Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000160200
3. cystathionine beta-synt…
- 2. AHCY
  3. adenosylhomocysteinase
  4. 1.000
  5. Metabolic
- 2. MAT2A
  3. methionine adenosyltran…
  4. 1.000
  5. Metabolic
- 2. MAT1A
  3. methionine adenosyltran…
  4. 1.000
  5. Metabolic
- 2. ENO1
  3. enolase 1
  4. 0.999
  5. Metabolic
- 2. ENO2
  3. enolase 2
  4. 0.999
  5. Metabolic
- 2. RACK1
  3. receptor for activated …
  4. 0.999
  5. Metabolic
- 2. MSRA
  3. methionine sulfoxide re…
  4. 0.999
  5. Metabolic
- 2. CTH
  3. cystathionine gamma-lya…
  4. 0.998
  5. Complex
- 2. PPA1
  3. inorganic pyrophosphata…
  4. 0.998
  5. Metabolic
- 2. RPLP0
  3. ribosomal protein later…
  4. 0.998
  5. Complex
- 2. GAPDH
  3. glyceraldehyde-3-phosph…
  4. 0.998
  5. Metabolic
- 2. RPS5
  3. ribosomal protein S5
  4. 0.998
  5. Metabolic
- 2. FARSA
  3. phenylalanyl-tRNA synth…
  4. 0.998
  5. Metabolic
- 2. GPI
  3. glucose-6-phosphate iso…
  4. 0.998
  5. Metabolic
- 2. PPA2
  3. inorganic pyrophosphata…
  4. 0.997
  5. Metabolic
- 2. KARS1
  3. lysyl-tRNA synthetase 1
  4. 0.996
  5. Metabolic
- 2. ENO3
  3. enolase 3
  4. 0.996
  5. Metabolic
- 2. GLUD1
  3. glutamate dehydrogenase…
  4. 0.994
  5. Metabolic
- 2. HSP90AB1
  3. heat shock protein 90 a…
  4. 0.994
  5. PPI
- 2. EEF2
  3. eukaryotic translation …
  4. 0.994
  5. Metabolic
- 2. GLUL
  3. glutamate-ammonia ligase
  4. 0.992
  5. Metabolic
- 2. HMGCS1
  3. 3-hydroxy-3-methylgluta…
  4. 0.991
  5. Metabolic
- 2. ASS1
  3. argininosuccinate synth…
  4. 0.990
  5. Metabolic
- 2. ALDH2
  3. aldehyde dehydrogenase …
  4. 0.989
  5. Metabolic
- 2. TUBB2A
  3. tubulin beta 2A class I…
  4. 0.987
  5. Metabolic
- 2. VCP
  3. valosin containing prot…
  4. 0.984
  5. Metabolic
- 2. SOD1
  3. superoxide dismutase 1
  4. 0.981
  5. Metabolic
- 2. ACO2
  3. aconitase 2
  4. 0.980
  5. Metabolic
- 2. OAT
  3. ornithine aminotransfer…
  4. 0.980
  5. Metabolic
- 2. CCT8
  3. chaperonin containing T…
  4. 0.980
  5. Metabolic

