Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000136872
3. aldolase, fructose-bisp…
- 2. ACAT1
  3. acetyl-CoA acetyltransf…
  4. 0.999
  5. Metabolic
- 2. AHCY
  3. adenosylhomocysteinase
  4. 0.999
  5. Metabolic
- 2. VDAC1
  3. voltage dependent anion…
  4. 0.998
  5. Metabolic
- 2. MDH1
  3. malate dehydrogenase 1
  4. 0.997
  5. Metabolic
- 2. MDH2
  3. malate dehydrogenase 2
  4. 0.997
  5. Metabolic
- 2. ATP6V1E1
  3. ATPase H+ transporting …
  4. 0.997
  5. PPI
- 2. SOD1
  3. superoxide dismutase 1
  4. 0.997
  5. Metabolic
- 2. ESD
  3. esterase D
  4. 0.995
  5. Metabolic
- 2. VDAC2
  3. voltage dependent anion…
  4. 0.995
  5. Metabolic
- 2. ENO3
  3. enolase 3
  4. 0.994
  5. Metabolic
- 2. DBI
  3. diazepam binding inhibi…
  4. 0.993
  5. Metabolic
- 2. GAPDH
  3. glyceraldehyde-3-phosph…
  4. 0.993
  5. Metabolic
- 2. TPI1
  3. triosephosphate isomera…
  4. 0.991
  5. Metabolic
- 2. GPI
  3. glucose-6-phosphate iso…
  4. 0.991
  5. Metabolic
- 2. ENO1
  3. enolase 1
  4. 0.991
  5. Metabolic
- 2. AGXT2
  3. alanine--glyoxylate ami…
  4. 0.991
  5. PPI
- 2. ATP5PO
  3. ATP synthase peripheral…
  4. 0.991
  5. Metabolic
- 2. ATP6V0D1
  3. ATPase H+ transporting …
  4. 0.990
  5. Metabolic
- 2. PGK1
  3. phosphoglycerate kinase…
  4. 0.989
  5. Metabolic
- 2. RACK1
  3. receptor for activated …
  4. 0.989
  5. Metabolic
- 2. RPS2
  3. ribosomal protein S2
  4. 0.989
  5. Metabolic
- 2. ATP5F1A
  3. ATP synthase F1 subunit…
  4. 0.988
  5. Metabolic
- 2. ALDH2
  3. aldehyde dehydrogenase …
  4. 0.986
  5. Metabolic
- 2. TALDO1
  3. transaldolase 1
  4. 0.986
  5. Metabolic
- 2. SUCLA2
  3. succinate-CoA ligase AD…
  4. 0.986
  5. Metabolic
- 2. GLUD1
  3. glutamate dehydrogenase…
  4. 0.985
  5. Metabolic
- 2. NME2
  3. NME/NM23 nucleoside dip…
  4. 0.983
  5. Metabolic
- 2. FBP1
  3. fructose-bisphosphatase…
  4. 0.982
  5. Metabolic
- 2. PPIA
  3. peptidylprolyl isomeras…
  4. 0.982
  5. Metabolic
- 2. PGM1
  3. phosphoglucomutase 1
  4. 0.982
  5. Metabolic

