Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000126821
3. sphingosine-1-phosphate…
- 2. GOLT1B
  3. golgi transport 1B
  4. 0.973
  5. PPI
- 2. TM2D2
  3. TM2 domain containing 2
  4. 0.933
  5. PPI
- 2. LPCAT4
  3. lysophosphatidylcholine…
  4. 0.880
  5. Metabolic
- 2. LPCAT1
  3. lysophosphatidylcholine…
  4. 0.871
  5. Metabolic
- 2. SLC39A8
  3. solute carrier family 3…
  4. 0.870
  5. PPI
- 2. KDSR
  3. 3-ketodihydrosphingosin…
  4. 0.805
  5. Metabolic
- 2. UBC
  3. ubiquitin C
  4. 0.780
  5. PPI
- 2. SELENOT
  3. selenoprotein T
  4. 0.753
  5. Metabolic
- 2. LPCAT2
  3. lysophosphatidylcholine…
  4. 0.750
  5. Metabolic
- 2. ATP10D
  3. ATPase phospholipid tra…
  4. 0.726
  5. Metabolic
- 2. ALG8
  3. ALG8 alpha-1,3-glucosyl…
  4. 0.723
  5. Metabolic
- 2. RNF170
  3. ring finger protein 170
  4. 0.711
  5. Metabolic
- 2. RPS21
  3. ribosomal protein S21
  4. 0.708
  5. Complex
- 2. RNFT1
  3. ring finger protein, tr…
  4. 0.706
  5. Metabolic
- 2. YIPF3
  3. Yip1 domain family memb…
  4. 0.697
  5. PPI
- 2. TMEM258
  3. transmembrane protein 2…
  4. 0.695
  5. Metabolic
- 2. STT3B
  3. STT3 oligosaccharyltran…
  4. 0.681
  5. Metabolic
- 2. TMX1
  3. thioredoxin related tra…
  4. 0.668
  5. Complex
- 2. NUP85
  3. nucleoporin 85
  4. 0.666
  5. Metabolic
- 2. ORMDL1
  3. ORMDL sphingolipid bios…
  4. 0.664
  5. Metabolic
- 2. MAGT1
  3. magnesium transporter 1
  4. 0.652
  5. Metabolic
- 2. TUBG1
  3. tubulin gamma 1
  4. 0.619
  5. PPI
- 2. MCCC2
  3. methylcrotonoyl-CoA car…
  4. 0.603
  5. Metabolic
- 2. DDX21
  3. DExD-box helicase 21
  4. 0.599
  5. Metabolic
- 2. EDEM1
  3. ER degradation enhancin…
  4. 0.598
  5. Metabolic
- 2. MOGS
  3. mannosyl-oligosaccharid…
  4. 0.566
  5. Metabolic
- 2. UBAC2
  3. UBA domain containing 2
  4. 0.566
  5. Metabolic
- 2. ZDHHC7
  3. zinc finger DHHC-type p…
  4. 0.555
  5. Complex
- 2. ERLIN1
  3. ER lipid raft associate…
  4. 0.554
  5. Complex
- 2. NOMO1
  3. NODAL modulator 1
  4. 0.550
  5. Metabolic

Subnetwork gene interactions

ENSG00000126821

sphingosine-1-phosphate phosphatase 1

FunCoup

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Ensembl

ENSG00000126821

UniProt

Q9BX95

NCBI

81537

TMEM258

transmembrane protein 258

FunCoup

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Ensembl

ENSG00000134825

UniProt

NCBI

TMX1

thioredoxin related transmembrane protein 1

FunCoup

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Ensembl

ENSG00000139921

UniProt

NCBI

81542

TUBG1

tubulin gamma 1

FunCoup

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Ensembl

ENSG00000131462

UniProt

NCBI

7283

RPS21

ribosomal protein S21

FunCoup

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Ensembl

ENSG00000171858

UniProt

NCBI

6227

ATP10D

ATPase phospholipid transporting 10D (putative)

