Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000147168
3. interleukin 2 receptor …
- 2. IL2RB
  3. interleukin 2 receptor …
  4. 1.000
  5. PPI
- 2. IL7R
  3. interleukin 7 receptor
  4. 0.999
  5. PPI
- 2. IL2RA
  3. interleukin 2 receptor …
  4. 0.999
  5. PPI
- 2. JAK3
  3. Janus kinase 3
  4. 0.999
  5. PPI
- 2. IL15RA
  3. interleukin 15 receptor…
  4. 0.997
  5. PPI
- 2. IL15
  3. interleukin 15
  4. 0.996
  5. PPI
- 2. IL13RA1
  3. interleukin 13 receptor…
  4. 0.995
  5. PPI
- 2. KLRK1
  3. killer cell lectin like…
  4. 0.982
  5. PPI
- 2. JAK1
  3. Janus kinase 1
  4. 0.972
  5. PPI
- 2. PTPRC
  3. protein tyrosine phosph…
  4. 0.933
  5. Metabolic
- 2. HCST
  3. hematopoietic cell sign…
  4. 0.928
  5. PPI
- 2. SHC1
  3. SHC adaptor protein 1
  4. 0.902
  5. PPI
- 2. AXL
  3. AXL receptor tyrosine k…
  4. 0.888
  5. PPI
- 2. STK4
  3. serine/threonine kinase…
  4. 0.883
  5. PPI
- 2. FCER1G
  3. Fc fragment of IgE rece…
  4. 0.868
  5. Metabolic
- 2. CD8B
  3. CD8b molecule
  4. 0.861
  5. PPI
- 2. ITGB2
  3. integrin subunit beta 2
  4. 0.815
  5. Metabolic
- 2. CAPNS1
  3. calpain small subunit 1
  4. 0.791
  5. PPI
- 2. CD37
  3. CD37 molecule
  4. 0.749
  5. Signaling
- 2. GRB2
  3. growth factor receptor …
  4. 0.733
  5. PPI
- 2. FLVCR1
  3. FLVCR heme transporter 1
  4. 0.705
  5. PPI
- 2. HLA-A
  3. major histocompatibilit…
  4. 0.697
  5. Metabolic
- 2. HLA-C
  3. major histocompatibilit…
  4. 0.678
  5. Metabolic
- 2. CD3G
  3. CD3g molecule
  4. 0.678
  5. Metabolic
- 2. HLA-B
  3. major histocompatibilit…
  4. 0.676
  5. Metabolic
- 2. CD6
  3. CD6 molecule
  4. 0.672
  5. Metabolic
- 2. CD69
  3. CD69 molecule
  4. 0.655
  5. Metabolic
- 2. CORO1A
  3. coronin 1A
  4. 0.648
  5. Metabolic
- 2. CD320
  3. CD320 molecule
  4. 0.626
  5. PPI
- 2. IL21
  3. interleukin 21
  4. 0.626
  5. PPI

