Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000152942
3. RAD17 checkpoint clamp …
- 2. RAD50
  3. RAD50 double strand bre…
  4. 1.000
  5. PPI
- 2. MRE11
  3. MRE11 homolog, double s…
  4. 1.000
  5. PPI
- 2. NBN
  3. nibrin
  4. 1.000
  5. PPI
- 2. RFC4
  3. replication factor C su…
  4. 0.999
  5. Complex
- 2. RAD9A
  3. RAD9 checkpoint clamp c…
  4. 0.999
  5. PPI
- 2. HAT1
  3. histone acetyltransfera…
  4. 0.997
  5. Metabolic
- 2. RAD1
  3. RAD1 checkpoint DNA exo…
  4. 0.996
  5. Metabolic
- 2. RNMT
  3. RNA guanine-7 methyltra…
  4. 0.992
  5. Metabolic
- 2. TOP2B
  3. DNA topoisomerase II be…
  4. 0.992
  5. Metabolic
- 2. RAD9B
  3. RAD9 checkpoint clamp c…
  4. 0.991
  5. PPI
- 2. RAD23B
  3. RAD23 homolog B, nucleo…
  4. 0.987
  5. Metabolic
- 2. SMC3
  3. structural maintenance …
  4. 0.986
  5. Metabolic
- 2. KRR1
  3. KRR1 small subunit proc…
  4. 0.985
  5. Metabolic
- 2. SET
  3. SET nuclear proto-oncog…
  4. 0.985
  5. Metabolic
- 2. DHX15
  3. DEAH-box helicase 15
  4. 0.982
  5. Metabolic
- 2. CCNL1
  3. cyclin L1
  4. 0.979
  5. Complex
- 2. CCNB1
  3. cyclin B1
  4. 0.978
  5. Metabolic
- 2. RAD23A
  3. RAD23 homolog A, nucleo…
  4. 0.977
  5. Metabolic
- 2. SPRTN
  3. SprT-like N-terminal do…
  4. 0.977
  5. Metabolic
- 2. PIK3CB
  3. phosphatidylinositol-4,…
  4. 0.976
  5. PPI
- 2. UBA1
  3. ubiquitin like modifier…
  4. 0.976
  5. Metabolic
- 2. TBP
  3. TATA-box binding protein
  4. 0.976
  5. Metabolic
- 2. WDHD1
  3. WD repeat and HMG-box D…
  4. 0.975
  5. Metabolic
- 2. SIN3A
  3. SIN3 transcription regu…
  4. 0.975
  5. Metabolic
- 2. RUVBL1
  3. RuvB like AAA ATPase 1
  4. 0.971
  5. Metabolic
- 2. CCNB2
  3. cyclin B2
  4. 0.971
  5. Metabolic
- 2. SKP2
  3. S-phase kinase associat…
  4. 0.970
  5. Metabolic
- 2. RRN3
  3. RRN3 homolog, RNA polym…
  4. 0.970
  5. Metabolic
- 2. CNOT7
  3. CCR4-NOT transcription …
  4. 0.969
  5. Metabolic
- 2. RFC1
  3. replication factor C su…
  4. 0.967
  5. Metabolic

