Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000135587
3. sphingomyelin phosphodi…
- 2. TMEM30A
  3. transmembrane protein 3…
  4. 0.969
  5. PPI
- 2. ANAPC10
  3. anaphase promoting comp…
  4. 0.914
  5. PPI
- 2. CPT2
  3. carnitine palmitoyltran…
  4. 0.865
  5. Metabolic
- 2. ORAI1
  3. ORAI calcium release-ac…
  4. 0.795
  5. Complex
- 2. STIM1
  3. stromal interaction mol…
  4. 0.740
  5. Complex
- 2. FANCD2
  3. FA complementation grou…
  4. 0.652
  5. PPI
- 2. LMAN2
  3. lectin, mannose binding…
  4. 0.587
  5. Metabolic
- 2. PLPP1
  3. phospholipid phosphatas…
  4. 0.549
  5. Metabolic
- 2. SLC16A5
  3. solute carrier family 1…
  4. 0.507
  5. Metabolic
- 2. ATP7A
  3. ATPase copper transport…
  4. 0.474
  5. Metabolic
- 2. PLPP2
  3. phospholipid phosphatas…
  4. 0.461
  5. Metabolic
- 2. TMED6
  3. transmembrane p24 traff…
  4. 0.460
  5. PPI
- 2. PSEN1
  3. presenilin 1
  4. 0.436
  5. Metabolic
- 2. MAPK3
  3. mitogen-activated prote…
  4. 0.430
  5. Metabolic
- 2. ORMDL2
  3. ORMDL sphingolipid bios…
  4. 0.430
  5. Complex
- 2. RANGRF
  3. RAN guanine nucleotide …
  4. 0.412
  5. Metabolic
- 2. PCDHAC2
  3. protocadherin alpha sub…
  4. 0.411
  5. PPI
- 2. PSEN2
  3. presenilin 2
  4. 0.409
  5. Metabolic

Subnetwork gene interactions

ENSG00000135587

sphingomyelin phosphodiesterase 2

FunCoup

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Ensembl

ENSG00000135587

UniProt

NCBI

6610

ATP7A

ATPase copper transporting alpha

FunCoup

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Ensembl

ENSG00000165240

UniProt

NCBI

LMAN2

lectin, mannose binding 2

FunCoup

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Ensembl

ENSG00000169223

UniProt

NCBI

10960

ORMDL2

ORMDL sphingolipid biosynthesis regulator 2

FunCoup

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Ensembl

ENSG00000123353

UniProt

NCBI

29095

PSEN1

presenilin 1

FunCoup

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Ensembl

ENSG00000080815

UniProt

NCBI

5663

MAPK3

mitogen-activated protein kinase 3

FunCoup

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Ensembl

ENSG00000102882

UniProt

NCBI

5595

TMEM30A

transmembrane protein 30A

FunCoup

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Ensembl

ENSG00000112697

UniProt

NCBI

55754

SLC16A5

solute carrier family 16 member 5

FunCoup

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Ensembl

ENSG00000170190

UniProt

NCBI

9121

PLPP2

phospholipid phosphatase 2

FunCoup

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Ensembl

ENSG00000141934

UniProt

NCBI

8612

TMED6

transmembrane p24 trafficking protein 6

FunCoup

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Ensembl

ENSG00000157315

UniProt

Q8WW62

NCBI

146456

ORAI1

ORAI calcium release-activated calcium modulator 1

FunCoup

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Ensembl

ENSG00000276045

UniProt

Q96D31

NCBI

84876

PSEN2

presenilin 2

FunCoup

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Ensembl

ENSG00000143801

UniProt

NCBI

5664

PLPP1

phospholipid phosphatase 1

FunCoup

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Ensembl

ENSG00000067113

UniProt

NCBI

8611

ANAPC10

anaphase promoting complex subunit 10

FunCoup

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Ensembl

ENSG00000164162

UniProt

NCBI

10393

STIM1

stromal interaction molecule 1

FunCoup

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Ensembl

ENSG00000167323

UniProt

NCBI

6786

CPT2

carnitine palmitoyltransferase 2

FunCoup

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Ensembl

ENSG00000157184

UniProt

NCBI

1376

FANCD2

FA complementation group D2

FunCoup

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Ensembl

ENSG00000144554

UniProt

NCBI

2177

PCDHAC2

protocadherin alpha subfamily C, 2

FunCoup

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Ensembl

ENSG00000243232

UniProt

Q9Y5I4

NCBI

56134

RANGRF

RAN guanine nucleotide release factor

FunCoup

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Ensembl

ENSG00000108961

UniProt

Q9HD47

NCBI

29098

Query genes

		Identifier	Description
18	ENSG00000135587	ENSG00000135587	sphingomyelin phosphodiesterase 2
		UniProt	H0Y5N2 O60906
		NCBI	6610
		KEGG signaling	Sphingolipid signaling pathway
		KEGG metabolic	Sphingolipid metabolism