Subnetwork gene interactions

ENSG00000147168

interleukin 2 receptor subunit gamma

FunCoup

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Ensembl

ENSG00000147168

UniProt

NCBI

3561

HLA-A

major histocompatibility complex, class I, A

FunCoup

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Ensembl

ENSG00000206503

UniProt

NCBI

3105

FCER1G

Fc fragment of IgE receptor Ig

FunCoup

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Ensembl

ENSG00000158869

UniProt

NCBI

2207

CD6

CD6 molecule

FunCoup

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Ensembl

ENSG00000013725

UniProt

NCBI

IL2RA

interleukin 2 receptor subunit alpha

FunCoup

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Ensembl

ENSG00000134460

UniProt

NCBI

3559

PTPRC

protein tyrosine phosphatase receptor type C

FunCoup

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Ensembl

ENSG00000081237

UniProt

NCBI

5788

KLRK1

killer cell lectin like receptor K1

FunCoup

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Ensembl

ENSG00000213809

UniProt

NCBI

CD8B

CD8b molecule

FunCoup

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Ensembl

ENSG00000172116

UniProt

NCBI

CORO1A

coronin 1A

FunCoup

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Ensembl

ENSG00000102879

UniProt

NCBI

11151

JAK3

Janus kinase 3

FunCoup

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Ensembl

ENSG00000105639

UniProt

P52333

NCBI

3718

JAK1

Janus kinase 1

FunCoup

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Ensembl

ENSG00000162434

UniProt

NCBI

3716

IL7R

interleukin 7 receptor

FunCoup

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Ensembl

ENSG00000168685

UniProt

NCBI

3575

ITGB2

integrin subunit beta 2

FunCoup

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Ensembl

ENSG00000160255

UniProt

NCBI

3689

IL15RA

interleukin 15 receptor subunit alpha

FunCoup

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Ensembl

ENSG00000134470

UniProt

NCBI

3601

IL15

interleukin 15

FunCoup

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Ensembl

ENSG00000164136

UniProt

P40933

NCBI

3600

CD3G

CD3g molecule

FunCoup

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Ensembl

ENSG00000160654

UniProt

NCBI

IL2RB

interleukin 2 receptor subunit beta

FunCoup

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Ensembl

ENSG00000100385

UniProt

NCBI

3560

CD69

CD69 molecule

FunCoup

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Ensembl

ENSG00000110848

UniProt

NCBI

CD320

CD320 molecule

FunCoup

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Ensembl

ENSG00000167775

UniProt

NCBI

51293

CD37

CD37 molecule

FunCoup

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Ensembl

ENSG00000104894

UniProt

NCBI

STK4

serine/threonine kinase 4

FunCoup

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Ensembl

ENSG00000101109

UniProt

NCBI

6789

AXL

AXL receptor tyrosine kinase

FunCoup

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Ensembl

ENSG00000167601

UniProt

NCBI

GRB2

growth factor receptor bound protein 2

FunCoup

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Ensembl

ENSG00000177885

UniProt

NCBI

2885

HCST

hematopoietic cell signal transducer

FunCoup

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Ensembl

ENSG00000126264

UniProt

Q9UBK5

NCBI

10870

HLA-B

major histocompatibility complex, class I, B

FunCoup

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Ensembl

ENSG00000234745

UniProt

NCBI

3106

IL21

interleukin 21

FunCoup

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Ensembl

ENSG00000138684

UniProt

Q9HBE4

NCBI

59067

SHC1

SHC adaptor protein 1

FunCoup

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Ensembl

ENSG00000160691

UniProt

NCBI

6464

HLA-C

major histocompatibility complex, class I, C

FunCoup

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Ensembl

ENSG00000204525

UniProt

NCBI

3107

CAPNS1

calpain small subunit 1

FunCoup

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Ensembl

ENSG00000126247

UniProt

NCBI

FLVCR1

FLVCR heme transporter 1

FunCoup

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Ensembl

ENSG00000162769

UniProt

NCBI

28982

IL13RA1

interleukin 13 receptor subunit alpha 1

FunCoup

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Ensembl

ENSG00000131724

UniProt

NCBI

3597

Query genes

		Identifier	Description
30	ENSG00000147168	ENSG00000147168	interleukin 2 receptor subunit gamma
		UniProt	D6R964 D6RDW9 H0Y8J6 P31785 Q5FC10
		NCBI	3561
		KEGG signaling	JAK-STAT signaling pathway PI3K-Akt signaling pathway Viral protein interaction with cytokine and cytokine receptor Cytokine-cytokine receptor interaction
		KEGG metabolic	Endocytosis

