Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000175595
3. ERCC excision repair 4,…
- 2. ERCC1
  3. ERCC excision repair 1,…
  4. 1.000
  5. PPI
- 2. MSH2
  3. mutS homolog 2
  4. 1.000
  5. PPI
- 2. SLX4
  3. SLX4 structure-specific…
  4. 1.000
  5. PPI
- 2. DDB1
  3. damage specific DNA bin…
  4. 1.000
  5. Complex
- 2. RPA1
  3. replication protein A1
  4. 1.000
  5. PPI
- 2. DNA2
  3. DNA replication helicas…
  4. 1.000
  5. PPI
- 2. SLX1B
  3. SLX1 homolog B, structu…
  4. 0.999
  5. PPI
- 2. SLX1A
  3. SLX1 homolog A, structu…
  4. 0.999
  5. PPI
- 2. XPA
  3. XPA, DNA damage recogni…
  4. 0.999
  5. PPI
- 2. RNF20
  3. ring finger protein 20
  4. 0.999
  5. Complex
- 2. INO80
  3. INO80 complex ATPase su…
  4. 0.999
  5. Complex
- 2. AATF
  3. apoptosis antagonizing …
  4. 0.998
  5. Complex
- 2. CUL4A
  3. cullin 4A
  4. 0.998
  5. Complex
- 2. DCAF1
  3. DDB1 and CUL4 associate…
  4. 0.997
  5. Complex
- 2. COPS7A
  3. COP9 signalosome subuni…
  4. 0.997
  5. Complex
- 2. PLK1
  3. polo like kinase 1
  4. 0.997
  5. PPI
- 2. MUS81
  3. MUS81 structure-specifi…
  4. 0.997
  5. PPI
- 2. ERCC6
  3. ERCC excision repair 6,…
  4. 0.996
  5. PPI
- 2. CUL1
  3. cullin 1
  4. 0.994
  5. Complex
- 2. POLR2A
  3. RNA polymerase II subun…
  4. 0.993
  5. PPI
- 2. TPR
  3. translocated promoter r…
  4. 0.991
  5. Complex
- 2. RUVBL2
  3. RuvB like AAA ATPase 2
  4. 0.990
  5. PPI
- 2. GPI
  3. glucose-6-phosphate iso…
  4. 0.990
  5. Metabolic
- 2. RNF8
  3. ring finger protein 8
  4. 0.989
  5. PPI
- 2. ATG3
  3. autophagy related 3
  4. 0.987
  5. Complex
- 2. MTA3
  3. metastasis associated 1…
  4. 0.985
  5. Complex
- 2. GTF2H1
  3. general transcription f…
  4. 0.984
  5. PPI
- 2. LIG4
  3. DNA ligase 4
  4. 0.976
  5. Metabolic
- 2. PRPF19
  3. pre-mRNA processing fac…
  4. 0.974
  5. PPI
- 2. SPTAN1
  3. spectrin alpha, non-ery…
  4. 0.974
  5. PPI

