Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000173559
3. nucleic acid binding pr…
- 2. INIP
  3. INTS3 and NABP interact…
  4. 0.998
  5. PPI
- 2. INTS3
  3. integrator complex subu…
  4. 0.995
  5. Complex
- 2. INTS6
  3. integrator complex subu…
  4. 0.982
  5. PPI
- 2. HAT1
  3. histone acetyltransfera…
  4. 0.974
  5. Metabolic
- 2. TP53
  3. tumor protein p53
  4. 0.943
  5. PPI
- 2. NHP2
  3. NHP2 ribonucleoprotein
  4. 0.928
  5. Metabolic
- 2. GAR1
  3. GAR1 ribonucleoprotein
  4. 0.928
  5. Metabolic
- 2. ORC4
  3. origin recognition comp…
  4. 0.920
  5. Metabolic
- 2. INTS5
  3. integrator complex subu…
  4. 0.884
  5. PPI
- 2. RBMX
  3. RNA binding motif prote…
  4. 0.860
  5. PPI
- 2. ERCC1
  3. ERCC excision repair 1,…
  4. 0.779
  5. Metabolic
- 2. RPA2
  3. replication protein A2
  4. 0.779
  5. Metabolic
- 2. INTS11
  3. integrator complex subu…
  4. 0.770
  5. Complex
- 2. ACTR6
  3. actin related protein 6
  4. 0.763
  5. Metabolic
- 2. SNF8
  3. SNF8 subunit of ESCRT-II
  4. 0.754
  5. Metabolic
- 2. UCHL5
  3. ubiquitin C-terminal hy…
  4. 0.751
  5. Metabolic
- 2. NOP58
  3. NOP58 ribonucleoprotein
  4. 0.735
  5. Metabolic
- 2. RPF2
  3. ribosome production fac…
  4. 0.725
  5. Metabolic
- 2. IMP3
  3. IMP U3 small nucleolar …
  4. 0.723
  5. Metabolic
- 2. NCL
  3. nucleolin
  4. 0.720
  5. Metabolic
- 2. UTP4
  3. UTP4 small subunit proc…
  4. 0.714
  5. Metabolic
- 2. RAD1
  3. RAD1 checkpoint DNA exo…
  4. 0.708
  5. Metabolic
- 2. NUDC
  3. nuclear distribution C,…
  4. 0.706
  5. Metabolic
- 2. ESF1
  3. ESF1 nucleolar pre-rRNA…
  4. 0.704
  5. Metabolic
- 2. POLR2C
  3. RNA polymerase II subun…
  4. 0.701
  5. Metabolic
- 2. MRE11
  3. MRE11 homolog, double s…
  4. 0.694
  5. Metabolic
- 2. WDR82
  3. WD repeat domain 82
  4. 0.692
  5. Metabolic
- 2. ORC5
  3. origin recognition comp…
  4. 0.691
  5. Metabolic
- 2. GOLT1B
  3. golgi transport 1B
  4. 0.689
  5. PPI
- 2. ACTL6A
  3. actin like 6A
  4. 0.680
  5. Metabolic

