Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000110108
3. transmembrane protein 1…
- 2. AIMP1
  3. aminoacyl tRNA syntheta…
  4. 1.000
  5. PPI
- 2. ATL3
  3. atlastin GTPase 3
  4. 0.996
  5. PPI
- 2. LMNA
  3. lamin A/C
  4. 0.992
  5. PPI
- 2. KLC2
  3. kinesin light chain 2
  4. 0.991
  5. PPI
- 2. ITPRIP
  3. inositol 1,4,5-trisphos…
  4. 0.985
  5. Complex
- 2. CRYAB
  3. crystallin alpha B
  4. 0.978
  5. PPI
- 2. RAB2A
  3. RAB2A, member RAS oncog…
  4. 0.977
  5. PPI
- 2. CALM1
  3. calmodulin 1
  4. 0.969
  5. PPI
- 2. HSPA9
  3. heat shock protein fami…
  4. 0.965
  5. Complex
- 2. VAPA
  3. VAMP associated protein…
  4. 0.956
  5. Complex
- 2. VAPB
  3. VAMP associated protein…
  4. 0.952
  5. Complex
- 2. MMGT1
  3. membrane magnesium tran…
  4. 0.950
  5. PPI
- 2. PRDX4
  3. peroxiredoxin 4
  4. 0.939
  5. Metabolic
- 2. CAPN1
  3. calpain 1
  4. 0.929
  5. Metabolic
- 2. GOLT1B
  3. golgi transport 1B
  4. 0.927
  5. PPI
- 2. HARS2
  3. histidyl-tRNA synthetas…
  4. 0.922
  5. Complex
- 2. CALR
  3. calreticulin
  4. 0.915
  5. Metabolic
- 2. STK4
  3. serine/threonine kinase…
  4. 0.902
  5. Complex
- 2. CLIC1
  3. chloride intracellular …
  4. 0.896
  5. Metabolic
- 2. RASSF1
  3. Ras association domain …
  4. 0.889
  5. Complex
- 2. CUL4B
  3. cullin 4B
  4. 0.888
  5. PPI
- 2. CISD2
  3. CDGSH iron sulfur domai…
  4. 0.880
  5. Complex
- 2. MCM2
  3. minichromosome maintena…
  4. 0.876
  5. PPI
- 2. MDH1
  3. malate dehydrogenase 1
  4. 0.860
  5. Metabolic
- 2. PDIA3
  3. protein disulfide isome…
  4. 0.854
  5. Metabolic
- 2. DYNC1H1
  3. dynein cytoplasmic 1 he…
  4. 0.852
  5. Metabolic
- 2. CYB5B
  3. cytochrome b5 type B
  4. 0.850
  5. Metabolic
- 2. RPL5
  3. ribosomal protein L5
  4. 0.845
  5. Metabolic
- 2. VCP
  3. valosin containing prot…
  4. 0.844
  5. Complex
- 2. LMAN2
  3. lectin, mannose binding…
  4. 0.833
  5. Metabolic

