Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000069966
3. G protein subunit beta 5
- 2. GNAI1
  3. G protein subunit alpha…
  4. 1.000
  5. PPI
- 2. GNAI2
  3. G protein subunit alpha…
  4. 1.000
  5. PPI
- 2. GNAI3
  3. G protein subunit alpha…
  4. 1.000
  5. PPI
- 2. GNAZ
  3. G protein subunit alpha…
  4. 1.000
  5. PPI
- 2. GNAO1
  3. G protein subunit alpha…
  4. 1.000
  5. PPI
- 2. GNA14
  3. G protein subunit alpha…
  4. 1.000
  5. PPI
- 2. GNAT2
  3. G protein subunit alpha…
  4. 1.000
  5. PPI
- 2. GNAT1
  3. G protein subunit alpha…
  4. 1.000
  5. PPI
- 2. GNAT3
  3. G protein subunit alpha…
  4. 1.000
  5. PPI
- 2. GNG2
  3. G protein subunit gamma…
  4. 1.000
  5. PPI
- 2. GNG3
  3. G protein subunit gamma…
  4. 1.000
  5. PPI
- 2. GNG7
  3. G protein subunit gamma…
  4. 0.999
  5. PPI
- 2. GNG13
  3. G protein subunit gamma…
  4. 0.999
  5. PPI
- 2. GNAL
  3. G protein subunit alpha…
  4. 0.997
  5. PPI
- 2. GNG5
  3. G protein subunit gamma…
  4. 0.997
  5. PPI
- 2. GNA12
  3. G protein subunit alpha…
  4. 0.995
  5. PPI
- 2. GNA11
  3. G protein subunit alpha…
  4. 0.995
  5. PPI
- 2. GNAQ
  3. G protein subunit alpha…
  4. 0.994
  5. PPI
- 2. RGS6
  3. regulator of G protein …
  4. 0.987
  5. PPI
- 2. GNA15
  3. G protein subunit alpha…
  4. 0.967
  5. PPI
- 2. CCT3
  3. chaperonin containing T…
  4. 0.962
  5. PPI
- 2. PFDN5
  3. prefoldin subunit 5
  4. 0.927
  5. PPI
- 2. OLFM2
  3. olfactomedin 2
  4. 0.925
  5. PPI
- 2. RGS7BP
  3. regulator of G protein …
  4. 0.916
  5. PPI
- 2. MAPK3
  3. mitogen-activated prote…
  4. 0.911
  5. PPI
- 2. CCT7
  3. chaperonin containing T…
  4. 0.908
  5. PPI
- 2. CIAPIN1
  3. cytokine induced apopto…
  4. 0.855
  5. Metabolic
- 2. NDRG4
  3. NDRG family member 4
  4. 0.827
  5. PPI
- 2. MAPK1
  3. mitogen-activated prote…
  4. 0.811
  5. PPI
- 2. MTOR
  3. mechanistic target of r…
  4. 0.759
  5. PPI

