Networks of functional couplings/associations

Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

More

2. ENSG00000129355
3. cyclin dependent kinase…
- 2. CDK4
  3. cyclin dependent kinase…
  4. 0.991
  5. PPI
- 2. CCND1
  3. cyclin D1
  4. 0.990
  5. PPI
- 2. LSM3
  3. LSM3 homolog, U6 small …
  4. 0.941
  5. PPI
- 2. TSG101
  3. tumor susceptibility 101
  4. 0.876
  5. PPI
- 2. CTBP1
  3. C-terminal binding prot…
  4. 0.785
  5. PPI
- 2. CCND2
  3. cyclin D2
  4. 0.729
  5. PPI
- 2. BRCA1
  3. BRCA1 DNA repair associ…
  4. 0.701
  5. PPI
- 2. CDK1
  3. cyclin dependent kinase…
  4. 0.662
  5. Metabolic
- 2. SH3GLB2
  3. SH3 domain containing G…
  4. 0.412
  5. PPI

Subnetwork gene interactions

ENSG00000129355

cyclin dependent kinase inhibitor 2D

FunCoup

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Ensembl

ENSG00000129355

UniProt

P55273

NCBI

1032

TSG101

tumor susceptibility 101

FunCoup

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Ensembl

ENSG00000074319

UniProt

NCBI

7251

CDK4

cyclin dependent kinase 4

FunCoup

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Ensembl

ENSG00000135446

UniProt

NCBI

1019

CTBP1

C-terminal binding protein 1

FunCoup

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Ensembl

ENSG00000159692

UniProt

NCBI

1487

CCND2

cyclin D2

FunCoup

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Ensembl

ENSG00000118971

UniProt

NCBI

894

CDK1

cyclin dependent kinase 1

FunCoup

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Ensembl

ENSG00000170312

UniProt

NCBI

983

LSM3

LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated

FunCoup

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Ensembl

ENSG00000170860

UniProt

P62310

NCBI

27258

CCND1

cyclin D1

FunCoup

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Ensembl

ENSG00000110092

UniProt

NCBI

595

BRCA1

BRCA1 DNA repair associated

FunCoup

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Ensembl

ENSG00000012048

UniProt

NCBI

672

SH3GLB2

SH3 domain containing GRB2 like, endophilin B2

FunCoup

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Ensembl

ENSG00000148341

UniProt

NCBI

56904

Query genes

		Identifier	Description
9	ENSG00000129355	ENSG00000129355	cyclin dependent kinase inhibitor 2D
		UniProt	P55273
		NCBI	1032
		KEGG signaling	FoxO signaling pathway Cell cycle

Subnetwork genes

		Identifier	Description
4	TSG101	ENSG00000074319	tumor susceptibility 101
		UniProt	F5H442 J3QKS4 J3QRU6 Q99816
		NCBI	7251
		KEGG metabolic	Endocytosis
7	CDK4	ENSG00000135446	cyclin dependent kinase 4
		UniProt	F8VTV8 F8VWX7 F8VXD2 F8VYH9 F8VYY1 F8VZ13 F8VZ51 F8VZZ0 F8W1L8 P11802 Q96BE9
		NCBI	1019
		KEGG signaling	p53 signaling pathway Tight junction T cell receptor signaling pathway Cell cycle PI3K-Akt signaling pathway
3	CTBP1	ENSG00000159692	C-terminal binding protein 1
		UniProt	A0A0D9SGE6 D6RAX2 E7EPF8 E7ESU7 E7EUB3 E9PGB1 H0Y8U5 H0Y8W7 H0Y913 H0Y9M9 Q13363
		NCBI	1487
		KEGG signaling	Wnt signaling pathway Notch signaling pathway
4	CCND2	ENSG00000118971	cyclin D2
		UniProt	H0YGD4 P30279
		NCBI	894
		KEGG signaling	p53 signaling pathway Focal adhesion JAK-STAT signaling pathway FoxO signaling pathway Wnt signaling pathway Cell cycle Hedgehog signaling pathway Prolactin signaling pathway PI3K-Akt signaling pathway Hippo signaling pathway
7	CDK1	ENSG00000170312	cyclin dependent kinase 1
		UniProt	A0A024QZP7 A0A087WZZ9 E5RIU6 P06493
		NCBI	983
		KEGG signaling	p53 signaling pathway Oocyte meiosis Gap junction Cell cycle Progesterone-mediated oocyte maturation
3	LSM3	ENSG00000170860	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
		UniProt	P62310
		NCBI	27258
		KEGG metabolic	RNA degradation Spliceosome
4	CCND1	ENSG00000110092	cyclin D1
		UniProt	F5H437 P24385
		NCBI	595
		KEGG signaling	Thyroid hormone signaling pathway Hedgehog signaling pathway AMPK signaling pathway Apelin signaling pathway PI3K-Akt signaling pathway Hippo signaling pathway p53 signaling pathway Focal adhesion JAK-STAT signaling pathway Tight junction FoxO signaling pathway Wnt signaling pathway Cell cycle Prolactin signaling pathway Oxytocin signaling pathway
3	BRCA1	ENSG00000012048	BRCA1 DNA repair associated
		UniProt	A0A0A0MSN1 A0A0U1RRA9 A0A2R8Y587 A0A2R8Y6Y9 A0A2R8Y7V5 A0A494C182 B7ZA85 C6YB45 C9IZW4 E7ENB7 E7EQW4 E7EUM2 E7EWN5 E9PC22 E9PH68 G1UI37 H0Y850 H0Y881 H0Y8B8 H0Y8D8 K7EJW3 K7EPC7 P38398 Q3B891 Q5YLB2
		NCBI	672
		KEGG signaling	PI3K-Akt signaling pathway
		KEGG metabolic	Fanconi anemia pathway Ubiquitin mediated proteolysis Homologous recombination
2	SH3GLB2	ENSG00000148341	SH3 domain containing GRB2 like, endophilin B2
		UniProt	B7ZC38 B7ZC39 F8WFB9 G5E9J1 H7C1Z6 Q9NR46
		NCBI	56904
		KEGG metabolic	Endocytosis

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

To use PathwAX, first use the button below to copy the subnetwork genes and then paste them in PathwAX

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	jSquid_subnetworks.xml	112.59 KB
	H.sapiens_subnetwork.tsv	3.89 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000129355

TSG101

CDK4

CTBP1

CCND2

CDK1

LSM3

CCND1

BRCA1

SH3GLB2

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