Subnetwork genes

		Identifier	Description
8	HLA-A	ENSG00000206503	major histocompatibility complex, class I, A
		UniProt	A0A1W2PS24 P04439 Q5SRN5 Q5SRN7
		NCBI	3105
		KEGG signaling	Antigen processing and presentation Natural killer cell mediated cytotoxicity Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome Endocytosis
8	FCER1G	ENSG00000158869	Fc fragment of IgE receptor Ig
		UniProt	A6NCQ8 P30273
		NCBI	2207
		KEGG signaling	Fc epsilon RI signaling pathway Natural killer cell mediated cytotoxicity Phospholipase D signaling pathway Sphingolipid signaling pathway C-type lectin receptor signaling pathway
8	CD6	ENSG00000013725	CD6 molecule
		UniProt	E7ER04 F5H835 F6UFK6 G5E973 H0YGL3 P30203
		NCBI	923
		KEGG signaling	Cell adhesion molecules (CAMs)
4	IL2RA	ENSG00000134460	interleukin 2 receptor subunit alpha
		UniProt	H0Y5Z0 P01589 Q5W005 Q5W006
		NCBI	3559
		KEGG signaling	JAK-STAT signaling pathway Hematopoietic cell lineage PI3K-Akt signaling pathway Viral protein interaction with cytokine and cytokine receptor Cytokine-cytokine receptor interaction
		KEGG metabolic	Endocytosis
15	PTPRC	ENSG00000081237	protein tyrosine phosphatase receptor type C
		UniProt	A0A075B788 A0A2R8Y5B1 A0A2R8YE81 E9PKH0 M3ZCP1 M9MMK8 M9MMK9 M9MML3 M9MML4 P08575
		NCBI	5788
		KEGG signaling	Fc gamma R-mediated phagocytosis T cell receptor signaling pathway Cell adhesion molecules (CAMs)
3	KLRK1	ENSG00000213809	killer cell lectin like receptor K1
		UniProt	P26718 Q8WZ67
		NCBI	100528032 22914
		KEGG signaling	Natural killer cell mediated cytotoxicity
12	CD8B	ENSG00000172116	CD8b molecule
		UniProt	E9PD41 P10966
		NCBI	926
		KEGG signaling	Antigen processing and presentation Hematopoietic cell lineage T cell receptor signaling pathway Cell adhesion molecules (CAMs)
12	CORO1A	ENSG00000102879	coronin 1A
		UniProt	H3BNA2 H3BRJ0 H3BRY3 H3BSL1 H3BTU6 H3BU76 P31146
		NCBI	11151
		KEGG metabolic	Phagosome
5	JAK3	ENSG00000105639	Janus kinase 3
		UniProt	P52333
		NCBI	3718
		KEGG signaling	JAK-STAT signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway
5	JAK1	ENSG00000162434	Janus kinase 1
		UniProt	A0A5F9ZH07 A0A5F9ZH32 A0A5F9ZH73 A0A5F9ZHI1 A0A5F9ZHK2 A0A5F9ZHN8 A0A5F9ZHW0 A0A5F9ZI01 A0A5F9ZI39 P23458
		NCBI	3716
		KEGG signaling	NOD-like receptor signaling pathway JAK-STAT signaling pathway PI3K-Akt signaling pathway
7	IL7R	ENSG00000168685	interleukin 7 receptor
		UniProt	B8YG18 D6RCR9 D6RDM4 D6RG28 H0YA41 P16871
		NCBI	3575
		KEGG signaling	JAK-STAT signaling pathway Hematopoietic cell lineage FoxO signaling pathway PI3K-Akt signaling pathway Cytokine-cytokine receptor interaction
12	ITGB2	ENSG00000160255	integrin subunit beta 2
		UniProt	A0A494C0X7 A8MVG7 D3DSM0 E5RFI0 E5RGK9 E5RHE6 E5RHT0 E5RIE4 E5RIG7 E5RK25 E5RK54 E7EVZ9 J3KNI6 P05107
		NCBI	3689
		KEGG signaling	Complement and coagulation cascades Rap1 signaling pathway Natural killer cell mediated cytotoxicity Leukocyte transendothelial migration Hippo signaling pathway Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome
5	IL15RA	ENSG00000134470	interleukin 15 receptor subunit alpha
		UniProt	A0A0A0MS77 E7ETI1 E9PQ64 H0Y4R3 H0Y6E8 H0YD11 K9N163 K9N1J3 K9N2Q6 K9N2S2 Q13261 Q5JVA3
		NCBI	3601
		KEGG signaling	JAK-STAT signaling pathway Intestinal immune network for IgA production Cytokine-cytokine receptor interaction
3	IL15	ENSG00000164136	interleukin 15
		UniProt	P40933
		NCBI	3600
		KEGG signaling	JAK-STAT signaling pathway Intestinal immune network for IgA production Cytokine-cytokine receptor interaction TNF signaling pathway
9	CD3G	ENSG00000160654	CD3g molecule
		UniProt	A0A3B3IUD8 A8MUH3 J3KNA5 P09693
		NCBI	917
		KEGG signaling	Hematopoietic cell lineage T cell receptor signaling pathway