Subnetwork gene interactions

ENSG00000175595

ERCC excision repair 4, endonuclease catalytic subunit

FunCoup

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Ensembl

ENSG00000175595

UniProt

NCBI

2072

AATF

apoptosis antagonizing transcription factor

FunCoup

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Ensembl

ENSG00000275700

UniProt

NCBI

26574

RNF20

ring finger protein 20

FunCoup

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Ensembl

ENSG00000155827

UniProt

NCBI

56254

PLK1

polo like kinase 1

FunCoup

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Ensembl

ENSG00000166851

UniProt

NCBI

5347

TPR

translocated promoter region, nuclear basket protein

FunCoup

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Ensembl

ENSG00000047410

UniProt

NCBI

7175

RNF8

ring finger protein 8

FunCoup

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Ensembl

ENSG00000112130

UniProt

NCBI

9025

PRPF19

pre-mRNA processing factor 19

FunCoup

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Ensembl

ENSG00000110107

UniProt

NCBI

27339

MUS81

MUS81 structure-specific endonuclease subunit

FunCoup

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Ensembl

ENSG00000172732

UniProt

NCBI

80198

DDB1

damage specific DNA binding protein 1

FunCoup

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Ensembl

ENSG00000167986

UniProt

NCBI

1642

XPA

XPA, DNA damage recognition and repair factor

FunCoup

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Ensembl

ENSG00000136936

UniProt

NCBI

7507

ERCC1

ERCC excision repair 1, endonuclease non-catalytic subunit

FunCoup

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Ensembl

ENSG00000012061

UniProt

NCBI

2067

LIG4

DNA ligase 4

FunCoup

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Ensembl

ENSG00000174405

UniProt

NCBI

3981

INO80

INO80 complex ATPase subunit

FunCoup

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Ensembl

ENSG00000128908

UniProt

NCBI

54617

RPA1

replication protein A1

FunCoup

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Ensembl

ENSG00000132383

UniProt

NCBI

6117

COPS7A

COP9 signalosome subunit 7A

FunCoup

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Ensembl

ENSG00000111652

UniProt

NCBI

50813

POLR2A

RNA polymerase II subunit A

FunCoup

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Ensembl

ENSG00000181222

UniProt

NCBI

5430

CUL1

cullin 1

FunCoup

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Ensembl

ENSG00000055130

UniProt

NCBI

8454

SLX1A

SLX1 homolog A, structure-specific endonuclease subunit

FunCoup

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Ensembl

ENSG00000132207

UniProt

NCBI

548593
79008

MTA3

metastasis associated 1 family member 3

FunCoup

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Ensembl

ENSG00000057935

UniProt

NCBI

57504

ERCC6

ERCC excision repair 6, chromatin remodeling factor

FunCoup

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Ensembl

ENSG00000225830

UniProt

NCBI

2074

SLX1B

SLX1 homolog B, structure-specific endonuclease subunit

FunCoup

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Ensembl

ENSG00000181625

UniProt

NCBI

548593
79008

ATG3

autophagy related 3

FunCoup

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Ensembl

ENSG00000144848

UniProt

NCBI

64422

GPI

glucose-6-phosphate isomerase

FunCoup

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Ensembl

ENSG00000105220

UniProt

NCBI

2821

DCAF1

DDB1 and CUL4 associated factor 1

FunCoup

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Ensembl

ENSG00000145041

UniProt

Q9Y4B6

NCBI

9730

MSH2

mutS homolog 2

FunCoup

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Ensembl

ENSG00000095002

UniProt

NCBI

4436

RUVBL2

RuvB like AAA ATPase 2

FunCoup

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Ensembl

ENSG00000183207

UniProt

NCBI

10856

SLX4

SLX4 structure-specific endonuclease subunit

FunCoup

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Ensembl

ENSG00000188827

UniProt

Q8IY92

NCBI

84464

DNA2

DNA replication helicase/nuclease 2

FunCoup

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Ensembl

ENSG00000138346

UniProt

NCBI

1763

CUL4A

cullin 4A

FunCoup

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Ensembl

ENSG00000139842

UniProt

NCBI

8451

GTF2H1

general transcription factor IIH subunit 1

FunCoup

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Ensembl

ENSG00000110768

UniProt

NCBI

2965

SPTAN1

spectrin alpha, non-erythrocytic 1

FunCoup

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Ensembl

ENSG00000197694

UniProt

NCBI

6709

Query genes

		Identifier	Description
30	ENSG00000175595	ENSG00000175595	ERCC excision repair 4, endonuclease catalytic subunit
		UniProt	I3L4K0 I3NI48 Q92889
		NCBI	2072
		KEGG metabolic	Fanconi anemia pathway Nucleotide excision repair

