Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000125656
3. caseinolytic mitochondr…
- 2. CLPX
  3. caseinolytic mitochondr…
  4. 1.000
  5. PPI
- 2. MRPL12
  3. mitochondrial ribosomal…
  4. 1.000
  5. PPI
- 2. PPA2
  3. inorganic pyrophosphata…
  4. 1.000
  5. PPI
- 2. SDHB
  3. succinate dehydrogenase…
  4. 1.000
  5. Complex
- 2. ECSIT
  3. ECSIT signaling integra…
  4. 0.999
  5. PPI
- 2. TUFM
  3. Tu translation elongati…
  4. 0.999
  5. Metabolic
- 2. NDUFA10
  3. NADH:ubiquinone oxidore…
  4. 0.999
  5. PPI
- 2. TRAP1
  3. TNF receptor associated…
  4. 0.999
  5. Complex
- 2. BIRC5
  3. baculoviral IAP repeat …
  4. 0.997
  5. Complex
- 2. DNAJC19
  3. DnaJ heat shock protein…
  4. 0.997
  5. Complex
- 2. IDH3G
  3. isocitrate dehydrogenas…
  4. 0.996
  5. Metabolic
- 2. LONP1
  3. lon peptidase 1, mitoch…
  4. 0.995
  5. Metabolic
- 2. MTG2
  3. mitochondrial ribosome …
  4. 0.994
  5. PPI
- 2. HSPE1
  3. heat shock protein fami…
  4. 0.993
  5. Metabolic
- 2. MRPS7
  3. mitochondrial ribosomal…
  4. 0.992
  5. Metabolic
- 2. NSUN4
  3. NOP2/Sun RNA methyltran…
  4. 0.992
  5. Complex
- 2. HSPA9
  3. heat shock protein fami…
  4. 0.991
  5. Metabolic
- 2. SUCLG1
  3. succinate-CoA ligase GD…
  4. 0.991
  5. Metabolic
- 2. ATP5F1B
  3. ATP synthase F1 subunit…
  4. 0.990
  5. Metabolic
- 2. GFM1
  3. G elongation factor mit…
  4. 0.990
  5. Complex
- 2. ATP5F1A
  3. ATP synthase F1 subunit…
  4. 0.990
  5. Complex
- 2. MRPS2
  3. mitochondrial ribosomal…
  4. 0.989
  5. Complex
- 2. GPX4
  3. glutathione peroxidase 4
  4. 0.989
  5. Complex
- 2. MRPL11
  3. mitochondrial ribosomal…
  4. 0.988
  5. Complex
- 2. COQ7
  3. coenzyme Q7, hydroxylase
  4. 0.987
  5. Complex
- 2. IDH3A
  3. isocitrate dehydrogenas…
  4. 0.987
  5. Complex
- 2. SNRNP27
  3. small nuclear ribonucle…
  4. 0.984
  5. PPI
- 2. NME2
  3. NME/NM23 nucleoside dip…
  4. 0.983
  5. Metabolic
- 2. ATP5PO
  3. ATP synthase peripheral…
  4. 0.983
  5. Metabolic
- 2. AFG3L2
  3. AFG3 like matrix AAA pe…
  4. 0.980
  5. Metabolic

