Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000115758
3. ornithine decarboxylase…
- 2. KARS1
  3. lysyl-tRNA synthetase 1
  4. 0.997
  5. Metabolic
- 2. OAZ1
  3. ornithine decarboxylase…
  4. 0.994
  5. PPI
- 2. TK1
  3. thymidine kinase 1
  4. 0.991
  5. PPI
- 2. ADSS2
  3. adenylosuccinate syntha…
  4. 0.986
  5. Metabolic
- 2. LARS1
  3. leucyl-tRNA synthetase 1
  4. 0.985
  5. PPI
- 2. HSPD1
  3. heat shock protein fami…
  4. 0.976
  5. Metabolic
- 2. TARS1
  3. threonyl-tRNA synthetas…
  4. 0.976
  5. PPI
- 2. TARS3
  3. threonyl-tRNA synthetas…
  4. 0.970
  5. PPI
- 2. GFM1
  3. G elongation factor mit…
  4. 0.968
  5. Complex
- 2. ADSS1
  3. adenylosuccinate syntha…
  4. 0.967
  5. Metabolic
- 2. PPA1
  3. inorganic pyrophosphata…
  4. 0.965
  5. Metabolic
- 2. SNRPD1
  3. small nuclear ribonucle…
  4. 0.962
  5. Metabolic
- 2. DHX15
  3. DEAH-box helicase 15
  4. 0.959
  5. Metabolic
- 2. IARS1
  3. isoleucyl-tRNA syntheta…
  4. 0.956
  5. Complex
- 2. RRM1
  3. ribonucleotide reductas…
  4. 0.954
  5. Metabolic
- 2. SARS1
  3. seryl-tRNA synthetase 1
  4. 0.952
  5. Metabolic
- 2. ASS1
  3. argininosuccinate synth…
  4. 0.949
  5. Metabolic
- 2. TOP2A
  3. DNA topoisomerase II al…
  4. 0.948
  5. Metabolic
- 2. TUFM
  3. Tu translation elongati…
  4. 0.948
  5. Complex
- 2. PPA2
  3. inorganic pyrophosphata…
  4. 0.945
  5. Metabolic
- 2. PSMD6
  3. proteasome 26S subunit,…
  4. 0.941
  5. Metabolic
- 2. MTHFR
  3. methylenetetrahydrofola…
  4. 0.938
  5. Metabolic
- 2. HSPA8
  3. heat shock protein fami…
  4. 0.938
  5. Metabolic
- 2. FARSA
  3. phenylalanyl-tRNA synth…
  4. 0.938
  5. Metabolic
- 2. PKM
  3. pyruvate kinase M1/2
  4. 0.937
  5. PPI
- 2. POLR1A
  3. RNA polymerase I subuni…
  4. 0.935
  5. Complex
- 2. GTPBP4
  3. GTP binding protein 4
  4. 0.935
  5. Metabolic
- 2. MRPL3
  3. mitochondrial ribosomal…
  4. 0.934
  5. Complex
- 2. CCT8
  3. chaperonin containing T…
  4. 0.927
  5. Metabolic
- 2. PGD
  3. phosphogluconate dehydr…
  4. 0.924
  5. PPI

