Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000114126
3. transcription factor Dp…
- 2. E2F5
  3. E2F transcription facto…
  4. 1.000
  5. PPI
- 2. E2F1
  3. E2F transcription facto…
  4. 1.000
  5. PPI
- 2. E2F4
  3. E2F transcription facto…
  4. 1.000
  5. PPI
- 2. RBL1
  3. RB transcriptional core…
  4. 1.000
  5. PPI
- 2. E2F2
  3. E2F transcription facto…
  4. 1.000
  5. PPI
- 2. RBL2
  3. RB transcriptional core…
  4. 1.000
  5. PPI
- 2. E2F3
  3. E2F transcription facto…
  4. 1.000
  5. PPI
- 2. TFDP1
  3. transcription factor Dp…
  4. 1.000
  5. Complex
- 2. LIN54
  3. lin-54 DREAM MuvB core …
  4. 0.999
  5. PPI
- 2. E2F6
  3. E2F transcription facto…
  4. 0.999
  5. PPI
- 2. CDK2
  3. cyclin dependent kinase…
  4. 0.999
  5. Complex
- 2. RBBP4
  3. RB binding protein 4, c…
  4. 0.998
  5. Complex
- 2. CCNA2
  3. cyclin A2
  4. 0.997
  5. Complex
- 2. MCMBP
  3. minichromosome maintena…
  4. 0.996
  5. PPI
- 2. L3MBTL2
  3. L3MBTL histone methyl-l…
  4. 0.995
  5. PPI
- 2. YWHAE
  3. tyrosine 3-monooxygenas…
  4. 0.994
  5. PPI
- 2. RB1
  3. RB transcriptional core…
  4. 0.993
  5. PPI
- 2. CCNB1
  3. cyclin B1
  4. 0.985
  5. Complex
- 2. LIN52
  3. lin-52 DREAM MuvB core …
  4. 0.985
  5. Complex
- 2. CCNE2
  3. cyclin E2
  4. 0.984
  5. Complex
- 2. RYBP
  3. RING1 and YY1 binding p…
  4. 0.981
  5. PPI
- 2. LIN37
  3. lin-37 DREAM MuvB core …
  4. 0.967
  5. PPI
- 2. CCNB2
  3. cyclin B2
  4. 0.948
  5. Metabolic
- 2. GSTM3
  3. glutathione S-transfera…
  4. 0.922
  5. Complex
- 2. CCNG1
  3. cyclin G1
  4. 0.905
  5. PPI
- 2. ISCU
  3. iron-sulfur cluster ass…
  4. 0.894
  5. Complex
- 2. LIN9
  3. lin-9 DREAM MuvB core c…
  4. 0.886
  5. PPI
- 2. RPS6KB2
  3. ribosomal protein S6 ki…
  4. 0.834
  5. Metabolic
- 2. SMC3
  3. structural maintenance …
  4. 0.819
  5. Complex
- 2. HDAC3
  3. histone deacetylase 3
  4. 0.818
  5. Metabolic