Subnetwork gene interactions

ENSG00000160200

cystathionine beta-synthase

FunCoup

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Ensembl

ENSG00000160200

UniProt

NCBI

GPI

glucose-6-phosphate isomerase

FunCoup

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Ensembl

ENSG00000105220

UniProt

NCBI

2821

VCP

valosin containing protein

FunCoup

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Ensembl

ENSG00000165280

UniProt

NCBI

7415

PPA2

inorganic pyrophosphatase 2

FunCoup

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Ensembl

ENSG00000138777

UniProt

NCBI

27068

EEF2

eukaryotic translation elongation factor 2

FunCoup

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Ensembl

ENSG00000167658

UniProt

NCBI

1938

RACK1

receptor for activated C kinase 1

FunCoup

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Ensembl

ENSG00000204628

UniProt

NCBI

10399

ASS1

argininosuccinate synthase 1

FunCoup

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Ensembl

ENSG00000130707

UniProt

NCBI

MAT2A

methionine adenosyltransferase 2A

FunCoup

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Ensembl

ENSG00000168906

UniProt

P31153

NCBI

4144

TUBB2A

tubulin beta 2A class IIa

FunCoup

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Ensembl

ENSG00000137267

UniProt

Q13885

NCBI

7280

CTH

cystathionine gamma-lyase

FunCoup

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Ensembl

ENSG00000116761

UniProt

P32929

NCBI

1491

GAPDH

glyceraldehyde-3-phosphate dehydrogenase

FunCoup

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Ensembl

ENSG00000111640

UniProt

NCBI

2597

MSRA

methionine sulfoxide reductase A

FunCoup

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Ensembl

ENSG00000175806

UniProt

NCBI

4482

GLUD1

glutamate dehydrogenase 1

FunCoup

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Ensembl

ENSG00000148672

UniProt

P00367

NCBI

2746

KARS1

lysyl-tRNA synthetase 1

FunCoup

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Ensembl

ENSG00000065427

UniProt

NCBI

3735

RPS5

ribosomal protein S5

FunCoup

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Ensembl

ENSG00000083845

UniProt

NCBI

6193

MAT1A

methionine adenosyltransferase 1A

FunCoup

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Ensembl

ENSG00000151224

UniProt

NCBI

4143

CCT8

chaperonin containing TCP1 subunit 8

FunCoup

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Ensembl

ENSG00000156261

UniProt

NCBI

10694

SOD1

superoxide dismutase 1

FunCoup

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Ensembl

ENSG00000142168

UniProt

NCBI

6647

ENO3

enolase 3

FunCoup

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Ensembl

ENSG00000108515

UniProt

NCBI

2027

FARSA

phenylalanyl-tRNA synthetase subunit alpha

FunCoup

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Ensembl

ENSG00000179115

UniProt

NCBI

2193

HSP90AB1

heat shock protein 90 alpha family class B member 1

FunCoup

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Ensembl

ENSG00000096384

UniProt

P08238

NCBI

3326

GLUL

glutamate-ammonia ligase

FunCoup

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Ensembl

ENSG00000135821

UniProt

NCBI

2752

RPLP0

ribosomal protein lateral stalk subunit P0

FunCoup

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Ensembl

ENSG00000089157

UniProt

NCBI

6175

PPA1

inorganic pyrophosphatase 1

FunCoup

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Ensembl

ENSG00000180817

UniProt

NCBI

5464

AHCY

adenosylhomocysteinase

FunCoup

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Ensembl

ENSG00000101444

UniProt

P23526

NCBI

OAT

ornithine aminotransferase

FunCoup

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Ensembl

ENSG00000065154

UniProt

P04181

NCBI

4942

ENO2

enolase 2

FunCoup

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Ensembl

ENSG00000111674

UniProt

NCBI

2026

ENO1

enolase 1

FunCoup

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Ensembl

ENSG00000074800

UniProt

NCBI

2023

ALDH2

aldehyde dehydrogenase 2 family member

FunCoup

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Ensembl

ENSG00000111275

UniProt

NCBI

ACO2

aconitase 2

FunCoup

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Ensembl

ENSG00000100412

UniProt

NCBI

HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1

FunCoup

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Ensembl

ENSG00000112972

UniProt

NCBI

3157

Query genes

		Identifier	Description
30	ENSG00000160200	ENSG00000160200	cystathionine beta-synthase
		UniProt	C9JMA6 H7C1W6 H7C2H4 H7C2W0 P35520
		NCBI	102724560 875
		KEGG metabolic	Cysteine and methionine metabolism Glycine, serine and threonine metabolism Biosynthesis of amino acids