Subnetwork gene interactions

ENSG00000069966

G protein subunit beta 5

FunCoup

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Ensembl

ENSG00000069966

UniProt

NCBI

10681

MTOR

mechanistic target of rapamycin kinase

FunCoup

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Ensembl

ENSG00000198793

UniProt

NCBI

2475

GNAT1

G protein subunit alpha transducin 1

FunCoup

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Ensembl

ENSG00000114349

UniProt

NCBI

2779

GNAQ

G protein subunit alpha q

FunCoup

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Ensembl

ENSG00000156052

UniProt

NCBI

2776

GNAT3

G protein subunit alpha transducin 3

FunCoup

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Ensembl

ENSG00000214415

UniProt

A8MTJ3

NCBI

346562

GNAI2

G protein subunit alpha i2

FunCoup

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Ensembl

ENSG00000114353

UniProt

NCBI

2771

GNAO1

G protein subunit alpha o1

FunCoup

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Ensembl

ENSG00000087258

UniProt

NCBI

2775

GNAZ

G protein subunit alpha z

FunCoup

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Ensembl

ENSG00000128266

UniProt

P19086

NCBI

2781

GNAI3

G protein subunit alpha i3

FunCoup

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Ensembl

ENSG00000065135

UniProt

P08754

NCBI

2773

GNA11

G protein subunit alpha 11

FunCoup

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Ensembl

ENSG00000088256

UniProt

NCBI

2767

GNAL

G protein subunit alpha L

FunCoup

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Ensembl

ENSG00000141404

UniProt

NCBI

2774

GNAT2

G protein subunit alpha transducin 2

FunCoup

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Ensembl

ENSG00000134183

UniProt

NCBI

2780

GNG7

G protein subunit gamma 7

FunCoup

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Ensembl

ENSG00000176533

UniProt

NCBI

2788

PFDN5

prefoldin subunit 5

FunCoup

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Ensembl

ENSG00000123349

UniProt

NCBI

5204

CCT3

chaperonin containing TCP1 subunit 3

FunCoup

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Ensembl

ENSG00000163468

UniProt

NCBI

7203

MAPK1

mitogen-activated protein kinase 1

FunCoup

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Ensembl

ENSG00000100030

UniProt

P28482

NCBI

5594

GNAI1

G protein subunit alpha i1

FunCoup

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Ensembl

ENSG00000127955

UniProt

NCBI

2770

CCT7

chaperonin containing TCP1 subunit 7

FunCoup

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Ensembl

ENSG00000135624

UniProt

NCBI

10574

MAPK3

mitogen-activated protein kinase 3

FunCoup

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Ensembl

ENSG00000102882

UniProt

NCBI

5595

GNA14

G protein subunit alpha 14

FunCoup

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Ensembl

ENSG00000156049

UniProt

O95837

NCBI

9630

GNG3

G protein subunit gamma 3

FunCoup

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Ensembl

ENSG00000162188

UniProt

P63215

NCBI

2785

CIAPIN1

cytokine induced apoptosis inhibitor 1

FunCoup

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Ensembl

ENSG00000005194

UniProt

NCBI

57019

OLFM2

olfactomedin 2

FunCoup

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Ensembl

ENSG00000105088

UniProt

NCBI

93145

GNG5

G protein subunit gamma 5

FunCoup

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Ensembl

ENSG00000174021

UniProt

P63218

NCBI

2787

GNA15

G protein subunit alpha 15

FunCoup

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Ensembl

ENSG00000060558

UniProt

NCBI

2769

GNA12

G protein subunit alpha 12

FunCoup

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Ensembl

ENSG00000146535

UniProt

NCBI

2768

GNG2

G protein subunit gamma 2

FunCoup

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Ensembl

ENSG00000186469

UniProt

NCBI

54331

GNG13

G protein subunit gamma 13

FunCoup

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Ensembl

ENSG00000127588

UniProt

Q9P2W3

NCBI

51764

RGS6

regulator of G protein signaling 6

FunCoup

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Ensembl

ENSG00000182732

UniProt

NCBI

9628

NDRG4

NDRG family member 4

FunCoup

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Ensembl

ENSG00000103034

UniProt

NCBI

65009

RGS7BP

regulator of G protein signaling 7 binding protein

FunCoup

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Ensembl

ENSG00000186479

UniProt

Q6MZT1

NCBI

401190

Query genes

		Identifier	Description
30	ENSG00000069966	ENSG00000069966	G protein subunit beta 5
		UniProt	H0YLU1 H0YNW7 O14775 Q96F32
		NCBI	10681
		KEGG signaling	Ras signaling pathway Dopaminergic synapse Apelin signaling pathway Relaxin signaling pathway PI3K-Akt signaling pathway GABAergic synapse Chemokine signaling pathway Serotonergic synapse Cholinergic synapse Glutamatergic synapse Retrograde endocannabinoid signaling

