Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000172732
3. MUS81 structure-specifi…
- 2. EME1
  3. essential meiotic struc…
  4. 1.000
  5. PPI
- 2. EME2
  3. essential meiotic struc…
  4. 1.000
  5. PPI
- 2. SLX4
  3. SLX4 structure-specific…
  4. 1.000
  5. PPI
- 2. FEN1
  3. flap structure-specific…
  4. 1.000
  5. PPI
- 2. PLK1
  3. polo like kinase 1
  4. 1.000
  5. PPI
- 2. ERCC1
  3. ERCC excision repair 1,…
  4. 1.000
  5. PPI
- 2. CHEK2
  3. checkpoint kinase 2
  4. 0.998
  5. PPI
- 2. DCAF1
  3. DDB1 and CUL4 associate…
  4. 0.998
  5. PPI
- 2. DDB1
  3. damage specific DNA bin…
  4. 0.998
  5. PPI
- 2. PCNA
  3. proliferating cell nucl…
  4. 0.998
  5. Complex
- 2. RIOK1
  3. RIO kinase 1
  4. 0.997
  5. PPI
- 2. CUL4A
  3. cullin 4A
  4. 0.997
  5. Complex
- 2. ERCC4
  3. ERCC excision repair 4,…
  4. 0.997
  5. PPI
- 2. SLX1B
  3. SLX1 homolog B, structu…
  4. 0.996
  5. PPI
- 2. SLX1A
  3. SLX1 homolog A, structu…
  4. 0.996
  5. PPI
- 2. RFC4
  3. replication factor C su…
  4. 0.995
  5. Metabolic
- 2. SF3B4
  3. splicing factor 3b subu…
  4. 0.994
  5. Metabolic
- 2. RAD54L
  3. RAD54 like
  4. 0.993
  5. PPI
- 2. IMP4
  3. IMP U3 small nucleolar …
  4. 0.991
  5. Metabolic
- 2. DIS3
  3. DIS3 homolog, exosome e…
  4. 0.987
  5. PPI
- 2. HNRNPU
  3. heterogeneous nuclear r…
  4. 0.985
  5. PPI
- 2. CCNB2
  3. cyclin B2
  4. 0.983
  5. PPI
- 2. UHRF1
  3. ubiquitin like with PHD…
  4. 0.982
  5. PPI
- 2. SMC5
  3. structural maintenance …
  4. 0.978
  5. Complex
- 2. RBM34
  3. RNA binding motif prote…
  4. 0.977
  5. Metabolic
- 2. MSH2
  3. mutS homolog 2
  4. 0.976
  5. Complex
- 2. RUVBL2
  3. RuvB like AAA ATPase 2
  4. 0.975
  5. Metabolic
- 2. PRMT1
  3. protein arginine methyl…
  4. 0.974
  5. Metabolic
- 2. SUMO2
  3. small ubiquitin like mo…
  4. 0.970
  5. PPI
- 2. UTP3
  3. UTP3 small subunit proc…
  4. 0.968
  5. Metabolic

