Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000069535
3. monoamine oxidase B
- 2. PGRMC1
  3. progesterone receptor m…
  4. 0.945
  5. Metabolic
- 2. BPHL
  3. biphenyl hydrolase like
  4. 0.939
  5. Metabolic
- 2. ATP2B2
  3. ATPase plasma membrane …
  4. 0.928
  5. PPI
- 2. NNT
  3. nicotinamide nucleotide…
  4. 0.916
  5. Metabolic
- 2. MTARC2
  3. mitochondrial amidoxime…
  4. 0.897
  5. Metabolic
- 2. SORD
  3. sorbitol dehydrogenase
  4. 0.865
  5. Metabolic
- 2. DDC
  3. dopa decarboxylase
  4. 0.846
  5. Metabolic
- 2. CAT
  3. catalase
  4. 0.831
  5. Metabolic
- 2. CYB5A
  3. cytochrome b5 type A
  4. 0.823
  5. Metabolic
- 2. ACADM
  3. acyl-CoA dehydrogenase …
  4. 0.815
  5. Metabolic
- 2. ASS1
  3. argininosuccinate synth…
  4. 0.813
  5. Metabolic
- 2. MAOA
  3. monoamine oxidase A
  4. 0.776
  5. Metabolic
- 2. HADHB
  3. hydroxyacyl-CoA dehydro…
  4. 0.736
  5. Metabolic
- 2. KMO
  3. kynurenine 3-monooxygen…
  4. 0.729
  5. Metabolic
- 2. VAT1
  3. vesicle amine transport…
  4. 0.726
  5. Complex
- 2. ULK1
  3. unc-51 like autophagy a…
  4. 0.715
  5. Metabolic
- 2. ETFDH
  3. electron transfer flavo…
  4. 0.699
  5. Metabolic
- 2. MGST1
  3. microsomal glutathione …
  4. 0.694
  5. Metabolic
- 2. OTC
  3. ornithine carbamoyltran…
  4. 0.692
  5. Metabolic
- 2. CRAT
  3. carnitine O-acetyltrans…
  4. 0.687
  5. Metabolic
- 2. FAM210B
  3. family with sequence si…
  4. 0.657
  5. Metabolic
- 2. LPIN1
  3. lipin 1
  4. 0.652
  5. Metabolic
- 2. MAPK3
  3. mitogen-activated prote…
  4. 0.636
  5. Metabolic
- 2. FECH
  3. ferrochelatase
  4. 0.627
  5. Metabolic
- 2. TRAP1
  3. TNF receptor associated…
  4. 0.627
  5. Metabolic
- 2. IVD
  3. isovaleryl-CoA dehydrog…
  4. 0.619
  5. Metabolic
- 2. BDH1
  3. 3-hydroxybutyrate dehyd…
  4. 0.579
  5. Metabolic
- 2. AIFM1
  3. apoptosis inducing fact…
  4. 0.573
  5. Metabolic
- 2. ALDH2
  3. aldehyde dehydrogenase …
  4. 0.571
  5. Metabolic
- 2. HEXA
  3. hexosaminidase subunit …
  4. 0.567
  5. Metabolic