Subnetwork genes

		Identifier	Description
15	MTOR	ENSG00000198793	mechanistic target of rapamycin kinase
		UniProt	B1AKP8 B1AKQ2 P42345
		NCBI	2475
		KEGG signaling	Adipocytokine signaling pathway JAK-STAT signaling pathway ErbB signaling pathway Thyroid hormone signaling pathway HIF-1 signaling pathway AMPK signaling pathway PI3K-Akt signaling pathway Apelin signaling pathway mTOR signaling pathway Phospholipase D signaling pathway Insulin signaling pathway
		KEGG metabolic	Autophagy - animal
4	GNAT1	ENSG00000114349	G protein subunit alpha transducin 1
		UniProt	C9JCV8 P11488
		NCBI	2779
		KEGG signaling	Phototransduction
6	GNAQ	ENSG00000156052	G protein subunit alpha q
		UniProt	B1AM21 P50148
		NCBI	2776
		KEGG signaling	Calcium signaling pathway Apelin signaling pathway Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Sphingolipid signaling pathway Long-term potentiation Rap1 signaling pathway Long-term depression Gap junction cGMP-PKG signaling pathway Melanogenesis Estrogen signaling pathway Dopaminergic synapse Serotonergic synapse Cholinergic synapse GnRH signaling pathway Glucagon signaling pathway Glutamatergic synapse Retrograde endocannabinoid signaling Oxytocin signaling pathway
8	GNAT3	ENSG00000214415	G protein subunit alpha transducin 3
		UniProt	A8MTJ3
		NCBI	346562
		KEGG signaling	Taste transduction
		KEGG metabolic	Carbohydrate digestion and absorption
17	GNAI2	ENSG00000114353	G protein subunit alpha i2
		UniProt	F8WBG4 F8WE78 P04899
		NCBI	2771
		KEGG signaling	Leukocyte transendothelial migration Apelin signaling pathway Adrenergic signaling in cardiomyocytes Chemokine signaling pathway Sphingolipid signaling pathway Rap1 signaling pathway Long-term depression cAMP signaling pathway Gap junction cGMP-PKG signaling pathway Melanogenesis Estrogen signaling pathway Dopaminergic synapse Relaxin signaling pathway Progesterone-mediated oocyte maturation GABAergic synapse Serotonergic synapse Cholinergic synapse Glutamatergic synapse Oxytocin signaling pathway Retrograde endocannabinoid signaling
13	GNAO1	ENSG00000087258	G protein subunit alpha o1
		UniProt	A0A087WTB6 A0A1W2PP38 A0A1W2PP87 A0A1W2PPG6 A0A1W2PQ24 A0A1W2PQK2 A0A1W2PRE1 A0A1W2PRJ7 A0A1W2PS82 H3BNR5 H3BTM2 P09471
		NCBI	2775
		KEGG signaling	Rap1 signaling pathway Long-term depression Melanogenesis Estrogen signaling pathway Dopaminergic synapse Relaxin signaling pathway GABAergic synapse Serotonergic synapse Cholinergic synapse Glutamatergic synapse Oxytocin signaling pathway Retrograde endocannabinoid signaling
8	GNAZ	ENSG00000128266	G protein subunit alpha z
		UniProt	P19086
		NCBI	2781
		KEGG signaling	Long-term depression
18	GNAI3	ENSG00000065135	G protein subunit alpha i3
		UniProt	P08754
		NCBI	2773
		KEGG signaling	Leukocyte transendothelial migration Apelin signaling pathway Adrenergic signaling in cardiomyocytes Chemokine signaling pathway Sphingolipid signaling pathway Rap1 signaling pathway Long-term depression cAMP signaling pathway Gap junction cGMP-PKG signaling pathway Melanogenesis Dopaminergic synapse Relaxin signaling pathway Estrogen signaling pathway Progesterone-mediated oocyte maturation GABAergic synapse Serotonergic synapse Cholinergic synapse Glutamatergic synapse Retrograde endocannabinoid signaling Oxytocin signaling pathway
10	GNA11	ENSG00000088256	G protein subunit alpha 11
		UniProt	A0A087WVZ3 K7EL62 P29992
		NCBI	2767
		KEGG signaling	Long-term depression Gap junction cGMP-PKG signaling pathway Calcium signaling pathway Vascular smooth muscle contraction Cholinergic synapse GnRH signaling pathway
3	GNAL	ENSG00000141404	G protein subunit alpha L
		UniProt	K7EMY6 K7EPE2 K7EQ80 P38405
		NCBI	2774
		KEGG signaling	Olfactory transduction Calcium signaling pathway Dopaminergic synapse
9	GNAT2	ENSG00000134183	G protein subunit alpha transducin 2
		UniProt	A0A087WZE5 P19087
		NCBI	2780
