992
  5. PPI
- 2. MECOM
  3. MDS1 and EVI1 complex l…
  4. 0.991
  5. PPI
- 2. NFAT5
  3. nuclear factor of activ…
  4. 0.988
  5. PPI
- 2. FOSL1
  3. FOS like 1, AP-1 transc…
  4. 0.986
  5. PPI
- 2. ATF1
  3. activating transcriptio…
  4. 0.986
  5. PPI
- 2. HIRA
  3. histone cell cycle regu…
  4. 0.983
  5. PPI
- 2. NFATC1
  3. nuclear factor of activ…
  4. 0.983
  5. PPI
- 2. TCF4
  3. transcription factor 4
  4. 0.981
  5. PPI

Subnetwork gene interactions

ENSG00000177606

Jun proto-oncogene, AP-1 transcription factor subunit

FunCoup

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Ensembl

ENSG00000177606

UniProt

P05412

NCBI

3725

RELA

RELA proto-oncogene, NF-kB subunit

FunCoup

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Ensembl

ENSG00000173039

UniProt

NCBI

5970

CTNNB1

catenin beta 1

FunCoup

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Ensembl

ENSG00000168036

UniProt

NCBI

1499

ATF1

activating transcription factor 1

FunCoup

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Ensembl

ENSG00000123268

UniProt

NCBI

ETS1

ETS proto-oncogene 1, transcription factor

FunCoup

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Ensembl

ENSG00000134954

UniProt

NCBI

2113

ATF4

activating transcription factor 4

FunCoup

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Ensembl

ENSG00000128272

UniProt

P18848

NCBI

SMAD3

SMAD family member 3

FunCoup

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Ensembl

ENSG00000166949

UniProt

NCBI

4088

JUNB

JunB proto-oncogene, AP-1 transcription factor subunit

FunCoup

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Ensembl

ENSG00000171223

UniProt

P17275

NCBI

3726

JUND

JunD proto-oncogene, AP-1 transcription factor subunit

FunCoup

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Ensembl

ENSG00000130522

UniProt

NCBI

3727

FOSL1

FOS like 1, AP-1 transcription factor subunit

FunCoup

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Ensembl

ENSG00000175592

UniProt

NCBI

8061

DDIT3

DNA damage inducible transcript 3

FunCoup

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Ensembl

ENSG00000175197

UniProt

NCBI

1649

GTF2B

general transcription factor IIB

FunCoup

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Ensembl

ENSG00000137947

UniProt

NCBI

2959

TEAD1

TEA domain transcription factor 1

FunCoup

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Ensembl

ENSG00000187079

UniProt

NCBI

7003

CREB5

cAMP responsive element binding protein 5

FunCoup

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Ensembl

ENSG00000146592

UniProt

NCBI

9586

KLF5

Kruppel like factor 5

FunCoup

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Ensembl

ENSG00000102554

UniProt

Q13887

NCBI

ETS2

ETS proto-oncogene 2, transcription factor

FunCoup

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Ensembl

ENSG00000157557

UniProt

NCBI

2114

ATF3

activating transcription factor 3

FunCoup

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Ensembl

ENSG00000162772

UniProt

NCBI

FOSL2

FOS like 2, AP-1 transcription factor subunit

FunCoup

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Ensembl

ENSG00000075426

UniProt

NCBI

2355

SMAD4

SMAD family member 4

FunCoup

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Ensembl

ENSG00000141646

UniProt

NCBI

4089

FOS

Fos proto-oncogene, AP-1 transcription factor subunit

FunCoup

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Ensembl

ENSG00000170345

UniProt

NCBI

2353

ATF7

activating transcription factor 7

FunCoup

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Ensembl

ENSG00000170653

UniProt

NCBI

11016

NFAT5

nuclear factor of activated T cells 5

FunCoup

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Ensembl

ENSG00000102908

UniProt

NCBI

10725

MECOM

MDS1 and EVI1 complex locus

FunCoup

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Ensembl

ENSG00000085276

UniProt

NCBI

2122

NFATC1

nuclear factor of activated T cells 1

FunCoup

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Ensembl

ENSG00000131196

UniProt

NCBI

4772

NFATC2

nuclear factor of activated T cells 2

FunCoup

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Ensembl

ENSG00000101096

UniProt

Q13469

NCBI

4773

KAT7

lysine acetyltransferase 7

FunCoup

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Ensembl

ENSG00000136504

UniProt

NCBI

11143

FOSB

FosB proto-oncogene, AP-1 transcription factor subunit

FunCoup

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Ensembl

ENSG00000125740

UniProt

NCBI

2354

NFYA

nuclear transcription factor Y subunit alpha

FunCoup

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Ensembl

ENSG00000001167

UniProt

P23511

NCBI

4800

TCF7L2

transcription factor 7 like 2

FunCoup

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Ensembl

ENSG00000148737

UniProt

NCBI

6934

TCF4

transcription factor 4

FunCoup

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Ensembl

ENSG00000196628

UniProt

NCBI

6925

HIRA

histone cell cycle regulator

FunCoup

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Ensembl

ENSG00000100084

UniProt

NCBI

7290

Query genes

		Identifier	Description
30	ENSG00000177606	ENSG00000177606	Jun proto-oncogene, AP-1 transcription factor subunit
		UniProt	P05412
		NCBI	3725
		KEGG signaling	MAPK signaling pathway Neurotrophin signaling pathway NOD-like receptor signaling pathway Toll-like receptor signaling pathway Focal adhesion Wnt signaling pathway B cell receptor signaling pathway cAMP signaling pathway Tight junction ErbB signaling pathway Apoptosis T cell receptor signaling pathway Relaxin signaling pathway Estrogen signaling pathway GnRH signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway Oxytocin signaling pathway IL-17 signaling pathway