Subnetwork gene interactions

ENSG00000125656

caseinolytic mitochondrial matrix peptidase proteolytic subunit

FunCoup

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Ensembl

ENSG00000125656

UniProt

NCBI

8192

HSPE1

heat shock protein family E (Hsp10) member 1

FunCoup

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Ensembl

ENSG00000115541

UniProt

NCBI

3336

GFM1

G elongation factor mitochondrial 1

FunCoup

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Ensembl

ENSG00000168827

UniProt

NCBI

85476

NME2

NME/NM23 nucleoside diphosphate kinase 2

FunCoup

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Ensembl

ENSG00000243678

UniProt

NCBI

4831
654364

AFG3L2

AFG3 like matrix AAA peptidase subunit 2

FunCoup

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Ensembl

ENSG00000141385

UniProt

NCBI

10939

NDUFA10

NADH:ubiquinone oxidoreductase subunit A10

FunCoup

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Ensembl

ENSG00000130414

UniProt

NCBI

4705

IDH3G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

FunCoup

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Ensembl

ENSG00000067829

UniProt

NCBI

3421

SDHB

succinate dehydrogenase complex iron sulfur subunit B

FunCoup

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Ensembl

ENSG00000117118

UniProt

NCBI

6390

TRAP1

TNF receptor associated protein 1

FunCoup

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Ensembl

ENSG00000126602

UniProt

NCBI

10131

ATP5F1A

ATP synthase F1 subunit alpha

FunCoup

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Ensembl

ENSG00000152234

UniProt

NCBI

ECSIT

ECSIT signaling integrator

FunCoup

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Ensembl

ENSG00000130159

UniProt

NCBI

51295

MTG2

mitochondrial ribosome associated GTPase 2

FunCoup

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Ensembl

ENSG00000101181

UniProt

NCBI

26164

TUFM

Tu translation elongation factor, mitochondrial

FunCoup

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Ensembl

ENSG00000178952

UniProt

NCBI

7284

MRPS2

mitochondrial ribosomal protein S2

FunCoup

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Ensembl

ENSG00000122140

UniProt

NCBI

51116

IDH3A

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

FunCoup

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Ensembl

ENSG00000166411

UniProt

NCBI

3419

MRPL11

mitochondrial ribosomal protein L11

FunCoup

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Ensembl

ENSG00000174547

UniProt

NCBI

65003

HSPA9

heat shock protein family A (Hsp70) member 9

FunCoup

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Ensembl

ENSG00000113013

UniProt

NCBI

3313

ATP5F1B

ATP synthase F1 subunit beta

FunCoup

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Ensembl

ENSG00000110955

UniProt

NCBI

ATP5PO

ATP synthase peripheral stalk subunit OSCP

FunCoup

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Ensembl

ENSG00000241837

UniProt

NCBI

LONP1

lon peptidase 1, mitochondrial

FunCoup

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Ensembl

ENSG00000196365

UniProt

NCBI

9361

MRPS7

mitochondrial ribosomal protein S7

FunCoup

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Ensembl

ENSG00000125445

UniProt

NCBI

51081

PPA2

inorganic pyrophosphatase 2

FunCoup

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Ensembl

ENSG00000138777

UniProt

NCBI

27068

MRPL12

mitochondrial ribosomal protein L12

FunCoup

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Ensembl

ENSG00000262814

UniProt

P52815

NCBI

6182

SUCLG1

succinate-CoA ligase GDP/ADP-forming subunit alpha

FunCoup

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Ensembl

ENSG00000163541

UniProt

NCBI

8802

COQ7

coenzyme Q7, hydroxylase

FunCoup

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Ensembl

ENSG00000167186

UniProt

NCBI

10229

NSUN4

NOP2/Sun RNA methyltransferase 4

FunCoup

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Ensembl

ENSG00000117481

UniProt

NCBI

387338

BIRC5

baculoviral IAP repeat containing 5

FunCoup

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Ensembl

ENSG00000089685

UniProt

NCBI

GPX4

glutathione peroxidase 4

FunCoup

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Ensembl

ENSG00000167468

UniProt

NCBI

2879

DNAJC19

DnaJ heat shock protein family (Hsp40) member C19

FunCoup

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Ensembl

ENSG00000205981

UniProt

NCBI

131118

CLPX

caseinolytic mitochondrial matrix peptidase chaperone subunit X

FunCoup

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Ensembl

ENSG00000166855

UniProt

NCBI

10845

SNRNP27

small nuclear ribonucleoprotein U4/U6.U5 subunit 27

FunCoup

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Ensembl

ENSG00000124380

UniProt

NCBI

11017

Query genes

		Identifier	Description
30	ENSG00000125656	ENSG00000125656	caseinolytic mitochondrial matrix peptidase proteolytic subunit
		UniProt	A0A2R8YEF5 M0QXE9 M0QYV5 M0R208 Q16740
		NCBI	8192

