Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000113924
3. homogentisate 1,2-dioxy…
- 2. HPD
  3. 4-hydroxyphenylpyruvate…
  4. 0.999
  5. Metabolic
- 2. ALDH7A1
  3. aldehyde dehydrogenase …
  4. 0.998
  5. Metabolic
- 2. FAH
  3. fumarylacetoacetate hyd…
  4. 0.998
  5. Metabolic
- 2. UPB1
  3. beta-ureidopropionase 1
  4. 0.981
  5. Metabolic
- 2. CTSD
  3. cathepsin D
  4. 0.976
  5. Metabolic
- 2. RAB5C
  3. RAB5C, member RAS oncog…
  4. 0.974
  5. Metabolic
- 2. RAB2A
  3. RAB2A, member RAS oncog…
  4. 0.973
  5. Metabolic
- 2. PEPD
  3. peptidase D
  4. 0.972
  5. Metabolic
- 2. MCCC1
  3. methylcrotonoyl-CoA car…
  4. 0.969
  5. Metabolic
- 2. RAB5B
  3. RAB5B, member RAS oncog…
  4. 0.967
  5. Metabolic
- 2. FBP1
  3. fructose-bisphosphatase…
  4. 0.967
  5. Metabolic
- 2. SERINC2
  3. serine incorporator 2
  4. 0.962
  5. Metabolic
- 2. C16orf70
  3. chromosome 16 open read…
  4. 0.959
  5. Metabolic
- 2. ALDH8A1
  3. aldehyde dehydrogenase …
  4. 0.958
  5. Metabolic
- 2. SGPL1
  3. sphingosine-1-phosphate…
  4. 0.952
  5. Metabolic
- 2. TP53I3
  3. tumor protein p53 induc…
  4. 0.950
  5. Metabolic
- 2. IVD
  3. isovaleryl-CoA dehydrog…
  4. 0.945
  5. Metabolic
- 2. PHYHD1
  3. phytanoyl-CoA dioxygena…
  4. 0.942
  5. Metabolic
- 2. RAB5A
  3. RAB5A, member RAS oncog…
  4. 0.938
  5. Metabolic
- 2. FBP2
  3. fructose-bisphosphatase…
  4. 0.938
  5. Metabolic
- 2. MTHFD1
  3. methylenetetrahydrofola…
  4. 0.936
  5. Metabolic
- 2. ESD
  3. esterase D
  4. 0.932
  5. Metabolic
- 2. PBLD
  3. phenazine biosynthesis …
  4. 0.931
  5. Metabolic
- 2. ATG9A
  3. autophagy related 9A
  4. 0.930
  5. Metabolic
- 2. P4HB
  3. prolyl 4-hydroxylase su…
  4. 0.923
  5. Metabolic
- 2. HADH
  3. hydroxyacyl-CoA dehydro…
  4. 0.923
  5. Metabolic
- 2. UFC1
  3. ubiquitin-fold modifier…
  4. 0.916
  5. Metabolic
- 2. SORD
  3. sorbitol dehydrogenase
  4. 0.915
  5. Metabolic
- 2. GSS
  3. glutathione synthetase
  4. 0.909
  5. Metabolic
- 2. FBXL2
  3. F-box and leucine rich …
  4. 0.907
  5. Metabolic