Subnetwork genes

		Identifier	Description
30	GPI	ENSG00000105220	glucose-6-phosphate isomerase
		UniProt	A0A0G2JLI6 A0A2R8Y6C7 A0A2R8YF08 A0A2U3TZU2 K7EIL4 K7ELR7 K7ENA0 K7EP41 K7EPY4 K7EQ48 K7ERC6 K7ERK8 P06744
		NCBI	2821
		KEGG metabolic	Starch and sucrose metabolism Pentose phosphate pathway Glycolysis / Gluconeogenesis Carbon metabolism Amino sugar and nucleotide sugar metabolism
29	VCP	ENSG00000165280	valosin containing protein
		UniProt	C9IZA5 C9JUP7 P55072
		NCBI	7415
		KEGG metabolic	Protein processing in endoplasmic reticulum
28	PPA2	ENSG00000138777	inorganic pyrophosphatase 2
		UniProt	A0A0C4DGB9 D6R967 D6RAD3 D6RGI1 D6RGV9 F8W7R6 H0Y8X2 H0Y9D8 H0YAK2 Q9H2U2
		NCBI	27068
		KEGG metabolic	Oxidative phosphorylation
30	EEF2	ENSG00000167658	eukaryotic translation elongation factor 2
		UniProt	M0R0I6 P13639
		NCBI	1938
		KEGG signaling	AMPK signaling pathway Oxytocin signaling pathway
30	RACK1	ENSG00000204628	receptor for activated C kinase 1
		UniProt	D6R909 D6R9L0 D6R9Z1 D6RAC2 D6RAU2 D6RBD0 D6RDI0 D6REE5 D6RF23 D6RFX4 D6RFZ9 D6RGK8 D6RHH4 D6RHJ5 E9PD14 H0Y8R5 H0Y8W2 H0Y9P0 H0YAF8 H0YAM7 J3KPE3 P63244
		NCBI	10399
30	ASS1	ENSG00000130707	argininosuccinate synthase 1
		UniProt	P00966 Q5T6L5 Q5T6L6
		NCBI	445
		KEGG metabolic	Alanine, aspartate and glutamate metabolism Biosynthesis of amino acids Arginine biosynthesis
30	MAT2A	ENSG00000168906	methionine adenosyltransferase 2A
		UniProt	P31153
		NCBI	4144
		KEGG metabolic	Cysteine and methionine metabolism Biosynthesis of amino acids
29	TUBB2A	ENSG00000137267	tubulin beta 2A class IIa
		UniProt	Q13885
		NCBI	7280
		KEGG signaling	Gap junction
		KEGG metabolic	Phagosome
29	CTH	ENSG00000116761	cystathionine gamma-lyase
		UniProt	P32929
		NCBI	1491
		KEGG metabolic	Cysteine and methionine metabolism Glycine, serine and threonine metabolism Selenocompound metabolism Biosynthesis of amino acids
30	GAPDH	ENSG00000111640	glyceraldehyde-3-phosphate dehydrogenase
		UniProt	E7EUT5 P04406
		NCBI	2597
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
27	MSRA	ENSG00000175806	methionine sulfoxide reductase A
		UniProt	E5RIA9 E5RJK1 E9PJ70 H0YAN3 Q9UJ68
		NCBI	4482
30	GLUD1	ENSG00000148672	glutamate dehydrogenase 1
		UniProt	P00367
		NCBI	2746
		KEGG metabolic	Nitrogen metabolism Alanine, aspartate and glutamate metabolism D-Glutamine and D-glutamate metabolism Carbon metabolism Arginine biosynthesis
29	KARS1	ENSG00000065427	lysyl-tRNA synthetase 1
		UniProt	H3BMR9 H3BPV7 H3BQK5 H3BRC9 H3BSN6 H3BVA8 J3KRL2 Q15046
		NCBI	3735
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
30	RPS5	ENSG00000083845	ribosomal protein S5
		UniProt	M0QZN2 M0R0F0 M0R0R2 P46782
		NCBI	6193
		KEGG metabolic	Ribosome
28	MAT1A	ENSG00000151224	methionine adenosyltransferase 1A
		UniProt	B1ANE6 Q00266
		NCBI	4143
		KEGG metabolic	Cysteine and methionine metabolism Biosynthesis of amino acids
29	CCT8	ENSG00000156261	chaperonin containing TCP1 subunit 8
		UniProt	H7C2U0 H7C4C8 P50990
		NCBI	10694
30	SOD1	ENSG00000142168	superoxide dismutase 1
		UniProt	H7BYH4 P00441
		NCBI	6647
		KEGG metabolic	Peroxisome
30	ENO3	ENSG00000108515	enolase 3
		UniProt	E5RG95 E5RGZ4 E5RI09 E5RJH5 K7EKN2 K7EP84 K7EPM1 P13929
		NCBI	2027
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	RNA degradation Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