Subnetwork genes

		Identifier	Description
7	RELA	ENSG00000173039	RELA proto-oncogene, NF-kB subunit
		UniProt	A0A087WVP0 A0A087X0W8 E9PI38 E9PJR1 E9PJZ9 E9PKH5 E9PKV4 E9PM47 E9PMD5 E9PN69 E9PNK5 E9PNV4 E9PQS6 E9PRX2 E9PSE4 H0YCB4 Q04206 Q2TAM5
		NCBI	5970
		KEGG signaling	MAPK signaling pathway NF-kappa B signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Adipocytokine signaling pathway Neurotrophin signaling pathway Cytosolic DNA-sensing pathway RIG-I-like receptor signaling pathway NOD-like receptor signaling pathway Toll-like receptor signaling pathway Ras signaling pathway cAMP signaling pathway B cell receptor signaling pathway Apoptosis HIF-1 signaling pathway T cell receptor signaling pathway Prolactin signaling pathway Relaxin signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway IL-17 signaling pathway
5	CTNNB1	ENSG00000168036	catenin beta 1
		UniProt	A0A2R8Y543 A0A2R8Y5A3 A0A2R8Y5C3 A0A2R8Y5Z1 A0A2R8Y6G0 A0A2R8Y750 A0A2R8Y7Z0 A0A2R8Y804 A0A2R8Y815 A0A2R8YCH5 A0A2R8YG06 B4DGU4 C9IZ65 P35222
		NCBI	1499
		KEGG signaling	Rap1 signaling pathway Focal adhesion Adherens junction Wnt signaling pathway Thyroid hormone signaling pathway Leukocyte transendothelial migration Melanogenesis Hippo signaling pathway
7	ATF1	ENSG00000123268	activating transcription factor 1
		UniProt	F8VRN2 F8VS03 F8VYE5 F8VYN3 P18846
		NCBI	466
7	ETS1	ENSG00000134954	ETS proto-oncogene 1, transcription factor
		UniProt	P14921 V9GYD6
		NCBI	2113
		KEGG signaling	Ras signaling pathway
8	ATF4	ENSG00000128272	activating transcription factor 4
		UniProt	P18848
		NCBI	468
		KEGG signaling	MAPK signaling pathway Adrenergic signaling in cardiomyocytes PI3K-Akt signaling pathway Neurotrophin signaling pathway Long-term potentiation Apoptosis cGMP-PKG signaling pathway Relaxin signaling pathway Estrogen signaling pathway Dopaminergic synapse Cholinergic synapse GnRH signaling pathway Glucagon signaling pathway TNF signaling pathway
		KEGG metabolic	Protein processing in endoplasmic reticulum
9	SMAD3	ENSG00000166949	SMAD family member 3
		UniProt	H0YKE2 H0YL71 H0YMP2 H0YMY0 H0YNV1 H3BP09 H3BQ00 H3BVD1 P84022
		NCBI	4088
		KEGG signaling	Adherens junction Wnt signaling pathway FoxO signaling pathway Cell cycle TGF-beta signaling pathway Apelin signaling pathway Hippo signaling pathway
		KEGG metabolic	Endocytosis
16	JUNB	ENSG00000171223	JunB proto-oncogene, AP-1 transcription factor subunit
		UniProt	P17275
		NCBI	3726
		KEGG signaling	TNF signaling pathway
16	JUND	ENSG00000130522	JunD proto-oncogene, AP-1 transcription factor subunit
		UniProt	P17535 U3KPR5
		NCBI	3727
		KEGG signaling	MAPK signaling pathway IL-17 signaling pathway