FunCoup

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Ensembl

ENSG00000145246

UniProt

NCBI

57205

STT3B

STT3 oligosaccharyltransferase complex catalytic subunit B

FunCoup

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Ensembl

ENSG00000163527

UniProt

Q8TCJ2

NCBI

201595

UBAC2

UBA domain containing 2

FunCoup

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Ensembl

ENSG00000134882

UniProt

NCBI

337867

UBC

ubiquitin C

FunCoup

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Ensembl

ENSG00000150991

UniProt

NCBI

7316

ORMDL1

ORMDL sphingolipid biosynthesis regulator 1

FunCoup

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Ensembl

ENSG00000128699

UniProt

NCBI

94101

RNFT1

ring finger protein, transmembrane 1

FunCoup

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Ensembl

ENSG00000189050

UniProt

NCBI

51136

SELENOT

selenoprotein T

FunCoup

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Ensembl

ENSG00000198843

UniProt

NCBI

51714

NUP85

nucleoporin 85

FunCoup

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Ensembl

ENSG00000125450

UniProt

NCBI

79902

LPCAT1

lysophosphatidylcholine acyltransferase 1

FunCoup

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Ensembl

ENSG00000153395

UniProt

Q8NF37

NCBI

79888

DDX21

DExD-box helicase 21

FunCoup

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Ensembl

ENSG00000165732

UniProt

Q9NR30

NCBI

9188

NOMO1

NODAL modulator 1

FunCoup

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Ensembl

ENSG00000103512

UniProt

NCBI

23420

ERLIN1

ER lipid raft associated 1

FunCoup

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Ensembl

ENSG00000107566

UniProt

NCBI

10613

GOLT1B

golgi transport 1B

FunCoup

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Ensembl

ENSG00000111711

UniProt

NCBI

51026

ZDHHC7

zinc finger DHHC-type palmitoyltransferase 7

FunCoup

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Ensembl

ENSG00000153786

UniProt

NCBI

55625

MOGS

mannosyl-oligosaccharide glucosidase

FunCoup

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Ensembl

ENSG00000115275

UniProt

NCBI

7841

ALG8

ALG8 alpha-1,3-glucosyltransferase

FunCoup

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Ensembl

ENSG00000159063

UniProt

NCBI

79053

TM2D2

TM2 domain containing 2

FunCoup

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Ensembl

ENSG00000169490

UniProt

NCBI

83877

LPCAT2

lysophosphatidylcholine acyltransferase 2

FunCoup

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Ensembl

ENSG00000087253

UniProt

NCBI

54947

MAGT1

magnesium transporter 1

FunCoup

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Ensembl

ENSG00000102158

UniProt

NCBI

84061

KDSR

3-ketodihydrosphingosine reductase

FunCoup

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Ensembl

ENSG00000119537

UniProt

NCBI

2531

MCCC2

methylcrotonoyl-CoA carboxylase 2

FunCoup

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Ensembl

ENSG00000131844

UniProt

NCBI

64087

RNF170

ring finger protein 170

FunCoup

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Ensembl

ENSG00000120925

UniProt

NCBI

81790

SLC39A8

solute carrier family 39 member 8

FunCoup

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Ensembl

ENSG00000138821

UniProt

Q9C0K1

NCBI

64116

YIPF3

Yip1 domain family member 3

FunCoup

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Ensembl

ENSG00000137207

UniProt

NCBI

25844

EDEM1

ER degradation enhancing alpha-mannosidase like protein 1

FunCoup

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Ensembl

ENSG00000134109

UniProt

NCBI

9695

LPCAT4

lysophosphatidylcholine acyltransferase 4

FunCoup

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Ensembl

ENSG00000176454

UniProt

NCBI

254531

Query genes

		Identifier	Description
30	ENSG00000126821	ENSG00000126821	sphingosine-1-phosphate phosphatase 1
		UniProt	Q9BX95
		NCBI	81537
		KEGG signaling	Sphingolipid signaling pathway
		KEGG metabolic	Sphingolipid metabolism