30	FARSA	ENSG00000179115	phenylalanyl-tRNA synthetase subunit alpha
		UniProt	K7EK06 K7EPH2 K7ER00 K7ER16 K7ERS0 Q9Y285
		NCBI	2193
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
28	HSP90AB1	ENSG00000096384	heat shock protein 90 alpha family class B member 1
		UniProt	P08238
		NCBI	3326
		KEGG signaling	Antigen processing and presentation NOD-like receptor signaling pathway PI3K-Akt signaling pathway Estrogen signaling pathway Progesterone-mediated oocyte maturation IL-17 signaling pathway
		KEGG metabolic	Protein processing in endoplasmic reticulum
27	GLUL	ENSG00000135821	glutamate-ammonia ligase
		UniProt	A0A2R8YDT1 P15104
		NCBI	2752
		KEGG signaling	GABAergic synapse Glutamatergic synapse
		KEGG metabolic	Nitrogen metabolism Alanine, aspartate and glutamate metabolism Biosynthesis of amino acids Arginine biosynthesis Glyoxylate and dicarboxylate metabolism
30	RPLP0	ENSG00000089157	ribosomal protein lateral stalk subunit P0
		UniProt	F8VPE8 F8VQY6 F8VRK7 F8VS58 F8VU65 F8VW21 F8VWS0 F8VWV4 F8VYN4 F8VZS0 F8W1K8 G3V210 P05388
		NCBI	6175
		KEGG metabolic	Ribosome
29	PPA1	ENSG00000180817	inorganic pyrophosphatase 1
		UniProt	Q15181 Q5SQT6
		NCBI	5464
		KEGG metabolic	Oxidative phosphorylation
30	AHCY	ENSG00000101444	adenosylhomocysteinase
		UniProt	P23526
		NCBI	191
		KEGG metabolic	Cysteine and methionine metabolism
29	OAT	ENSG00000065154	ornithine aminotransferase
		UniProt	P04181
		NCBI	4942
		KEGG metabolic	Arginine and proline metabolism
30	ENO2	ENSG00000111674	enolase 2
		UniProt	F5H0C8 F5H1C3 P09104 U3KQP4 U3KQQ1
		NCBI	2026
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	RNA degradation Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
30	ENO1	ENSG00000074800	enolase 1
		UniProt	A0A2R8Y6G6 A0A2R8Y6I8 A0A2R8Y798 A0A2R8Y879 A0A2R8YEG5 A0A2R8YEM5 K7EM90 K7ERS8 P06733
		NCBI	2023
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	RNA degradation Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
30	ALDH2	ENSG00000111275	aldehyde dehydrogenase 2 family member
		UniProt	F8VSB0 P05091 S4R3S4
		NCBI	217
		KEGG metabolic	Pyruvate metabolism Tryptophan metabolism Fatty acid degradation Valine, leucine and isoleucine degradation Histidine metabolism Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Arginine and proline metabolism Glycerolipid metabolism beta-Alanine metabolism Lysine degradation
28	ACO2	ENSG00000100412	aconitase 2
		UniProt	A2A274 Q99798
		NCBI	50
		KEGG metabolic	Biosynthesis of amino acids Citrate cycle (TCA cycle) Carbon metabolism 2-Oxocarboxylic acid metabolism Glyoxylate and dicarboxylate metabolism
27	HMGCS1	ENSG00000112972	3-hydroxy-3-methylglutaryl-CoA synthase 1
		UniProt	D6RIW1 Q01581
		NCBI	3157
		KEGG signaling	PPAR signaling pathway
		KEGG metabolic	Terpenoid backbone biosynthesis Synthesis and degradation of ketone bodies Valine, leucine and isoleucine degradation Butanoate metabolism

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	329.90 KB
	H.sapiens_subnetwork.tsv	93.18 KB

Species:

Network information:

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Network appearance:

ENSG00000160200

GPI

VCP

PPA2

EEF2

RACK1

ASS1

MAT2A

TUBB2A

CTH

GAPDH

MSRA

GLUD1

KARS1

RPS5

MAT1A

CCT8

SOD1

ENO3

FARSA

HSP90AB1

GLUL

RPLP0

PPA1

AHCY

OAT

ENO2

ENO1

ALDH2

ACO2

HMGCS1

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