Subnetwork gene interactions

ENSG00000115758

ornithine decarboxylase 1

FunCoup

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Ensembl

ENSG00000115758

UniProt

NCBI

4953

TARS3

threonyl-tRNA synthetase 3

FunCoup

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Ensembl

ENSG00000185418

UniProt

NCBI

123283

CCT8

chaperonin containing TCP1 subunit 8

FunCoup

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Ensembl

ENSG00000156261

UniProt

NCBI

10694

DHX15

DEAH-box helicase 15

FunCoup

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Ensembl

ENSG00000109606

UniProt

O43143

NCBI

1665

PPA1

inorganic pyrophosphatase 1

FunCoup

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Ensembl

ENSG00000180817

UniProt

NCBI

5464

RRM1

ribonucleotide reductase catalytic subunit M1

FunCoup

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Ensembl

ENSG00000167325

UniProt

NCBI

6240

TARS1

threonyl-tRNA synthetase 1

FunCoup

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Ensembl

ENSG00000113407

UniProt

NCBI

6897

ADSS1

adenylosuccinate synthase 1

FunCoup

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Ensembl

ENSG00000185100

UniProt

NCBI

122622

PKM

pyruvate kinase M1/2

FunCoup

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Ensembl

ENSG00000067225

UniProt

NCBI

5315

MRPL3

mitochondrial ribosomal protein L3

FunCoup

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Ensembl

ENSG00000114686

UniProt

NCBI

11222

KARS1

lysyl-tRNA synthetase 1

FunCoup

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Ensembl

ENSG00000065427

UniProt

NCBI

3735

SNRPD1

small nuclear ribonucleoprotein D1 polypeptide

FunCoup

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Ensembl

ENSG00000167088

UniProt

NCBI

6632

IARS1

isoleucyl-tRNA synthetase 1

FunCoup

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Ensembl

ENSG00000196305

UniProt

NCBI

3376

GFM1

G elongation factor mitochondrial 1

FunCoup

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Ensembl

ENSG00000168827

UniProt

NCBI

85476

HSPA8

heat shock protein family A (Hsp70) member 8

FunCoup

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Ensembl

ENSG00000109971

UniProt

NCBI

3312

TUFM

Tu translation elongation factor, mitochondrial

FunCoup

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Ensembl

ENSG00000178952

UniProt

NCBI

7284

ASS1

argininosuccinate synthase 1

FunCoup

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Ensembl

ENSG00000130707

UniProt

NCBI

TOP2A

DNA topoisomerase II alpha

FunCoup

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Ensembl

ENSG00000131747

UniProt

NCBI

7153

PPA2

inorganic pyrophosphatase 2

FunCoup

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Ensembl

ENSG00000138777

UniProt

NCBI

27068

SARS1

seryl-tRNA synthetase 1

FunCoup

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Ensembl

ENSG00000031698

UniProt

NCBI

6301

OAZ1

ornithine decarboxylase antizyme 1

FunCoup

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Ensembl

ENSG00000104904

UniProt

NCBI

4946

ADSS2

adenylosuccinate synthase 2

FunCoup

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Ensembl

ENSG00000035687

UniProt

P30520

NCBI

GTPBP4

GTP binding protein 4

FunCoup

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Ensembl

ENSG00000107937

UniProt

NCBI

23560

PGD

phosphogluconate dehydrogenase

FunCoup

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Ensembl

ENSG00000142657

UniProt

NCBI

5226

TK1

thymidine kinase 1

FunCoup

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Ensembl

ENSG00000167900

UniProt

NCBI

7083

FARSA

phenylalanyl-tRNA synthetase subunit alpha

FunCoup

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Ensembl

ENSG00000179115

UniProt

NCBI

2193

LARS1

leucyl-tRNA synthetase 1

FunCoup

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Ensembl

ENSG00000133706

UniProt

NCBI

51520

PSMD6

proteasome 26S subunit, non-ATPase 6

FunCoup

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Ensembl

ENSG00000163636

UniProt

NCBI

9861

HSPD1

heat shock protein family D (Hsp60) member 1

FunCoup

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Ensembl

ENSG00000144381

UniProt

NCBI

3329

POLR1A

RNA polymerase I subunit A

FunCoup

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Ensembl

ENSG00000068654

UniProt

NCBI

25885

MTHFR

methylenetetrahydrofolate reductase

FunCoup

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Ensembl

ENSG00000177000

UniProt

NCBI

4524

Query genes

		Identifier	Description
30	ENSG00000115758	ENSG00000115758	ornithine decarboxylase 1
		UniProt	C9JG30 P11926
		NCBI	4953
		KEGG metabolic	Glutathione metabolism Arginine and proline metabolism

