Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000145781
3. COMM domain containing …
- 2. COMMD8
  3. COMM domain containing 8
  4. 1.000
  5. PPI
- 2. COMMD2
  3. COMM domain containing 2
  4. 0.999
  5. PPI
- 2. COMMD1
  3. copper metabolism domai…
  4. 0.999
  5. PPI
- 2. COMMD3
  3. COMM domain containing 3
  4. 0.997
  5. PPI
- 2. COMMD5
  3. COMM domain containing 5
  4. 0.997
  5. PPI
- 2. CCDC93
  3. coiled-coil domain cont…
  4. 0.996
  5. PPI
- 2. COMMD9
  3. COMM domain containing 9
  4. 0.992
  5. PPI
- 2. CCDC22
  3. coiled-coil domain cont…
  4. 0.984
  5. PPI
- 2. TP53RK
  3. TP53 regulating kinase
  4. 0.980
  5. PPI
- 2. COMMD7
  3. COMM domain containing 7
  4. 0.979
  5. PPI
- 2. ACOT9
  3. acyl-CoA thioesterase 9
  4. 0.974
  5. PPI
- 2. TRAF7
  3. TNF receptor associated…
  4. 0.967
  5. PPI
- 2. COMMD4
  3. COMM domain containing 4
  4. 0.966
  5. PPI
- 2. VPS35L
  3. VPS35 endosomal protein…
  4. 0.965
  5. PPI
- 2. NFKB1
  3. nuclear factor kappa B …
  4. 0.933
  5. PPI
- 2. RAN
  3. RAN, member RAS oncogen…
  4. 0.896
  5. Metabolic
- 2. COMMD6
  3. COMM domain containing 6
  4. 0.870
  5. PPI
- 2. CMPK1
  3. cytidine/uridine monoph…
  4. 0.804
  5. Metabolic
- 2. NFU1
  3. NFU1 iron-sulfur cluste…
  4. 0.799
  5. Metabolic
- 2. EEF1E1
  3. eukaryotic translation …
  4. 0.753
  5. Metabolic
- 2. NFKB2
  3. nuclear factor kappa B …
  4. 0.748
  5. Complex
- 2. NPM1
  3. nucleophosmin 1
  4. 0.739
  5. Metabolic
- 2. FKBP15
  3. FKBP prolyl isomerase 15
  4. 0.737
  5. PPI
- 2. EIF4A3
  3. eukaryotic translation …
  4. 0.714
  5. Metabolic
- 2. ACTL6A
  3. actin like 6A
  4. 0.711
  5. Metabolic
- 2. DRG2
  3. developmentally regulat…
  4. 0.694
  5. Metabolic
- 2. SNRPD3
  3. small nuclear ribonucle…
  4. 0.690
  5. Metabolic
- 2. BUB3
  3. BUB3 mitotic checkpoint…
  4. 0.681
  5. Metabolic
- 2. TCTEX1D2
  3. Tctex1 domain containin…
  4. 0.677
  5. PPI
- 2. PSMA5
  3. proteasome 20S subunit …
  4. 0.675
  5. Metabolic