		KEGG signaling	Phototransduction
5	GNG7	ENSG00000176533	G protein subunit gamma 7
		UniProt	K7ESC6 O60262
		NCBI	2788
		KEGG signaling	Ras signaling pathway Olfactory transduction Dopaminergic synapse Apelin signaling pathway Relaxin signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway GABAergic synapse Serotonergic synapse Cholinergic synapse Glutamatergic synapse Retrograde endocannabinoid signaling
5	PFDN5	ENSG00000123349	prefoldin subunit 5
		UniProt	F8VNW6 F8VQZ2 H3BMQ1 H3BPF6 Q99471
		NCBI	5204
15	CCT3	ENSG00000163468	chaperonin containing TCP1 subunit 3
		UniProt	B4DUR8 E9PM09 E9PQ35 E9PRC8 E9PRM9 E9PRN0 P49368 Q5SZW8 Q5SZX6 Q5SZX9
		NCBI	7203
14	MAPK1	ENSG00000100030	mitogen-activated protein kinase 1
		UniProt	P28482
		NCBI	5594
		KEGG signaling	Adrenergic signaling in cardiomyocytes Chemokine signaling pathway Fc gamma R-mediated phagocytosis NOD-like receptor signaling pathway Fc epsilon RI signaling pathway Toll-like receptor signaling pathway FoxO signaling pathway cAMP signaling pathway B cell receptor signaling pathway Gap junction T cell receptor signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway TGF-beta signaling pathway PI3K-Akt signaling pathway mTOR signaling pathway Phospholipase D signaling pathway Vascular smooth muscle contraction Sphingolipid signaling pathway Oocyte meiosis Focal adhesion Prolactin signaling pathway Melanogenesis Estrogen signaling pathway Progesterone-mediated oocyte maturation GnRH signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Neurotrophin signaling pathway Long-term potentiation Adherens junction Relaxin signaling pathway Serotonergic synapse Cholinergic synapse Glutamatergic synapse Retrograde endocannabinoid signaling Oxytocin signaling pathway MAPK signaling pathway Apelin signaling pathway VEGF signaling pathway Rap1 signaling pathway Long-term depression Ras signaling pathway Apoptosis Natural killer cell mediated cytotoxicity ErbB signaling pathway IL-17 signaling pathway
		KEGG metabolic	Autophagy - animal
16	GNAI1	ENSG00000127955	G protein subunit alpha i1
		UniProt	A0A3B3IRK0 A0A3B3IS42 A0A3B3ITG4 A0A3B3ITM0 A0A3B3ITX3 A0A3B3IU77 A0A3B3IUA8 P63096
		NCBI	2770
		KEGG signaling	Leukocyte transendothelial migration Apelin signaling pathway Adrenergic signaling in cardiomyocytes Chemokine signaling pathway Sphingolipid signaling pathway Rap1 signaling pathway Long-term depression cAMP signaling pathway Gap junction cGMP-PKG signaling pathway Melanogenesis Estrogen signaling pathway Dopaminergic synapse Relaxin signaling pathway Progesterone-mediated oocyte maturation GABAergic synapse Serotonergic synapse Cholinergic synapse Glutamatergic synapse Oxytocin signaling pathway Retrograde endocannabinoid signaling
10	CCT7	ENSG00000135624	chaperonin containing TCP1 subunit 7
		UniProt	A0A0D9SG95 F8WAM2 F8WBP8 Q99832
		NCBI	10574
13	MAPK3	ENSG00000102882	mitogen-activated protein kinase 3
		UniProt	B3KR49 E9PBK7 E9PJF0 E9PQW4 E9PRH7 H0YDH9 H0YEX6 P27361
		NCBI	5595
		KEGG signaling	Adrenergic signaling in cardiomyocytes Chemokine signaling pathway Fc gamma R-mediated phagocytosis NOD-like receptor signaling pathway Fc epsilon RI signaling pathway Toll-like receptor signaling pathway FoxO signaling pathway B cell receptor signaling pathway cAMP signaling pathway Gap junction HIF-1 signaling pathway cGMP-PKG signaling pathway T cell receptor signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway TGF-beta signaling pathway PI3K-Akt signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Phospholipase D signaling pathway Sphingolipid signaling pathway Oocyte meiosis Focal adhesion Prolactin signaling pathway Melanogenesis Estrogen signaling pathway Progesterone-mediated oocyte maturation GnRH signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Neurotrophin signaling pathway Long-term potentiation Adherens junction Relaxin signaling pathway Serotonergic synapse Cholinergic synapse Glutamatergic synapse Oxytocin signaling pathway Retrograde endocannabinoid signaling MAPK signaling pathway Apelin signaling pathway VEGF signaling pathway Long-term depression Rap1 signaling pathway Ras signaling pathway Apoptosis Natural killer cell mediated cytotoxicity ErbB signaling pathway IL-17 signaling pathway
