Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000128829
3. eukaryotic translation …
- 2. EIF2A
  3. eukaryotic translation …
  4. 0.999
  5. Metabolic
- 2. GCN1
  3. GCN1 activator of EIF2A…
  4. 0.998
  5. Complex
- 2. HSPA8
  3. heat shock protein fami…
  4. 0.998
  5. Complex
- 2. PPP1CC
  3. protein phosphatase 1 c…
  4. 0.998
  5. PPI
- 2. HSP90AB1
  3. heat shock protein 90 a…
  4. 0.997
  5. PPI
- 2. BECN1
  3. beclin 1
  4. 0.997
  5. Complex
- 2. MRPL58
  3. mitochondrial ribosomal…
  4. 0.997
  5. Complex
- 2. PPP1CA
  3. protein phosphatase 1 c…
  4. 0.995
  5. PPI
- 2. CSNK1D
  3. casein kinase 1 delta
  4. 0.995
  5. PPI
- 2. CENPE
  3. centromere protein E
  4. 0.995
  5. Complex
- 2. RPTOR
  3. regulatory associated p…
  4. 0.994
  5. PPI
- 2. WDR36
  3. WD repeat domain 36
  4. 0.994
  5. PPI
- 2. SEPTIN8
  3. septin 8
  4. 0.994
  5. Complex
- 2. ZC3H14
  3. zinc finger CCCH-type c…
  4. 0.993
  5. Complex
- 2. SF3A3
  3. splicing factor 3a subu…
  4. 0.992
  5. Complex
- 2. PRPF8
  3. pre-mRNA processing fac…
  4. 0.992
  5. Metabolic
- 2. STK24
  3. serine/threonine kinase…
  4. 0.991
  5. Complex
- 2. ERCC5
  3. ERCC excision repair 5,…
  4. 0.990
  5. Complex
- 2. PPP2R5D
  3. protein phosphatase 2 r…
  4. 0.989
  5. Complex
- 2. MARK1
  3. microtubule affinity re…
  4. 0.984
  5. Complex
- 2. TNRC6A
  3. trinucleotide repeat co…
  4. 0.984
  5. PPI
- 2. PSMD2
  3. proteasome 26S subunit,…
  4. 0.984
  5. PPI
- 2. RPS4X
  3. ribosomal protein S4 X-…
  4. 0.982
  5. Complex
- 2. PRPF31
  3. pre-mRNA processing fac…
  4. 0.980
  5. Metabolic
- 2. NOL6
  3. nucleolar protein 6
  4. 0.978
  5. Metabolic
- 2. SEPTIN10
  3. septin 10
  4. 0.977
  5. Complex
- 2. RPS21
  3. ribosomal protein S21
  4. 0.977
  5. Metabolic
- 2. SART1
  3. spliceosome associated …
  4. 0.977
  5. Complex
- 2. IPO7
  3. importin 7
  4. 0.975
  5. Complex
- 2. SEPTIN2
  3. septin 2
  4. 0.974
  5. Complex