Subnetwork gene interactions

ENSG00000173559

nucleic acid binding protein 1

FunCoup

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Ensembl

ENSG00000173559

UniProt

NCBI

64859

ESF1

ESF1 nucleolar pre-rRNA processing protein homolog

FunCoup

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Ensembl

ENSG00000089048

UniProt

NCBI

51575

NHP2

NHP2 ribonucleoprotein

FunCoup

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Ensembl

ENSG00000145912

UniProt

NCBI

55651

ORC4

origin recognition complex subunit 4

FunCoup

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Ensembl

ENSG00000115947

UniProt

NCBI

5000

POLR2C

RNA polymerase II subunit C

FunCoup

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Ensembl

ENSG00000102978

UniProt

NCBI

5432

ACTL6A

actin like 6A

FunCoup

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Ensembl

ENSG00000136518

UniProt

NCBI

RPA2

replication protein A2

FunCoup

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Ensembl

ENSG00000117748

UniProt

NCBI

6118

MRE11

MRE11 homolog, double strand break repair nuclease

FunCoup

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Ensembl

ENSG00000020922

UniProt

NCBI

4361

GAR1

GAR1 ribonucleoprotein

FunCoup

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Ensembl

ENSG00000109534

UniProt

Q9NY12

NCBI

54433

UTP4

UTP4 small subunit processome component

FunCoup

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Ensembl

ENSG00000141076

UniProt

NCBI

84916

NCL

nucleolin

FunCoup

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Ensembl

ENSG00000115053

UniProt

NCBI

4691

ORC5

origin recognition complex subunit 5

FunCoup

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Ensembl

ENSG00000164815

UniProt

NCBI

5001

GOLT1B

golgi transport 1B

FunCoup

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Ensembl

ENSG00000111711

UniProt

NCBI

51026

RBMX

RNA binding motif protein X-linked

FunCoup

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Ensembl

ENSG00000147274

UniProt

NCBI

27316

HAT1

histone acetyltransferase 1

FunCoup

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Ensembl

ENSG00000128708

UniProt

NCBI

8520

ERCC1

ERCC excision repair 1, endonuclease non-catalytic subunit

FunCoup

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Ensembl

ENSG00000012061

UniProt

NCBI

2067

NUDC

nuclear distribution C, dynein complex regulator

FunCoup

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Ensembl

ENSG00000090273

UniProt

NCBI

10726

UCHL5

ubiquitin C-terminal hydrolase L5

FunCoup

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Ensembl

ENSG00000116750

UniProt

NCBI

51377

IMP3

IMP U3 small nucleolar ribonucleoprotein 3

FunCoup

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Ensembl

ENSG00000177971

UniProt

Q9NV31

NCBI

55272

INTS6

integrator complex subunit 6

FunCoup

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Ensembl

ENSG00000102786

UniProt

NCBI

26512

INTS3

integrator complex subunit 3

FunCoup

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Ensembl

ENSG00000143624

UniProt

NCBI

65123

WDR82

WD repeat domain 82

FunCoup

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Ensembl

ENSG00000164091

UniProt

NCBI

80335

RAD1

RAD1 checkpoint DNA exonuclease

FunCoup

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Ensembl

ENSG00000113456

UniProt

NCBI

5810

NOP58

NOP58 ribonucleoprotein

FunCoup

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Ensembl

ENSG00000055044

UniProt

NCBI

51602

INTS11

integrator complex subunit 11

FunCoup

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Ensembl

ENSG00000127054

UniProt

NCBI

54973

ACTR6

actin related protein 6

FunCoup

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Ensembl

ENSG00000075089

UniProt

NCBI

64431

SNF8

SNF8 subunit of ESCRT-II

FunCoup

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Ensembl

ENSG00000159210

UniProt

NCBI

11267

INIP

INTS3 and NABP interacting protein

FunCoup

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Ensembl

ENSG00000148153

UniProt

NCBI

58493

RPF2

ribosome production factor 2 homolog

FunCoup

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Ensembl

ENSG00000197498

UniProt

NCBI

84154

INTS5

integrator complex subunit 5

FunCoup

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Ensembl

ENSG00000185085

UniProt

Q6P9B9

NCBI

80789

TP53

tumor protein p53

FunCoup

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Ensembl

ENSG00000141510

UniProt

NCBI

7157

Query genes

		Identifier	Description
30	ENSG00000173559	ENSG00000173559	nucleic acid binding protein 1
		UniProt	F8WAF5 H7C0W4 Q96AH0
		NCBI	64859