Subnetwork genes

		Identifier	Description
11	TMEM258	ENSG00000134825	transmembrane protein 258
		UniProt	F5GWH5 F5H7Z5 P61165
		NCBI	746
11	TMX1	ENSG00000139921	thioredoxin related transmembrane protein 1
		UniProt	G3V448 Q9H3N1
		NCBI	81542
4	TUBG1	ENSG00000131462	tubulin gamma 1
		UniProt	K7EIS0 K7EKE5 P23258
		NCBI	7283
9	RPS21	ENSG00000171858	ribosomal protein S21
		UniProt	P63220 Q8WVC2 Q9BYK1 Q9BYK2
		NCBI	6227
		KEGG metabolic	Ribosome
5	ATP10D	ENSG00000145246	ATPase phospholipid transporting 10D (putative)
		UniProt	H0Y8M7 Q6PEW3 Q9P241
		NCBI	57205
19	STT3B	ENSG00000163527	STT3 oligosaccharyltransferase complex catalytic subunit B
		UniProt	Q8TCJ2
		NCBI	201595
		KEGG metabolic	N-Glycan biosynthesis Various types of N-glycan biosynthesis Protein processing in endoplasmic reticulum
6	UBAC2	ENSG00000134882	UBA domain containing 2
		UniProt	A0A087WXT1 Q5JUH4 Q8NBM4 X6R5E5
		NCBI	337867
6	UBC	ENSG00000150991	ubiquitin C
		UniProt	F5GXK7 F5GYU3 F5GZ39 F5H265 F5H2Z3 F5H388 F5H6Q2 F5H747 P0CG48 Q5PY61 Q96C32
		NCBI	7316
		KEGG signaling	PPAR signaling pathway
		KEGG metabolic	Ubiquitin mediated proteolysis
6	ORMDL1	ENSG00000128699	ORMDL sphingolipid biosynthesis regulator 1
		UniProt	A0A1B0GXE7 F6WST4 Q9P0S3
		NCBI	94101
10	RNFT1	ENSG00000189050	ring finger protein, transmembrane 1
		UniProt	E9PI44 H0YEZ8 K7EJ18 Q5M7Z0
		NCBI	51136
3	SELENOT	ENSG00000198843	selenoprotein T
		UniProt	A0A087WVA1 F8WBD0 P62341 Q6IAK0
		NCBI	51714
7	NUP85	ENSG00000125450	nucleoporin 85
		UniProt	F5H0W7 J3KRC0 J3KS87 J3KSH3 J3KT10 J3KTC7 J3QL49 J3QL54 J3QL91 J3QLD4 J3QLH0 J3QLV0 J3QRY3 J3QS63 Q9BW27
		NCBI	79902
		KEGG metabolic	RNA transport
5	LPCAT1	ENSG00000153395	lysophosphatidylcholine acyltransferase 1
		UniProt	Q8NF37
		NCBI	79888
		KEGG metabolic	Ether lipid metabolism Glycerophospholipid metabolism
3	DDX21	ENSG00000165732	DExD-box helicase 21
		UniProt	Q9NR30
		NCBI	9188
8	NOMO1	ENSG00000103512	NODAL modulator 1
		UniProt	A0A087WW46 A0A087X117 H3BUC9 Q15155
		NCBI	23420
11	ERLIN1	ENSG00000107566	ER lipid raft associated 1
		UniProt	B0QZ43 O75477
		NCBI	10613
9	GOLT1B	ENSG00000111711	golgi transport 1B
		UniProt	F5GWD8 F5GXH6 F5H6U7 G3V1U5 Q9Y3E0
		NCBI	51026
4	ZDHHC7	ENSG00000153786	zinc finger DHHC-type palmitoyltransferase 7
		UniProt	H3BMI0 H3BNQ9 Q9NXF8
		NCBI	55625
