Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000126581
3. beclin 1
- 2. PIK3R4
  3. phosphoinositide-3-kina…
  4. 1.000
  5. PPI
- 2. PIK3C3
  3. phosphatidylinositol 3-…
  4. 1.000
  5. PPI
- 2. UVRAG
  3. UV radiation resistance…
  4. 1.000
  5. PPI
- 2. NRBF2
  3. nuclear receptor bindin…
  4. 1.000
  5. PPI
- 2. BCL2L1
  3. BCL2 like 1
  4. 1.000
  5. PPI
- 2. ATG14
  3. autophagy related 14
  4. 1.000
  5. PPI
- 2. VPS18
  3. VPS18 core subunit of C…
  4. 1.000
  5. Complex
- 2. RAB5A
  3. RAB5A, member RAS oncog…
  4. 1.000
  5. PPI
- 2. VPS33A
  3. VPS33A core subunit of …
  4. 1.000
  5. Complex
- 2. HMGB1
  3. high mobility group box…
  4. 1.000
  5. PPI
- 2. SH3GLB1
  3. SH3 domain containing G…
  4. 1.000
  5. Complex
- 2. USP14
  3. ubiquitin specific pept…
  4. 1.000
  5. PPI
- 2. MAP3K7
  3. mitogen-activated prote…
  4. 1.000
  5. PPI
- 2. BCL2
  3. BCL2 apoptosis regulator
  4. 0.999
  5. PPI
- 2. EXOC8
  3. exocyst complex compone…
  4. 0.999
  5. PPI
- 2. KDELR2
  3. KDEL endoplasmic reticu…
  4. 0.999
  5. PPI
- 2. RUBCN
  3. rubicon autophagy regul…
  4. 0.999
  5. PPI
- 2. YWHAB
  3. tyrosine 3-monooxygenas…
  4. 0.999
  5. Complex
- 2. PYCARD
  3. PYD and CARD domain con…
  4. 0.999
  5. PPI
- 2. STX18
  3. syntaxin 18
  4. 0.999
  5. Complex
- 2. AMBRA1
  3. autophagy and beclin 1 …
  4. 0.999
  5. PPI
- 2. ZW10
  3. zw10 kinetochore protein
  4. 0.999
  5. Complex
- 2. ULK1
  3. unc-51 like autophagy a…
  4. 0.999
  5. PPI
- 2. CYBB
  3. cytochrome b-245 beta c…
  4. 0.999
  5. PPI
- 2. RINT1
  3. RAD50 interactor 1
  4. 0.999
  5. Complex
- 2. BMI1
  3. BMI1 proto-oncogene, po…
  4. 0.999
  5. PPI
- 2. SNX4
  3. sorting nexin 4
  4. 0.999
  5. PPI
- 2. VMP1
  3. vacuole membrane protei…
  4. 0.999
  5. PPI
- 2. TGFBRAP1
  3. transforming growth fac…
  4. 0.998
  5. Complex
- 2. GOPC
  3. golgi associated PDZ an…
  4. 0.998
  5. PPI

