Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000095383
3. TBC1 domain family memb…
- 2. AURKA
  3. aurora kinase A
  4. 0.994
  5. PPI
- 2. CCND1
  3. cyclin D1
  4. 0.933
  5. PPI
- 2. CDC42
  3. cell division cycle 42
  4. 0.891
  5. PPI
- 2. GABARAPL1
  3. GABA type A receptor as…
  4. 0.810
  5. PPI
- 2. UBA1
  3. ubiquitin like modifier…
  4. 0.774
  5. Metabolic
- 2. SPTAN1
  3. spectrin alpha, non-ery…
  4. 0.765
  5. Complex
- 2. DNM1L
  3. dynamin 1 like
  4. 0.630
  5. Metabolic
- 2. PPM1B
  3. protein phosphatase, Mg…
  4. 0.606
  5. Metabolic
- 2. POLD1
  3. DNA polymerase delta 1,…
  4. 0.605
  5. Metabolic
- 2. PPM1A
  3. protein phosphatase, Mg…
  4. 0.561
  5. Metabolic
- 2. SF3B3
  3. splicing factor 3b subu…
  4. 0.553
  5. Metabolic
- 2. RAN
  3. RAN, member RAS oncogen…
  4. 0.520
  5. Metabolic
- 2. FEM1C
  3. fem-1 homolog C
  4. 0.509
  5. Metabolic
- 2. TTC4
  3. tetratricopeptide repea…
  4. 0.506
  5. Metabolic
- 2. MLH3
  3. mutL homolog 3
  4. 0.505
  5. PPI
- 2. SART3
  3. spliceosome associated …
  4. 0.464
  5. Metabolic
- 2. RFC1
  3. replication factor C su…
  4. 0.455
  5. Metabolic
- 2. MAPK14
  3. mitogen-activated prote…
  4. 0.444
  5. Metabolic
- 2. DDX11
  3. DEAD/H-box helicase 11
  4. 0.412
  5. Metabolic
- 2. CLCN5
  3. chloride voltage-gated …
  4. 0.407
  5. Metabolic
- 2. ACTR2
  3. actin related protein 2
  4. 0.406
  5. Complex
- 2. ANXA11
  3. annexin A11
  4. 0.406
  5. Metabolic

