Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000104687
3. glutathione-disulfide r…
- 2. GOT2
  3. glutamic-oxaloacetic tr…
  4. 0.990
  5. Metabolic
- 2. MCM2
  3. minichromosome maintena…
  4. 0.960
  5. PPI
- 2. ATP6V1C1
  3. ATPase H+ transporting …
  4. 0.954
  5. PPI
- 2. SHMT2
  3. serine hydroxymethyltra…
  4. 0.953
  5. Metabolic
- 2. NPEPPS
  3. aminopeptidase puromyci…
  4. 0.946
  5. Metabolic
- 2. PRDX1
  3. peroxiredoxin 1
  4. 0.930
  5. Metabolic
- 2. PSMA5
  3. proteasome 20S subunit …
  4. 0.927
  5. Metabolic
- 2. EIF4A1
  3. eukaryotic translation …
  4. 0.917
  5. Metabolic
- 2. RAN
  3. RAN, member RAS oncogen…
  4. 0.916
  5. Metabolic
- 2. SHMT1
  3. serine hydroxymethyltra…
  4. 0.913
  5. Metabolic
- 2. PSMB5
  3. proteasome 20S subunit …
  4. 0.901
  5. Metabolic
- 2. PSMA2
  3. proteasome 20S subunit …
  4. 0.896
  5. Metabolic
- 2. DNAJA2
  3. DnaJ heat shock protein…
  4. 0.887
  5. Metabolic
- 2. PTPA
  3. protein phosphatase 2 p…
  4. 0.881
  5. Metabolic
- 2. EEF2
  3. eukaryotic translation …
  4. 0.873
  5. Metabolic
- 2. VDAC1
  3. voltage dependent anion…
  4. 0.870
  5. Metabolic
- 2. VPS28
  3. VPS28 subunit of ESCRT-I
  4. 0.870
  5. Metabolic
- 2. DYNC1H1
  3. dynein cytoplasmic 1 he…
  4. 0.848
  5. Metabolic
- 2. CAP1
  3. cyclase associated acti…
  4. 0.845
  5. Metabolic
- 2. SLC17A5
  3. solute carrier family 1…
  4. 0.845
  5. Metabolic
- 2. PGD
  3. phosphogluconate dehydr…
  4. 0.844
  5. Metabolic
- 2. FH
  3. fumarate hydratase
  4. 0.843
  5. Metabolic
- 2. USP14
  3. ubiquitin specific pept…
  4. 0.843
  5. Complex
- 2. VDAC3
  3. voltage dependent anion…
  4. 0.839
  5. Metabolic
- 2. CSE1L
  3. chromosome segregation …
  4. 0.839
  5. Metabolic
- 2. PDIA3
  3. protein disulfide isome…
  4. 0.838
  5. Metabolic
- 2. ASL
  3. argininosuccinate lyase
  4. 0.837
  5. Metabolic
- 2. NUTF2
  3. nuclear transport facto…
  4. 0.835
  5. Metabolic
- 2. PSMB4
  3. proteasome 20S subunit …
  4. 0.833
  5. Metabolic
- 2. HSPA8
  3. heat shock protein fami…
  4. 0.833
  5. PPI