Subnetwork genes

		Identifier	Description
28	TARS3	ENSG00000185418	threonyl-tRNA synthetase 3
		UniProt	A2RTX5 B7ZLP8 H0YKB9
		NCBI	123283
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
28	CCT8	ENSG00000156261	chaperonin containing TCP1 subunit 8
		UniProt	H7C2U0 H7C4C8 P50990
		NCBI	10694
25	DHX15	ENSG00000109606	DEAH-box helicase 15
		UniProt	O43143
		NCBI	1665
		KEGG metabolic	Spliceosome
26	PPA1	ENSG00000180817	inorganic pyrophosphatase 1
		UniProt	Q15181 Q5SQT6
		NCBI	5464
		KEGG metabolic	Oxidative phosphorylation
29	RRM1	ENSG00000167325	ribonucleotide reductase catalytic subunit M1
		UniProt	E9PJ62 E9PL69 E9PP77 E9PRY9 H0YCY7 P23921
		NCBI	6240
		KEGG metabolic	Drug metabolism - other enzymes Glutathione metabolism Purine metabolism Pyrimidine metabolism
28	TARS1	ENSG00000113407	threonyl-tRNA synthetase 1
		UniProt	D6R9F8 D6RBR8 D6RCA5 D6RCS6 D6RDJ6 D6RHV7 D6RJ97 P26639
		NCBI	6897
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
22	ADSS1	ENSG00000185100	adenylosuccinate synthase 1
		UniProt	G3V232 G3V2N1 G3V5D8 Q8N142
		NCBI	122622
		KEGG metabolic	Alanine, aspartate and glutamate metabolism Purine metabolism
29	PKM	ENSG00000067225	pyruvate kinase M1/2
		UniProt	B4DNK4 H3BN34 H3BQ34 H3BQZ3 H3BR70 H3BT25 H3BTJ2 H3BTN5 H3BU13 H3BUW1 P14618
		NCBI	5315
		KEGG signaling	Glucagon signaling pathway
		KEGG metabolic	Pyruvate metabolism Glycolysis / Gluconeogenesis Purine metabolism Biosynthesis of amino acids Carbon metabolism
28	MRPL3	ENSG00000114686	mitochondrial ribosomal protein L3
		UniProt	D6RBQ5 D6RC14 E7ETU7 E9PF06 H0Y9G6 P09001
		NCBI	11222
		KEGG metabolic	Ribosome
30	KARS1	ENSG00000065427	lysyl-tRNA synthetase 1
		UniProt	H3BMR9 H3BPV7 H3BQK5 H3BRC9 H3BSN6 H3BVA8 J3KRL2 Q15046
		NCBI	3735
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
27	SNRPD1	ENSG00000167088	small nuclear ribonucleoprotein D1 polypeptide
		UniProt	J3QLI9 J3QLR7 P62314
		NCBI	6632
		KEGG metabolic	Spliceosome
28	IARS1	ENSG00000196305	isoleucyl-tRNA synthetase 1
		UniProt	A0A0A0MSX9 J3KR24 P41252 Q5TCC6 Q5TCC9 Q5TCD1
		NCBI	3376
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
27	GFM1	ENSG00000168827	G elongation factor mitochondrial 1
		UniProt	C9IZ01 C9JA25 F8WAU4 H7C5M4 Q96RP9
		NCBI	85476
27	HSPA8	ENSG00000109971	heat shock protein family A (Hsp70) member 8
		UniProt	A8K7Q2 E9PI65 E9PK54 E9PKE3 E9PLF4 E9PM13 E9PN25 E9PN89 E9PNE6 E9PPY6 E9PQK7 E9PQQ4 E9PS65 P11142
		NCBI	3312
		KEGG signaling	Antigen processing and presentation MAPK signaling pathway Estrogen signaling pathway
		KEGG metabolic	Spliceosome Endocytosis Protein processing in endoplasmic reticulum
27	TUFM	ENSG00000178952	Tu translation elongation factor, mitochondrial
		UniProt	H3BNU3 P49411
		NCBI	7284
26	ASS1	ENSG00000130707	argininosuccinate synthase 1
		UniProt	P00966 Q5T6L5 Q5T6L6
