Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000111445
3. replication factor C su…
- 2. RFC2
  3. replication factor C su…
  4. 1.000
  5. PPI
- 2. PCNA
  3. proliferating cell nucl…
  4. 1.000
  5. PPI
- 2. RFC4
  3. replication factor C su…
  4. 1.000
  5. PPI
- 2. RFC1
  3. replication factor C su…
  4. 1.000
  5. PPI
- 2. RUVBL2
  3. RuvB like AAA ATPase 2
  4. 1.000
  5. Complex
- 2. CHTF18
  3. chromosome transmission…
  4. 1.000
  5. PPI
- 2. RPA1
  3. replication protein A1
  4. 1.000
  5. PPI
- 2. RFC3
  3. replication factor C su…
  4. 1.000
  5. PPI
- 2. DSCC1
  3. DNA replication and sis…
  4. 1.000
  5. PPI
- 2. RUVBL1
  3. RuvB like AAA ATPase 1
  4. 1.000
  5. PPI
- 2. NOP56
  3. NOP56 ribonucleoprotein
  4. 1.000
  5. PPI
- 2. EED
  3. embryonic ectoderm deve…
  4. 1.000
  5. PPI
- 2. PRIM2
  3. DNA primase subunit 2
  4. 1.000
  5. Metabolic
- 2. EEF1A1
  3. eukaryotic translation …
  4. 1.000
  5. PPI
- 2. RPA3
  3. replication protein A3
  4. 1.000
  5. PPI
- 2. CDC5L
  3. cell division cycle 5 l…
  4. 1.000
  5. PPI
- 2. PRIM1
  3. DNA primase subunit 1
  4. 1.000
  5. Metabolic
- 2. GRWD1
  3. glutamate rich WD repea…
  4. 1.000
  5. Metabolic
- 2. RPA2
  3. replication protein A2
  4. 1.000
  5. PPI
- 2. VCP
  3. valosin containing prot…
  4. 1.000
  5. PPI
- 2. LIG1
  3. DNA ligase 1
  4. 1.000
  5. PPI
- 2. SUMO3
  3. small ubiquitin like mo…
  4. 0.999
  5. PPI
- 2. ECT2
  3. epithelial cell transfo…
  4. 0.999
  5. PPI
- 2. WDHD1
  3. WD repeat and HMG-box D…
  4. 0.999
  5. PPI
- 2. POLD1
  3. DNA polymerase delta 1,…
  4. 0.999
  5. Metabolic
- 2. SMARCAD1
  3. SWI/SNF-related, matrix…
  4. 0.999
  5. PPI
- 2. POLA1
  3. DNA polymerase alpha 1,…
  4. 0.999
  5. Metabolic
- 2. MCM2
  3. minichromosome maintena…
  4. 0.999
  5. Metabolic
- 2. SNW1
  3. SNW domain containing 1
  4. 0.999
  5. PPI
- 2. H2AX
  3. H2A.X variant histone
  4. 0.999
  5. Metabolic