Subnetwork gene interactions

ENSG00000114126

transcription factor Dp-2

FunCoup

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Ensembl

ENSG00000114126

UniProt

NCBI

7029

CCNE2

cyclin E2

FunCoup

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Ensembl

ENSG00000175305

UniProt

NCBI

9134

CCNB1

cyclin B1

FunCoup

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Ensembl

ENSG00000134057

UniProt

NCBI

E2F5

E2F transcription factor 5

FunCoup

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Ensembl

ENSG00000133740

UniProt

NCBI

1875

MCMBP

minichromosome maintenance complex binding protein

FunCoup

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Ensembl

ENSG00000197771

UniProt

Q9BTE3

NCBI

79892

TFDP1

transcription factor Dp-1

FunCoup

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Ensembl

ENSG00000198176

UniProt

NCBI

7027

E2F1

E2F transcription factor 1

FunCoup

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Ensembl

ENSG00000101412

UniProt

Q01094

NCBI

1869

HDAC3

histone deacetylase 3

FunCoup

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Ensembl

ENSG00000171720

UniProt

NCBI

8841

LIN37

lin-37 DREAM MuvB core complex component

FunCoup

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Ensembl

ENSG00000267796

UniProt

NCBI

55957

LIN52

lin-52 DREAM MuvB core complex component

FunCoup

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Ensembl

ENSG00000205659

UniProt

NCBI

91750

LIN54

lin-54 DREAM MuvB core complex component

FunCoup

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Ensembl

ENSG00000189308

UniProt

NCBI

132660

RBL2

RB transcriptional corepressor like 2

FunCoup

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Ensembl

ENSG00000103479

UniProt

NCBI

5934

E2F3

E2F transcription factor 3

FunCoup

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Ensembl

ENSG00000112242

UniProt

NCBI

1871

RYBP

RING1 and YY1 binding protein

FunCoup

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Ensembl

ENSG00000163602

UniProt

Q8N488

NCBI

23429

RBBP4

RB binding protein 4, chromatin remodeling factor

FunCoup

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Ensembl

ENSG00000162521

UniProt

NCBI

5928

RBL1

RB transcriptional corepressor like 1

FunCoup

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Ensembl

ENSG00000080839

UniProt

NCBI

5933

SMC3

structural maintenance of chromosomes 3

FunCoup

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Ensembl

ENSG00000108055

UniProt

Q9UQE7

NCBI

9126

E2F2

E2F transcription factor 2

FunCoup

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Ensembl

ENSG00000007968

UniProt

Q14209

NCBI

1870

E2F4

E2F transcription factor 4

FunCoup

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Ensembl

ENSG00000205250

UniProt

NCBI

1874

CCNB2

cyclin B2

FunCoup

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Ensembl

ENSG00000157456

UniProt

NCBI

9133

LIN9

lin-9 DREAM MuvB core complex component

FunCoup

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Ensembl

ENSG00000183814

UniProt

NCBI

286826

CCNA2

cyclin A2

FunCoup

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Ensembl

ENSG00000145386

UniProt

P20248

NCBI

RB1

RB transcriptional corepressor 1

FunCoup

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Ensembl

ENSG00000139687

UniProt

NCBI

5925

GSTM3

glutathione S-transferase mu 3

FunCoup

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Ensembl

ENSG00000134202

UniProt

NCBI

2947

ISCU

iron-sulfur cluster assembly enzyme

FunCoup

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Ensembl

ENSG00000136003

UniProt

NCBI

23479

CDK2

cyclin dependent kinase 2

FunCoup

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Ensembl

ENSG00000123374

UniProt

NCBI

1017

L3MBTL2

L3MBTL histone methyl-lysine binding protein 2

FunCoup

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Ensembl

ENSG00000100395

UniProt

NCBI

83746

RPS6KB2

ribosomal protein S6 kinase B2

FunCoup

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Ensembl

ENSG00000175634

UniProt

NCBI

6199

YWHAE

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

FunCoup

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Ensembl

ENSG00000108953

UniProt

NCBI

7531

CCNG1

cyclin G1

FunCoup

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Ensembl

ENSG00000113328

UniProt

NCBI

E2F6

E2F transcription factor 6

FunCoup

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Ensembl

ENSG00000169016

UniProt

NCBI

1876

Query genes

		Identifier	Description
30	ENSG00000114126	ENSG00000114126	transcription factor Dp-2
		UniProt	C9J461 C9J5D5 C9J872 C9J977 C9JCY5 C9JNB6 C9JTZ9 F8WAY9 H7C5C2 Q14188 R4GN09
		NCBI	7029
		KEGG signaling	Cell cycle