Subnetwork gene interactions

ENSG00000110108

transmembrane protein 109

FunCoup

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Ensembl

ENSG00000110108

UniProt

Q9BVC6

NCBI

79073

ATL3

atlastin GTPase 3

FunCoup

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Ensembl

ENSG00000184743

UniProt

NCBI

25923

PDIA3

protein disulfide isomerase family A member 3

FunCoup

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Ensembl

ENSG00000167004

UniProt

NCBI

2923

VAPA

VAMP associated protein A

FunCoup

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Ensembl

ENSG00000101558

UniProt

NCBI

9218

RASSF1

Ras association domain family member 1

FunCoup

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Ensembl

ENSG00000068028

UniProt

Q9NS23

NCBI

11186

CUL4B

cullin 4B

FunCoup

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Ensembl

ENSG00000158290

UniProt

NCBI

8450

VCP

valosin containing protein

FunCoup

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Ensembl

ENSG00000165280

UniProt

NCBI

7415

RPL5

ribosomal protein L5

FunCoup

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Ensembl

ENSG00000122406

UniProt

NCBI

6125

AIMP1

aminoacyl tRNA synthetase complex interacting multifunctional protein 1

FunCoup

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Ensembl

ENSG00000164022

UniProt

NCBI

9255

CYB5B

cytochrome b5 type B

FunCoup

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Ensembl

ENSG00000103018

UniProt

NCBI

80777

LMAN2

lectin, mannose binding 2

FunCoup

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Ensembl

ENSG00000169223

UniProt

NCBI

10960

CISD2

CDGSH iron sulfur domain 2

FunCoup

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Ensembl

ENSG00000145354

UniProt

NCBI

493856

MCM2

minichromosome maintenance complex component 2

FunCoup

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Ensembl

ENSG00000073111

UniProt

NCBI

4171

CALR

calreticulin

FunCoup

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Ensembl

ENSG00000179218

UniProt

NCBI

CALM1

calmodulin 1

FunCoup

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Ensembl

ENSG00000198668

UniProt

NCBI

MDH1

malate dehydrogenase 1

FunCoup

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Ensembl

ENSG00000014641

UniProt

NCBI

4190

PRDX4

peroxiredoxin 4

FunCoup

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Ensembl

ENSG00000123131

UniProt

NCBI

10549

DYNC1H1

dynein cytoplasmic 1 heavy chain 1

FunCoup

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Ensembl

ENSG00000197102

UniProt

NCBI

1778

LMNA

lamin A/C

FunCoup

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Ensembl

ENSG00000160789

UniProt

NCBI

4000

RAB2A

RAB2A, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000104388

UniProt

NCBI

5862

GOLT1B

golgi transport 1B

FunCoup

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Ensembl

ENSG00000111711

UniProt

NCBI

51026

KLC2

kinesin light chain 2

FunCoup

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Ensembl

ENSG00000174996

UniProt

NCBI

64837

HARS2

histidyl-tRNA synthetase 2, mitochondrial

FunCoup

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Ensembl

ENSG00000112855

UniProt

NCBI

23438

HSPA9

heat shock protein family A (Hsp70) member 9

FunCoup

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Ensembl

ENSG00000113013

UniProt

NCBI

3313

CLIC1

chloride intracellular channel 1

FunCoup

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Ensembl

ENSG00000213719

UniProt

O00299

NCBI

1192

CAPN1

calpain 1

FunCoup

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Ensembl

ENSG00000014216

UniProt

NCBI

VAPB

VAMP associated protein B and C

FunCoup

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Ensembl

ENSG00000124164

UniProt

NCBI

9217

STK4

serine/threonine kinase 4

FunCoup

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Ensembl

ENSG00000101109

UniProt

NCBI

6789

MMGT1

membrane magnesium transporter 1

FunCoup

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Ensembl

ENSG00000169446

UniProt

Q8N4V1

NCBI

93380

CRYAB

crystallin alpha B

FunCoup

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Ensembl

ENSG00000109846

UniProt

NCBI

1410

ITPRIP

inositol 1,4,5-trisphosphate receptor interacting protein

FunCoup

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Ensembl

ENSG00000148841

UniProt

NCBI

85450

Query genes

		Identifier	Description
30	ENSG00000110108	ENSG00000110108	transmembrane protein 109
		UniProt	Q9BVC6
		NCBI	79073