Subnetwork gene interactions

ENSG00000145781

COMM domain containing 10

FunCoup

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Ensembl

ENSG00000145781

UniProt

NCBI

51397

ACTL6A

actin like 6A

FunCoup

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Ensembl

ENSG00000136518

UniProt

NCBI

SNRPD3

small nuclear ribonucleoprotein D3 polypeptide

FunCoup

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Ensembl

ENSG00000100028

UniProt

P62318

NCBI

6634

NFU1

NFU1 iron-sulfur cluster scaffold

FunCoup

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Ensembl

ENSG00000169599

UniProt

NCBI

27247

EIF4A3

eukaryotic translation initiation factor 4A3

FunCoup

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Ensembl

ENSG00000141543

UniProt

NCBI

9775

DRG2

developmentally regulated GTP binding protein 2

FunCoup

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Ensembl

ENSG00000108591

UniProt

NCBI

1819

TP53RK

TP53 regulating kinase

FunCoup

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Ensembl

ENSG00000172315

UniProt

NCBI

112858

RAN

RAN, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000132341

UniProt

NCBI

5901

ACOT9

acyl-CoA thioesterase 9

FunCoup

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Ensembl

ENSG00000123130

UniProt

NCBI

23597

COMMD9

COMM domain containing 9

FunCoup

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Ensembl

ENSG00000110442

UniProt

NCBI

29099

CCDC93

coiled-coil domain containing 93

FunCoup

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Ensembl

ENSG00000125633

UniProt

NCBI

54520

COMMD5

COMM domain containing 5

FunCoup

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Ensembl

ENSG00000170619

UniProt

NCBI

28991

COMMD1

copper metabolism domain containing 1

FunCoup

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Ensembl

ENSG00000173163

UniProt

NCBI

150684

CMPK1

cytidine/uridine monophosphate kinase 1

FunCoup

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Ensembl

ENSG00000162368

UniProt

NCBI

51727

EEF1E1

eukaryotic translation elongation factor 1 epsilon 1

FunCoup

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Ensembl

ENSG00000124802

UniProt

NCBI

9521

NPM1

nucleophosmin 1

FunCoup

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Ensembl

ENSG00000181163

UniProt

NCBI

4869

BUB3

BUB3 mitotic checkpoint protein

FunCoup

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Ensembl

ENSG00000154473

UniProt

NCBI

9184

COMMD6

COMM domain containing 6

FunCoup

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Ensembl

ENSG00000188243

UniProt

NCBI

170622

NFKB1

nuclear factor kappa B subunit 1

FunCoup

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Ensembl

ENSG00000109320

UniProt

NCBI

4790

NFKB2

nuclear factor kappa B subunit 2

FunCoup

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Ensembl

ENSG00000077150

UniProt

NCBI

4791

PSMA5

proteasome 20S subunit alpha 5

FunCoup

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Ensembl

ENSG00000143106

UniProt

P28066

NCBI

5686

COMMD8

COMM domain containing 8

FunCoup

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Ensembl

ENSG00000169019

UniProt

Q9NX08

NCBI

54951

COMMD4

COMM domain containing 4

FunCoup

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Ensembl

ENSG00000140365

UniProt

NCBI

54939

COMMD2

COMM domain containing 2

FunCoup

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Ensembl

ENSG00000114744

UniProt

NCBI

51122

COMMD3

COMM domain containing 3

FunCoup

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Ensembl

ENSG00000148444

UniProt

NCBI

23412

CCDC22

coiled-coil domain containing 22

FunCoup

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Ensembl

ENSG00000101997

UniProt

O60826

NCBI

28952

VPS35L

VPS35 endosomal protein sorting factor like

FunCoup

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Ensembl

ENSG00000103544

UniProt

NCBI

57020

COMMD7

COMM domain containing 7

FunCoup

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Ensembl

ENSG00000149600

UniProt

NCBI

149951

TCTEX1D2

Tctex1 domain containing 2

FunCoup

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Ensembl

ENSG00000213123

UniProt

NCBI

255758

FKBP15

FKBP prolyl isomerase 15

FunCoup

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Ensembl

ENSG00000119321

UniProt

Q5T1M5

NCBI

23307

TRAF7

TNF receptor associated factor 7

FunCoup

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Ensembl

ENSG00000131653

UniProt

NCBI

84231

Query genes

		Identifier	Description
30	ENSG00000145781	ENSG00000145781	COMM domain containing 10
		UniProt	D6RC04 D6RJ90 H0Y9N4 Q9Y6G5
		NCBI	51397