Subnetwork gene interactions

ENSG00000069535

monoamine oxidase B

FunCoup

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Ensembl

ENSG00000069535

UniProt

P27338

NCBI

4129

OTC

ornithine carbamoyltransferase

FunCoup

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Ensembl

ENSG00000036473

UniProt

NCBI

5009

SORD

sorbitol dehydrogenase

FunCoup

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Ensembl

ENSG00000140263

UniProt

NCBI

6652

IVD

isovaleryl-CoA dehydrogenase

FunCoup

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Ensembl

ENSG00000128928

UniProt

NCBI

3712

ACADM

acyl-CoA dehydrogenase medium chain

FunCoup

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Ensembl

ENSG00000117054

UniProt

NCBI

FECH

ferrochelatase

FunCoup

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Ensembl

ENSG00000066926

UniProt

NCBI

2235

AIFM1

apoptosis inducing factor mitochondria associated 1

FunCoup

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Ensembl

ENSG00000156709

UniProt

NCBI

9131

CRAT

carnitine O-acetyltransferase

FunCoup

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Ensembl

ENSG00000095321

UniProt

NCBI

1384

BPHL

biphenyl hydrolase like

FunCoup

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Ensembl

ENSG00000137274

UniProt

NCBI

TRAP1

TNF receptor associated protein 1

FunCoup

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Ensembl

ENSG00000126602

UniProt

NCBI

10131

ASS1

argininosuccinate synthase 1

FunCoup

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Ensembl

ENSG00000130707

UniProt

NCBI

MGST1

microsomal glutathione S-transferase 1

FunCoup

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Ensembl

ENSG00000008394

UniProt

NCBI

4257

ETFDH

electron transfer flavoprotein dehydrogenase

FunCoup

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Ensembl

ENSG00000171503

UniProt

NCBI

2110

PGRMC1

progesterone receptor membrane component 1

FunCoup

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Ensembl

ENSG00000101856

UniProt

O00264

NCBI

10857

CYB5A

cytochrome b5 type A

FunCoup

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Ensembl

ENSG00000166347

UniProt

NCBI

1528

HADHB

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

FunCoup

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Ensembl

ENSG00000138029

UniProt

NCBI

3032

MAPK3

mitogen-activated protein kinase 3

FunCoup

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Ensembl

ENSG00000102882

UniProt

NCBI

5595

MTARC2

mitochondrial amidoxime reducing component 2

FunCoup

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Ensembl

ENSG00000117791

UniProt

NCBI

54996

ALDH2

aldehyde dehydrogenase 2 family member

FunCoup

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Ensembl

ENSG00000111275

UniProt

NCBI

MAOA

monoamine oxidase A

FunCoup

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Ensembl

ENSG00000189221

UniProt

P21397

NCBI

4128

LPIN1

lipin 1

FunCoup

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Ensembl

ENSG00000134324

UniProt

NCBI

23175

CAT

catalase

FunCoup

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Ensembl

ENSG00000121691

UniProt

NCBI

BDH1

3-hydroxybutyrate dehydrogenase 1

FunCoup

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Ensembl

ENSG00000161267

UniProt

NCBI

ULK1

unc-51 like autophagy activating kinase 1

FunCoup

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Ensembl

ENSG00000177169

UniProt

O75385

NCBI

8408

VAT1

vesicle amine transport 1

FunCoup

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Ensembl

ENSG00000108828

UniProt

NCBI

10493

DDC

dopa decarboxylase

FunCoup

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Ensembl

ENSG00000132437

UniProt

NCBI

1644

NNT

nicotinamide nucleotide transhydrogenase

FunCoup

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Ensembl

ENSG00000112992

UniProt

NCBI

23530

KMO

kynurenine 3-monooxygenase

FunCoup

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Ensembl

ENSG00000117009

UniProt

NCBI

8564

FAM210B

family with sequence similarity 210 member B

FunCoup

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Ensembl

ENSG00000124098

UniProt

NCBI

116151

HEXA

hexosaminidase subunit alpha

FunCoup

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Ensembl

ENSG00000213614

UniProt

NCBI

3073

ATP2B2

ATPase plasma membrane Ca2+ transporting 2

FunCoup

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Ensembl

ENSG00000157087

UniProt

NCBI

Query genes

		Identifier	Description
30	ENSG00000069535	ENSG00000069535	monoamine oxidase B
		UniProt	P27338
		NCBI	4129
		KEGG signaling	Dopaminergic synapse Serotonergic synapse
		KEGG metabolic	Tryptophan metabolism Phenylalanine metabolism Glycine, serine and threonine metabolism Histidine metabolism Tyrosine metabolism Arginine and proline metabolism Drug metabolism - cytochrome P450