		NCBI	445
		KEGG metabolic	Alanine, aspartate and glutamate metabolism Biosynthesis of amino acids Arginine biosynthesis
28	TOP2A	ENSG00000131747	DNA topoisomerase II alpha
		UniProt	J3KTB7 J3QR57 P11388
		NCBI	7153
26	PPA2	ENSG00000138777	inorganic pyrophosphatase 2
		UniProt	A0A0C4DGB9 D6R967 D6RAD3 D6RGI1 D6RGV9 F8W7R6 H0Y8X2 H0Y9D8 H0YAK2 Q9H2U2
		NCBI	27068
		KEGG metabolic	Oxidative phosphorylation
27	SARS1	ENSG00000031698	seryl-tRNA synthetase 1
		UniProt	P49591 Q5T5C7
		NCBI	6301
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
6	OAZ1	ENSG00000104904	ornithine decarboxylase antizyme 1
		UniProt	J3QQY4 K7EPM6 K7ERW1 P54368
		NCBI	4946
27	ADSS2	ENSG00000035687	adenylosuccinate synthase 2
		UniProt	P30520
		NCBI	159
		KEGG metabolic	Alanine, aspartate and glutamate metabolism Purine metabolism
27	GTPBP4	ENSG00000107937	GTP binding protein 4
		UniProt	Q5T3R7 Q9BZE4
		NCBI	23560
		KEGG metabolic	Ribosome biogenesis in eukaryotes
28	PGD	ENSG00000142657	phosphogluconate dehydrogenase
		UniProt	K7EJT3 K7ELN9 K7EM49 K7EMN2 K7EPF6 P52209
		NCBI	5226
		KEGG metabolic	Pentose phosphate pathway Glutathione metabolism Carbon metabolism
9	TK1	ENSG00000167900	thymidine kinase 1
		UniProt	K7ENW5 K7ERJ1 K7ERV3 K7ES52 P04183
		NCBI	7083
		KEGG metabolic	Drug metabolism - other enzymes Pyrimidine metabolism
28	FARSA	ENSG00000179115	phenylalanyl-tRNA synthetase subunit alpha
		UniProt	K7EK06 K7EPH2 K7ER00 K7ER16 K7ERS0 Q9Y285
		NCBI	2193
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
28	LARS1	ENSG00000133706	leucyl-tRNA synthetase 1
		UniProt	A0A087WXY1 Q9P2J5
		NCBI	51520
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
24	PSMD6	ENSG00000163636	proteasome 26S subunit, non-ATPase 6
		UniProt	C9J0E9 C9J7B7 H7C531 Q15008
		NCBI	9861
		KEGG metabolic	Proteasome
28	HSPD1	ENSG00000144381	heat shock protein family D (Hsp60) member 1
		UniProt	C9J0S9 C9JCQ4 C9JL19 C9JL25 E7ESH4 E7EXB4 F8WBB1 P10809
		NCBI	3329
		KEGG metabolic	RNA degradation
20	POLR1A	ENSG00000068654	RNA polymerase I subunit A
		UniProt	B9ZVN9 F2Z3I7 O95602
		NCBI	25885
		KEGG metabolic	RNA polymerase
13	MTHFR	ENSG00000177000	methylenetetrahydrofolate reductase
		UniProt	A0A1B0GXD9 A0A286YF17 A0A286YF47 A0A286YFD0 F8W9T8 L7P8G6 P42898 Q5SNW5 Q5SNW7
		NCBI	4524
		KEGG metabolic	One carbon pool by folate Carbon metabolism

Enrichment analysis

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	jSquid_subnetworks.xml	307.40 KB
	H.sapiens_subnetwork.tsv	79.57 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000115758

TARS3

CCT8

DHX15

PPA1

RRM1

TARS1

ADSS1

PKM

MRPL3

KARS1

SNRPD1

IARS1

GFM1

HSPA8

TUFM

ASS1

TOP2A

PPA2

SARS1

OAZ1

ADSS2

GTPBP4

PGD

TK1

FARSA

LARS1

PSMD6

HSPD1

POLR1A

MTHFR

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