Subnetwork gene interactions

ENSG00000095383

TBC1 domain family member 2

FunCoup

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Ensembl

ENSG00000095383

UniProt

Q9BYX2

NCBI

55357

POLD1

DNA polymerase delta 1, catalytic subunit

FunCoup

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Ensembl

ENSG00000062822

UniProt

NCBI

5424

AURKA

aurora kinase A

FunCoup

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Ensembl

ENSG00000087586

UniProt

NCBI

6790

RAN

RAN, member RAS oncogene family

FunCoup

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Ensembl

ENSG00000132341

UniProt

NCBI

5901

CDC42

cell division cycle 42

FunCoup

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Ensembl

ENSG00000070831

UniProt

NCBI

RFC1

replication factor C subunit 1

FunCoup

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Ensembl

ENSG00000035928

UniProt

NCBI

5981

SF3B3

splicing factor 3b subunit 3

FunCoup

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Ensembl

ENSG00000189091

UniProt

NCBI

23450

SART3

spliceosome associated factor 3, U4/U6 recycling protein

FunCoup

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Ensembl

ENSG00000075856

UniProt

NCBI

9733

DNM1L

dynamin 1 like

FunCoup

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Ensembl

ENSG00000087470

UniProt

NCBI

10059

SPTAN1

spectrin alpha, non-erythrocytic 1

FunCoup

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Ensembl

ENSG00000197694

UniProt

NCBI

6709

PPM1A

protein phosphatase, Mg2+/Mn2+ dependent 1A

FunCoup

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Ensembl

ENSG00000100614

UniProt

NCBI

5494

MLH3

mutL homolog 3

FunCoup

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Ensembl

ENSG00000119684

UniProt

NCBI

27030

MAPK14

mitogen-activated protein kinase 14

FunCoup

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Ensembl

ENSG00000112062

UniProt

NCBI

1432

TTC4

tetratricopeptide repeat domain 4

FunCoup

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Ensembl

ENSG00000243725

UniProt

O95801

NCBI

7268

GABARAPL1

GABA type A receptor associated protein like 1

FunCoup

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Ensembl

ENSG00000139112

UniProt

NCBI

23710

UBA1

ubiquitin like modifier activating enzyme 1

FunCoup

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Ensembl

ENSG00000130985

UniProt

NCBI

7317

ACTR2

actin related protein 2

FunCoup

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Ensembl

ENSG00000138071

UniProt

NCBI

10097

ANXA11

annexin A11

FunCoup

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Ensembl

ENSG00000122359

UniProt

NCBI

DDX11

DEAD/H-box helicase 11

FunCoup

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Ensembl

ENSG00000013573

UniProt

NCBI

1663

FEM1C

fem-1 homolog C

FunCoup

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Ensembl

ENSG00000145780

UniProt

Q96JP0

NCBI

56929

CCND1

cyclin D1

FunCoup

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Ensembl

ENSG00000110092

UniProt

NCBI

CLCN5

chloride voltage-gated channel 5

FunCoup

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Ensembl

ENSG00000171365

UniProt

NCBI

1184

PPM1B

protein phosphatase, Mg2+/Mn2+ dependent 1B

FunCoup

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Ensembl

ENSG00000138032

UniProt

NCBI

5495

Query genes

		Identifier	Description
22	ENSG00000095383	ENSG00000095383	TBC1 domain family member 2
		UniProt	Q9BYX2
		NCBI	55357