Subnetwork gene interactions

ENSG00000111445

replication factor C subunit 5

FunCoup

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Ensembl

ENSG00000111445

UniProt

NCBI

5985

MCM2

minichromosome maintenance complex component 2

FunCoup

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Ensembl

ENSG00000073111

UniProt

NCBI

4171

RPA1

replication protein A1

FunCoup

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Ensembl

ENSG00000132383

UniProt

NCBI

6117

DSCC1

DNA replication and sister chromatid cohesion 1

FunCoup

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Ensembl

ENSG00000136982

UniProt

Q9BVC3

NCBI

79075

POLA1

DNA polymerase alpha 1, catalytic subunit

FunCoup

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Ensembl

ENSG00000101868

UniProt

NCBI

5422

PRIM1

DNA primase subunit 1

FunCoup

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Ensembl

ENSG00000198056

UniProt

NCBI

5557

POLD1

DNA polymerase delta 1, catalytic subunit

FunCoup

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Ensembl

ENSG00000062822

UniProt

NCBI

5424

CDC5L

cell division cycle 5 like

FunCoup

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Ensembl

ENSG00000096401

UniProt

Q99459

NCBI

GRWD1

glutamate rich WD repeat containing 1

FunCoup

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Ensembl

ENSG00000105447

UniProt

NCBI

83743

VCP

valosin containing protein

FunCoup

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Ensembl

ENSG00000165280

UniProt

NCBI

7415

H2AX

H2A.X variant histone

FunCoup

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Ensembl

ENSG00000188486

UniProt

P16104

NCBI

3014

LIG1

DNA ligase 1

FunCoup

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Ensembl

ENSG00000105486

UniProt

NCBI

3978

RFC2

replication factor C subunit 2

FunCoup

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Ensembl

ENSG00000049541

UniProt

NCBI

5982

SNW1

SNW domain containing 1

FunCoup

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Ensembl

ENSG00000100603

UniProt

NCBI

22938

PRIM2

DNA primase subunit 2

FunCoup

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Ensembl

ENSG00000146143

UniProt

NCBI

5558

RPA3

replication protein A3

FunCoup

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Ensembl

ENSG00000106399

UniProt

NCBI

6119

RPA2

replication protein A2

FunCoup

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Ensembl

ENSG00000117748

UniProt

NCBI

6118

EEF1A1

eukaryotic translation elongation factor 1 alpha 1

FunCoup

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Ensembl

ENSG00000156508

UniProt

NCBI

1915

RUVBL1

RuvB like AAA ATPase 1

FunCoup

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Ensembl

ENSG00000175792

UniProt

NCBI

8607

ECT2

epithelial cell transforming 2

FunCoup

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Ensembl

ENSG00000114346

UniProt

NCBI

1894

RFC4

replication factor C subunit 4

FunCoup

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Ensembl

ENSG00000163918

UniProt

NCBI

5984

WDHD1

WD repeat and HMG-box DNA binding protein 1

FunCoup

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Ensembl

ENSG00000198554

UniProt

NCBI

11169

SMARCAD1

SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1

FunCoup

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Ensembl

ENSG00000163104

UniProt

NCBI

56916

EED

embryonic ectoderm development

FunCoup

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Ensembl

ENSG00000074266

UniProt

NCBI

8726

PCNA

proliferating cell nuclear antigen

FunCoup

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Ensembl

ENSG00000132646

UniProt

P12004

NCBI

5111

NOP56

NOP56 ribonucleoprotein

FunCoup

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Ensembl

ENSG00000101361

UniProt

NCBI

10528

RUVBL2

RuvB like AAA ATPase 2

FunCoup

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Ensembl

ENSG00000183207

UniProt

NCBI

10856

CHTF18

chromosome transmission fidelity factor 18

FunCoup

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Ensembl

ENSG00000127586

UniProt

NCBI

63922

RFC3

replication factor C subunit 3

FunCoup

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Ensembl

ENSG00000133119

UniProt

NCBI

5983

RFC1

replication factor C subunit 1

FunCoup

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Ensembl

ENSG00000035928

UniProt

NCBI

5981

SUMO3

small ubiquitin like modifier 3

FunCoup

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Ensembl

ENSG00000184900

UniProt

NCBI

6612

Query genes

		Identifier	Description
30	ENSG00000111445	ENSG00000111445	replication factor C subunit 5
		UniProt	C9JH72 E9PEP3 F5H0U6 F5H304 F5H5S0 P40937
		NCBI	5985
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair

Subnetwork genes

		Identifier	Description
30	MCM2	ENSG00000073111	minichromosome maintenance complex component 2
		UniProt	C9J013 C9JZ21 F8WDM3 H0Y8E6 H7C4N9 P49736
		NCBI	4171
		KEGG signaling	Cell cycle
		KEGG metabolic	DNA replication
30	RPA1	ENSG00000132383	replication protein A1
		UniProt	I3L2M5 I3L4R8 I3L524 P27694
		NCBI	6117
		KEGG metabolic	DNA replication Fanconi anemia pathway Homologous recombination Mismatch repair Nucleotide excision repair
25	DSCC1	ENSG00000136982	DNA replication and sister chromatid cohesion 1
		UniProt	Q9BVC3
		NCBI	79075
29	POLA1	ENSG00000101868	DNA polymerase alpha 1, catalytic subunit
		UniProt	A0A087WU64 A0A5F9ZHW2 A6NMQ1 P09884
		NCBI	5422
		KEGG metabolic	DNA replication
30	PRIM1	ENSG00000198056	DNA primase subunit 1
		UniProt	A0A5F9ZHB6 F8VNY2 F8VSB2 H0YIP2 P49642
		NCBI	5557
		KEGG metabolic	DNA replication
29	POLD1	ENSG00000062822	DNA polymerase delta 1, catalytic subunit
		UniProt	A0A087WYJ2 A0A2R8Y705 A0A2R8Y7K6 M0QXE6 M0QXQ2 M0QZR8 M0R2B7 M0R2J2 P28340
		NCBI	5424
		KEGG metabolic	DNA replication Homologous recombination Mismatch repair Nucleotide excision repair Base excision repair
29	CDC5L	ENSG00000096401	cell division cycle 5 like
		UniProt	Q99459
		NCBI	988
		KEGG metabolic	Spliceosome
28	GRWD1	ENSG00000105447	glutamate rich WD repeat containing 1
		UniProt	M0QX71 Q9BQ67
		NCBI	83743
25	VCP	ENSG00000165280	valosin containing protein
		UniProt	C9IZA5 C9JUP7 P55072
		NCBI	7415
		KEGG metabolic	Protein processing in endoplasmic reticulum
26	H2AX	ENSG00000188486	H2A.X variant histone
		UniProt	P16104
		NCBI	3014
27	LIG1	ENSG00000105486	DNA ligase 1
		UniProt	B4E135 F5GZ28 M0QY71 M0R0Q7 M0R1G7 M0R1S4 M0R254 P18858
		NCBI	3978
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair Base excision repair
30	RFC2	ENSG00000049541	replication factor C subunit 2
		UniProt	A0A087WVY3 F8WC37 F8WDC9 H7C596 H7C5A0 H7C5G4 H7C5P1 H7C5P4 H7C5Q7 H7C5S7 P35250
		NCBI	5982
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair
21	SNW1	ENSG00000100603	SNW domain containing 1
		UniProt	G3V3A4 G3V4E0 G3V4X8 G3V5R3 Q13573
		NCBI	22938
		KEGG signaling	Notch signaling pathway
		KEGG metabolic	Spliceosome
30	PRIM2	ENSG00000146143	DNA primase subunit 2
		UniProt	A0A096LP51 A0A5F9ZHR0 A0A5F9ZHU7 P49643
		NCBI	5558
		KEGG metabolic	DNA replication
27	RPA3	ENSG00000106399	replication protein A3
		UniProt	B5MC59 P35244
		NCBI	6119
		KEGG metabolic	DNA replication Fanconi anemia pathway Homologous recombination Mismatch repair Nucleotide excision repair
29	RPA2	ENSG00000117748	replication protein A2
		UniProt	P15927 Q5TEJ0 Q5TEJ7
		NCBI	6118
		KEGG metabolic	DNA replication Fanconi anemia pathway Homologous recombination Mismatch repair Nucleotide excision repair
24	EEF1A1	ENSG00000156508	eukaryotic translation elongation factor 1 alpha 1
		UniProt	A0A087WV01 A0A087WVQ9 A6PW80 P68104 Q5JR01
		NCBI	1915
		KEGG metabolic	RNA transport
30	RUVBL1	ENSG00000175792	RuvB like AAA ATPase 1
		UniProt	E7ETR0 H7C4G5 H7C4I3 J3QLR1 Q9Y265
		NCBI	8607
		KEGG signaling	Wnt signaling pathway
20	ECT2	ENSG00000114346	epithelial cell transforming 2
		UniProt	C9J0L6 C9J1C4 C9JB41 C9JDB4 C9JDV9 C9JTI2 H7C103 H7C3G1 Q9H8V3
		NCBI	1894
30	RFC4	ENSG00000163918	replication factor C subunit 4
		UniProt	C9J8M3 C9JGY5 C9JTT7 C9JW34 C9JXZ7 C9JZI1 F8WE44 H7C1P0 P35249
		NCBI	5984
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair
28	WDHD1	ENSG00000198554	WD repeat and HMG-box DNA binding protein 1
		UniProt	C9JYB3 H3BSQ1 O75717
		NCBI	11169
26	SMARCAD1	ENSG00000163104	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
		UniProt	D6RAY8 F8W9M2 Q9H4L7
		NCBI	56916
25	EED	ENSG00000074266	embryonic ectoderm development
		UniProt	A0A5F9ZI63 E9PJK2 E9PMU3 H0YEL4 O75530
		NCBI	8726
30	PCNA	ENSG00000132646	proliferating cell nuclear antigen
		UniProt	P12004
		NCBI	5111
		KEGG signaling	Tight junction Cell cycle
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair Base excision repair
29	NOP56	ENSG00000101361	NOP56 ribonucleoprotein
		UniProt	A0A494C128 H0Y653 H0YDU4 O00567 Q5JXT2
		NCBI	10528
		KEGG metabolic	Ribosome biogenesis in eukaryotes
28	RUVBL2	ENSG00000183207	RuvB like AAA ATPase 2
		UniProt	A0A1W2PS22 A0A1W2PS48 M0QXI6 M0QXZ7 M0QYD8 M0R0Y3 M0R0Z0 Q9Y230 X6R2L4
		NCBI	10856
28	CHTF18	ENSG00000127586	chromosome transmission fidelity factor 18
		UniProt	A0A0D9SF58 E7EXA6 F8WCC1 H0Y7D3 H3BN43 H3BT35 Q8WVB6
		NCBI	63922
30	RFC3	ENSG00000133119	replication factor C subunit 3
		UniProt	A0A087X270 P40938
		NCBI	5983
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair
30	RFC1	ENSG00000035928	replication factor C subunit 1
		UniProt	A0A1W2PP02 D6RAD2 E0CX09 H0Y8U4 H0Y9P8 P35251
		NCBI	5981
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair
25	SUMO3	ENSG00000184900	small ubiquitin like modifier 3
		UniProt	A8MU27 A8MUA9 P55854
		NCBI	6612
		KEGG metabolic	RNA transport

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	345.23 KB
	H.sapiens_subnetwork.tsv	81.97 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000111445

MCM2

RPA1

DSCC1

POLA1

PRIM1

POLD1

CDC5L

GRWD1

VCP

H2AX

LIG1

RFC2

SNW1

PRIM2

RPA3

RPA2

EEF1A1

RUVBL1

ECT2

RFC4

WDHD1

SMARCAD1

EED

PCNA

NOP56

RUVBL2

CHTF18

RFC3

RFC1

SUMO3

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