Subnetwork genes

		Identifier	Description
21	AATF	ENSG00000275700	apoptosis antagonizing transcription factor
		UniProt	A0A087WTH8 A0A087WW41 A0A087WWS8 Q9NY61
		NCBI	26574
22	RNF20	ENSG00000155827	ring finger protein 20
		UniProt	C9J0A5 C9JWJ4 C9JXC9 Q5VTR2
		NCBI	56254
15	PLK1	ENSG00000166851	polo like kinase 1
		UniProt	I3L2H5 I3L309 I3L387 P53350
		NCBI	5347
		KEGG signaling	Oocyte meiosis FoxO signaling pathway Cell cycle Progesterone-mediated oocyte maturation
22	TPR	ENSG00000047410	translocated promoter region, nuclear basket protein
		UniProt	P12270 Q5SWX9
		NCBI	7175
		KEGG metabolic	RNA transport
5	RNF8	ENSG00000112130	ring finger protein 8
		UniProt	C9J858 F8WDH8 F8WEW6 H7C4L7 O76064
		NCBI	9025
17	PRPF19	ENSG00000110107	pre-mRNA processing factor 19
		UniProt	F5GY56 F5H2I0 H0YGF3 H0YGZ5 Q9UMS4
		NCBI	27339
		KEGG metabolic	Spliceosome Ubiquitin mediated proteolysis
16	MUS81	ENSG00000172732	MUS81 structure-specific endonuclease subunit
		UniProt	E9PII7 E9PL60 E9PRI1 H0YDE3 H0YDK3 H0YDU2 H0YE94 Q96NY9
		NCBI	80198
		KEGG metabolic	Fanconi anemia pathway Homologous recombination
26	DDB1	ENSG00000167986	damage specific DNA binding protein 1
		UniProt	F5GWI0 F5GY55 F5GYG8 F5GZY8 F5H198 F5H2L3 Q16531
		NCBI	1642
		KEGG metabolic	Ubiquitin mediated proteolysis Nucleotide excision repair
11	XPA	ENSG00000136936	XPA, DNA damage recognition and repair factor
		UniProt	F2Z2T2 P23025
		NCBI	7507
		KEGG metabolic	Nucleotide excision repair
19	ERCC1	ENSG00000012061	ERCC excision repair 1, endonuclease non-catalytic subunit
		UniProt	K7EJL2 K7EJW9 K7EK97 K7EMT9 K7EP14 K7ER60 K7ER89 K7ES46 P07992
		NCBI	2067
		KEGG metabolic	Fanconi anemia pathway Nucleotide excision repair
12	LIG4	ENSG00000174405	DNA ligase 4
		UniProt	A0A0C4DGV9 P49917
		NCBI	3981
		KEGG metabolic	Non-homologous end-joining
19	INO80	ENSG00000128908	INO80 complex ATPase subunit
		UniProt	A0A087X0U7 H0YKH3 H0YMN5 H0YNL3 Q9ULG1
		NCBI	54617
22	RPA1	ENSG00000132383	replication protein A1
		UniProt	I3L2M5 I3L4R8 I3L524 P27694
		NCBI	6117
		KEGG metabolic	DNA replication Fanconi anemia pathway Homologous recombination Mismatch repair Nucleotide excision repair
13	COPS7A	ENSG00000111652	COP9 signalosome subunit 7A
		UniProt	F5GXT7 F5GYF7 F5H248 F5H3M6 F5H4U8 F5H4Z0 F5H7C6 G3XAP1 Q9UBW8
		NCBI	50813
19	POLR2A	ENSG00000181222	RNA polymerase II subunit A
		UniProt	A0A590UJN4 A0A590UKB6 P24928
		NCBI	5430
		KEGG metabolic	RNA polymerase
17	CUL1	ENSG00000055130	cullin 1
		UniProt	A0A0C4DGX4 A0A590UJ21 A0A590UJ50 A0A590UJ56 A0A590UJ59 A0A590UJ97 A0A590UJA0 A0A590UJC4 A0A590UJM8 A0A590UJR3 A0A590UK34 Q13616
		NCBI	8454
		KEGG signaling	Oocyte meiosis Wnt signaling pathway Cell cycle Hedgehog signaling pathway TGF-beta signaling pathway
		KEGG metabolic	Ubiquitin mediated proteolysis Protein processing in endoplasmic reticulum