Subnetwork gene interactions

ENSG00000113924

homogentisate 1,2-dioxygenase

FunCoup

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Ensembl

ENSG00000113924

UniProt

NCBI

3081

PEPD

peptidase D

FunCoup

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Ensembl

ENSG00000124299

UniProt

NCBI

5184

RAB5B

RAB5B, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000111540

UniProt

NCBI

5869

SGPL1

sphingosine-1-phosphate lyase 1

FunCoup

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Ensembl

ENSG00000166224

UniProt

NCBI

8879

MTHFD1

methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

FunCoup

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Ensembl

ENSG00000100714

UniProt

NCBI

4522

SORD

sorbitol dehydrogenase

FunCoup

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Ensembl

ENSG00000140263

UniProt

NCBI

6652

FBXL2

F-box and leucine rich repeat protein 2

FunCoup

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Ensembl

ENSG00000153558

UniProt

NCBI

25827

FBP2

fructose-bisphosphatase 2

FunCoup

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Ensembl

ENSG00000130957

UniProt

O00757

NCBI

8789

UFC1

ubiquitin-fold modifier conjugating enzyme 1

FunCoup

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Ensembl

ENSG00000143222

UniProt

Q9Y3C8

NCBI

51506

IVD

isovaleryl-CoA dehydrogenase

FunCoup

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Ensembl

ENSG00000128928

UniProt

NCBI

3712

CTSD

cathepsin D

FunCoup

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Ensembl

ENSG00000117984

UniProt

NCBI

1509

RAB2A

RAB2A, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000104388

UniProt

NCBI

5862

ATG9A

autophagy related 9A

FunCoup

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Ensembl

ENSG00000198925

UniProt

NCBI

79065

ALDH7A1

aldehyde dehydrogenase 7 family member A1

FunCoup

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Ensembl

ENSG00000164904

UniProt

NCBI

SERINC2

serine incorporator 2

FunCoup

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Ensembl

ENSG00000168528

UniProt

Q96SA4

NCBI

347735

ESD

esterase D

FunCoup

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Ensembl

ENSG00000139684

UniProt

NCBI

2098

TP53I3

tumor protein p53 inducible protein 3

FunCoup

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Ensembl

ENSG00000115129

UniProt

NCBI

9540

C16orf70

chromosome 16 open reading frame 70

FunCoup

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Ensembl

ENSG00000125149

UniProt

NCBI

80262

MCCC1

methylcrotonoyl-CoA carboxylase 1

FunCoup

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Ensembl

ENSG00000078070

UniProt

NCBI

56922

RAB5C

RAB5C, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000108774

UniProt

NCBI

5878

FAH

fumarylacetoacetate hydrolase

FunCoup

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Ensembl

ENSG00000103876

UniProt

NCBI

2184

FBP1

fructose-bisphosphatase 1

FunCoup

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Ensembl

ENSG00000165140

UniProt

NCBI

2203

HPD

4-hydroxyphenylpyruvate dioxygenase

FunCoup

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Ensembl

ENSG00000158104

UniProt

NCBI

3242

P4HB

prolyl 4-hydroxylase subunit beta

FunCoup

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Ensembl

ENSG00000185624

UniProt

NCBI

5034

HADH

hydroxyacyl-CoA dehydrogenase

FunCoup

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Ensembl

ENSG00000138796

UniProt

NCBI

3033

PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

FunCoup

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Ensembl

ENSG00000175287

UniProt

NCBI

254295

GSS

glutathione synthetase

FunCoup

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Ensembl

ENSG00000100983

UniProt

NCBI

2937

RAB5A

RAB5A, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000144566

UniProt

NCBI

5868

UPB1

beta-ureidopropionase 1

FunCoup

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Ensembl

ENSG00000100024

UniProt

NCBI

51733

ALDH8A1

aldehyde dehydrogenase 8 family member A1

FunCoup

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Ensembl

ENSG00000118514

UniProt

NCBI

64577

PBLD

phenazine biosynthesis like protein domain containing

FunCoup

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Ensembl

ENSG00000108187

UniProt

NCBI

64081

Query genes

		Identifier	Description
30	ENSG00000113924	ENSG00000113924	homogentisate 1,2-dioxygenase
		UniProt	C9JTX9 H7C4R8 H7C576 H7C5G7 Q93099
		NCBI	3081
		KEGG metabolic	Tyrosine metabolism