Subnetwork gene interactions

ENSG00000136872

aldolase, fructose-bisphosphate B

FunCoup

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Ensembl

ENSG00000136872

UniProt

NCBI

PGM1

phosphoglucomutase 1

FunCoup

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Ensembl

ENSG00000079739

UniProt

NCBI

5236

MDH1

malate dehydrogenase 1

FunCoup

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Ensembl

ENSG00000014641

UniProt

NCBI

4190

MDH2

malate dehydrogenase 2

FunCoup

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Ensembl

ENSG00000146701

UniProt

NCBI

4191

ESD

esterase D

FunCoup

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Ensembl

ENSG00000139684

UniProt

NCBI

2098

ACAT1

acetyl-CoA acetyltransferase 1

FunCoup

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Ensembl

ENSG00000075239

UniProt

NCBI

SOD1

superoxide dismutase 1

FunCoup

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Ensembl

ENSG00000142168

UniProt

NCBI

6647

ATP5PO

ATP synthase peripheral stalk subunit OSCP

FunCoup

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Ensembl

ENSG00000241837

UniProt

NCBI

TPI1

triosephosphate isomerase 1

FunCoup

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Ensembl

ENSG00000111669

UniProt

NCBI

7167

VDAC2

voltage dependent anion channel 2

FunCoup

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Ensembl

ENSG00000165637

UniProt

NCBI

7417

SUCLA2

succinate-CoA ligase ADP-forming subunit beta

FunCoup

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Ensembl

ENSG00000136143

UniProt

NCBI

8803

AHCY

adenosylhomocysteinase

FunCoup

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Ensembl

ENSG00000101444

UniProt

P23526

NCBI

RACK1

receptor for activated C kinase 1

FunCoup

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Ensembl

ENSG00000204628

UniProt

NCBI

10399

GLUD1

glutamate dehydrogenase 1

FunCoup

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Ensembl

ENSG00000148672

UniProt

P00367

NCBI

2746

GAPDH

glyceraldehyde-3-phosphate dehydrogenase

FunCoup

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Ensembl

ENSG00000111640

UniProt

NCBI

2597

GPI

glucose-6-phosphate isomerase

FunCoup

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Ensembl

ENSG00000105220

UniProt

NCBI

2821

DBI

diazepam binding inhibitor, acyl-CoA binding protein

FunCoup

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Ensembl

ENSG00000155368

UniProt

NCBI

1622

PPIA

peptidylprolyl isomerase A

FunCoup

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Ensembl

ENSG00000196262

UniProt

NCBI

5478

ATP5F1A

ATP synthase F1 subunit alpha

FunCoup

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Ensembl

ENSG00000152234

UniProt

NCBI

ENO1

enolase 1

FunCoup

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Ensembl

ENSG00000074800

UniProt

NCBI

2023

ALDH2

aldehyde dehydrogenase 2 family member

FunCoup

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Ensembl

ENSG00000111275

UniProt

NCBI

ATP6V0D1

ATPase H+ transporting V0 subunit d1

FunCoup

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Ensembl

ENSG00000159720

UniProt

NCBI

9114

NME2

NME/NM23 nucleoside diphosphate kinase 2

FunCoup

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Ensembl

ENSG00000243678

UniProt

NCBI

4831
654364

FBP1

fructose-bisphosphatase 1

FunCoup

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Ensembl

ENSG00000165140

UniProt

NCBI

2203

PGK1

phosphoglycerate kinase 1

FunCoup

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Ensembl

ENSG00000102144

UniProt

P00558

NCBI

5230

ATP6V1E1

ATPase H+ transporting V1 subunit E1

FunCoup

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Ensembl

ENSG00000131100

UniProt

NCBI

ENO3

enolase 3

FunCoup

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Ensembl

ENSG00000108515

UniProt

NCBI

2027

VDAC1

voltage dependent anion channel 1

FunCoup

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Ensembl

ENSG00000213585

UniProt

NCBI

7416

AGXT2

alanine--glyoxylate aminotransferase 2

FunCoup

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Ensembl

ENSG00000113492

UniProt

Q9BYV1

NCBI

64902

RPS2

ribosomal protein S2

FunCoup

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Ensembl

ENSG00000140988

UniProt

NCBI

6187

TALDO1

transaldolase 1

FunCoup

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Ensembl

ENSG00000177156

UniProt

NCBI

6888

Query genes

		Identifier	Description
30	ENSG00000136872	ENSG00000136872	aldolase, fructose-bisphosphate B
		UniProt	A0A087WXX2 A0A3B3IS80 A0A3B3ITZ0 P05062
		NCBI	229
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	Pentose phosphate pathway Fructose and mannose metabolism Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism

Subnetwork genes

		Identifier	Description
30	PGM1	ENSG00000079739	phosphoglucomutase 1
		UniProt	A0A3B3ITK7 P36871
		NCBI	5236
		KEGG metabolic	Starch and sucrose metabolism Pentose phosphate pathway Galactose metabolism Purine metabolism Glycolysis / Gluconeogenesis Amino sugar and nucleotide sugar metabolism
29	MDH1	ENSG00000014641	malate dehydrogenase 1
		UniProt	A0A5K1VW95 B8ZZ51 B9A041 C9IZI0 C9JF79 C9JLV6 C9JRL4 F8WFC2 P40925
		NCBI	4190
		KEGG metabolic	Pyruvate metabolism Cysteine and methionine metabolism Citrate cycle (TCA cycle) Carbon metabolism Glyoxylate and dicarboxylate metabolism
29	MDH2	ENSG00000146701	malate dehydrogenase 2
		UniProt	G3XAL0 P40926 U3KQ63
		NCBI	4191
		KEGG metabolic	Pyruvate metabolism Cysteine and methionine metabolism Citrate cycle (TCA cycle) Carbon metabolism Glyoxylate and dicarboxylate metabolism
29	ESD	ENSG00000139684	esterase D
		UniProt	H7BZT7 P10768 U3KQT1 X6RA14
		NCBI	2098
		KEGG metabolic	Carbon metabolism
29	ACAT1	ENSG00000075239	acetyl-CoA acetyltransferase 1
		UniProt	A0A5F9ZHD4 A0A5F9ZHH9 A0A5F9ZHJ0 A0A5F9ZHJ7 A0A5F9ZHL1 A0A5F9ZHL7 A0A5F9ZI66 E9PRQ6 H0YEL7 P24752
		NCBI	38
		KEGG metabolic	Synthesis and degradation of ketone bodies Tryptophan metabolism Valine, leucine and isoleucine degradation Fatty acid degradation Fat digestion and absorption Pyruvate metabolism Terpenoid backbone biosynthesis Carbon metabolism Butanoate metabolism Glyoxylate and dicarboxylate metabolism Propanoate metabolism Lysine degradation Fatty acid metabolism
29	SOD1	ENSG00000142168	superoxide dismutase 1
		UniProt	H7BYH4 P00441
		NCBI	6647
		KEGG metabolic	Peroxisome
29	ATP5PO	ENSG00000241837	ATP synthase peripheral stalk subunit OSCP
		UniProt	A0A494C0K9 H7C068 H7C086 H7C239 H7C2P9 P48047
		NCBI	539
		KEGG metabolic	Oxidative phosphorylation
29	TPI1	ENSG00000111669	triosephosphate isomerase 1
		UniProt	P60174 U3KPS5 U3KPZ0 U3KQF3
		NCBI	7167
		KEGG metabolic	Fructose and mannose metabolism Glycolysis / Gluconeogenesis Biosynthesis of amino acids Inositol phosphate metabolism Carbon metabolism
30	VDAC2	ENSG00000165637	voltage dependent anion channel 2
		UniProt	A0A0A0MR02 A2A3S1 P45880 Q5JSD1 Q5JSD2
		NCBI	7417
		KEGG signaling	NOD-like receptor signaling pathway cGMP-PKG signaling pathway Calcium signaling pathway
30	SUCLA2	ENSG00000136143	succinate-CoA ligase ADP-forming subunit beta
		UniProt	A0A0U1RQF8 A0A0U1RQL1 A0A0U1RQU7 A0A0U1RRI1 A0A2R8Y5P4 A0A2R8Y5P6 A0A2R8Y6E6 A0A2R8Y6Y7 A0A2R8YDQ9 A0A2R8YF84 Q5T9Q5 Q5T9Q8 Q9P2R7
		NCBI	8803
		KEGG metabolic	Citrate cycle (TCA cycle) Carbon metabolism Propanoate metabolism
29	AHCY	ENSG00000101444	adenosylhomocysteinase
		UniProt	P23526
		NCBI	191
		KEGG metabolic	Cysteine and methionine metabolism
28	RACK1	ENSG00000204628	receptor for activated C kinase 1
		UniProt	D6R909 D6R9L0 D6R9Z1 D6RAC2 D6RAU2 D6RBD0 D6RDI0 D6REE5 D6RF23 D6RFX4 D6RFZ9 D6RGK8 D6RHH4 D6RHJ5 E9PD14 H0Y8R5 H0Y8W2 H0Y9P0 H0YAF8 H0YAM7 J3KPE3 P63244
		NCBI	10399
30	GLUD1	ENSG00000148672	glutamate dehydrogenase 1
		UniProt	P00367
		NCBI	2746
		KEGG metabolic	Nitrogen metabolism Alanine, aspartate and glutamate metabolism D-Glutamine and D-glutamate metabolism Carbon metabolism Arginine biosynthesis
29	GAPDH	ENSG00000111640	glyceraldehyde-3-phosphate dehydrogenase
		UniProt	E7EUT5 P04406
		NCBI	2597
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
29	GPI	ENSG00000105220	glucose-6-phosphate isomerase
		UniProt	A0A0G2JLI6 A0A2R8Y6C7 A0A2R8YF08 A0A2U3TZU2 K7EIL4 K7ELR7 K7ENA0 K7EP41 K7EPY4 K7EQ48 K7ERC6 K7ERK8 P06744
		NCBI	2821
		KEGG metabolic	Starch and sucrose metabolism Pentose phosphate pathway Glycolysis / Gluconeogenesis Carbon metabolism Amino sugar and nucleotide sugar metabolism
29	DBI	ENSG00000155368	diazepam binding inhibitor, acyl-CoA binding protein