Subnetwork gene interactions

ENSG00000152942

RAD17 checkpoint clamp loader component

FunCoup

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Ensembl

ENSG00000152942

UniProt

NCBI

5884

CCNB1

cyclin B1

FunCoup

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Ensembl

ENSG00000134057

UniProt

NCBI

RUVBL1

RuvB like AAA ATPase 1

FunCoup

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Ensembl

ENSG00000175792

UniProt

NCBI

8607

RAD23A

RAD23 homolog A, nucleotide excision repair protein

FunCoup

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Ensembl

ENSG00000179262

UniProt

NCBI

5886

CNOT7

CCR4-NOT transcription complex subunit 7

FunCoup

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Ensembl

ENSG00000198791

UniProt

NCBI

29883

WDHD1

WD repeat and HMG-box DNA binding protein 1

FunCoup

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Ensembl

ENSG00000198554

UniProt

NCBI

11169

RAD50

RAD50 double strand break repair protein

FunCoup

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Ensembl

ENSG00000113522

UniProt

NCBI

10111

UBA1

ubiquitin like modifier activating enzyme 1

FunCoup

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Ensembl

ENSG00000130985

UniProt

NCBI

7317

RAD23B

RAD23 homolog B, nucleotide excision repair protein

FunCoup

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Ensembl

ENSG00000119318

UniProt

NCBI

5887

MRE11

MRE11 homolog, double strand break repair nuclease

FunCoup

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Ensembl

ENSG00000020922

UniProt

NCBI

4361

SMC3

structural maintenance of chromosomes 3

FunCoup

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Ensembl

ENSG00000108055

UniProt

Q9UQE7

NCBI

9126

RNMT

RNA guanine-7 methyltransferase

FunCoup

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Ensembl

ENSG00000101654

UniProt

NCBI

8731

SIN3A

SIN3 transcription regulator family member A

FunCoup

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Ensembl

ENSG00000169375

UniProt

NCBI

25942

DHX15

DEAH-box helicase 15

FunCoup

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Ensembl

ENSG00000109606

UniProt

O43143

NCBI

1665

RRN3

RRN3 homolog, RNA polymerase I transcription factor

FunCoup

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Ensembl

ENSG00000085721

UniProt

NCBI

54700

HAT1

histone acetyltransferase 1

FunCoup

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Ensembl

ENSG00000128708

UniProt

NCBI

8520

KRR1

KRR1 small subunit processome component homolog

FunCoup

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Ensembl

ENSG00000111615

UniProt

Q13601

NCBI

11103

SET

SET nuclear proto-oncogene

FunCoup

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Ensembl

ENSG00000119335

UniProt

NCBI

6418

RAD1

RAD1 checkpoint DNA exonuclease

FunCoup

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Ensembl

ENSG00000113456

UniProt

NCBI

5810

NBN

nibrin

FunCoup

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Ensembl

ENSG00000104320

UniProt

NCBI

4683

RFC4

replication factor C subunit 4

FunCoup

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Ensembl

ENSG00000163918

UniProt

NCBI

5984

RAD9A

RAD9 checkpoint clamp component A

FunCoup

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Ensembl

ENSG00000172613

UniProt

NCBI

5883

RFC1

replication factor C subunit 1

FunCoup

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Ensembl

ENSG00000035928

UniProt

NCBI

5981

CCNL1

cyclin L1

FunCoup

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Ensembl

ENSG00000163660

UniProt

NCBI

57018

RAD9B

RAD9 checkpoint clamp component B

FunCoup

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Ensembl

ENSG00000151164

UniProt

NCBI

144715

TOP2B

DNA topoisomerase II beta

FunCoup

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Ensembl

ENSG00000077097

UniProt

NCBI

7155

SKP2

S-phase kinase associated protein 2

FunCoup

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Ensembl

ENSG00000145604

UniProt

NCBI

6502

SPRTN

SprT-like N-terminal domain

FunCoup

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Ensembl

ENSG00000010072

UniProt

NCBI

83932

PIK3CB

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

FunCoup

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Ensembl

ENSG00000051382

UniProt

NCBI

5291

CCNB2

cyclin B2

FunCoup

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Ensembl

ENSG00000157456

UniProt

NCBI

9133

TBP

TATA-box binding protein

FunCoup

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Ensembl

ENSG00000112592

UniProt

NCBI

6908

Query genes

		Identifier	Description
30	ENSG00000152942	ENSG00000152942	RAD17 checkpoint clamp loader component
		UniProt	D6RA84 D6RAW6 D6RHU1 H0Y9J8 H0Y9T7 O75943
		NCBI	5884