Subnetwork genes

		Identifier	Description
26	HSPE1	ENSG00000115541	heat shock protein family E (Hsp10) member 1
		UniProt	B8ZZ54 B8ZZL8 P61604
		NCBI	3336
25	GFM1	ENSG00000168827	G elongation factor mitochondrial 1
		UniProt	C9IZ01 C9JA25 F8WAU4 H7C5M4 Q96RP9
		NCBI	85476
29	NME2	ENSG00000243678	NME/NM23 nucleoside diphosphate kinase 2
		UniProt	F6XY72 P22392
		NCBI	4831 654364
		KEGG metabolic	Drug metabolism - other enzymes Purine metabolism Pyrimidine metabolism
25	AFG3L2	ENSG00000141385	AFG3 like matrix AAA peptidase subunit 2
		UniProt	K7EP56 Q9Y4W6
		NCBI	10939
25	NDUFA10	ENSG00000130414	NADH:ubiquinone oxidoreductase subunit A10
		UniProt	A0A087WXC5 C9J6X0 E7ESZ7 F8WEH0 H7C1Y7 H7C2W5 H7C2X4 O95299 Q8N1B9
		NCBI	4705
		KEGG signaling	Retrograde endocannabinoid signaling
		KEGG metabolic	Oxidative phosphorylation
24	IDH3G	ENSG00000067829	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
		UniProt	E7EQB8 E9PF84 G5E9Q7 H0Y5Q7 H7C1W2 P51553
		NCBI	3421
		KEGG metabolic	Citrate cycle (TCA cycle) Biosynthesis of amino acids Carbon metabolism 2-Oxocarboxylic acid metabolism
26	SDHB	ENSG00000117118	succinate dehydrogenase complex iron sulfur subunit B
		UniProt	A0A087WWT1 A0A087WXX8 P21912
		NCBI	6390
		KEGG metabolic	Oxidative phosphorylation Citrate cycle (TCA cycle) Carbon metabolism
26	TRAP1	ENSG00000126602	TNF receptor associated protein 1
		UniProt	I3L0K7 I3L0P6 I3L239 I3L253 I3L2D5 I3L3L4 I3L4L7 Q12931
		NCBI	10131
28	ATP5F1A	ENSG00000152234	ATP synthase F1 subunit alpha
		UniProt	A0A0A0MTS3 K7EJP1 K7EK77 K7EKV9 K7EM08 K7ENJ4 K7EQH4 K7EQU6 K7ERX7 K7ESA0 P25705
		NCBI	498
		KEGG metabolic	Oxidative phosphorylation
24	ECSIT	ENSG00000130159	ECSIT signaling integrator
		UniProt	J3KTF5 K7EIK2 K7EJG5 K7EJI1 K7EM98 K7EN32 K7EPL5 K7ESM8 Q9BQ95
		NCBI	51295
		KEGG signaling	MAPK signaling pathway
23	MTG2	ENSG00000101181	mitochondrial ribosome associated GTPase 2
		UniProt	B4DRC1 Q5JXJ0 Q9H4K7
		NCBI	26164
24	TUFM	ENSG00000178952	Tu translation elongation factor, mitochondrial
		UniProt	H3BNU3 P49411
		NCBI	7284
25	MRPS2	ENSG00000122140	mitochondrial ribosomal protein S2
		UniProt	Q5T8A0 Q9Y399
		NCBI	51116
		KEGG metabolic	Ribosome
24	IDH3A	ENSG00000166411	isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
		UniProt	A0A0G2JL95 H0YKD0 H0YL05 H0YL72 H0YLF8 H0YLI6 H0YM46 H0YM64 H0YMU3 H0YMY5 H0YNF5 H0YNF8 P50213 Q68D72
		NCBI	3419
		KEGG metabolic	Citrate cycle (TCA cycle) Biosynthesis of amino acids Carbon metabolism 2-Oxocarboxylic acid metabolism
29	MRPL11	ENSG00000174547	mitochondrial ribosomal protein L11
		UniProt	E9PQB6 H0YCD5 Q9Y3B7
		NCBI	65003
		KEGG metabolic	Ribosome
27	HSPA9	ENSG00000113013	heat shock protein family A (Hsp70) member 9
		UniProt	A0A3B3ITI4 A0A3B3ITN1 D6RA73 D6RCD7 D6RDH7 D6RJI2 H0Y8K0 H0Y8S0 H0YBG6 P38646