Subnetwork gene interactions

ENSG00000172732

MUS81 structure-specific endonuclease subunit

FunCoup

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Ensembl

ENSG00000172732

UniProt

NCBI

80198

FEN1

flap structure-specific endonuclease 1

FunCoup

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Ensembl

ENSG00000168496

UniProt

NCBI

2237

CCNB2

cyclin B2

FunCoup

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Ensembl

ENSG00000157456

UniProt

NCBI

9133

PLK1

polo like kinase 1

FunCoup

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Ensembl

ENSG00000166851

UniProt

NCBI

5347

PCNA

proliferating cell nuclear antigen

FunCoup

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Ensembl

ENSG00000132646

UniProt

P12004

NCBI

5111

RBM34

RNA binding motif protein 34

FunCoup

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Ensembl

ENSG00000188739

UniProt

NCBI

23029

RFC4

replication factor C subunit 4

FunCoup

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Ensembl

ENSG00000163918

UniProt

NCBI

5984

DDB1

damage specific DNA binding protein 1

FunCoup

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Ensembl

ENSG00000167986

UniProt

NCBI

1642

DIS3

DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease

FunCoup

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Ensembl

ENSG00000083520

UniProt

NCBI

22894

RAD54L

RAD54 like

FunCoup

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Ensembl

ENSG00000085999

UniProt

NCBI

8438

SLX1B

SLX1 homolog B, structure-specific endonuclease subunit

FunCoup

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Ensembl

ENSG00000181625

UniProt

NCBI

548593
79008

HNRNPU

heterogeneous nuclear ribonucleoprotein U

FunCoup

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Ensembl

ENSG00000153187

UniProt

NCBI

3192

SLX1A

SLX1 homolog A, structure-specific endonuclease subunit

FunCoup

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Ensembl

ENSG00000132207

UniProt

NCBI

548593
79008

RUVBL2

RuvB like AAA ATPase 2

FunCoup

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Ensembl

ENSG00000183207

UniProt

NCBI

10856

UTP3

UTP3 small subunit processome component

FunCoup

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Ensembl

ENSG00000132467

UniProt

Q9NQZ2

NCBI

57050

EME1

essential meiotic structure-specific endonuclease 1

FunCoup

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Ensembl

ENSG00000154920

UniProt

NCBI

146956

IMP4

IMP U3 small nucleolar ribonucleoprotein 4

FunCoup

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Ensembl

ENSG00000136718

UniProt

NCBI

92856

MSH2

mutS homolog 2

FunCoup

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Ensembl

ENSG00000095002

UniProt

NCBI

4436

PRMT1

protein arginine methyltransferase 1

FunCoup

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Ensembl

ENSG00000126457

UniProt

NCBI

3276

SF3B4

splicing factor 3b subunit 4

FunCoup

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Ensembl

ENSG00000143368

UniProt

NCBI

10262

DCAF1

DDB1 and CUL4 associated factor 1

FunCoup

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Ensembl

ENSG00000145041

UniProt

Q9Y4B6

NCBI

9730

SUMO2

small ubiquitin like modifier 2

FunCoup

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Ensembl

ENSG00000188612

UniProt

NCBI

6613

ERCC1

ERCC excision repair 1, endonuclease non-catalytic subunit

FunCoup

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Ensembl

ENSG00000012061

UniProt

NCBI

2067

RIOK1

RIO kinase 1

FunCoup

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Ensembl

ENSG00000124784

UniProt

NCBI

83732

CUL4A

cullin 4A

FunCoup

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Ensembl

ENSG00000139842

UniProt

NCBI

8451

SMC5

structural maintenance of chromosomes 5

FunCoup

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Ensembl

ENSG00000198887

UniProt

Q8IY18

NCBI

23137

ERCC4

ERCC excision repair 4, endonuclease catalytic subunit

FunCoup

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Ensembl

ENSG00000175595

UniProt

NCBI

2072

SLX4

SLX4 structure-specific endonuclease subunit

FunCoup

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Ensembl

ENSG00000188827

UniProt

Q8IY92

NCBI

84464

CHEK2

checkpoint kinase 2

FunCoup

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Ensembl

ENSG00000183765

UniProt

NCBI

11200

UHRF1

ubiquitin like with PHD and ring finger domains 1

FunCoup

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Ensembl

ENSG00000276043

UniProt

NCBI

29128

EME2

essential meiotic structure-specific endonuclease subunit 2

FunCoup

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Ensembl

ENSG00000197774

UniProt

NCBI

197342

Query genes

		Identifier	Description
30	ENSG00000172732	ENSG00000172732	MUS81 structure-specific endonuclease subunit
		UniProt	E9PII7 E9PL60 E9PRI1 H0YDE3 H0YDK3 H0YDU2 H0YE94 Q96NY9
		NCBI	80198
		KEGG metabolic	Fanconi anemia pathway Homologous recombination