Subnetwork genes

		Identifier	Description
12	ATL3	ENSG00000184743	atlastin GTPase 3
		UniProt	F5GWF8 F5H6I7 Q6DD88
		NCBI	25923
22	PDIA3	ENSG00000167004	protein disulfide isomerase family A member 3
		UniProt	F8WBS6 F8WBW5 H7BZJ3 P30101
		NCBI	2923
		KEGG signaling	Antigen processing and presentation
		KEGG metabolic	Protein processing in endoplasmic reticulum
24	VAPA	ENSG00000101558	VAMP associated protein A
		UniProt	J3QKM9 Q9P0L0
		NCBI	9218
5	RASSF1	ENSG00000068028	Ras association domain family member 1
		UniProt	Q9NS23
		NCBI	11186
		KEGG signaling	Ras signaling pathway Hippo signaling pathway - multiple species Hippo signaling pathway
4	CUL4B	ENSG00000158290	cullin 4B
		UniProt	A6NE76 K4DI93 Q13620
		NCBI	8450
		KEGG metabolic	Ubiquitin mediated proteolysis Nucleotide excision repair
25	VCP	ENSG00000165280	valosin containing protein
		UniProt	C9IZA5 C9JUP7 P55072
		NCBI	7415
		KEGG metabolic	Protein processing in endoplasmic reticulum
19	RPL5	ENSG00000122406	ribosomal protein L5
		UniProt	A0A2R8Y4A2 A0A2R8Y6J3 P46777 Q5T7N0 R4GNJ2
		NCBI	6125
		KEGG metabolic	Ribosome
15	AIMP1	ENSG00000164022	aminoacyl tRNA synthetase complex interacting multifunctional protein 1
		UniProt	A0A5F9ZHC5 D6R937 Q12904
		NCBI	9255
18	CYB5B	ENSG00000103018	cytochrome b5 type B
		UniProt	A0A499FJ32 D6RFH4 H3BUX2 J3QR91 O43169
		NCBI	80777
22	LMAN2	ENSG00000169223	lectin, mannose binding 2
		UniProt	D6RBH1 D6RBV2 D6RDX1 D6RIU4 Q12907
		NCBI	10960
		KEGG metabolic	Protein processing in endoplasmic reticulum
10	CISD2	ENSG00000145354	CDGSH iron sulfur domain 2
		UniProt	A0A2R8Y4Y3 A0A2R8Y540 D6RCF4 I3L1N9 Q8N5K1
		NCBI	493856
15	MCM2	ENSG00000073111	minichromosome maintenance complex component 2
		UniProt	C9J013 C9JZ21 F8WDM3 H0Y8E6 H7C4N9 P49736
		NCBI	4171
		KEGG signaling	Cell cycle
		KEGG metabolic	DNA replication
23	CALR	ENSG00000179218	calreticulin
		UniProt	K7EJB9 K7EL50 K7ELE2 P27797
		NCBI	811
		KEGG signaling	Antigen processing and presentation
		KEGG metabolic	Phagosome Protein processing in endoplasmic reticulum
17	CALM1	ENSG00000198668	calmodulin 1
		UniProt	A0A590UK56 G3V226 G3V361 G3V479 M0QZ52 P0DP23 Q96HY3
		NCBI	801 805 808
		KEGG signaling	Calcium signaling pathway Apelin signaling pathway Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Phosphatidylinositol signaling system Neurotrophin signaling pathway Phototransduction Long-term potentiation Oocyte meiosis Rap1 signaling pathway Ras signaling pathway Olfactory transduction cAMP signaling pathway cGMP-PKG signaling pathway Melanogenesis Estrogen signaling pathway Dopaminergic synapse GnRH signaling pathway Glucagon signaling pathway C-type lectin receptor signaling pathway Oxytocin signaling pathway Insulin signaling pathway
14	MDH1	ENSG00000014641	malate dehydrogenase 1
		UniProt	A0A5K1VW95 B8ZZ51 B9A041 C9IZI0 C9JF79 C9JLV6 C9JRL4 F8WFC2 P40925