Subnetwork genes

		Identifier	Description
24	PEPD	ENSG00000124299	peptidase D
		UniProt	A0A494C165 A0A494C194 K7ES25 P12955 V9GYE4 V9GYL0
		NCBI	5184
19	RAB5B	ENSG00000111540	RAB5B, member RAS oncogene family
		UniProt	F8VPW9 F8VUA5 F8VVZ0 F8VWZ7 P61020
		NCBI	5869
		KEGG signaling	Ras signaling pathway
		KEGG metabolic	Phagosome Endocytosis
17	SGPL1	ENSG00000166224	sphingosine-1-phosphate lyase 1
		UniProt	H0Y3V8 H7BXL7 O95470
		NCBI	8879
		KEGG signaling	Sphingolipid signaling pathway
		KEGG metabolic	Sphingolipid metabolism
24	MTHFD1	ENSG00000100714	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
		UniProt	A0A384N5Y3 A0A494C1T2 F5H2F4 P11586 V9GY75 V9GYY3 V9GZ32 V9GZ78
		NCBI	4522
		KEGG metabolic	One carbon pool by folate
21	SORD	ENSG00000140263	sorbitol dehydrogenase
		UniProt	H0YKB3 H0YLA4 Q00796
		NCBI	6652
		KEGG metabolic	Fructose and mannose metabolism Pentose and glucuronate interconversions
5	FBXL2	ENSG00000153558	F-box and leucine rich repeat protein 2
		UniProt	F8WB01 F8WBS9 F8WBW7 F8WC58 F8WCQ8 F8WE99 Q9UKC9
		NCBI	25827
15	FBP2	ENSG00000130957	fructose-bisphosphatase 2
		UniProt	O00757
		NCBI	8789
		KEGG signaling	AMPK signaling pathway Glucagon signaling pathway Insulin signaling pathway
		KEGG metabolic	Pentose phosphate pathway Fructose and mannose metabolism Glycolysis / Gluconeogenesis Carbon metabolism
18	UFC1	ENSG00000143222	ubiquitin-fold modifier conjugating enzyme 1
		UniProt	Q9Y3C8
		NCBI	51506
16	IVD	ENSG00000128928	isovaleryl-CoA dehydrogenase
		UniProt	A0A087WVD3 A0A0A0MT83 A0A0S2Z4K7 H0YKV0 H0YLC3 H0YN10 H0YNA4 H0YNT5 H7C4G6 P26440
		NCBI	3712
		KEGG metabolic	Valine, leucine and isoleucine degradation
24	CTSD	ENSG00000117984	cathepsin D
		UniProt	A0A1B0GV01 A0A1B0GV23 A0A1B0GVD5 A0A1B0GVP3 A0A1B0GW44 A0A1B0GWE8 C9JH19 F8W787 F8WD96 H7C1V0 P07339
		NCBI	1509
		KEGG signaling	Apoptosis Estrogen signaling pathway Sphingolipid signaling pathway
		KEGG metabolic	Lysosome Autophagy - animal
22	RAB2A	ENSG00000104388	RAB2A, member RAS oncogene family
		UniProt	A0A1D5RMT4 E9PKL7 H0YD31 H0YDL5 H7C125 P61019
		NCBI	5862
		KEGG signaling	AMPK signaling pathway
12	ATG9A	ENSG00000198925	autophagy related 9A
		UniProt	C9IYZ9 C9JD65 C9JDK4 C9JFV2 C9JKV7 C9JS65 C9JX27 C9JXG2 F2Z3I6 H7C1G6 Q7Z3C6
		NCBI	79065
		KEGG metabolic	Autophagy - animal
25	ALDH7A1	ENSG00000164904	aldehyde dehydrogenase 7 family member A1
		UniProt	A0A0J9YWF7 A0A0J9YWK1 A0A0J9YWM6 A0A1B0GTG2 A0A1B0GTJ4 A0A1B0GTY9 A0A1B0GUA1 A0A1B0GUY0 A0A1B0GV49 A0A1B0GVU0 A0A1B0GW65 A0A1B0GW77 A0A1B0GW82 F8VVF2 F8WD33 F8WDY6 H0YHM6 P49419
		NCBI	501
		KEGG metabolic	Pyruvate metabolism Tryptophan metabolism Fatty acid degradation Valine, leucine and isoleucine degradation Glycine, serine and threonine metabolism Histidine metabolism Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Arginine and proline metabolism Glycerolipid metabolism beta-Alanine metabolism Lysine degradation
17	SERINC2	ENSG00000168528	serine incorporator 2
		UniProt	Q96SA4
		NCBI	347735
21	ESD	ENSG00000139684	esterase D
		UniProt	H7BZT7 P10768 U3KQT1 X6RA14
		NCBI	2098
		KEGG metabolic	Carbon metabolism
9	TP53I3	ENSG00000115129	tumor protein p53 inducible protein 3
		UniProt	H7BZH6 Q53FA7
		NCBI	9540
		KEGG signaling	p53 signaling pathway
10	C16orf70	ENSG00000125149	chromosome 16 open reading frame 70