Subnetwork genes

		Identifier	Description
22	CCNB1	ENSG00000134057	cyclin B1
		UniProt	D6RHI0 E9PC90 H0Y9U8 H0YA62 P14635
		NCBI	891
		KEGG signaling	p53 signaling pathway Oocyte meiosis FoxO signaling pathway Cell cycle Progesterone-mediated oocyte maturation
26	RUVBL1	ENSG00000175792	RuvB like AAA ATPase 1
		UniProt	E7ETR0 H7C4G5 H7C4I3 J3QLR1 Q9Y265
		NCBI	8607
		KEGG signaling	Wnt signaling pathway
24	RAD23A	ENSG00000179262	RAD23 homolog A, nucleotide excision repair protein
		UniProt	A0A494C0B4 K7ELU6 K7ELW1 K7ENJ0 K7EQ16 P54725
		NCBI	5886
		KEGG metabolic	Protein processing in endoplasmic reticulum Nucleotide excision repair
20	CNOT7	ENSG00000198791	CCR4-NOT transcription complex subunit 7
		UniProt	E5RGA8 E5RGH2 E5RHV9 E5RJE0 H0YAV9 H0YBT3 Q9UIV1
		NCBI	29883
		KEGG metabolic	RNA degradation
26	WDHD1	ENSG00000198554	WD repeat and HMG-box DNA binding protein 1
		UniProt	C9JYB3 H3BSQ1 O75717
		NCBI	11169
23	RAD50	ENSG00000113522	RAD50 double strand break repair protein
		UniProt	A0A494BZW0 A0A494BZX5 A0A494BZX8 A0A494C0Y7 A0A494C122 A0A494C1B7 C9JNH8 E7EN38 E7ESD9 E9PM98 H7C0P8 H7C0V2 Q92878
		NCBI	10111
		KEGG metabolic	Non-homologous end-joining Homologous recombination
24	UBA1	ENSG00000130985	ubiquitin like modifier activating enzyme 1
		UniProt	P22314 Q5JRR6 Q5JRR9 Q5JRS0 Q5JRS1 Q5JRS2 Q5JRS3
		NCBI	7317
		KEGG metabolic	Ubiquitin mediated proteolysis
23	RAD23B	ENSG00000119318	RAD23 homolog B, nucleotide excision repair protein
		UniProt	H0Y579 P54727 Q5W0S4 Q5W0S5
		NCBI	5887
		KEGG metabolic	Protein processing in endoplasmic reticulum Nucleotide excision repair
26	MRE11	ENSG00000020922	MRE11 homolog, double strand break repair nuclease
		UniProt	F5GXT0 F5H256 F5H742 F8W7U8 P49959
		NCBI	4361
		KEGG metabolic	Non-homologous end-joining Homologous recombination
25	SMC3	ENSG00000108055	structural maintenance of chromosomes 3
		UniProt	Q9UQE7
		NCBI	9126
		KEGG signaling	Oocyte meiosis Cell cycle
19	RNMT	ENSG00000101654	RNA guanine-7 methyltransferase
		UniProt	K7EP06 K7EPP5 K7ERH6 O43148
		NCBI	8731
		KEGG metabolic	mRNA surveillance pathway
22	SIN3A	ENSG00000169375	SIN3 transcription regulator family member A
		UniProt	H3BMA2 H3BNA0 H3BNZ3 H3BP90 H3BQ76 H3BQ88 H3BQL7 H3BT34 Q96ST3
		NCBI	25942
		KEGG signaling	Thyroid hormone signaling pathway
26	DHX15	ENSG00000109606	DEAH-box helicase 15
		UniProt	O43143
		NCBI	1665
		KEGG metabolic	Spliceosome
23	RRN3	ENSG00000085721	RRN3 homolog, RNA polymerase I transcription factor
		UniProt	F5H148 H3BMT1 Q9NYV6
		NCBI	54700
30	HAT1	ENSG00000128708	histone acetyltransferase 1
		UniProt	F8W9G7 F8WEW1 O14929
		NCBI	8520
26	KRR1	ENSG00000111615	KRR1 small subunit processome component homolog
		UniProt	Q13601
		NCBI	11103
23	SET	ENSG00000119335	SET nuclear proto-oncogene
		UniProt	A0A0C4DFV9 B2REB7 Q01105
		NCBI	6418
28	RAD1	ENSG00000113456	RAD1 checkpoint DNA exonuclease
		UniProt	D6R9A1 O60671
		NCBI	5810
10	NBN	ENSG00000104320	nibrin
		UniProt	A0A087X1V5 A0A0C4DG07 E2QRP0 E5RGN7 E5RGR7 E5RGU1 O60934
		NCBI	4683
		KEGG metabolic	Homologous recombination
26	RFC4	ENSG00000163918	replication factor C subunit 4