Subnetwork gene interactions

ENSG00000126581

beclin 1

FunCoup

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Ensembl

ENSG00000126581

UniProt

NCBI

8678

ZW10

zw10 kinetochore protein

FunCoup

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Ensembl

ENSG00000086827

UniProt

NCBI

9183

VPS18

VPS18 core subunit of CORVET and HOPS complexes

FunCoup

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Ensembl

ENSG00000104142

UniProt

NCBI

57617

PIK3C3

phosphatidylinositol 3-kinase catalytic subunit type 3

FunCoup

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Ensembl

ENSG00000078142

UniProt

NCBI

5289

YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

FunCoup

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Ensembl

ENSG00000166913

UniProt

NCBI

7529

RINT1

RAD50 interactor 1

FunCoup

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Ensembl

ENSG00000135249

UniProt

NCBI

60561

KDELR2

KDEL endoplasmic reticulum protein retention receptor 2

FunCoup

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Ensembl

ENSG00000136240

UniProt

NCBI

11014

STX18

syntaxin 18

FunCoup

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Ensembl

ENSG00000168818

UniProt

NCBI

53407

BCL2

BCL2 apoptosis regulator

FunCoup

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Ensembl

ENSG00000171791

UniProt

P10415

NCBI

VMP1

vacuole membrane protein 1

FunCoup

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Ensembl

ENSG00000062716

UniProt

NCBI

81671

SH3GLB1

SH3 domain containing GRB2 like, endophilin B1

FunCoup

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Ensembl

ENSG00000097033

UniProt

NCBI

51100

HMGB1

high mobility group box 1

FunCoup

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Ensembl

ENSG00000189403

UniProt

NCBI

3146

UVRAG

UV radiation resistance associated

FunCoup

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Ensembl

ENSG00000198382

UniProt

NCBI

7405

USP14

ubiquitin specific peptidase 14

FunCoup

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Ensembl

ENSG00000101557

UniProt

NCBI

9097

GOPC

golgi associated PDZ and coiled-coil motif containing

FunCoup

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Ensembl

ENSG00000047932

UniProt

NCBI

57120

BMI1

BMI1 proto-oncogene, polycomb ring finger

FunCoup

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Ensembl

ENSG00000168283

UniProt

NCBI

ATG14

autophagy related 14

FunCoup

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Ensembl

ENSG00000126775

UniProt

Q6ZNE5

NCBI

22863

NRBF2

nuclear receptor binding factor 2

FunCoup

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Ensembl

ENSG00000148572

UniProt

Q96F24

NCBI

29982

ULK1

unc-51 like autophagy activating kinase 1

FunCoup

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Ensembl

ENSG00000177169

UniProt

O75385

NCBI

8408

EXOC8

exocyst complex component 8

FunCoup

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Ensembl

ENSG00000116903

UniProt

Q8IYI6

NCBI

149371

CYBB

cytochrome b-245 beta chain

FunCoup

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Ensembl

ENSG00000165168

UniProt

P04839

NCBI

1536

RAB5A

RAB5A, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000144566

UniProt

NCBI

5868

SNX4

sorting nexin 4

FunCoup

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Ensembl

ENSG00000114520

UniProt

NCBI

8723

TGFBRAP1

transforming growth factor beta receptor associated protein 1

FunCoup

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Ensembl

ENSG00000135966

UniProt

Q8WUH2

NCBI

9392

VPS33A

VPS33A core subunit of CORVET and HOPS complexes

FunCoup

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Ensembl

ENSG00000139719

UniProt

NCBI

65082

RUBCN

rubicon autophagy regulator

FunCoup

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Ensembl

ENSG00000145016

UniProt

NCBI

9711

PIK3R4

phosphoinositide-3-kinase regulatory subunit 4

FunCoup

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Ensembl

ENSG00000196455

UniProt

NCBI

30849

AMBRA1

autophagy and beclin 1 regulator 1

FunCoup

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Ensembl

ENSG00000110497

UniProt

NCBI

55626

PYCARD

PYD and CARD domain containing

FunCoup

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Ensembl

ENSG00000103490

UniProt

NCBI

29108

BCL2L1

BCL2 like 1

FunCoup

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Ensembl

ENSG00000171552

UniProt

NCBI

MAP3K7

mitogen-activated protein kinase kinase kinase 7

FunCoup

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Ensembl

ENSG00000135341

UniProt

NCBI

6885

Query genes

		Identifier	Description
30	ENSG00000126581	ENSG00000126581	beclin 1
		UniProt	A0A087WVZ2 E7EV84 K7EKK2 K7EL88 K7ELY9 K7EMA2 K7EN35 K7EQQ7 K7ER46 K7ERY0 K7ES83 Q14457
		NCBI	8678
		KEGG signaling	Apelin signaling pathway
		KEGG metabolic	Autophagy - animal