Subnetwork gene interactions

ENSG00000128829

eukaryotic translation initiation factor 2 alpha kinase 4

FunCoup

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Ensembl

ENSG00000128829

UniProt

NCBI

440275

IPO7

importin 7

FunCoup

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Ensembl

ENSG00000205339

UniProt

NCBI

10527

RPS21

ribosomal protein S21

FunCoup

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Ensembl

ENSG00000171858

UniProt

NCBI

6227

WDR36

WD repeat domain 36

FunCoup

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Ensembl

ENSG00000134987

UniProt

NCBI

134430

EIF2A

eukaryotic translation initiation factor 2A

FunCoup

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Ensembl

ENSG00000144895

UniProt

NCBI

83939

PSMD2

proteasome 26S subunit, non-ATPase 2

FunCoup

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Ensembl

ENSG00000175166

UniProt

NCBI

5708

PPP1CA

protein phosphatase 1 catalytic subunit alpha

FunCoup

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Ensembl

ENSG00000172531

UniProt

NCBI

5499

GCN1

GCN1 activator of EIF2AK4

FunCoup

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Ensembl

ENSG00000089154

UniProt

Q92616

NCBI

10985

SEPTIN8

septin 8

FunCoup

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Ensembl

ENSG00000164402

UniProt

NCBI

23176

RPTOR

regulatory associated protein of MTOR complex 1

FunCoup

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Ensembl

ENSG00000141564

UniProt

NCBI

57521

PPP1CC

protein phosphatase 1 catalytic subunit gamma

FunCoup

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Ensembl

ENSG00000186298

UniProt

NCBI

5501

BECN1

beclin 1

FunCoup

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Ensembl

ENSG00000126581

UniProt

NCBI

8678

MRPL58

mitochondrial ribosomal protein L58

FunCoup

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Ensembl

ENSG00000167862

UniProt

NCBI

3396

RPS4X

ribosomal protein S4 X-linked

FunCoup

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Ensembl

ENSG00000198034

UniProt

P62701

NCBI

6191

SF3A3

splicing factor 3a subunit 3

FunCoup

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Ensembl

ENSG00000183431

UniProt

Q12874

NCBI

10946

ZC3H14

zinc finger CCCH-type containing 14

FunCoup

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Ensembl

ENSG00000100722

UniProt

NCBI

79882

CSNK1D

casein kinase 1 delta

FunCoup

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Ensembl

ENSG00000141551

UniProt

NCBI

1453

PPP2R5D

protein phosphatase 2 regulatory subunit B'delta

FunCoup

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Ensembl

ENSG00000112640

UniProt

NCBI

5528

CENPE

centromere protein E

FunCoup

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Ensembl

ENSG00000138778

UniProt

NCBI

1062

PRPF8

pre-mRNA processing factor 8

FunCoup

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Ensembl

ENSG00000174231

UniProt

NCBI

10594

STK24

serine/threonine kinase 24

FunCoup

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Ensembl

ENSG00000102572

UniProt

NCBI

8428

HSPA8

heat shock protein family A (Hsp70) member 8

FunCoup

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Ensembl

ENSG00000109971

UniProt

NCBI

3312

ERCC5

ERCC excision repair 5, endonuclease

FunCoup

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Ensembl

ENSG00000134899

UniProt

NCBI

2073

SEPTIN10

septin 10

FunCoup

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Ensembl

ENSG00000186522

UniProt

NCBI

151011

PRPF31

pre-mRNA processing factor 31

FunCoup

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Ensembl

ENSG00000105618

UniProt

NCBI

26121

HSP90AB1

heat shock protein 90 alpha family class B member 1

FunCoup

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Ensembl

ENSG00000096384

UniProt

P08238

NCBI

3326

MARK1

microtubule affinity regulating kinase 1

FunCoup

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Ensembl

ENSG00000116141

UniProt

NCBI

4139

SART1

spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP

FunCoup

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Ensembl

ENSG00000175467

UniProt

NCBI

9092

NOL6

nucleolar protein 6

FunCoup

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Ensembl

ENSG00000165271

UniProt

NCBI

65083

SEPTIN2

septin 2

FunCoup

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Ensembl

ENSG00000168385

UniProt

NCBI

4735

TNRC6A

trinucleotide repeat containing adaptor 6A

FunCoup

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Ensembl

ENSG00000090905

UniProt

NCBI

27327

Query genes

		Identifier	Description
30	ENSG00000128829	ENSG00000128829	eukaryotic translation initiation factor 2 alpha kinase 4
		UniProt	H0YME5 H0YND8 H0YNY9 Q9P2K8
		NCBI	440275
		KEGG metabolic	Protein processing in endoplasmic reticulum Autophagy - animal