6	FOSL1	ENSG00000175592	FOS like 1, AP-1 transcription factor subunit
		UniProt	E9PKL5 E9PPX2 E9PQT6 P15407
		NCBI	8061
		KEGG signaling	Wnt signaling pathway IL-17 signaling pathway
8	DDIT3	ENSG00000175197	DNA damage inducible transcript 3
		UniProt	F8W133 P35638
		NCBI	1649
		KEGG signaling	Apoptosis MAPK signaling pathway
		KEGG metabolic	Protein processing in endoplasmic reticulum
7	GTF2B	ENSG00000137947	general transcription factor IIB
		UniProt	B1APE1 B1APE2 Q00403
		NCBI	2959
		KEGG metabolic	Basal transcription factors
5	TEAD1	ENSG00000187079	TEA domain transcription factor 1
		UniProt	E9PKB7 H0YCZ6 H0YE88 H0YEJ9 P28347
		NCBI	7003
		KEGG signaling	Hippo signaling pathway - multiple species Hippo signaling pathway
7	CREB5	ENSG00000146592	cAMP responsive element binding protein 5
		UniProt	C9JN33 H0YFV2 H9KVC5 Q02930
		NCBI	9586
		KEGG signaling	cAMP signaling pathway cGMP-PKG signaling pathway AMPK signaling pathway Relaxin signaling pathway Estrogen signaling pathway Dopaminergic synapse Adrenergic signaling in cardiomyocytes PI3K-Akt signaling pathway Cholinergic synapse Glucagon signaling pathway TNF signaling pathway
7	KLF5	ENSG00000102554	Kruppel like factor 5
		UniProt	Q13887
		NCBI	688
4	ETS2	ENSG00000157557	ETS proto-oncogene 2, transcription factor
		UniProt	A0A0C4DG47 A0A590UJP9 A0A590UJR2 C9JAG2 P15036
		NCBI	2114
		KEGG signaling	Ras signaling pathway
14	ATF3	ENSG00000162772	activating transcription factor 3
		UniProt	A0A0A0MRJ2 P18847 Q5VTZ4
		NCBI	467
8	FOSL2	ENSG00000075426	FOS like 2, AP-1 transcription factor subunit
		UniProt	C9JCN8 P15408
		NCBI	2355
10	SMAD4	ENSG00000141646	SMAD family member 4
		UniProt	A0A087WUF3 K7EIJ2 K7EIU8 K7EL15 K7EL18 K7ELK2 K7ENG1 K7ENG8 K7ES96 Q13485
		NCBI	4089
		KEGG signaling	Adherens junction Wnt signaling pathway FoxO signaling pathway Cell cycle TGF-beta signaling pathway Apelin signaling pathway Hippo signaling pathway
19	FOS	ENSG00000170345	Fos proto-oncogene, AP-1 transcription factor subunit
		UniProt	G3V289 G3V2V7 G3V5J9 G3V5N7 G3V5N9 H0YJM3 P01100
		NCBI	2353
		KEGG signaling	MAPK signaling pathway Toll-like receptor signaling pathway B cell receptor signaling pathway cAMP signaling pathway Apoptosis T cell receptor signaling pathway Prolactin signaling pathway Relaxin signaling pathway Estrogen signaling pathway Dopaminergic synapse Cholinergic synapse TNF signaling pathway IL-17 signaling pathway Oxytocin signaling pathway
11	ATF7	ENSG00000170653	activating transcription factor 7
		UniProt	F8VWG7 K7EKZ7 K7ESA4 P17544
		NCBI	11016
2	NFAT5	ENSG00000102908	nuclear factor of activated T cells 5
		UniProt	A0A494C020 A0A499FIS8 A0A499FJX5 H3BP21 J3KRL6 J3QKS5 O94916
		NCBI	10725