		UniProt	H3BRA5 H3BS58 H3BSG0 J3QRI8 Q9BSU1
		NCBI	80262
18	MCCC1	ENSG00000078070	methylcrotonoyl-CoA carboxylase 1
		UniProt	E9PG35 E9PHF7 F2Z2Z7 F2Z3E2 F5GYT8 F8WDI3 F8WF46 G5E9X5 Q96RQ3
		NCBI	56922
		KEGG metabolic	Valine, leucine and isoleucine degradation
23	RAB5C	ENSG00000108774	RAB5C, member RAS oncogene family
		UniProt	F8VSF8 F8VVK3 F8VWU4 K7ENY4 P51148
		NCBI	5878
		KEGG signaling	Ras signaling pathway
		KEGG metabolic	Phagosome Endocytosis
20	FAH	ENSG00000103876	fumarylacetoacetate hydrolase
		UniProt	H0YLC7 H3BNP8 P16930
		NCBI	2184
		KEGG metabolic	Tyrosine metabolism
18	FBP1	ENSG00000165140	fructose-bisphosphatase 1
		UniProt	A0A3B3IUC7 P09467 Q5VZC3
		NCBI	2203
		KEGG signaling	AMPK signaling pathway Glucagon signaling pathway Insulin signaling pathway
		KEGG metabolic	Pentose phosphate pathway Fructose and mannose metabolism Glycolysis / Gluconeogenesis Carbon metabolism
24	HPD	ENSG00000158104	4-hydroxyphenylpyruvate dioxygenase
		UniProt	A0A0B4J1R4 P32754
		NCBI	3242
		KEGG metabolic	Phenylalanine metabolism Ubiquinone and other terpenoid-quinone biosynthesis Tyrosine metabolism
23	P4HB	ENSG00000185624	prolyl 4-hydroxylase subunit beta
		UniProt	H0Y3Z3 H7BZ94 I3L0S0 I3L1Y5 I3L312 I3L398 I3L3P5 I3L3U6 I3L4M2 I3L514 I3NI03 P07237
		NCBI	5034
		KEGG metabolic	Protein processing in endoplasmic reticulum
16	HADH	ENSG00000138796	hydroxyacyl-CoA dehydrogenase
		UniProt	A0A0A0MSE2 A0A0D9SFP2 A0A1W2PNM1 A0A1W2PP40 A0A1W2PQ55 A0A1W2PQ78 A0A1W2PQC2 A0A1W2PQV5 A0A1W2PRM6 A0A1W2PRT2 E9PF18 J3KR89 Q16836
		NCBI	3033
		KEGG metabolic	Tryptophan metabolism Fatty acid degradation Valine, leucine and isoleucine degradation Fatty acid elongation Butanoate metabolism Lysine degradation Fatty acid metabolism
15	PHYHD1	ENSG00000175287	phytanoyl-CoA dioxygenase domain containing 1
		UniProt	F8WCG7 G5E9M0 H7C2Q0 H7C3M4 I7HJS6 Q5SRE7 X6RCI6 X6RFQ9 X6RJK6
		NCBI	254295
20	GSS	ENSG00000100983	glutathione synthetase
		UniProt	A0A0S2Z4J7 A0A2R8Y2F2 A0A2R8Y2X9 A0A2R8Y430 A0A2R8Y446 A0A2R8Y4V9 A0A2R8Y5T7 A0A2R8Y6Q7 A0A2R8Y6Y6 A0A2R8Y790 A0A2R8Y7I7 A0A2R8YF34 P48637
		NCBI	2937
		KEGG metabolic	Cysteine and methionine metabolism Glutathione metabolism
18	RAB5A	ENSG00000144566	RAB5A, member RAS oncogene family
		UniProt	C9J3X8 F8WCY6 F8WD79 P20339
		NCBI	5868
		KEGG signaling	Ras signaling pathway
		KEGG metabolic	Phagosome Endocytosis
13	UPB1	ENSG00000100024	beta-ureidopropionase 1
		UniProt	F8WC94 Q6AHZ8 Q9UBR1
		NCBI	51733
		KEGG metabolic	Drug metabolism - other enzymes Pyrimidine metabolism Pantothenate and CoA biosynthesis beta-Alanine metabolism
8	ALDH8A1	ENSG00000118514	aldehyde dehydrogenase 8 family member A1
		UniProt	E9PKV1 H0YF40 Q9H2A2
		NCBI	64577
		KEGG metabolic	Tryptophan metabolism
5	PBLD	ENSG00000108187	phenazine biosynthesis like protein domain containing
		UniProt	A0A0C4DFS0 P30039 V9GY00
		NCBI	64081

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	273.78 KB
	H.sapiens_subnetwork.tsv	51.61 KB

Species:

Network information:

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Network appearance:

ENSG00000113924

PEPD

RAB5B

SGPL1

MTHFD1

SORD

FBXL2

FBP2

UFC1

IVD

CTSD

RAB2A

ATG9A

ALDH7A1

SERINC2

ESD

TP53I3

C16orf70

MCCC1

RAB5C

FAH

FBP1

HPD

P4HB

HADH

PHYHD1

GSS

RAB5A

UPB1

ALDH8A1

PBLD

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