Subnetwork genes

		Identifier	Description
19	IPO7	ENSG00000205339	importin 7
		UniProt	E9PLB2 E9PLJ0 O95373
		NCBI	10527
17	RPS21	ENSG00000171858	ribosomal protein S21
		UniProt	P63220 Q8WVC2 Q9BYK1 Q9BYK2
		NCBI	6227
		KEGG metabolic	Ribosome
21	WDR36	ENSG00000134987	WD repeat domain 36
		UniProt	A0A0A0MTB8 Q8NI36
		NCBI	134430
		KEGG metabolic	Ribosome biogenesis in eukaryotes
16	EIF2A	ENSG00000144895	eukaryotic translation initiation factor 2A
		UniProt	C9IZE1 F8WAE5 F8WAT3 F8WF18 H7C5Q3 H7C5Q4 H7C5R5 Q9BY44
		NCBI	83939
25	PSMD2	ENSG00000175166	proteasome 26S subunit, non-ATPase 2
		UniProt	C9JPC0 F8WBS8 H7C1H2 H7C2Q3 Q13200
		NCBI	5708
		KEGG metabolic	Proteasome
23	PPP1CA	ENSG00000172531	protein phosphatase 1 catalytic subunit alpha
		UniProt	E9PMD7 F5H037 F5H1L6 P62136
		NCBI	5499
		KEGG signaling	Long-term potentiation Focal adhesion Oocyte meiosis cAMP signaling pathway cGMP-PKG signaling pathway Adrenergic signaling in cardiomyocytes Dopaminergic synapse Vascular smooth muscle contraction Hippo signaling pathway Insulin signaling pathway Oxytocin signaling pathway
		KEGG metabolic	mRNA surveillance pathway
15	GCN1	ENSG00000089154	GCN1 activator of EIF2AK4
		UniProt	Q92616
		NCBI	10985
8	SEPTIN8	ENSG00000164402	septin 8
		UniProt	A0A087X142 A0A0A0MRP8 A6NFQ9 A6NMH6 C9J4G8 C9JV02 F8W8I8 Q92599
		NCBI	23176
18	RPTOR	ENSG00000141564	regulatory associated protein of MTOR complex 1
		UniProt	I3L2I3 I3L436 Q8N122
		NCBI	57521
		KEGG signaling	AMPK signaling pathway PI3K-Akt signaling pathway mTOR signaling pathway Insulin signaling pathway
		KEGG metabolic	Autophagy - animal
22	PPP1CC	ENSG00000186298	protein phosphatase 1 catalytic subunit gamma
		UniProt	A0A087WYY5 F8VR82 F8VYE8 F8W0V8 F8W0W8 F8W1A0 P36873
		NCBI	5501
		KEGG signaling	Long-term potentiation Focal adhesion Oocyte meiosis cAMP signaling pathway cGMP-PKG signaling pathway Adrenergic signaling in cardiomyocytes Dopaminergic synapse Vascular smooth muscle contraction Hippo signaling pathway Insulin signaling pathway Oxytocin signaling pathway
		KEGG metabolic	mRNA surveillance pathway
11	BECN1	ENSG00000126581	beclin 1
		UniProt	A0A087WVZ2 E7EV84 K7EKK2 K7EL88 K7ELY9 K7EMA2 K7EN35 K7EQQ7 K7ER46 K7ERY0 K7ES83 Q14457
		NCBI	8678
		KEGG signaling	Apelin signaling pathway
		KEGG metabolic	Autophagy - animal
15	MRPL58	ENSG00000167862	mitochondrial ribosomal protein L58
		UniProt	J3KS15 J3QRF8 Q14197
		NCBI	3396
20	RPS4X	ENSG00000198034	ribosomal protein S4 X-linked
		UniProt	P62701
		NCBI	6191
		KEGG metabolic	Ribosome
19	SF3A3	ENSG00000183431	splicing factor 3a subunit 3
		UniProt	Q12874
		NCBI	10946
		KEGG metabolic	Spliceosome
17	ZC3H14	ENSG00000100722	zinc finger CCCH-type containing 14
		UniProt	A0A087WTC9 A0A3B3IT62 G3V240 G3V256 G3V2X4 G3V3R9 G3V3Y4 G3V411 G3V473 G3V4R5 G3V572 G3V5I6 H0YJ51 H0YJ87 H0YJA2 Q6PJT7
		NCBI	79882
18	CSNK1D	ENSG00000141551	casein kinase 1 delta
		UniProt	B4DLF1 H0Y2N6 H7BYT1 J3KRM8 J3KRS6 J3QQI9 J3QQU8 J3QS70 P48730
		NCBI	1453
		KEGG signaling	Gap junction Hedgehog signaling pathway Hippo signaling pathway