Subnetwork genes

		Identifier	Description
16	ACTL6A	ENSG00000136518	actin like 6A
		UniProt	C9JQT2 H7C5S0 O96019
		NCBI	86
13	SNRPD3	ENSG00000100028	small nuclear ribonucleoprotein D3 polypeptide
		UniProt	P62318
		NCBI	6634
		KEGG metabolic	Spliceosome
9	NFU1	ENSG00000169599	NFU1 iron-sulfur cluster scaffold
		UniProt	C9J8Q1 F8W9P7 F8WAV1 F8WET4 H7C537 Q9UMS0
		NCBI	27247
12	EIF4A3	ENSG00000141543	eukaryotic translation initiation factor 4A3
		UniProt	I3L3H2 P38919
		NCBI	9775
		KEGG metabolic	Spliceosome RNA transport mRNA surveillance pathway
11	DRG2	ENSG00000108591	developmentally regulated GTP binding protein 2
		UniProt	A8MZF9 J3KRL5 J3QKV7 J3QKW7 J3QL90 J3QLF3 J3QQI1 J3QR71 J3QRI9 P55039
		NCBI	1819
9	TP53RK	ENSG00000172315	TP53 regulating kinase
		UniProt	Q5JZ02 Q96S44
		NCBI	112858
25	RAN	ENSG00000132341	RAN, member RAS oncogene family
		UniProt	A0A087X0W0 B4DV51 B5MDF5 F5H018 H0YFC6 J3KQE5 P62826
		NCBI	5901
		KEGG metabolic	Ribosome biogenesis in eukaryotes RNA transport
6	ACOT9	ENSG00000123130	acyl-CoA thioesterase 9
		UniProt	C9J7L8 F8WDI2 H7C5Q2 Q9Y305
		NCBI	23597
15	COMMD9	ENSG00000110442	COMM domain containing 9
		UniProt	E9PJ95 Q9P000
		NCBI	29099
13	CCDC93	ENSG00000125633	coiled-coil domain containing 93
		UniProt	F8W9X7 H7C050 Q567U6
		NCBI	54520
16	COMMD5	ENSG00000170619	COMM domain containing 5
		UniProt	E9PJE4 H0YEQ6 Q9GZQ3
		NCBI	28991
16	COMMD1	ENSG00000173163	copper metabolism domain containing 1
		UniProt	E9PE85 H0Y7J4 H7C169 H7C377 Q8N668
		NCBI	150684
12	CMPK1	ENSG00000162368	cytidine/uridine monophosphate kinase 1
		UniProt	A0A494BXC7 E9PJD2 P30085 Q5T0D2
		NCBI	51727
		KEGG metabolic	Drug metabolism - other enzymes Pyrimidine metabolism
12	EEF1E1	ENSG00000124802	eukaryotic translation elongation factor 1 epsilon 1
		UniProt	D6RBD7 D6RCQ0 H0YAH9 H0YAL7 O43324
		NCBI	9521
9	NPM1	ENSG00000181163	nucleophosmin 1
		UniProt	E5RGW4 E5RI98 P06748
		NCBI	4869
10	BUB3	ENSG00000154473	BUB3 mitotic checkpoint protein
		UniProt	J3QSX4 J3QT28 O43684
		NCBI	9184
		KEGG signaling	Cell cycle
13	COMMD6	ENSG00000188243	COMM domain containing 6
		UniProt	B0QZ40 H7C607 Q7Z4G1
		NCBI	170622
13	NFKB1	ENSG00000109320	nuclear factor kappa B subunit 1
		UniProt	A0A494C157 A0A494C1E9 D6RC45 D6RDI9 D6RF93 D6RH30 P19838
		NCBI	4790
		KEGG signaling	MAPK signaling pathway NF-kappa B signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Adipocytokine signaling pathway Neurotrophin signaling pathway Cytosolic DNA-sensing pathway RIG-I-like receptor signaling pathway NOD-like receptor signaling pathway Toll-like receptor signaling pathway Ras signaling pathway cAMP signaling pathway B cell receptor signaling pathway Apoptosis HIF-1 signaling pathway T cell receptor signaling pathway Prolactin signaling pathway Relaxin signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway IL-17 signaling pathway
6	NFKB2	ENSG00000077150	nuclear factor kappa B subunit 2
		UniProt	M0QZX1 Q00653
		NCBI	4791
		KEGG signaling	MAPK signaling pathway NF-kappa B signaling pathway C-type lectin receptor signaling pathway
20	PSMA5	ENSG00000143106	proteasome 20S subunit alpha 5
		UniProt	P28066
		NCBI	5686
		KEGG metabolic	Proteasome
19	COMMD8	ENSG00000169019	COMM domain containing 8
		UniProt	Q9NX08
		NCBI	54951
15	COMMD4	ENSG00000140365	COMM domain containing 4
		UniProt	A0A0B4J287 H3BM91 H3BPG2 H3BQF2 H3BRX0 H3BTV9 Q9H0A8
		NCBI	54939
15	COMMD2	ENSG00000114744	COMM domain containing 2
		UniProt	F8WBW1 F8WC41 Q86X83
		NCBI	51122
16	COMMD3	ENSG00000148444	COMM domain containing 3
		UniProt	H0Y4E5 H0Y4W0 H0Y6Z9 Q9UBI1 R4GN06 R4GNF2
		NCBI	23412
14	CCDC22	ENSG00000101997	coiled-coil domain containing 22
		UniProt	O60826
		NCBI	28952
13	VPS35L	ENSG00000103544	VPS35 endosomal protein sorting factor like
		UniProt	C9J7I2 E7EWW0 F5H7K1 F6S1J4 H0YFG6 H3BNX2 H3BRV8 H3BTI5 H3BUS7 H3BV68 H3BVG8 I3L1U5 Q7Z3J2
		NCBI	57020
13	COMMD7	ENSG00000149600	COMM domain containing 7
		UniProt	Q86VX2 V9GY66 V9GYC5
		NCBI	149951
1	TCTEX1D2	ENSG00000213123	Tctex1 domain containing 2
		UniProt	E7ER86 F8WD40 Q8WW35
		NCBI	255758
1	FKBP15	ENSG00000119321	FKBP prolyl isomerase 15
		UniProt	Q5T1M5
		NCBI	23307
1	TRAF7	ENSG00000131653	TNF receptor associated factor 7
		UniProt	A0A087WUB0 H3BR17 H3BUP4 Q6Q0C0
		NCBI	84231

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	272.04 KB
	H.sapiens_subnetwork.tsv	29.03 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000145781

ACTL6A

SNRPD3

NFU1

EIF4A3

DRG2

TP53RK

RAN

ACOT9

COMMD9

CCDC93

COMMD5

COMMD1

CMPK1

EEF1E1

NPM1

BUB3

COMMD6

NFKB1

NFKB2

PSMA5

COMMD8

COMMD4

COMMD2

COMMD3

CCDC22

VPS35L

COMMD7

TCTEX1D2

FKBP15

TRAF7

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