Subnetwork genes

		Identifier	Description
27	FEN1	ENSG00000168496	flap structure-specific endonuclease 1
		UniProt	F5H1Y3 I3L3E9 P39748
		NCBI	2237
		KEGG metabolic	DNA replication Non-homologous end-joining Base excision repair
13	CCNB2	ENSG00000157456	cyclin B2
		UniProt	H0YMP3 H1UBN3 O95067
		NCBI	9133
		KEGG signaling	p53 signaling pathway Oocyte meiosis FoxO signaling pathway Cell cycle Progesterone-mediated oocyte maturation
22	PLK1	ENSG00000166851	polo like kinase 1
		UniProt	I3L2H5 I3L309 I3L387 P53350
		NCBI	5347
		KEGG signaling	Oocyte meiosis FoxO signaling pathway Cell cycle Progesterone-mediated oocyte maturation
27	PCNA	ENSG00000132646	proliferating cell nuclear antigen
		UniProt	P12004
		NCBI	5111
		KEGG signaling	Tight junction Cell cycle
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair Base excision repair
18	RBM34	ENSG00000188739	RNA binding motif protein 34
		UniProt	A2A2V2 H7C5M1 P42696 Q5TCT4
		NCBI	23029
27	RFC4	ENSG00000163918	replication factor C subunit 4
		UniProt	C9J8M3 C9JGY5 C9JTT7 C9JW34 C9JXZ7 C9JZI1 F8WE44 H7C1P0 P35249
		NCBI	5984
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair
23	DDB1	ENSG00000167986	damage specific DNA binding protein 1
		UniProt	F5GWI0 F5GY55 F5GYG8 F5GZY8 F5H198 F5H2L3 Q16531
		NCBI	1642
		KEGG metabolic	Ubiquitin mediated proteolysis Nucleotide excision repair
17	DIS3	ENSG00000083520	DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
		UniProt	F2Z2C0 G3V1J5 Q9Y2L1
		NCBI	22894
		KEGG metabolic	RNA degradation
19	RAD54L	ENSG00000085999	RAD54 like
		UniProt	A0A087WTB0 A0A087WV39 A0A087WVW5 A0A087WW72 A0A087WWG5 A0A087X124 A0A590UJ71 A0A590UJ90 A0A590UJJ7 A0A590UJQ8 Q92698 V9GYD3 V9GYX6
		NCBI	8438
		KEGG metabolic	Homologous recombination
11	SLX1B	ENSG00000181625	SLX1 homolog B, structure-specific endonuclease subunit
		UniProt	H3BRR6 Q9BQ83
		NCBI	548593 79008
		KEGG metabolic	Fanconi anemia pathway
12	HNRNPU	ENSG00000153187	heterogeneous nuclear ribonucleoprotein U
		UniProt	A0A087WVI9 A0A087WZF3 A0A1W2PNG3 A0A1W2PP22 A0A1W2PP34 A0A1W2PP35 A0A1W2PPE9 A0A1W2PPH7 A0A1W2PPL4 A0A1W2PPS1 A0A1W2PQ74 A0A1W2PQD4 A0A1W2PQL0 A0A1W2PRI6 A0A1W2PRZ7 A0A1X7SBS1 Q00839 Q5RI18
		NCBI	3192
		KEGG metabolic	Spliceosome
11	SLX1A	ENSG00000132207	SLX1 homolog A, structure-specific endonuclease subunit
		UniProt	H3BPC3 Q9BQ83
		NCBI	548593 79008
		KEGG metabolic	Fanconi anemia pathway
22	RUVBL2	ENSG00000183207	RuvB like AAA ATPase 2
		UniProt	A0A1W2PS22 A0A1W2PS48 M0QXI6 M0QXZ7 M0QYD8 M0R0Y3 M0R0Z0 Q9Y230 X6R2L4
		NCBI	10856
19	UTP3	ENSG00000132467	UTP3 small subunit processome component
		UniProt	Q9NQZ2
		NCBI	57050
20	EME1	ENSG00000154920	essential meiotic structure-specific endonuclease 1
		UniProt	D6RIT8 F8W714 H0Y9Z4 Q96AY2
		NCBI	146956
		KEGG metabolic	Fanconi anemia pathway Homologous recombination