Subnetwork gene interactions

ENSG00000104687

glutathione-disulfide reductase

FunCoup

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Ensembl

ENSG00000104687

UniProt

NCBI

2936

DYNC1H1

dynein cytoplasmic 1 heavy chain 1

FunCoup

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Ensembl

ENSG00000197102

UniProt

NCBI

1778

CAP1

cyclase associated actin cytoskeleton regulatory protein 1

FunCoup

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Ensembl

ENSG00000131236

UniProt

NCBI

10487

RAN

RAN, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000132341

UniProt

NCBI

5901

PDIA3

protein disulfide isomerase family A member 3

FunCoup

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Ensembl

ENSG00000167004

UniProt

NCBI

2923

PTPA

protein phosphatase 2 phosphatase activator

FunCoup

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Ensembl

ENSG00000119383

UniProt

NCBI

5524

HSPA8

heat shock protein family A (Hsp70) member 8

FunCoup

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Ensembl

ENSG00000109971

UniProt

NCBI

3312

VPS28

VPS28 subunit of ESCRT-I

FunCoup

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Ensembl

ENSG00000160948

UniProt

NCBI

51160

MCM2

minichromosome maintenance complex component 2

FunCoup

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Ensembl

ENSG00000073111

UniProt

NCBI

4171

EIF4A1

eukaryotic translation initiation factor 4A1

FunCoup

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Ensembl

ENSG00000161960

UniProt

NCBI

1973

SHMT2

serine hydroxymethyltransferase 2

FunCoup

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Ensembl

ENSG00000182199

UniProt

NCBI

6472

SLC17A5

solute carrier family 17 member 5

FunCoup

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Ensembl

ENSG00000119899

UniProt

Q9NRA2

NCBI

26503

NUTF2

nuclear transport factor 2

FunCoup

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Ensembl

ENSG00000102898

UniProt

NCBI

10204

PSMA2

proteasome 20S subunit alpha 2

FunCoup

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Ensembl

ENSG00000106588

UniProt

NCBI

5683

PGD

phosphogluconate dehydrogenase

FunCoup

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Ensembl

ENSG00000142657

UniProt

NCBI

5226

DNAJA2

DnaJ heat shock protein family (Hsp40) member A2

FunCoup

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Ensembl

ENSG00000069345

UniProt

NCBI

10294

ATP6V1C1

ATPase H+ transporting V1 subunit C1

FunCoup

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Ensembl

ENSG00000155097

UniProt

NCBI

PSMB4

proteasome 20S subunit beta 4

FunCoup

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Ensembl

ENSG00000159377

UniProt

P28070

NCBI

5692

CSE1L

chromosome segregation 1 like

FunCoup

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Ensembl

ENSG00000124207

UniProt

P55060

NCBI

1434

FH

fumarate hydratase

FunCoup

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Ensembl

ENSG00000091483

UniProt

P07954

NCBI

2271

GOT2

glutamic-oxaloacetic transaminase 2

FunCoup

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Ensembl

ENSG00000125166

UniProt

NCBI

2806

PRDX1

peroxiredoxin 1

FunCoup

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Ensembl

ENSG00000117450

UniProt

NCBI

5052

USP14

ubiquitin specific peptidase 14

FunCoup

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Ensembl

ENSG00000101557

UniProt

NCBI

9097

VDAC1

voltage dependent anion channel 1

FunCoup

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Ensembl

ENSG00000213585

UniProt

NCBI

7416

VDAC3

voltage dependent anion channel 3

FunCoup

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Ensembl

ENSG00000078668

UniProt

NCBI

7419

PSMB5

proteasome 20S subunit beta 5

FunCoup

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Ensembl

ENSG00000100804

UniProt

NCBI

5693

PSMA5

proteasome 20S subunit alpha 5

FunCoup

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Ensembl

ENSG00000143106

UniProt

P28066

NCBI

5686

EEF2

eukaryotic translation elongation factor 2

FunCoup

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Ensembl

ENSG00000167658

UniProt

NCBI

1938

NPEPPS

aminopeptidase puromycin sensitive

FunCoup

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Ensembl

ENSG00000141279

UniProt

NCBI

9520

SHMT1

serine hydroxymethyltransferase 1

FunCoup

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Ensembl

ENSG00000176974

UniProt

NCBI

6470

ASL

argininosuccinate lyase

FunCoup

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Ensembl

ENSG00000126522

UniProt

NCBI

Query genes

		Identifier	Description
30	ENSG00000104687	ENSG00000104687	glutathione-disulfide reductase
		UniProt	A0A2R8YF59 H0YC68 P00390
		NCBI	2936
		KEGG metabolic	Glutathione metabolism