		UniProt	C9J8M3 C9JGY5 C9JTT7 C9JW34 C9JXZ7 C9JZI1 F8WE44 H7C1P0 P35249
		NCBI	5984
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair
15	RAD9A	ENSG00000172613	RAD9 checkpoint clamp component A
		UniProt	A0A0G2JMD0 F5H492 F5H4F1 F5H8A2 Q99638
		NCBI	5883
26	RFC1	ENSG00000035928	replication factor C subunit 1
		UniProt	A0A1W2PP02 D6RAD2 E0CX09 H0Y8U4 H0Y9P8 P35251
		NCBI	5981
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair
20	CCNL1	ENSG00000163660	cyclin L1
		UniProt	H7C4G1 Q9UK58
		NCBI	57018
7	RAD9B	ENSG00000151164	RAD9 checkpoint clamp component B
		UniProt	B4DX60 B4DYM6 H7BY23 J3KPN7 Q6WBX8
		NCBI	144715
25	TOP2B	ENSG00000077097	DNA topoisomerase II beta
		UniProt	E9PCY5 H7BZ82 Q02880
		NCBI	7155
17	SKP2	ENSG00000145604	S-phase kinase associated protein 2
		UniProt	A0A0A0MTL5 D6R9R7 D6RAG5 D6RF40 H0Y9I9 Q13309
		NCBI	6502
		KEGG signaling	FoxO signaling pathway Cell cycle mTOR signaling pathway
		KEGG metabolic	Ubiquitin mediated proteolysis
15	SPRTN	ENSG00000010072	SprT-like N-terminal domain
		UniProt	B1AKT1 Q9H040
		NCBI	83932
6	PIK3CB	ENSG00000051382	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
		UniProt	C9J345 C9JNF6 C9JYX0 F8WDJ8 H0Y871 H7C527 H7C565 H7C5C3 P42338 Q68DL0
		NCBI	5291
		KEGG signaling	Thyroid hormone signaling pathway Chemokine signaling pathway Neurotrophin signaling pathway Fc gamma R-mediated phagocytosis Toll-like receptor signaling pathway Fc epsilon RI signaling pathway FoxO signaling pathway cAMP signaling pathway B cell receptor signaling pathway HIF-1 signaling pathway T cell receptor signaling pathway Relaxin signaling pathway Cholinergic synapse C-type lectin receptor signaling pathway TNF signaling pathway Leukocyte transendothelial migration AMPK signaling pathway PI3K-Akt signaling pathway mTOR signaling pathway VEGF signaling pathway Phospholipase D signaling pathway Sphingolipid signaling pathway Phosphatidylinositol signaling system Focal adhesion Rap1 signaling pathway JAK-STAT signaling pathway Ras signaling pathway Natural killer cell mediated cytotoxicity ErbB signaling pathway Apoptosis Prolactin signaling pathway Estrogen signaling pathway Progesterone-mediated oocyte maturation Insulin signaling pathway
		KEGG metabolic	Carbohydrate digestion and absorption Autophagy - animal Inositol phosphate metabolism
16	CCNB2	ENSG00000157456	cyclin B2
		UniProt	H0YMP3 H1UBN3 O95067
		NCBI	9133
		KEGG signaling	p53 signaling pathway Oocyte meiosis FoxO signaling pathway Cell cycle Progesterone-mediated oocyte maturation
21	TBP	ENSG00000112592	TATA-box binding protein
		UniProt	A0A1B0GVC6 H0Y6D8 P20226 Q32MN6 Q7Z6S4 Q7Z6S5
		NCBI	6908
		KEGG metabolic	Basal transcription factors

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	317.34 KB
	H.sapiens_subnetwork.tsv	62.39 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000152942

CCNB1

RUVBL1

RAD23A

CNOT7

WDHD1

RAD50

UBA1

RAD23B

MRE11

SMC3

RNMT

SIN3A

DHX15

RRN3

HAT1

KRR1

SET

RAD1

NBN

RFC4

RAD9A

RFC1

CCNL1

RAD9B

TOP2B

SKP2

SPRTN

PIK3CB

CCNB2

TBP

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