7	MECOM	ENSG00000085276	MDS1 and EVI1 complex locus
		UniProt	A0A0C3SFZ7 A0A1B0GXI8 C9JU02 E7EPY2 E7ERX0 E7EU48 E7EUL6 E9PGE9 H9KVD4 Q03112
		NCBI	2122
		KEGG signaling	MAPK signaling pathway
9	NFATC1	ENSG00000131196	nuclear factor of activated T cells 1
		UniProt	F5H4S8 K7EQ04 K7ER53 O95644
		NCBI	4772
		KEGG signaling	Wnt signaling pathway cAMP signaling pathway B cell receptor signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway cGMP-PKG signaling pathway MAPK signaling pathway C-type lectin receptor signaling pathway Oxytocin signaling pathway
3	NFATC2	ENSG00000101096	nuclear factor of activated T cells 2
		UniProt	Q13469
		NCBI	4773
		KEGG signaling	B cell receptor signaling pathway Wnt signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway cGMP-PKG signaling pathway VEGF signaling pathway C-type lectin receptor signaling pathway Oxytocin signaling pathway
3	KAT7	ENSG00000136504	lysine acetyltransferase 7
		UniProt	D6RFZ5 E7EUP3 O95251
		NCBI	11143
8	FOSB	ENSG00000125740	FosB proto-oncogene, AP-1 transcription factor subunit
		UniProt	K7EJ89 K7EKA0 K7EKC1 K7ERZ8 P53539
		NCBI	2354
		KEGG signaling	IL-17 signaling pathway
3	NFYA	ENSG00000001167	nuclear transcription factor Y subunit alpha
		UniProt	P23511
		NCBI	4800
		KEGG signaling	Antigen processing and presentation
3	TCF7L2	ENSG00000148737	transcription factor 7 like 2
		UniProt	A0A0A0MTL7 A0A0D9SGH8 A0A1B0GU84 A0A1B0GUV5 A0A1B0GVE1 C6ZRJ6 C6ZRJ7 C6ZRK5 E2GH26 H0YEE5 Q5JRY3 Q5JRY4 Q5JRY5 Q5VVR5 Q5VVR7 Q5VVR8 Q9NQB0
		NCBI	6934
		KEGG signaling	Adherens junction Wnt signaling pathway Melanogenesis Hippo signaling pathway
5	TCF4	ENSG00000196628	transcription factor 4
		UniProt	A0A075B723 A0A0D9SEK1 A0A0D9SEX8 A0A0D9SEZ3 A0A0D9SF18 A0A0D9SF97 A0A0D9SFU5 A0A0D9SFX5 A0A0D9SFZ1 A0A0D9SG44 A0A0D9SG55 A0A0D9SG61 A0A0D9SG78 A0A0D9SGE4 A0A0D9SGE5 A0A0D9SGE7 A0A0D9SGH7 A0A0D9SGJ4 A0A0E3D6N2 A0A1B0GTP2 A0A1B0GUT3 A0A1B0GV10 A0A1B0GVB8 A0A1B0GVR6 A0A1B0GW91 A0A1B0GWD5 A0A1B0GXH5 A0A590UK26 E9PH57 G0LNT4 G0LNT7 H3BMC8 H3BME8 H3BML7 H3BNI2 H3BNZ2 H3BP59 H3BPG3 H3BPJ7 H3BRF7 H3BT24 H3BT95 H3BTC3 H3BTM9 H3BTP3 H3BTZ0 H3BUQ3 K7ESI6 P15884
		NCBI	6925
6	HIRA	ENSG00000100084	histone cell cycle regulator
		UniProt	H7C2A7 P54198
		NCBI	7290

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	271.48 KB
	H.sapiens_subnetwork.tsv	19.43 KB

Species:

Network information:

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Network appearance:

ENSG00000177606

RELA

CTNNB1

ATF1

ETS1

ATF4

SMAD3

JUNB

JUND

FOSL1

DDIT3

GTF2B

TEAD1

CREB5

KLF5

ETS2

ATF3

FOSL2

SMAD4

FOS

ATF7

NFAT5

MECOM

NFATC1

NFATC2

KAT7

FOSB

NFYA

TCF7L2

TCF4

HIRA

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