Subnetwork genes

		Identifier	Description
28	DYNC1H1	ENSG00000197102	dynein cytoplasmic 1 heavy chain 1
		UniProt	A0A2R8Y542 A0A2R8Y5T0 A0A2R8Y6H2 A0A2R8Y6I5 A0A2R8Y706 A0A2R8YFZ7 A0A2R8YGC7 H0YJ21 Q14204
		NCBI	1778
		KEGG metabolic	Phagosome
30	CAP1	ENSG00000131236	cyclase associated actin cytoskeleton regulatory protein 1
		UniProt	Q01518 Q5T0R1 Q5T0R2 Q5T0R3 Q5T0R4 Q5T0R5 Q5T0R6 Q5T0R7 Q5T0R8 Q5T0R9 Q5T0S3
		NCBI	10487
30	RAN	ENSG00000132341	RAN, member RAS oncogene family
		UniProt	A0A087X0W0 B4DV51 B5MDF5 F5H018 H0YFC6 J3KQE5 P62826
		NCBI	5901
		KEGG metabolic	Ribosome biogenesis in eukaryotes RNA transport
30	PDIA3	ENSG00000167004	protein disulfide isomerase family A member 3
		UniProt	F8WBS6 F8WBW5 H7BZJ3 P30101
		NCBI	2923
		KEGG signaling	Antigen processing and presentation
		KEGG metabolic	Protein processing in endoplasmic reticulum
29	PTPA	ENSG00000119383	protein phosphatase 2 phosphatase activator
		UniProt	A6PVN5 A6PVN6 A6PVN7 A6PVN8 A6PVN9 B4DDQ6 B7ZBP7 B7ZBP9 B7ZBQ0 C9IZ76 F6WIT2 H0Y562 H0Y6E5 Q15257 Q5T948 Q5T949 Q68CR8
		NCBI	5524
30	HSPA8	ENSG00000109971	heat shock protein family A (Hsp70) member 8
		UniProt	A8K7Q2 E9PI65 E9PK54 E9PKE3 E9PLF4 E9PM13 E9PN25 E9PN89 E9PNE6 E9PPY6 E9PQK7 E9PQQ4 E9PS65 P11142
		NCBI	3312
		KEGG signaling	Antigen processing and presentation MAPK signaling pathway Estrogen signaling pathway
		KEGG metabolic	Spliceosome Endocytosis Protein processing in endoplasmic reticulum
23	VPS28	ENSG00000160948	VPS28 subunit of ESCRT-I
		UniProt	E9PLM9 E9PM90 E9PQR7 E9PR04 Q9UK41
		NCBI	51160
		KEGG metabolic	Endocytosis
26	MCM2	ENSG00000073111	minichromosome maintenance complex component 2
		UniProt	C9J013 C9JZ21 F8WDM3 H0Y8E6 H7C4N9 P49736
		NCBI	4171
		KEGG signaling	Cell cycle
		KEGG metabolic	DNA replication
29	EIF4A1	ENSG00000161960	eukaryotic translation initiation factor 4A1
		UniProt	J3KRC2 J3KS25 J3KS93 J3KSP3 J3KSZ0 J3KT04 J3KT12 J3KTB5 J3KTN0 J3QKZ9 J3QL43 J3QL52 J3QLN6 J3QQP0 J3QR64 J3QRP5 J3QS69 P60842
		NCBI	1973
		KEGG metabolic	RNA transport
30	SHMT2	ENSG00000182199	serine hydroxymethyltransferase 2
		UniProt	G3V241 G3V2D2 G3V2E4 G3V2W0 G3V2Y1 G3V2Y4 G3V3C6 G3V3Y8 G3V4T0 G3V4W5 G3V4X0 G3V540 G3V5L0 H0YIZ0 P34897
		NCBI	6472
		KEGG metabolic	Glycine, serine and threonine metabolism One carbon pool by folate Biosynthesis of amino acids Carbon metabolism Glyoxylate and dicarboxylate metabolism
21	SLC17A5	ENSG00000119899	solute carrier family 17 member 5
		UniProt	Q9NRA2
		NCBI	26503
		KEGG metabolic	Lysosome
28	NUTF2	ENSG00000102898	nuclear transport factor 2
		UniProt	H3BRV9 P61970
		NCBI	10204
30	PSMA2	ENSG00000106588	proteasome 20S subunit alpha 2
		UniProt	C9JCK5 F8WEG3 H7C3A7 H7C402 P25787
		NCBI	5683
		KEGG metabolic	Proteasome
29	PGD	ENSG00000142657	phosphogluconate dehydrogenase
		UniProt	K7EJT3 K7ELN9 K7EM49 K7EMN2 K7EPF6 P52209
		NCBI	5226
		KEGG metabolic	Pentose phosphate pathway Glutathione metabolism Carbon metabolism
29	DNAJA2	ENSG00000069345	DnaJ heat shock protein family (Hsp40) member A2
		UniProt	A0A087WT48 I3L320 O60884
		NCBI	10294
		KEGG metabolic	Protein processing in endoplasmic reticulum
29	ATP6V1C1	ENSG00000155097	ATPase H+ transporting V1 subunit C1