		KEGG metabolic	Autophagy - animal
4	GNA14	ENSG00000156049	G protein subunit alpha 14
		UniProt	O95837
		NCBI	9630
		KEGG signaling	Calcium signaling pathway
9	GNG3	ENSG00000162188	G protein subunit gamma 3
		UniProt	P63215
		NCBI	2785
		KEGG signaling	Ras signaling pathway Dopaminergic synapse Apelin signaling pathway Relaxin signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway GABAergic synapse Serotonergic synapse Cholinergic synapse Glutamatergic synapse Retrograde endocannabinoid signaling
2	CIAPIN1	ENSG00000005194	cytokine induced apoptosis inhibitor 1
		UniProt	H3BPG7 H3BQ23 H3BT65 H3BTT4 H3BTZ8 H3BUG4 H3BV90 Q6FI81
		NCBI	57019
1	OLFM2	ENSG00000105088	olfactomedin 2
		UniProt	K7EIS8 K7EKW2 K7ELC6 O95897
		NCBI	93145
5	GNG5	ENSG00000174021	G protein subunit gamma 5
		UniProt	P63218
		NCBI	2787
		KEGG signaling	Ras signaling pathway Dopaminergic synapse Apelin signaling pathway Relaxin signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway GABAergic synapse Serotonergic synapse Cholinergic synapse Glutamatergic synapse Retrograde endocannabinoid signaling
1	GNA15	ENSG00000060558	G protein subunit alpha 15
		UniProt	K7EP74 P30679
		NCBI	2769
		KEGG signaling	Calcium signaling pathway Relaxin signaling pathway
5	GNA12	ENSG00000146535	G protein subunit alpha 12
		UniProt	C9J2Y7 E9PC54 Q03113
		NCBI	2768
		KEGG signaling	Long-term depression cGMP-PKG signaling pathway MAPK signaling pathway Phospholipase D signaling pathway Vascular smooth muscle contraction Sphingolipid signaling pathway
7	GNG2	ENSG00000186469	G protein subunit gamma 2
		UniProt	G3V2C9 G3V2N0 G3V2W5 G3V3J9 G3V415 P59768
		NCBI	54331
		KEGG signaling	Ras signaling pathway Dopaminergic synapse Apelin signaling pathway Relaxin signaling pathway PI3K-Akt signaling pathway GABAergic synapse Chemokine signaling pathway Serotonergic synapse Cholinergic synapse Glutamatergic synapse Retrograde endocannabinoid signaling
4	GNG13	ENSG00000127588	G protein subunit gamma 13
		UniProt	Q9P2W3
		NCBI	51764
		KEGG signaling	Apelin signaling pathway PI3K-Akt signaling pathway Chemokine signaling pathway Taste transduction Ras signaling pathway Olfactory transduction Dopaminergic synapse Relaxin signaling pathway GABAergic synapse Serotonergic synapse Cholinergic synapse Glutamatergic synapse Retrograde endocannabinoid signaling
1	RGS6	ENSG00000182732	regulator of G protein signaling 6
		UniProt	A0A087WTW9 A0A0A0MRA9 A0A2R8Y8A2 B7Z2N1 B7Z7N5 P49758
		NCBI	9628
1	NDRG4	ENSG00000103034	NDRG family member 4
		UniProt	B7Z9X4 H3BM40 H3BM44 H3BM83 H3BMG5 H3BMR6 H3BN53 H3BN97 H3BNB4 H3BNE7 H3BNK4 H3BNQ1 H3BNX9 H3BPH8 H3BPQ3 H3BPT6 H3BPY2 H3BQ01 H3BQ86 H3BQJ4 H3BR92 H3BRT9 H3BS80 H3BSC3 H3BST8 H3BU08 H3BU25 H3BUH4 H3BUK1 H3BVB0 H3BVF3 Q9ULP0
		NCBI	65009
1	RGS7BP	ENSG00000186479	regulator of G protein signaling 7 binding protein
		UniProt	Q6MZT1
		NCBI	401190

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

To use PathwAX, first use the button below to copy the subnetwork genes and then paste them in PathwAX

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	jSquid_subnetworks.xml	269.91 KB
	H.sapiens_subnetwork.tsv	21.04 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000069966

MTOR

GNAT1

GNAQ

GNAT3

GNAI2

GNAO1

GNAZ

GNAI3

GNA11

GNAL

GNAT2

GNG7

PFDN5

CCT3

MAPK1

GNAI1

CCT7

MAPK3

GNA14

GNG3

CIAPIN1

OLFM2

GNG5

GNA15

GNA12

GNG2

GNG13

RGS6

NDRG4

RGS7BP

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