Subnetwork genes

		Identifier	Description
15	OTC	ENSG00000036473	ornithine carbamoyltransferase
		UniProt	A0A2R8Y829 P00480
		NCBI	5009
		KEGG metabolic	Biosynthesis of amino acids Arginine biosynthesis
24	SORD	ENSG00000140263	sorbitol dehydrogenase
		UniProt	H0YKB3 H0YLA4 Q00796
		NCBI	6652
		KEGG metabolic	Fructose and mannose metabolism Pentose and glucuronate interconversions
23	IVD	ENSG00000128928	isovaleryl-CoA dehydrogenase
		UniProt	A0A087WVD3 A0A0A0MT83 A0A0S2Z4K7 H0YKV0 H0YLC3 H0YN10 H0YNA4 H0YNT5 H7C4G6 P26440
		NCBI	3712
		KEGG metabolic	Valine, leucine and isoleucine degradation
20	ACADM	ENSG00000117054	acyl-CoA dehydrogenase medium chain
		UniProt	B7Z9I1 E9PIX8 E9PJM9 E9PLN7 E9PQA8 E9PRX4 H0YDT5 P11310 Q5T4U5
		NCBI	34
		KEGG signaling	PPAR signaling pathway
		KEGG metabolic	Valine, leucine and isoleucine degradation Fatty acid degradation Fatty acid metabolism
21	FECH	ENSG00000066926	ferrochelatase
		UniProt	A0A499FJN5 K7EJM8 K7EJX5 K7ELX4 P22830
		NCBI	2235
		KEGG metabolic	Porphyrin and chlorophyll metabolism
19	AIFM1	ENSG00000156709	apoptosis inducing factor mitochondria associated 1
		UniProt	E9PMA0 E9PMQ8 E9PRR0 O95831
		NCBI	9131
		KEGG signaling	Apoptosis
18	CRAT	ENSG00000095321	carnitine O-acetyltransferase
		UniProt	A6PVN3 B7ZBP5 F2Z2C5 H0Y4Z7 H7C0E1 P43155
		NCBI	1384
22	BPHL	ENSG00000137274	biphenyl hydrolase like
		UniProt	B4DML3 F2Z2Q1 H7C0M3 Q49AI2 Q86WA6
		NCBI	670
21	TRAP1	ENSG00000126602	TNF receptor associated protein 1
		UniProt	I3L0K7 I3L0P6 I3L239 I3L253 I3L2D5 I3L3L4 I3L4L7 Q12931
		NCBI	10131
24	ASS1	ENSG00000130707	argininosuccinate synthase 1
		UniProt	P00966 Q5T6L5 Q5T6L6
		NCBI	445
		KEGG metabolic	Alanine, aspartate and glutamate metabolism Biosynthesis of amino acids Arginine biosynthesis
13	MGST1	ENSG00000008394	microsomal glutathione S-transferase 1
		UniProt	F5GX73 F5H613 F5H6X2 F5H760 F5H7F6 P10620
		NCBI	4257
		KEGG metabolic	Drug metabolism - other enzymes Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450
24	ETFDH	ENSG00000171503	electron transfer flavoprotein dehydrogenase
		UniProt	D6RAD5 D6RJF8 Q16134
		NCBI	2110
26	PGRMC1	ENSG00000101856	progesterone receptor membrane component 1
		UniProt	O00264
		NCBI	10857
23	CYB5A	ENSG00000166347	cytochrome b5 type A
		UniProt	J3KNC7 P00167
		NCBI	1528
23	HADHB	ENSG00000138029	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
		UniProt	B5MD38 C9JE81 C9JEY0 C9K0M0 F5GZQ3 P55084
		NCBI	3032
		KEGG metabolic	Valine, leucine and isoleucine degradation Fatty acid degradation Fatty acid elongation Fatty acid metabolism
5	MAPK3	ENSG00000102882	mitogen-activated protein kinase 3
		UniProt	B3KR49 E9PBK7 E9PJF0 E9PQW4 E9PRH7 H0YDH9 H0YEX6 P27361
		NCBI	5595
		KEGG signaling	Adrenergic signaling in cardiomyocytes Chemokine signaling pathway Fc gamma R-mediated phagocytosis NOD-like receptor signaling pathway Fc epsilon RI signaling pathway Toll-like receptor signaling pathway FoxO signaling pathway B cell receptor signaling pathway cAMP signaling pathway Gap junction HIF-1 signaling pathway cGMP-PKG signaling pathway T cell receptor signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway TGF-beta signaling pathway PI3K-Akt signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Phospholipase D signaling pathway Sphingolipid signaling pathway Oocyte meiosis Focal adhesion Prolactin signaling pathway Melanogenesis Estrogen signaling pathway Progesterone-mediated oocyte maturation GnRH signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Neurotrophin signaling pathway Long-term potentiation Adherens junction Relaxin signaling pathway Serotonergic synapse Cholinergic synapse Glutamatergic synapse Oxytocin signaling pathway Retrograde endocannabinoid signaling MAPK signaling pathway Apelin signaling pathway VEGF signaling pathway Long-term depression Rap1 signaling pathway Ras signaling pathway Apoptosis Natural killer cell mediated cytotoxicity ErbB signaling pathway IL-17 signaling pathway