16	IMP4	ENSG00000136718	IMP U3 small nucleolar ribonucleoprotein 4
		UniProt	B8ZZ47 B9A008 E7ENR5 F8WCN0 H0Y714 Q96G21
		NCBI	92856
		KEGG metabolic	Ribosome biogenesis in eukaryotes
27	MSH2	ENSG00000095002	mutS homolog 2
		UniProt	A0A2R8Y6P0 A0A2R8Y713 A0A2R8Y7S8 A0A2R8YFH0 A0A2R8YG02 C9J809 E9PHA6 P43246
		NCBI	4436
		KEGG metabolic	Mismatch repair
22	PRMT1	ENSG00000126457	protein arginine methyltransferase 1
		UniProt	E9PIE2 E9PIX6 E9PKG1 E9PMW9 E9PMZ2 E9PNR9 E9PQ98 H0YDE4 Q99873
		NCBI	3276
		KEGG signaling	FoxO signaling pathway Glucagon signaling pathway
21	SF3B4	ENSG00000143368	splicing factor 3b subunit 4
		UniProt	Q15427 Q5SZ64
		NCBI	10262
		KEGG metabolic	Spliceosome
15	DCAF1	ENSG00000145041	DDB1 and CUL4 associated factor 1
		UniProt	Q9Y4B6
		NCBI	9730
14	SUMO2	ENSG00000188612	small ubiquitin like modifier 2
		UniProt	J3KRH1 P61956
		NCBI	6613
		KEGG metabolic	RNA transport
20	ERCC1	ENSG00000012061	ERCC excision repair 1, endonuclease non-catalytic subunit
		UniProt	K7EJL2 K7EJW9 K7EK97 K7EMT9 K7EP14 K7ER60 K7ER89 K7ES46 P07992
		NCBI	2067
		KEGG metabolic	Fanconi anemia pathway Nucleotide excision repair
18	RIOK1	ENSG00000124784	RIO kinase 1
		UniProt	E9PFQ8 Q9BRS2
		NCBI	83732
		KEGG metabolic	Ribosome biogenesis in eukaryotes
11	CUL4A	ENSG00000139842	cullin 4A
		UniProt	A0A087WWN2 A0A0A0MR50 Q13619
		NCBI	8451
		KEGG metabolic	Ubiquitin mediated proteolysis Nucleotide excision repair
21	SMC5	ENSG00000198887	structural maintenance of chromosomes 5
		UniProt	Q8IY18
		NCBI	23137
21	ERCC4	ENSG00000175595	ERCC excision repair 4, endonuclease catalytic subunit
		UniProt	I3L4K0 I3NI48 Q92889
		NCBI	2072
		KEGG metabolic	Fanconi anemia pathway Nucleotide excision repair
13	SLX4	ENSG00000188827	SLX4 structure-specific endonuclease subunit
		UniProt	Q8IY92
		NCBI	84464
		KEGG metabolic	Fanconi anemia pathway
10	CHEK2	ENSG00000183765	checkpoint kinase 2
		UniProt	A0A087X102 A0A3B3ITA7 B7ZBF2 B7ZBF6 B7ZBF7 B7ZBF8 C9JFD7 F8WCV2 H0Y4V6 H0Y820 H7BZ30 H7C0V7 O96017
		NCBI	11200
		KEGG signaling	p53 signaling pathway Cell cycle
14	UHRF1	ENSG00000276043	ubiquitin like with PHD and ring finger domains 1
		UniProt	A0A087WTW0 A0A087WVR3 A0A087WWG9 Q96T88
		NCBI	29128
3	EME2	ENSG00000197774	essential meiotic structure-specific endonuclease subunit 2
		UniProt	A4GXA9 H3BSZ6 H3BV62
		NCBI	197342
		KEGG metabolic	Fanconi anemia pathway

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	299.03 KB
	H.sapiens_subnetwork.tsv	51.13 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000172732

FEN1

CCNB2

PLK1

PCNA

RBM34

RFC4

DDB1

DIS3

RAD54L

SLX1B

HNRNPU

SLX1A

RUVBL2

UTP3

EME1

IMP4

MSH2

PRMT1

SF3B4

DCAF1

SUMO2

ERCC1

RIOK1

CUL4A

SMC5

ERCC4

SLX4

CHEK2

UHRF1

EME2

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