8	SLX1A	ENSG00000132207	SLX1 homolog A, structure-specific endonuclease subunit
		UniProt	H3BPC3 Q9BQ83
		NCBI	548593 79008
		KEGG metabolic	Fanconi anemia pathway
8	MTA3	ENSG00000057935	metastasis associated 1 family member 3
		UniProt	C9JR73 E7EQY4 E7EV10 E9PCS8 E9PF88 F6RRE2 Q9BTC8
		NCBI	57504
11	ERCC6	ENSG00000225830	ERCC excision repair 6, chromatin remodeling factor
		UniProt	A0A096LNQ7 D6R9X7 P0DP91 Q03468
		NCBI	2074
		KEGG metabolic	Nucleotide excision repair
8	SLX1B	ENSG00000181625	SLX1 homolog B, structure-specific endonuclease subunit
		UniProt	H3BRR6 Q9BQ83
		NCBI	548593 79008
		KEGG metabolic	Fanconi anemia pathway
6	ATG3	ENSG00000144848	autophagy related 3
		UniProt	C9JNW8 F8WDI0 Q9NT62
		NCBI	64422
		KEGG metabolic	Autophagy - animal
13	GPI	ENSG00000105220	glucose-6-phosphate isomerase
		UniProt	A0A0G2JLI6 A0A2R8Y6C7 A0A2R8YF08 A0A2U3TZU2 K7EIL4 K7ELR7 K7ENA0 K7EP41 K7EPY4 K7EQ48 K7ERC6 K7ERK8 P06744
		NCBI	2821
		KEGG metabolic	Starch and sucrose metabolism Pentose phosphate pathway Glycolysis / Gluconeogenesis Carbon metabolism Amino sugar and nucleotide sugar metabolism
15	DCAF1	ENSG00000145041	DDB1 and CUL4 associated factor 1
		UniProt	Q9Y4B6
		NCBI	9730
21	MSH2	ENSG00000095002	mutS homolog 2
		UniProt	A0A2R8Y6P0 A0A2R8Y713 A0A2R8Y7S8 A0A2R8YFH0 A0A2R8YG02 C9J809 E9PHA6 P43246
		NCBI	4436
		KEGG metabolic	Mismatch repair
20	RUVBL2	ENSG00000183207	RuvB like AAA ATPase 2
		UniProt	A0A1W2PS22 A0A1W2PS48 M0QXI6 M0QXZ7 M0QYD8 M0R0Y3 M0R0Z0 Q9Y230 X6R2L4
		NCBI	10856
15	SLX4	ENSG00000188827	SLX4 structure-specific endonuclease subunit
		UniProt	Q8IY92
		NCBI	84464
		KEGG metabolic	Fanconi anemia pathway
18	DNA2	ENSG00000138346	DNA replication helicase/nuclease 2
		UniProt	F8VPM6 F8VR31 H0Y455 P51530
		NCBI	1763
		KEGG metabolic	DNA replication
13	CUL4A	ENSG00000139842	cullin 4A
		UniProt	A0A087WWN2 A0A0A0MR50 Q13619
		NCBI	8451
		KEGG metabolic	Ubiquitin mediated proteolysis Nucleotide excision repair
8	GTF2H1	ENSG00000110768	general transcription factor IIH subunit 1
		UniProt	E9PI26 E9PL58 E9PM51 F5H0Y9 P32780
		NCBI	2965
		KEGG metabolic	Basal transcription factors Nucleotide excision repair
4	SPTAN1	ENSG00000197694	spectrin alpha, non-erythrocytic 1
		UniProt	A0A0D9SF54 A0A0D9SFF6 A0A0D9SFH4 A0A0D9SGF6 A0A1B0GTB7 A0A1B0GTD1 A0A1B0GUH3 A0A1B0GUN2 A0A1B0GV13 A0A1B0GW19 A0A1B0GWE2 A0A5F9ZHC3 Q13813
		NCBI	6709
		KEGG signaling	Apoptosis

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	290.38 KB
	H.sapiens_subnetwork.tsv	41.22 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000175595

AATF

RNF20

PLK1

TPR

RNF8

PRPF19

MUS81

DDB1

XPA

ERCC1

LIG4

INO80

RPA1

COPS7A

POLR2A

CUL1

SLX1A

MTA3

ERCC6

SLX1B

ATG3

GPI

DCAF1

MSH2

RUVBL2

SLX4

DNA2

CUL4A

GTF2H1

SPTAN1

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