16	PPP2R5D	ENSG00000112640	protein phosphatase 2 regulatory subunit B'delta
		UniProt	E9PFR3 H0Y8C4 H7C5Q9 H7C5Z1 Q14738
		NCBI	5528
		KEGG signaling	Oocyte meiosis AMPK signaling pathway Dopaminergic synapse PI3K-Akt signaling pathway Adrenergic signaling in cardiomyocytes Sphingolipid signaling pathway
		KEGG metabolic	mRNA surveillance pathway
7	CENPE	ENSG00000138778	centromere protein E
		UniProt	A0A087X0P0 A0A5F9ZH24 D6RHK2 Q02224
		NCBI	1062
23	PRPF8	ENSG00000174231	pre-mRNA processing factor 8
		UniProt	I3L0J9 I3L1T8 I3L3Z8 Q6P2Q9
		NCBI	10594
		KEGG metabolic	Spliceosome
12	STK24	ENSG00000102572	serine/threonine kinase 24
		UniProt	B4DR80 H0Y630 Q5JV98 Q5JV99 Q9Y6E0
		NCBI	8428
25	HSPA8	ENSG00000109971	heat shock protein family A (Hsp70) member 8
		UniProt	A8K7Q2 E9PI65 E9PK54 E9PKE3 E9PLF4 E9PM13 E9PN25 E9PN89 E9PNE6 E9PPY6 E9PQK7 E9PQQ4 E9PS65 P11142
		NCBI	3312
		KEGG signaling	Antigen processing and presentation MAPK signaling pathway Estrogen signaling pathway
		KEGG metabolic	Spliceosome Endocytosis Protein processing in endoplasmic reticulum
11	ERCC5	ENSG00000134899	ERCC excision repair 5, endonuclease
		UniProt	A0A090HNM7 A0A494C0S2 A0A494C113 F2Z2A1 P28715 R4GMW8
		NCBI	2073
		KEGG metabolic	Nucleotide excision repair
6	SEPTIN10	ENSG00000186522	septin 10
		UniProt	B5ME97 C9JEQ7 C9JEW2 C9JNR7 E7EW69 E7EX04 F5GYV2 F5H1F2 F5H1W3 F8WC85 Q9P0V9
		NCBI	151011
12	PRPF31	ENSG00000105618	pre-mRNA processing factor 31
		UniProt	E7EN72 E7ESX0 E7EU94 E7EVX8 Q8WWY3
		NCBI	26121
		KEGG metabolic	Spliceosome
21	HSP90AB1	ENSG00000096384	heat shock protein 90 alpha family class B member 1
		UniProt	P08238
		NCBI	3326
		KEGG signaling	Antigen processing and presentation NOD-like receptor signaling pathway PI3K-Akt signaling pathway Estrogen signaling pathway Progesterone-mediated oocyte maturation IL-17 signaling pathway
		KEGG metabolic	Protein processing in endoplasmic reticulum
8	MARK1	ENSG00000116141	microtubule affinity regulating kinase 1
		UniProt	A0A087X0I6 B4DIB3 Q9P0L2
		NCBI	4139
18	SART1	ENSG00000175467	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
		UniProt	E9PQI8 O43290
		NCBI	9092
		KEGG metabolic	Spliceosome
20	NOL6	ENSG00000165271	nucleolar protein 6
		UniProt	A0A0A0MRW6 A0A0C4DFX0 Q9H6R4
		NCBI	65083
		KEGG metabolic	Ribosome biogenesis in eukaryotes
11	SEPTIN2	ENSG00000168385	septin 2
		UniProt	A0A1B0GXJ2 B5MCX3 B5MD47 C9IY94 C9IZU3 C9J2Q4 C9J938 C9JB25 C9JFT1 C9JG93 C9JQJ4 C9JSE7 C9JT15 C9JZI2 F8WB65 F8WCX3 H7C1T1 H7C2Y0 H7C310 Q15019
		NCBI	4735
2	TNRC6A	ENSG00000090905	trinucleotide repeat containing adaptor 6A
		UniProt	H3BRT3 H3BTQ1 H7C269 I3L218 I3L3S5 Q8NDV7
		NCBI	27327

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	305.87 KB
	H.sapiens_subnetwork.tsv	48.93 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000128829

IPO7

RPS21

WDR36

EIF2A

PSMD2

PPP1CA

GCN1

SEPTIN8

RPTOR

PPP1CC

BECN1

MRPL58

RPS4X

SF3A3

ZC3H14

CSNK1D

PPP2R5D

CENPE

PRPF8

STK24

HSPA8

ERCC5

SEPTIN10

PRPF31

HSP90AB1

MARK1

SART1

NOL6

SEPTIN2

TNRC6A

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