		NCBI	4190
		KEGG metabolic	Pyruvate metabolism Cysteine and methionine metabolism Citrate cycle (TCA cycle) Carbon metabolism Glyoxylate and dicarboxylate metabolism
19	PRDX4	ENSG00000123131	peroxiredoxin 4
		UniProt	A6NG45 A6NJJ0 H7C3T4 Q13162
		NCBI	10549
20	DYNC1H1	ENSG00000197102	dynein cytoplasmic 1 heavy chain 1
		UniProt	A0A2R8Y542 A0A2R8Y5T0 A0A2R8Y6H2 A0A2R8Y6I5 A0A2R8Y706 A0A2R8YFZ7 A0A2R8YGC7 H0YJ21 Q14204
		NCBI	1778
		KEGG metabolic	Phagosome
9	LMNA	ENSG00000160789	lamin A/C
		UniProt	A0A0C4DGC5 D6RB20 H0YAB0 P02545 Q3BDU5 Q5TCI8
		NCBI	4000
		KEGG signaling	Apoptosis
17	RAB2A	ENSG00000104388	RAB2A, member RAS oncogene family
		UniProt	A0A1D5RMT4 E9PKL7 H0YD31 H0YDL5 H7C125 P61019
		NCBI	5862
		KEGG signaling	AMPK signaling pathway
8	GOLT1B	ENSG00000111711	golgi transport 1B
		UniProt	F5GWD8 F5GXH6 F5H6U7 G3V1U5 Q9Y3E0
		NCBI	51026
8	KLC2	ENSG00000174996	kinesin light chain 2
		UniProt	A8MX29 A8MZ87 C9JHT2 E9PI24 E9PM83 E9PP09 E9PQ02 Q9H0B6
		NCBI	64837
6	HARS2	ENSG00000112855	histidyl-tRNA synthetase 2, mitochondrial
		UniProt	A0A2R8Y3N3 A0A2R8Y4X6 A0A2R8Y5E8 A0A2R8Y5P7 A0A2R8Y6I1 B4DQ67 D6R9M5 D6RB22 D6RJE6 P49590
		NCBI	23438
		KEGG metabolic	Aminoacyl-tRNA biosynthesis
23	HSPA9	ENSG00000113013	heat shock protein family A (Hsp70) member 9
		UniProt	A0A3B3ITI4 A0A3B3ITN1 D6RA73 D6RCD7 D6RDH7 D6RJI2 H0Y8K0 H0Y8S0 H0YBG6 P38646
		NCBI	3313
		KEGG metabolic	RNA degradation
20	CLIC1	ENSG00000213719	chloride intracellular channel 1
		UniProt	O00299
		NCBI	1192
17	CAPN1	ENSG00000014216	calpain 1
		UniProt	E9PIA9 E9PJA6 E9PJJ3 E9PL37 E9PLC9 E9PLX0 E9PMC6 E9PQB3 E9PRM1 E9PSA6 P07384
		NCBI	823
		KEGG signaling	Apoptosis
		KEGG metabolic	Protein processing in endoplasmic reticulum
15	VAPB	ENSG00000124164	VAMP associated protein B and C
		UniProt	E5RK64 O95292
		NCBI	9217
8	STK4	ENSG00000101109	serine/threonine kinase 4
		UniProt	A0A087WVN8 A0A087WYT4 F5H5B4 Q13043
		NCBI	6789
		KEGG signaling	Ras signaling pathway FoxO signaling pathway MAPK signaling pathway
8	MMGT1	ENSG00000169446	membrane magnesium transporter 1
		UniProt	Q8N4V1
		NCBI	93380
8	CRYAB	ENSG00000109846	crystallin alpha B
		UniProt	A0A024R3B9 E9PJL7 E9PNH7 E9PRA8 E9PS12 P02511
		NCBI	1410
		KEGG metabolic	Protein processing in endoplasmic reticulum
5	ITPRIP	ENSG00000148841	inositol 1,4,5-trisphosphate receptor interacting protein
		UniProt	Q8IWB1 X6RK76
		NCBI	85450

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	289.89 KB
	H.sapiens_subnetwork.tsv	40.00 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000110108

ATL3

PDIA3

VAPA

RASSF1

CUL4B

VCP

RPL5

AIMP1

CYB5B

LMAN2

CISD2

MCM2

CALR

CALM1

MDH1

PRDX4

DYNC1H1

LMNA

RAB2A

GOLT1B

KLC2

HARS2

HSPA9

CLIC1

CAPN1

VAPB

STK4

MMGT1

CRYAB

ITPRIP

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