		UniProt	A0A0A0MTI5 B8ZWD1 P07108
		NCBI	1622
		KEGG signaling	PPAR signaling pathway
29	PPIA	ENSG00000196262	peptidylprolyl isomerase A
		UniProt	C9J5S7 E5RIZ5 F8WE65 P62937
		NCBI	5478
29	ATP5F1A	ENSG00000152234	ATP synthase F1 subunit alpha
		UniProt	A0A0A0MTS3 K7EJP1 K7EK77 K7EKV9 K7EM08 K7ENJ4 K7EQH4 K7EQU6 K7ERX7 K7ESA0 P25705
		NCBI	498
		KEGG metabolic	Oxidative phosphorylation
29	ENO1	ENSG00000074800	enolase 1
		UniProt	A0A2R8Y6G6 A0A2R8Y6I8 A0A2R8Y798 A0A2R8Y879 A0A2R8YEG5 A0A2R8YEM5 K7EM90 K7ERS8 P06733
		NCBI	2023
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	RNA degradation Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
30	ALDH2	ENSG00000111275	aldehyde dehydrogenase 2 family member
		UniProt	F8VSB0 P05091 S4R3S4
		NCBI	217
		KEGG metabolic	Pyruvate metabolism Tryptophan metabolism Fatty acid degradation Valine, leucine and isoleucine degradation Histidine metabolism Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Arginine and proline metabolism Glycerolipid metabolism beta-Alanine metabolism Lysine degradation
30	ATP6V0D1	ENSG00000159720	ATPase H+ transporting V0 subunit d1
		UniProt	F5GYQ1 F8WEN9 H3BPS0 H3BQB4 H3BQJ1 H3BSG7 H3BTB4 H3BTB5 H3BUQ0 J3QL14 P61421 R4GN72
		NCBI	9114
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Oxidative phosphorylation Phagosome Lysosome
29	NME2	ENSG00000243678	NME/NM23 nucleoside diphosphate kinase 2
		UniProt	F6XY72 P22392
		NCBI	4831 654364
		KEGG metabolic	Drug metabolism - other enzymes Purine metabolism Pyrimidine metabolism
27	FBP1	ENSG00000165140	fructose-bisphosphatase 1
		UniProt	A0A3B3IUC7 P09467 Q5VZC3
		NCBI	2203
		KEGG signaling	AMPK signaling pathway Glucagon signaling pathway Insulin signaling pathway
		KEGG metabolic	Pentose phosphate pathway Fructose and mannose metabolism Glycolysis / Gluconeogenesis Carbon metabolism
29	PGK1	ENSG00000102144	phosphoglycerate kinase 1
		UniProt	P00558
		NCBI	5230
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
29	ATP6V1E1	ENSG00000131100	ATPase H+ transporting V1 subunit E1
		UniProt	C9J8H1 P36543
		NCBI	529
		KEGG signaling	Synaptic vesicle cycle mTOR signaling pathway
		KEGG metabolic	Oxidative phosphorylation Phagosome
29	ENO3	ENSG00000108515	enolase 3
		UniProt	E5RG95 E5RGZ4 E5RI09 E5RJH5 K7EKN2 K7EP84 K7EPM1 P13929
		NCBI	2027
		KEGG signaling	HIF-1 signaling pathway
		KEGG metabolic	RNA degradation Glycolysis / Gluconeogenesis Biosynthesis of amino acids Carbon metabolism
30	VDAC1	ENSG00000213585	voltage dependent anion channel 1
		UniProt	C9JI87 P21796
		NCBI	7416
		KEGG signaling	NOD-like receptor signaling pathway cGMP-PKG signaling pathway Calcium signaling pathway
8	AGXT2	ENSG00000113492	alanine--glyoxylate aminotransferase 2
		UniProt	Q9BYV1
		NCBI	64902
		KEGG metabolic	Cysteine and methionine metabolism Valine, leucine and isoleucine degradation Alanine, aspartate and glutamate metabolism Glycine, serine and threonine metabolism
28	RPS2	ENSG00000140988	ribosomal protein S2
		UniProt	E9PM36 E9PMM9 E9PPT0 E9PQD7 H0YE27 H0YEN5 H3BNG3 I3L404 P15880
		NCBI	6187
		KEGG metabolic	Ribosome
29	TALDO1	ENSG00000177156	transaldolase 1
		UniProt	E9PKI8 E9PM01 F2Z393 P37837
		NCBI	6888
		KEGG metabolic	Pentose phosphate pathway Biosynthesis of amino acids Carbon metabolism

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	336.36 KB
	H.sapiens_subnetwork.tsv	90.23 KB

Species:

Network information:

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Network appearance:

ENSG00000136872

PGM1

MDH1

MDH2

ESD

ACAT1

SOD1

ATP5PO

TPI1

VDAC2

SUCLA2

AHCY

RACK1

GLUD1

GAPDH

GPI

DBI

PPIA

ATP5F1A

ENO1

ALDH2

ATP6V0D1

NME2

FBP1

PGK1

ATP6V1E1

ENO3

VDAC1

AGXT2

RPS2

TALDO1

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