10	MOGS	ENSG00000115275	mannosyl-oligosaccharide glucosidase
		UniProt	A0A3B3IRI1 A0A3B3IRI7 A0A3B3IRK6 A0A3B3IRW2 A0A3B3IS52 A0A3B3ITC1 A0A3B3ITU6 A0A3B3IU81 B4E3B8 B8ZZE2 C9JDQ1 Q13724
		NCBI	7841
		KEGG metabolic	N-Glycan biosynthesis Protein processing in endoplasmic reticulum
14	ALG8	ENSG00000159063	ALG8 alpha-1,3-glucosyltransferase
		UniProt	E9PK79 E9PKA5 E9PLP7 E9PNE2 E9PP04 E9PP80 E9PP96 E9PR58 H0YCV0 H0YD42 H0YDD3 H0YDQ1 H0YDV4 H0YEE0 Q9BVK2
		NCBI	79053
		KEGG metabolic	N-Glycan biosynthesis
2	TM2D2	ENSG00000169490	TM2 domain containing 2
		UniProt	E5RIQ5 E5RIT0 E5RJK9 Q9BX73
		NCBI	83877
2	LPCAT2	ENSG00000087253	lysophosphatidylcholine acyltransferase 2
		UniProt	H3BU68 Q7L5N7
		NCBI	54947
		KEGG metabolic	Ether lipid metabolism Glycerophospholipid metabolism
12	MAGT1	ENSG00000102158	magnesium transporter 1
		UniProt	A0A087WU53 Q9H0U3
		NCBI	84061
4	KDSR	ENSG00000119537	3-ketodihydrosphingosine reductase
		UniProt	A0A2R8Y7U3 A0A2R8YF70 K7EQS7 K7ERC8 Q06136
		NCBI	2531
		KEGG metabolic	Sphingolipid metabolism
1	MCCC2	ENSG00000131844	methylcrotonoyl-CoA carboxylase 2
		UniProt	D6R9R1 D6RD67 D6RDF7 Q9HCC0
		NCBI	64087
		KEGG metabolic	Valine, leucine and isoleucine degradation
3	RNF170	ENSG00000120925	ring finger protein 170
		UniProt	E9PNG8 E9PP55 Q96K19
		NCBI	81790
1	SLC39A8	ENSG00000138821	solute carrier family 39 member 8
		UniProt	Q9C0K1
		NCBI	64116
4	YIPF3	ENSG00000137207	Yip1 domain family member 3
		UniProt	D6RA04 D6RAY4 D6RBQ1 D6RFI3 D6RGY8 E7EQR8 H0Y9A1 Q9GZM5
		NCBI	25844
3	EDEM1	ENSG00000134109	ER degradation enhancing alpha-mannosidase like protein 1
		UniProt	F8WE67 F8WER9 Q92611
		NCBI	9695
		KEGG metabolic	Protein processing in endoplasmic reticulum
1	LPCAT4	ENSG00000176454	lysophosphatidylcholine acyltransferase 4
		UniProt	A0A0C4DGT4 H3BMK4 Q643R3
		NCBI	254531
		KEGG metabolic	Ether lipid metabolism Glycerophospholipid metabolism

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	252.45 KB
	H.sapiens_subnetwork.tsv	19.33 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000126821

TMEM258

TMX1

TUBG1

RPS21

ATP10D

STT3B

UBAC2

UBC

ORMDL1

RNFT1

SELENOT

NUP85

LPCAT1

DDX21

NOMO1

ERLIN1

GOLT1B

ZDHHC7

MOGS

ALG8

TM2D2

LPCAT2

MAGT1

KDSR

MCCC2

RNF170

SLC39A8

YIPF3

EDEM1

LPCAT4

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