Subnetwork genes

		Identifier	Description
22	ESF1	ENSG00000089048	ESF1 nucleolar pre-rRNA processing protein homolog
		UniProt	A0A087WX71 Q9H501
		NCBI	51575
23	NHP2	ENSG00000145912	NHP2 ribonucleoprotein
		UniProt	D6RC52 D6RCB9 H0YC83 J3QSY4 Q9NX24
		NCBI	55651
		KEGG metabolic	Ribosome biogenesis in eukaryotes
21	ORC4	ENSG00000115947	origin recognition complex subunit 4
		UniProt	C9J2X8 C9JGH7 O43929 Q53SE3
		NCBI	5000
		KEGG signaling	Cell cycle
22	POLR2C	ENSG00000102978	RNA polymerase II subunit C
		UniProt	H3BRR2 P19387
		NCBI	5432
		KEGG metabolic	RNA polymerase
20	ACTL6A	ENSG00000136518	actin like 6A
		UniProt	C9JQT2 H7C5S0 O96019
		NCBI	86
24	RPA2	ENSG00000117748	replication protein A2
		UniProt	P15927 Q5TEJ0 Q5TEJ7
		NCBI	6118
		KEGG metabolic	DNA replication Fanconi anemia pathway Homologous recombination Mismatch repair Nucleotide excision repair
21	MRE11	ENSG00000020922	MRE11 homolog, double strand break repair nuclease
		UniProt	F5GXT0 F5H256 F5H742 F8W7U8 P49959
		NCBI	4361
		KEGG metabolic	Non-homologous end-joining Homologous recombination
22	GAR1	ENSG00000109534	GAR1 ribonucleoprotein
		UniProt	Q9NY12
		NCBI	54433
		KEGG metabolic	Ribosome biogenesis in eukaryotes
19	UTP4	ENSG00000141076	UTP4 small subunit processome component
		UniProt	H3BPD7 H3BRM8 H3BSH7 I3L4T9 J3KSE6 J3KSI1 J3KTR0 Q969X6
		NCBI	84916
		KEGG metabolic	Ribosome biogenesis in eukaryotes
19	NCL	ENSG00000115053	nucleolin
		UniProt	C9J1H7 C9JLB1 C9JWL1 C9JYW2 H7BY16 P19338
		NCBI	4691
23	ORC5	ENSG00000164815	origin recognition complex subunit 5
		UniProt	G3V0H0 O43913
		NCBI	5001
		KEGG signaling	Cell cycle
8	GOLT1B	ENSG00000111711	golgi transport 1B
		UniProt	F5GWD8 F5GXH6 F5H6U7 G3V1U5 Q9Y3E0
		NCBI	51026
6	RBMX	ENSG00000147274	RNA binding motif protein X-linked
		UniProt	H0Y6E7 H3BNC1 H3BR27 H3BT71 H3BUY5 P38159
		NCBI	27316
		KEGG metabolic	Spliceosome
24	HAT1	ENSG00000128708	histone acetyltransferase 1
		UniProt	F8W9G7 F8WEW1 O14929
		NCBI	8520
16	ERCC1	ENSG00000012061	ERCC excision repair 1, endonuclease non-catalytic subunit
		UniProt	K7EJL2 K7EJW9 K7EK97 K7EMT9 K7EP14 K7ER60 K7ER89 K7ES46 P07992
		NCBI	2067
		KEGG metabolic	Fanconi anemia pathway Nucleotide excision repair
23	NUDC	ENSG00000090273	nuclear distribution C, dynein complex regulator
		UniProt	A0A0A0MSS4 A0A0A0MSU9 Q9Y266
		NCBI	10726
21	UCHL5	ENSG00000116750	ubiquitin C-terminal hydrolase L5
		UniProt	H0Y4E0 H0Y4K0 H0Y636 H0Y6Y4 Q5LJA5 Q5LJA9 Q5LJB0 Q5LJB1 Q9Y5K5
		NCBI	51377
22	IMP3	ENSG00000177971	IMP U3 small nucleolar ribonucleoprotein 3
		UniProt	Q9NV31
		NCBI	55272
		KEGG metabolic	Ribosome biogenesis in eukaryotes
8	INTS6	ENSG00000102786	integrator complex subunit 6
		UniProt	B3KQH5 C9J885 C9JAV7 C9JVX2 C9JXP6 C9K0V7 F8WAV7 G5E9X1 Q9UL03
		NCBI	26512
7	INTS3	ENSG00000143624	integrator complex subunit 3
		UniProt	A0A096LNW8 A0A096LPB9 H0Y8Z1 Q68E01
		NCBI	65123
21	WDR82	ENSG00000164091	WD repeat domain 82
		UniProt	C9J355 C9JBU3 Q6UXN9
		NCBI	80335
		KEGG metabolic	mRNA surveillance pathway
25	RAD1	ENSG00000113456	RAD1 checkpoint DNA exonuclease
		UniProt	D6R9A1 O60671
		NCBI	5810
22	NOP58	ENSG00000055044	NOP58 ribonucleoprotein
		UniProt	F8WED0 H7BZ72 Q9Y2X3
		NCBI	51602
		KEGG metabolic	Ribosome biogenesis in eukaryotes
6	INTS11	ENSG00000127054	integrator complex subunit 11
		UniProt	A0A087WXT8 A0A087WYI0 C9IYS7 C9J979 E9PI75 E9PIG1 E9PIL7 E9PIS0 E9PIX9 E9PJG0 E9PKA4 E9PMA2 E9PNH9 E9PNS4 E9PQF0 H0YCE0 H0YDB1 H0YE15 H0YEQ9 H7C247 J3QRY6 Q5TA45 Q96HV7
		NCBI	54973
21	ACTR6	ENSG00000075089	actin related protein 6
		UniProt	F8VP72 F8VRL1 F8VSD1 F8W043 F8W057 F8W0Q1 G3V1Y1 Q9GZN1
		NCBI	64431
13	SNF8	ENSG00000159210	SNF8 subunit of ESCRT-II
		UniProt	D6RBI1 D6RFY6 D6RJ86 H0Y8S5 I3L2X5 I3L457 K7EPV2 Q96H20
		NCBI	11267
		KEGG metabolic	Endocytosis
3	INIP	ENSG00000148153	INTS3 and NABP interacting protein
		UniProt	Q5VWJ6 Q9NRY2 X6R8P6
		NCBI	58493
22	RPF2	ENSG00000197498	ribosome production factor 2 homolog
		UniProt	Q5VXM9 Q5VXN0 Q9H7B2 U3KQN5
		NCBI	84154
6	INTS5	ENSG00000185085	integrator complex subunit 5
		UniProt	Q6P9B9
		NCBI	80789
4	TP53	ENSG00000141510	tumor protein p53
		UniProt	A0A087WT22 A0A087WXZ1 A0A087WZU8 A0A087X1Q1 A0A0U1RQC9 E7EMR6 E7EQX7 E7ESS1 E9PCY9 E9PFT5 I3L0W9 J3KP33 P04637 S4R334
		NCBI	7157
		KEGG signaling	Neurotrophin signaling pathway p53 signaling pathway Wnt signaling pathway Thyroid hormone signaling pathway Apoptosis Cell cycle MAPK signaling pathway PI3K-Akt signaling pathway Sphingolipid signaling pathway

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	300.52 KB
	H.sapiens_subnetwork.tsv	48.61 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000173559

ESF1

NHP2

ORC4

POLR2C

ACTL6A

RPA2

MRE11

GAR1

UTP4

NCL

ORC5

GOLT1B

RBMX

HAT1

ERCC1

NUDC

UCHL5

IMP3

INTS6

INTS3

WDR82

RAD1

NOP58

INTS11

ACTR6

SNF8

INIP

RPF2

INTS5

TP53

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