Subnetwork genes

		Identifier	Description
12	POLD1	ENSG00000062822	DNA polymerase delta 1, catalytic subunit
		UniProt	A0A087WYJ2 A0A2R8Y705 A0A2R8Y7K6 M0QXE6 M0QXQ2 M0QZR8 M0R2B7 M0R2J2 P28340
		NCBI	5424
		KEGG metabolic	DNA replication Homologous recombination Mismatch repair Nucleotide excision repair Base excision repair
9	AURKA	ENSG00000087586	aurora kinase A
		UniProt	A3KFJ0 A3KFJ1 A3KFJ2 O14965 Q5QPD1 Q5QPD2 Q5QPD4
		NCBI	6790
		KEGG signaling	Oocyte meiosis Progesterone-mediated oocyte maturation
16	RAN	ENSG00000132341	RAN, member RAS oncogene family
		UniProt	A0A087X0W0 B4DV51 B5MDF5 F5H018 H0YFC6 J3KQE5 P62826
		NCBI	5901
		KEGG metabolic	Ribosome biogenesis in eukaryotes RNA transport
9	CDC42	ENSG00000070831	cell division cycle 42
		UniProt	A0A3B3IRV0 A0A494BZX6 A0A494C1M1 A0A590UJK8 P60953 Q5JYX0
		NCBI	998
		KEGG signaling	Leukocyte transendothelial migration MAPK signaling pathway VEGF signaling pathway Chemokine signaling pathway Neurotrophin signaling pathway Fc gamma R-mediated phagocytosis Rap1 signaling pathway Focal adhesion Ras signaling pathway Adherens junction Tight junction T cell receptor signaling pathway GnRH signaling pathway
		KEGG metabolic	Endocytosis
14	RFC1	ENSG00000035928	replication factor C subunit 1
		UniProt	A0A1W2PP02 D6RAD2 E0CX09 H0Y8U4 H0Y9P8 P35251
		NCBI	5981
		KEGG metabolic	DNA replication Mismatch repair Nucleotide excision repair
11	SF3B3	ENSG00000189091	splicing factor 3b subunit 3
		UniProt	H3BMB0 I3L4G7 J3QKV4 J3QL37 J3QRB2 Q15393
		NCBI	23450
		KEGG metabolic	Spliceosome
12	SART3	ENSG00000075856	spliceosome associated factor 3, U4/U6 recycling protein
		UniProt	A0A494C0L2 A0A499FI31 F8VVK9 F8VZM2 F8W667 H0YHU8 Q15020
		NCBI	9733
15	DNM1L	ENSG00000087470	dynamin 1 like
		UniProt	B4DDQ3 B4DPZ9 F8VR28 F8VUJ9 F8VYL3 F8VZ52 F8W1W3 H0YHY4 H0YI79 O00429
		NCBI	10059
		KEGG signaling	NOD-like receptor signaling pathway TNF signaling pathway
9	SPTAN1	ENSG00000197694	spectrin alpha, non-erythrocytic 1
		UniProt	A0A0D9SF54 A0A0D9SFF6 A0A0D9SFH4 A0A0D9SGF6 A0A1B0GTB7 A0A1B0GTD1 A0A1B0GUH3 A0A1B0GUN2 A0A1B0GV13 A0A1B0GW19 A0A1B0GWE2 A0A5F9ZHC3 Q13813
		NCBI	6709
		KEGG signaling	Apoptosis
9	PPM1A	ENSG00000100614	protein phosphatase, Mg2+/Mn2+ dependent 1A
		UniProt	E9PJN3 E9PKB5 E9PL75 E9PNE1 E9PP44 P35813
		NCBI	5494
		KEGG signaling	MAPK signaling pathway
1	MLH3	ENSG00000119684	mutL homolog 3
		UniProt	G3V384 G3V3E0 G3V419 H0YJ15 H0YJA3 H0YJB4 H0YJU3 Q9UHC1
		NCBI	27030
		KEGG metabolic	Mismatch repair
11	MAPK14	ENSG00000112062	mitogen-activated protein kinase 14
		UniProt	B4E0K5 B5TY33 E7EX54 H7C4E2 Q16539
		NCBI	1432
		KEGG signaling	MAPK signaling pathway Leukocyte transendothelial migration Adrenergic signaling in cardiomyocytes VEGF signaling pathway Sphingolipid signaling pathway Neurotrophin signaling pathway RIG-I-like receptor signaling pathway NOD-like receptor signaling pathway Fc epsilon RI signaling pathway Oocyte meiosis Rap1 signaling pathway Toll-like receptor signaling pathway FoxO signaling pathway T cell receptor signaling pathway Prolactin signaling pathway Dopaminergic synapse Relaxin signaling pathway Progesterone-mediated oocyte maturation GnRH signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway IL-17 signaling pathway Retrograde endocannabinoid signaling
15	TTC4	ENSG00000243725	tetratricopeptide repeat domain 4
		UniProt	O95801
		NCBI	7268
3	GABARAPL1	ENSG00000139112	GABA type A receptor associated protein like 1
		UniProt	A0A0G2JKT8 F5GX12 F5GYD9 F5GZY7 F5H007 G3V1T7 Q9H0R8
		NCBI	23710
		KEGG signaling	NOD-like receptor signaling pathway FoxO signaling pathway Apelin signaling pathway GABAergic synapse
		KEGG metabolic	Autophagy - animal
20	UBA1	ENSG00000130985	ubiquitin like modifier activating enzyme 1
		UniProt	P22314 Q5JRR6 Q5JRR9 Q5JRS0 Q5JRS1 Q5JRS2 Q5JRS3
		NCBI	7317
		KEGG metabolic	Ubiquitin mediated proteolysis
16	ACTR2	ENSG00000138071	actin related protein 2
		UniProt	A0A1B0GWD0 A0A1B0GWH0 F5H6T1 P61160
		NCBI	10097
		KEGG signaling	Tight junction
8	ANXA11	ENSG00000122359	annexin A11
		UniProt	H0Y6E1 P50995 Q5T0G7
		NCBI	311
8	DDX11	ENSG00000013573	DEAD/H-box helicase 11
		UniProt	B4DMS8 C9K0E8 F5GXJ8 F5GXL6 F5GYY1 F5H235 F5H2V9 F6WZM0 H0YFY8 H0YGL4 H0YGX9 Q96FC9 R4GNE1
		NCBI	1663
8	FEM1C	ENSG00000145780	fem-1 homolog C
		UniProt	Q96JP0
		NCBI	56929
3	CCND1	ENSG00000110092	cyclin D1
		UniProt	F5H437 P24385
		NCBI	595
		KEGG signaling	Thyroid hormone signaling pathway Hedgehog signaling pathway AMPK signaling pathway Apelin signaling pathway PI3K-Akt signaling pathway Hippo signaling pathway p53 signaling pathway Focal adhesion JAK-STAT signaling pathway Tight junction FoxO signaling pathway Wnt signaling pathway Cell cycle Prolactin signaling pathway Oxytocin signaling pathway
5	CLCN5	ENSG00000171365	chloride voltage-gated channel 5
		UniProt	A0A2R8Y6C4 A0A2R8YF14 A0A2R8YGW0 P51795 V9GYG7
		NCBI	1184
8	PPM1B	ENSG00000138032	protein phosphatase, Mg2+/Mn2+ dependent 1B
		UniProt	B8ZZF0 C9JIR6 O75688
		NCBI	5495
		KEGG signaling	MAPK signaling pathway

Enrichment analysis

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	jSquid_subnetworks.xml	206.66 KB
	H.sapiens_subnetwork.tsv	22.79 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000095383

POLD1

AURKA

RAN

CDC42

RFC1

SF3B3

SART3

DNM1L

SPTAN1

PPM1A

MLH3

MAPK14

TTC4

GABARAPL1

UBA1

ACTR2

ANXA11

DDX11

FEM1C

CCND1

CLCN5

PPM1B

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