Subnetwork genes

		Identifier	Description
16	CCNE2	ENSG00000175305	cyclin E2
		UniProt	E5RHN2 E5RK20 H0YBQ2 O96020 Q8WUE3
		NCBI	9134
		KEGG signaling	p53 signaling pathway Oocyte meiosis Cell cycle PI3K-Akt signaling pathway
18	CCNB1	ENSG00000134057	cyclin B1
		UniProt	D6RHI0 E9PC90 H0Y9U8 H0YA62 P14635
		NCBI	891
		KEGG signaling	p53 signaling pathway Oocyte meiosis FoxO signaling pathway Cell cycle Progesterone-mediated oocyte maturation
22	E2F5	ENSG00000133740	E2F transcription factor 5
		UniProt	C9JYE9 E5RHD4 H0YBK0 H0YBW8 Q15329
		NCBI	1875
		KEGG signaling	Cell cycle TGF-beta signaling pathway
16	MCMBP	ENSG00000197771	minichromosome maintenance complex binding protein
		UniProt	Q9BTE3
		NCBI	79892
29	TFDP1	ENSG00000198176	transcription factor Dp-1
		UniProt	F5H452 Q14186 Q5JSB5 Q5JSB6
		NCBI	7027
		KEGG signaling	Cell cycle TGF-beta signaling pathway
17	E2F1	ENSG00000101412	E2F transcription factor 1
		UniProt	Q01094
		NCBI	1869
		KEGG signaling	Cell cycle
17	HDAC3	ENSG00000171720	histone deacetylase 3
		UniProt	E7ESJ6 E7EW19 O15379
		NCBI	8841
		KEGG signaling	Thyroid hormone signaling pathway
17	LIN37	ENSG00000267796	lin-37 DREAM MuvB core complex component
		UniProt	K7ELP2 K7EMY4 M0QYM3 Q96GY3
		NCBI	55957
17	LIN52	ENSG00000205659	lin-52 DREAM MuvB core complex component
		UniProt	G3V5T8 Q52LA3
		NCBI	91750
18	LIN54	ENSG00000189308	lin-54 DREAM MuvB core complex component
		UniProt	D6REW4 Q6MZP7
		NCBI	132660
26	RBL2	ENSG00000103479	RB transcriptional corepressor like 2
		UniProt	F5H837 J3KSF7 Q08999
		NCBI	5934
		KEGG signaling	FoxO signaling pathway Cell cycle PI3K-Akt signaling pathway
12	E2F3	ENSG00000112242	E2F transcription factor 3
		UniProt	A0A087X0B6 O00716
		NCBI	1871
		KEGG signaling	Cell cycle
5	RYBP	ENSG00000163602	RING1 and YY1 binding protein
		UniProt	Q8N488
		NCBI	23429
25	RBBP4	ENSG00000162521	RB binding protein 4, chromatin remodeling factor
		UniProt	C9JPP3 E9PIC4 E9PND5 E9PNS2 E9PNS6 H0YCT5 H0YDK2 H0YEU5 H0YF10 Q09028
		NCBI	5928
23	RBL1	ENSG00000080839	RB transcriptional corepressor like 1
		UniProt	E9PNB6 H0YE05 P28749
		NCBI	5933
		KEGG signaling	Cell cycle TGF-beta signaling pathway
15	SMC3	ENSG00000108055	structural maintenance of chromosomes 3
		UniProt	Q9UQE7
		NCBI	9126
		KEGG signaling	Oocyte meiosis Cell cycle
9	E2F2	ENSG00000007968	E2F transcription factor 2
		UniProt	Q14209
		NCBI	1870
		KEGG signaling	Cell cycle
24	E2F4	ENSG00000205250	E2F transcription factor 4
		UniProt	H3BMP3 H3BTM3 H3BVE4 I3L1B6 Q16254
		NCBI	1874
		KEGG signaling	Cell cycle TGF-beta signaling pathway
14	CCNB2	ENSG00000157456	cyclin B2
		UniProt	H0YMP3 H1UBN3 O95067
		NCBI	9133
		KEGG signaling	p53 signaling pathway Oocyte meiosis FoxO signaling pathway Cell cycle Progesterone-mediated oocyte maturation
19	LIN9	ENSG00000183814	lin-9 DREAM MuvB core complex component
		UniProt	B1B047 C9J5J4 H0Y322 H7C4T7 Q5TKA1
		NCBI	286826
21	CCNA2	ENSG00000145386	cyclin A2
		UniProt	P20248
		NCBI	890
		KEGG signaling	Cell cycle AMPK signaling pathway Progesterone-mediated oocyte maturation
14	RB1	ENSG00000139687	RB transcriptional corepressor 1
		UniProt	A0A2R8Y743 A0A2R8YFL6 A0A3B3IS71 P06400 Q92728
		NCBI	5925
		KEGG signaling	Cell cycle
11	GSTM3	ENSG00000134202	glutathione S-transferase mu 3
		UniProt	A0A0A0MTN3 P21266
		NCBI	2947
		KEGG metabolic	Drug metabolism - other enzymes Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450
13	ISCU	ENSG00000136003	iron-sulfur cluster assembly enzyme
		UniProt	B3KQ30 B4DNC9 F5H5N2 F5H672 Q9H1K1
		NCBI	23479
23	CDK2	ENSG00000123374	cyclin dependent kinase 2
		UniProt	E7ESI2 G3V317 G3V5T9 P24941
		NCBI	1017
		KEGG signaling	p53 signaling pathway Oocyte meiosis FoxO signaling pathway Cell cycle PI3K-Akt signaling pathway Progesterone-mediated oocyte maturation
14	L3MBTL2	ENSG00000100395	L3MBTL histone methyl-lysine binding protein 2
		UniProt	F8WBL1 H0Y5M2 H7C228 Q969R5
		NCBI	83746
4	RPS6KB2	ENSG00000175634	ribosomal protein S6 kinase B2
		UniProt	E9PIP7 E9PQF6 G3V2F1 Q9UBS0 R4GN47
		NCBI	6199
		KEGG signaling	Fc gamma R-mediated phagocytosis ErbB signaling pathway HIF-1 signaling pathway TGF-beta signaling pathway AMPK signaling pathway PI3K-Akt signaling pathway Apelin signaling pathway mTOR signaling pathway Insulin signaling pathway
		KEGG metabolic	Autophagy - animal
10	YWHAE	ENSG00000108953	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
		UniProt	B4DJF2 I3L0W5 I3L3T1 K7EIT4 K7EM20 P62258
		NCBI	7531
		KEGG signaling	Neurotrophin signaling pathway NOD-like receptor signaling pathway Oocyte meiosis Cell cycle PI3K-Akt signaling pathway Hippo signaling pathway
9	CCNG1	ENSG00000113328	cyclin G1
		UniProt	D6RCC5 D6RD30 D6RGX3 E7ERZ1 P51959
		NCBI	900
		KEGG signaling	p53 signaling pathway
4	E2F6	ENSG00000169016	E2F transcription factor 6
		UniProt	F8WC40 F8WEZ5 O75461 Q2Z196 Q2Z197
		NCBI	1876

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	272.16 KB
	H.sapiens_subnetwork.tsv	40.61 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000114126

CCNE2

CCNB1

E2F5

MCMBP

TFDP1

E2F1

HDAC3

LIN37

LIN52

LIN54

RBL2

E2F3

RYBP

RBBP4

RBL1

SMC3

E2F2

E2F4

CCNB2

LIN9

CCNA2

RB1

GSTM3

ISCU

CDK2

L3MBTL2

RPS6KB2

YWHAE

CCNG1

E2F6

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