Subnetwork genes

		Identifier	Description
9	ZW10	ENSG00000086827	zw10 kinetochore protein
		UniProt	F5H3C1 O43264
		NCBI	9183
16	VPS18	ENSG00000104142	VPS18 core subunit of CORVET and HOPS complexes
		UniProt	H0YLM6 H0YMC9 Q9P253
		NCBI	57617
21	PIK3C3	ENSG00000078142	phosphatidylinositol 3-kinase catalytic subunit type 3
		UniProt	A0A0B4J2B1 A0A1W2PS05 A8MYT4 K7EIV6 K7EKH3 K7ENH3 M0R308 M0R386 Q8NEB9
		NCBI	5289
		KEGG signaling	Apelin signaling pathway Phosphatidylinositol signaling system
		KEGG metabolic	Phagosome Autophagy - animal Inositol phosphate metabolism
9	YWHAB	ENSG00000166913	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
		UniProt	A0A0J9YWE8 A0A0J9YWZ2 P31946 Q4VY19 Q4VY20
		NCBI	7529
		KEGG signaling	Oocyte meiosis Cell cycle PI3K-Akt signaling pathway Hippo signaling pathway
7	RINT1	ENSG00000135249	RAD50 interactor 1
		UniProt	C9J5S3 F8WAZ2 F8WC46 F8WDC5 Q6NUQ1
		NCBI	60561
9	KDELR2	ENSG00000136240	KDEL endoplasmic reticulum protein retention receptor 2
		UniProt	H7BYF7 P33947
		NCBI	11014
10	STX18	ENSG00000168818	syntaxin 18
		UniProt	D6RC71 D6RF48 Q9P2W9
		NCBI	53407
		KEGG signaling	SNARE interactions in vesicular transport
		KEGG metabolic	Phagosome SNARE interactions in vesicular transport
6	BCL2	ENSG00000171791	BCL2 apoptosis regulator
		UniProt	P10415
		NCBI	596
		KEGG signaling	Hedgehog signaling pathway NF-kappa B signaling pathway Adrenergic signaling in cardiomyocytes PI3K-Akt signaling pathway Sphingolipid signaling pathway Neurotrophin signaling pathway NOD-like receptor signaling pathway p53 signaling pathway Focal adhesion JAK-STAT signaling pathway Apoptosis HIF-1 signaling pathway Estrogen signaling pathway Cholinergic synapse
		KEGG metabolic	Protein processing in endoplasmic reticulum Autophagy - animal
7	VMP1	ENSG00000062716	vacuole membrane protein 1
		UniProt	K7EK01 K7EL46 K7EL74 K7EL93 K7ELS2 K7EM96 K7EMI0 K7EMN6 K7ENU2 K7EPE7 Q96GC9
		NCBI	81671
		KEGG metabolic	Autophagy - animal
9	SH3GLB1	ENSG00000097033	SH3 domain containing GRB2 like, endophilin B1
		UniProt	A0A087WW40 Q9Y371
		NCBI	51100
		KEGG metabolic	Endocytosis Autophagy - animal
9	HMGB1	ENSG00000189403	high mobility group box 1
		UniProt	P09429 Q5T7C4
		NCBI	3146
		KEGG metabolic	Autophagy - animal Base excision repair
19	UVRAG	ENSG00000198382	UV radiation resistance associated
		UniProt	E9PK00 E9PR71 H0YDD1 Q9P2Y5
		NCBI	7405
		KEGG metabolic	Autophagy - animal
12	USP14	ENSG00000101557	ubiquitin specific peptidase 14
		UniProt	A6NJA2 J3KS55 J3QQT6 P54578 R4GNB0
		NCBI	9097
5	GOPC	ENSG00000047932	golgi associated PDZ and coiled-coil motif containing
		UniProt	F5H1Y4 Q9HD26
		NCBI	57120
4	BMI1	ENSG00000168283	BMI1 proto-oncogene, polycomb ring finger
		UniProt	P35226 Q5T8Z2 Q5T8Z4 Q5T8Z6
		NCBI	100532731 648
9	ATG14	ENSG00000126775	autophagy related 14
		UniProt	Q6ZNE5
		NCBI	22863
		KEGG metabolic	Autophagy - animal
9	NRBF2	ENSG00000148572	nuclear receptor binding factor 2
		UniProt	Q96F24
		NCBI	29982
		KEGG metabolic	Autophagy - animal