		UniProt	E7EV59 P21283
		NCBI	528
		KEGG signaling	Synaptic vesicle cycle mTOR signaling pathway
		KEGG metabolic	Oxidative phosphorylation Phagosome
29	PSMB4	ENSG00000159377	proteasome 20S subunit beta 4
		UniProt	P28070
		NCBI	5692
		KEGG metabolic	Proteasome
29	CSE1L	ENSG00000124207	chromosome segregation 1 like
		UniProt	P55060
		NCBI	1434
28	FH	ENSG00000091483	fumarate hydratase
		UniProt	P07954
		NCBI	2271
		KEGG metabolic	Pyruvate metabolism Citrate cycle (TCA cycle) Carbon metabolism
28	GOT2	ENSG00000125166	glutamic-oxaloacetic transaminase 2
		UniProt	H3BRE7 P00505
		NCBI	2806
		KEGG metabolic	Fat digestion and absorption Phenylalanine, tyrosine and tryptophan biosynthesis Cysteine and methionine metabolism Phenylalanine metabolism Alanine, aspartate and glutamate metabolism Tyrosine metabolism Biosynthesis of amino acids Carbon metabolism 2-Oxocarboxylic acid metabolism Arginine biosynthesis Arginine and proline metabolism
30	PRDX1	ENSG00000117450	peroxiredoxin 1
		UniProt	A0A0A0MRQ5 A0A0A0MSI0 Q06830
		NCBI	5052
		KEGG metabolic	Peroxisome
30	USP14	ENSG00000101557	ubiquitin specific peptidase 14
		UniProt	A6NJA2 J3KS55 J3QQT6 P54578 R4GNB0
		NCBI	9097
30	VDAC1	ENSG00000213585	voltage dependent anion channel 1
		UniProt	C9JI87 P21796
		NCBI	7416
		KEGG signaling	NOD-like receptor signaling pathway cGMP-PKG signaling pathway Calcium signaling pathway
30	VDAC3	ENSG00000078668	voltage dependent anion channel 3
		UniProt	E5RFL1 E5RFP6 E5RHE1 E5RHZ6 E5RJN6 E5RK27 Q9Y277
		NCBI	7419
		KEGG signaling	NOD-like receptor signaling pathway cGMP-PKG signaling pathway Calcium signaling pathway
29	PSMB5	ENSG00000100804	proteasome 20S subunit beta 5
		UniProt	G3V3K3 G8JLC2 H0YJM8 P28074
		NCBI	5693
		KEGG metabolic	Proteasome
30	PSMA5	ENSG00000143106	proteasome 20S subunit alpha 5
		UniProt	P28066
		NCBI	5686
		KEGG metabolic	Proteasome
30	EEF2	ENSG00000167658	eukaryotic translation elongation factor 2
		UniProt	M0R0I6 P13639
		NCBI	1938
		KEGG signaling	AMPK signaling pathway Oxytocin signaling pathway
29	NPEPPS	ENSG00000141279	aminopeptidase puromycin sensitive
		UniProt	E9PI82 E9PJ74 E9PJF9 E9PJY4 E9PLK3 E9PP11 E9PPD4 E9PPZ2 E9PRQ5 H0YCQ5 H0YDG0 P55786
		NCBI	9520
29	SHMT1	ENSG00000176974	serine hydroxymethyltransferase 1
		UniProt	A0A087WTD8 J3KRK5 J3KRZ5 P34896
		NCBI	6470
		KEGG metabolic	Glycine, serine and threonine metabolism One carbon pool by folate Biosynthesis of amino acids Carbon metabolism Glyoxylate and dicarboxylate metabolism
22	ASL	ENSG00000126522	argininosuccinate lyase
		UniProt	A0A5F9ZHC6 A0A5F9ZHM8 A0A5F9ZI35 F8W943 P04424
		NCBI	435
		KEGG metabolic	Alanine, aspartate and glutamate metabolism Biosynthesis of amino acids Arginine biosynthesis

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	309.24 KB
	H.sapiens_subnetwork.tsv	88.16 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000104687

DYNC1H1

CAP1

RAN

PDIA3

PTPA

HSPA8

VPS28

MCM2

EIF4A1

SHMT2

SLC17A5

NUTF2

PSMA2

PGD

DNAJA2

ATP6V1C1

PSMB4

CSE1L

FH

GOT2

PRDX1

USP14

VDAC1

VDAC3

PSMB5

PSMA5

EEF2

NPEPPS

SHMT1

ASL

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