Subnetwork genes

		Identifier	Description
5	ATP7A	ENSG00000165240	ATPase copper transporting alpha
		UniProt	A0A2R8YD60 Q04656
		NCBI	538
6	LMAN2	ENSG00000169223	lectin, mannose binding 2
		UniProt	D6RBH1 D6RBV2 D6RDX1 D6RIU4 Q12907
		NCBI	10960
		KEGG metabolic	Protein processing in endoplasmic reticulum
2	ORMDL2	ENSG00000123353	ORMDL sphingolipid biosynthesis regulator 2
		UniProt	F8VWV8 F8VXD5 Q53FV1
		NCBI	29095
5	PSEN1	ENSG00000080815	presenilin 1
		UniProt	E7ES96 G3V2B1 G3V2G7 G3V3P0 G3V3Z0 G3V449 G3V490 G3V499 G3V4M0 G3V4P4 G3V519 G3V5B1 H0YM52 H0YNU4 P49768
		NCBI	5663
		KEGG signaling	Neurotrophin signaling pathway Wnt signaling pathway Notch signaling pathway
2	MAPK3	ENSG00000102882	mitogen-activated protein kinase 3
		UniProt	B3KR49 E9PBK7 E9PJF0 E9PQW4 E9PRH7 H0YDH9 H0YEX6 P27361
		NCBI	5595
		KEGG signaling	Adrenergic signaling in cardiomyocytes Chemokine signaling pathway Fc gamma R-mediated phagocytosis NOD-like receptor signaling pathway Fc epsilon RI signaling pathway Toll-like receptor signaling pathway FoxO signaling pathway B cell receptor signaling pathway cAMP signaling pathway Gap junction HIF-1 signaling pathway cGMP-PKG signaling pathway T cell receptor signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway TGF-beta signaling pathway PI3K-Akt signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Phospholipase D signaling pathway Sphingolipid signaling pathway Oocyte meiosis Focal adhesion Prolactin signaling pathway Melanogenesis Estrogen signaling pathway Progesterone-mediated oocyte maturation GnRH signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Neurotrophin signaling pathway Long-term potentiation Adherens junction Relaxin signaling pathway Serotonergic synapse Cholinergic synapse Glutamatergic synapse Oxytocin signaling pathway Retrograde endocannabinoid signaling MAPK signaling pathway Apelin signaling pathway VEGF signaling pathway Long-term depression Rap1 signaling pathway Ras signaling pathway Apoptosis Natural killer cell mediated cytotoxicity ErbB signaling pathway IL-17 signaling pathway
		KEGG metabolic	Autophagy - animal
6	TMEM30A	ENSG00000112697	transmembrane protein 30A
		UniProt	E5RG19 Q9NV96
		NCBI	55754
1	SLC16A5	ENSG00000170190	solute carrier family 16 member 5
		UniProt	J3KS19 J3KT93 J3QL40 J3QQW5 O15375
		NCBI	9121
4	PLPP2	ENSG00000141934	phospholipid phosphatase 2
		UniProt	A0A0J9YXA3 K7EMK9 K7ENH4 O43688
		NCBI	8612
		KEGG signaling	Fc gamma R-mediated phagocytosis Phospholipase D signaling pathway
		KEGG metabolic	Fat digestion and absorption Ether lipid metabolism Sphingolipid metabolism Glycerolipid metabolism Glycerophospholipid metabolism
1	TMED6	ENSG00000157315	transmembrane p24 trafficking protein 6
		UniProt	Q8WW62
		NCBI	146456
2	ORAI1	ENSG00000276045	ORAI calcium release-activated calcium modulator 1
		UniProt	Q96D31
		NCBI	84876
		KEGG signaling	cAMP signaling pathway Calcium signaling pathway
4	PSEN2	ENSG00000143801	presenilin 2
		UniProt	B1AP22 E5RFW4 E5RG63 E5RHT1 E5RJM5 P49810
		NCBI	5664
		KEGG signaling	Neurotrophin signaling pathway Notch signaling pathway
2	PLPP1	ENSG00000067113	phospholipid phosphatase 1
		UniProt	D6REC3 O14494
		NCBI	8611
		KEGG signaling	Fc gamma R-mediated phagocytosis Phospholipase D signaling pathway
		KEGG metabolic	Fat digestion and absorption Ether lipid metabolism Sphingolipid metabolism Glycerolipid metabolism Glycerophospholipid metabolism
1	ANAPC10	ENSG00000164162	anaphase promoting complex subunit 10
		UniProt	A0A286YEY6 D6R9Q5 D6RA92 D6RB36 D6RD74 Q9UM13
		NCBI	10393
		KEGG signaling	Oocyte meiosis Cell cycle Progesterone-mediated oocyte maturation
		KEGG metabolic	Ubiquitin mediated proteolysis
2	STIM1	ENSG00000167323	stromal interaction molecule 1
		UniProt	E9PIQ8 E9PJ19 E9PMB4 E9PN27 E9PNJ4 E9PR07 E9PR09 E9PRE4 E9PRZ7 G0XQ39 H0YDB2 Q13586
		NCBI	6786
		KEGG signaling	Calcium signaling pathway
3	CPT2	ENSG00000157184	carnitine palmitoyltransferase 2
		UniProt	A0A1B0GTB8 A0A1B0GTL9 A0A1B0GTM0 A0A1B0GUB8 A0A1B0GUD9 A0A1B0GV75 A0A1B0GVF3 A0A1B0GWC0 P23786
		NCBI	1376
		KEGG signaling	PPAR signaling pathway
		KEGG metabolic	Fatty acid degradation Fatty acid metabolism
3	FANCD2	ENSG00000144554	FA complementation group D2
		UniProt	F8WE37 H7BZJ7 Q9BXW9
		NCBI	2177
		KEGG metabolic	Fanconi anemia pathway
1	PCDHAC2	ENSG00000243232	protocadherin alpha subfamily C, 2
		UniProt	Q9Y5I4
		NCBI	56134
2	RANGRF	ENSG00000108961	RAN guanine nucleotide release factor
		UniProt	Q9HD47
		NCBI	29098

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	145.31 KB
	H.sapiens_subnetwork.tsv	6.54 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000135587

ATP7A

LMAN2

ORMDL2

PSEN1

MAPK3

TMEM30A

SLC16A5

PLPP2

TMED6

ORAI1

PSEN2

PLPP1

ANAPC10

STIM1

CPT2

FANCD2

PCDHAC2

RANGRF

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