9	ULK1	ENSG00000177169	unc-51 like autophagy activating kinase 1
		UniProt	O75385
		NCBI	8408
		KEGG signaling	AMPK signaling pathway mTOR signaling pathway
		KEGG metabolic	Autophagy - animal
11	EXOC8	ENSG00000116903	exocyst complex component 8
		UniProt	Q8IYI6
		NCBI	149371
7	CYBB	ENSG00000165168	cytochrome b-245 beta chain
		UniProt	P04839
		NCBI	1536
		KEGG signaling	NOD-like receptor signaling pathway HIF-1 signaling pathway Leukocyte transendothelial migration
		KEGG metabolic	Phagosome
14	RAB5A	ENSG00000144566	RAB5A, member RAS oncogene family
		UniProt	C9J3X8 F8WCY6 F8WD79 P20339
		NCBI	5868
		KEGG signaling	Ras signaling pathway
		KEGG metabolic	Phagosome Endocytosis
6	SNX4	ENSG00000114520	sorting nexin 4
		UniProt	F8W9T3 F8WDD4 O95219
		NCBI	8723
		KEGG metabolic	Endocytosis
8	TGFBRAP1	ENSG00000135966	transforming growth factor beta receptor associated protein 1
		UniProt	Q8WUH2
		NCBI	9392
13	VPS33A	ENSG00000139719	VPS33A core subunit of CORVET and HOPS complexes
		UniProt	A0A2R8Y5F6 A0A2R8Y5U3 A0A2R8YF87 F5H2X5 F5H6Y0 F5H7N5 Q96AX1
		NCBI	65082
13	RUBCN	ENSG00000145016	rubicon autophagy regulator
		UniProt	A0A096LNI3 E9PEM3 H0Y6E6 H7C357 H7C3H3 Q92622
		NCBI	9711
		KEGG metabolic	Autophagy - animal
17	PIK3R4	ENSG00000196455	phosphoinositide-3-kinase regulatory subunit 4
		UniProt	D6RAC3 D6RBB7 D6RJ98 Q99570
		NCBI	30849
		KEGG signaling	Apelin signaling pathway
		KEGG metabolic	Autophagy - animal
10	AMBRA1	ENSG00000110497	autophagy and beclin 1 regulator 1
		UniProt	A0A075B6T1 E9PL55 H0YE34 Q9C0C7
		NCBI	55626
		KEGG metabolic	Autophagy - animal
3	PYCARD	ENSG00000103490	PYD and CARD domain containing
		UniProt	H3BP42 Q9ULZ3
		NCBI	29108
		KEGG signaling	Cytosolic DNA-sensing pathway NOD-like receptor signaling pathway C-type lectin receptor signaling pathway
6	BCL2L1	ENSG00000171552	BCL2 like 1
		UniProt	Q07817 Q5QP56 Q5QP59 Q5TE64 Q9H1R6
		NCBI	598
		KEGG signaling	NOD-like receptor signaling pathway p53 signaling pathway Ras signaling pathway JAK-STAT signaling pathway Apoptosis NF-kappa B signaling pathway PI3K-Akt signaling pathway
		KEGG metabolic	Autophagy - animal
3	MAP3K7	ENSG00000135341	mitogen-activated protein kinase kinase kinase 7
		UniProt	O43318 Q9UG54
		NCBI	6885
		KEGG signaling	RIG-I-like receptor signaling pathway NOD-like receptor signaling pathway Toll-like receptor signaling pathway Adherens junction Wnt signaling pathway T cell receptor signaling pathway MAPK signaling pathway AMPK signaling pathway NF-kappa B signaling pathway TNF signaling pathway IL-17 signaling pathway
		KEGG metabolic	Autophagy - animal

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	276.13 KB
	H.sapiens_subnetwork.tsv	26.80 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000126581

ZW10

VPS18

PIK3C3

YWHAB

RINT1

KDELR2

STX18

BCL2

VMP1

SH3GLB1

HMGB1

UVRAG

USP14

GOPC

BMI1

ATG14

NRBF2

ULK1

EXOC8

CYBB

RAB5A

SNX4

TGFBRAP1

VPS33A

RUBCN

PIK3R4

AMBRA1

PYCARD

BCL2L1

MAP3K7

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