14	IL2RB	ENSG00000100385	interleukin 2 receptor subunit beta
		UniProt	B0QYC0 B0QYC1 B0QYC2 H7C1H9 P14784
		NCBI	3560
		KEGG signaling	JAK-STAT signaling pathway PI3K-Akt signaling pathway Viral protein interaction with cytokine and cytokine receptor Cytokine-cytokine receptor interaction
		KEGG metabolic	Endocytosis
6	CD69	ENSG00000110848	CD69 molecule
		UniProt	B4E009 Q07108
		NCBI	969
1	CD320	ENSG00000167775	CD320 molecule
		UniProt	M0R100 M0R1C4 Q9NPF0
		NCBI	51293
6	CD37	ENSG00000104894	CD37 molecule
		UniProt	B7ZAN3 M0QZ33 M0QZP6 M0R083 M0R1J1 P11049 Q96LM7
		NCBI	951
		KEGG signaling	Hematopoietic cell lineage
3	STK4	ENSG00000101109	serine/threonine kinase 4
		UniProt	A0A087WVN8 A0A087WYT4 F5H5B4 Q13043
		NCBI	6789
		KEGG signaling	Ras signaling pathway FoxO signaling pathway MAPK signaling pathway
3	AXL	ENSG00000167601	AXL receptor tyrosine kinase
		UniProt	M0R0W6 P30530
		NCBI	558
7	GRB2	ENSG00000177885	growth factor receptor bound protein 2
		UniProt	J3KT38 J3QLF6 J3QRL5 P62993
		NCBI	2885
		KEGG signaling	MAPK signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway mTOR signaling pathway Phospholipase D signaling pathway Neurotrophin signaling pathway Fc epsilon RI signaling pathway Focal adhesion Ras signaling pathway JAK-STAT signaling pathway FoxO signaling pathway B cell receptor signaling pathway Natural killer cell mediated cytotoxicity ErbB signaling pathway Gap junction T cell receptor signaling pathway Prolactin signaling pathway Estrogen signaling pathway Relaxin signaling pathway GnRH signaling pathway Insulin signaling pathway
4	HCST	ENSG00000126264	hematopoietic cell signal transducer
		UniProt	Q9UBK5
		NCBI	10870
		KEGG signaling	Natural killer cell mediated cytotoxicity
13	HLA-B	ENSG00000234745	major histocompatibility complex, class I, B
		UniProt	A0A1W2PP29 A0A1W2PPR8 A0A1W2PQE2 F6U0H7 P01889
		NCBI	3106
		KEGG signaling	Antigen processing and presentation Natural killer cell mediated cytotoxicity Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome Endocytosis
1	IL21	ENSG00000138684	interleukin 21
		UniProt	Q9HBE4
		NCBI	59067
		KEGG signaling	JAK-STAT signaling pathway Cytokine-cytokine receptor interaction
4	SHC1	ENSG00000160691	SHC adaptor protein 1
		UniProt	H0Y539 P29353 Q5T181 Q5T182 Q5T187 Q5T188 X6R6D0
		NCBI	6464
		KEGG signaling	Neurotrophin signaling pathway Focal adhesion Ras signaling pathway Natural killer cell mediated cytotoxicity ErbB signaling pathway Prolactin signaling pathway Estrogen signaling pathway Relaxin signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Insulin signaling pathway
12	HLA-C	ENSG00000204525	major histocompatibility complex, class I, C
		UniProt	A0A140T9E1 A0A1W2PRU9 A2AEA2 F8W9Z8 P10321
		NCBI	3107
		KEGG signaling	Antigen processing and presentation Natural killer cell mediated cytotoxicity Cell adhesion molecules (CAMs)
		KEGG metabolic	Phagosome Endocytosis
2	CAPNS1	ENSG00000126247	calpain small subunit 1
		UniProt	A0A075B7C0 A0A0C4DGQ5 K7EIV0 K7EKD8 K7ELJ7 K7EM73 K7EMQ1 K7ES78 P04632 S4R3F9 U3KPR7 U3KQE2
		NCBI	826
1	FLVCR1	ENSG00000162769	FLVCR heme transporter 1
		UniProt	H7C3Z2 Q9Y5Y0
		NCBI	28982
1	IL13RA1	ENSG00000131724	interleukin 13 receptor subunit alpha 1
		UniProt	A0A494C1C4 P78552
		NCBI	3597
		KEGG signaling	JAK-STAT signaling pathway Cytokine-cytokine receptor interaction

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	239.67 KB
	H.sapiens_subnetwork.tsv	17.20 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000147168

HLA-A

FCER1G

CD6

IL2RA

PTPRC

KLRK1

CD8B

CORO1A

JAK3

JAK1

IL7R

ITGB2

IL15RA

IL15

CD3G

IL2RB

CD69

CD320

CD37

STK4

AXL

GRB2

HCST

HLA-B

IL21

SHC1

HLA-C

CAPNS1

FLVCR1

IL13RA1

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