		NCBI	3313
		KEGG metabolic	RNA degradation
28	ATP5F1B	ENSG00000110955	ATP synthase F1 subunit beta
		UniProt	F8W079 F8W0P7 H0YH81 H0YI37 P06576
		NCBI	506
		KEGG metabolic	Oxidative phosphorylation
28	ATP5PO	ENSG00000241837	ATP synthase peripheral stalk subunit OSCP
		UniProt	A0A494C0K9 H7C068 H7C086 H7C239 H7C2P9 P48047
		NCBI	539
		KEGG metabolic	Oxidative phosphorylation
24	LONP1	ENSG00000196365	lon peptidase 1, mitochondrial
		UniProt	K7EJE8 K7EKE6 K7EQF8 K7ER27 K7ER56 K7ERR6 K7ERS1 P36776
		NCBI	9361
30	MRPS7	ENSG00000125445	mitochondrial ribosomal protein S7
		UniProt	J3KSI8 J3KSV8 J3QKW2 J3QLS3 J3QQS1 Q9Y2R9
		NCBI	51081
		KEGG metabolic	Ribosome
20	PPA2	ENSG00000138777	inorganic pyrophosphatase 2
		UniProt	A0A0C4DGB9 D6R967 D6RAD3 D6RGI1 D6RGV9 F8W7R6 H0Y8X2 H0Y9D8 H0YAK2 Q9H2U2
		NCBI	27068
		KEGG metabolic	Oxidative phosphorylation
29	MRPL12	ENSG00000262814	mitochondrial ribosomal protein L12
		UniProt	P52815
		NCBI	6182
		KEGG metabolic	Ribosome
26	SUCLG1	ENSG00000163541	succinate-CoA ligase GDP/ADP-forming subunit alpha
		UniProt	A0A494C0D1 H7C233 P53597
		NCBI	8802
		KEGG metabolic	Citrate cycle (TCA cycle) Carbon metabolism Propanoate metabolism
22	COQ7	ENSG00000167186	coenzyme Q7, hydroxylase
		UniProt	H3BP28 H3BS11 H3BSZ3 H3BTN8 I3L1T0 Q99807
		NCBI	10229
		KEGG metabolic	Ubiquinone and other terpenoid-quinone biosynthesis
9	NSUN4	ENSG00000117481	NOP2/Sun RNA methyltransferase 4
		UniProt	A0A087WT36 A0A087WUV3 A0A087X0V6 M0R1K5 Q6ZRQ1 Q96CB9
		NCBI	387338
10	BIRC5	ENSG00000089685	baculoviral IAP repeat containing 5
		UniProt	A0A0B4J1S3 H3BLT4 K7ELG2 K7EMW2 K7EP76 O15392
		NCBI	332
		KEGG signaling	Apoptosis Hippo signaling pathway
17	GPX4	ENSG00000167468	glutathione peroxidase 4
		UniProt	A0A087WT12 A0A087X247 A0A087X2I2 A0A0A0MTT1 K7EJ20 K7EKX7 K7ENB4 K7ERP4 P36969 R4GNE4
		NCBI	2879
		KEGG metabolic	Glutathione metabolism
26	DNAJC19	ENSG00000205981	DnaJ heat shock protein family (Hsp40) member C19
		UniProt	A0A2R8Y817 A0A2R8Y839 F2Z3A7 G5E9V2 Q96DA6
		NCBI	131118
25	CLPX	ENSG00000166855	caseinolytic mitochondrial matrix peptidase chaperone subunit X
		UniProt	H0YK07 H0YM48 O76031
		NCBI	10845
8	SNRNP27	ENSG00000124380	small nuclear ribonucleoprotein U4/U6.U5 subunit 27
		UniProt	B8ZZ98 H0YBW5 Q8WVK2
		NCBI	11017
		KEGG metabolic	Spliceosome

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	326.76 KB
	H.sapiens_subnetwork.tsv	70.82 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000125656

HSPE1

GFM1

NME2

AFG3L2

NDUFA10

IDH3G

SDHB

TRAP1

ATP5F1A

ECSIT

MTG2

TUFM

MRPS2

IDH3A

MRPL11

HSPA9

ATP5F1B

ATP5PO

LONP1

MRPS7

PPA2

MRPL12

SUCLG1

COQ7

NSUN4

BIRC5

GPX4

DNAJC19

CLPX

SNRNP27

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