		KEGG metabolic	Autophagy - animal
24	MTARC2	ENSG00000117791	mitochondrial amidoxime reducing component 2
		UniProt	F6V6Z1 Q969Z3 X1WI34
		NCBI	54996
17	ALDH2	ENSG00000111275	aldehyde dehydrogenase 2 family member
		UniProt	F8VSB0 P05091 S4R3S4
		NCBI	217
		KEGG metabolic	Pyruvate metabolism Tryptophan metabolism Fatty acid degradation Valine, leucine and isoleucine degradation Histidine metabolism Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Arginine and proline metabolism Glycerolipid metabolism beta-Alanine metabolism Lysine degradation
15	MAOA	ENSG00000189221	monoamine oxidase A
		UniProt	P21397
		NCBI	4128
		KEGG signaling	Dopaminergic synapse Serotonergic synapse
		KEGG metabolic	Tryptophan metabolism Phenylalanine metabolism Glycine, serine and threonine metabolism Histidine metabolism Tyrosine metabolism Arginine and proline metabolism Drug metabolism - cytochrome P450
17	LPIN1	ENSG00000134324	lipin 1
		UniProt	A0A0A0MS66 C9IYP2 C9J278 H7C3T1 Q14693
		NCBI	23175
		KEGG signaling	mTOR signaling pathway
		KEGG metabolic	Glycerolipid metabolism Glycerophospholipid metabolism
26	CAT	ENSG00000121691	catalase
		UniProt	A0A3B3ITJ0 P04040
		NCBI	847
		KEGG signaling	FoxO signaling pathway
		KEGG metabolic	Peroxisome Tryptophan metabolism Carbon metabolism Glyoxylate and dicarboxylate metabolism
15	BDH1	ENSG00000161267	3-hydroxybutyrate dehydrogenase 1
		UniProt	A0A494C1C0 C9JB83 C9JEB9 C9JM78 C9JQ90 C9K0G7 E9PCG9 H7C2W1 Q02338
		NCBI	622
		KEGG metabolic	Synthesis and degradation of ketone bodies Butanoate metabolism
10	ULK1	ENSG00000177169	unc-51 like autophagy activating kinase 1
		UniProt	O75385
		NCBI	8408
		KEGG signaling	AMPK signaling pathway mTOR signaling pathway
		KEGG metabolic	Autophagy - animal
19	VAT1	ENSG00000108828	vesicle amine transport 1
		UniProt	K7EJM4 K7EM19 K7ENX2 K7ER81 K7ERT7 K7ESA3 Q99536
		NCBI	10493
5	DDC	ENSG00000132437	dopa decarboxylase
		UniProt	A0A087WU57 A0A087WV24 C9JMP0 F8WER1 H7BZF7 P20711
		NCBI	1644
		KEGG signaling	Dopaminergic synapse Serotonergic synapse
		KEGG metabolic	Tryptophan metabolism Phenylalanine metabolism Tyrosine metabolism
19	NNT	ENSG00000112992	nicotinamide nucleotide transhydrogenase
		UniProt	A0A590UJA4 A0A590UJI3 A0A590UJM2 A0A590UJM7 A0A590UJV8 A0A590UK15 A0A590UK29 A0A590UKC7 D6RAI5 D6RCR6 D6RHU2 E9PCX7 H0Y9R2 Q13423
		NCBI	23530
		KEGG metabolic	Nicotinate and nicotinamide metabolism
12	KMO	ENSG00000117009	kynurenine 3-monooxygenase
		UniProt	H0Y320 O15229
		NCBI	8564
		KEGG metabolic	Tryptophan metabolism
7	FAM210B	ENSG00000124098	family with sequence similarity 210 member B
		UniProt	H0Y456 Q96KR6
		NCBI	116151
10	HEXA	ENSG00000213614	hexosaminidase subunit alpha
		UniProt	A0A087WTY2 H3BP20 H3BQ04 H3BRP6 H3BS10 H3BT62 H3BTD4 H3BU85 H3BVH8 P06865
		NCBI	3073
		KEGG metabolic	Other glycan degradation Various types of N-glycan biosynthesis Glycosphingolipid biosynthesis - globo and isoglobo series Glycosphingolipid biosynthesis - ganglio series Lysosome Glycosaminoglycan degradation Amino sugar and nucleotide sugar metabolism
1	ATP2B2	ENSG00000157087	ATPase plasma membrane Ca2+ transporting 2
		UniProt	A0A2R8Y4R4 A0A2R8Y535 A0A2U3TZI3 A0A2U3U055 Q01814
		NCBI	491
		KEGG signaling	cAMP signaling pathway cGMP-PKG signaling pathway Calcium signaling pathway Adrenergic signaling in cardiomyocytes

Enrichment analysis

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	jSquid_subnetworks.xml	276.16 KB
	H.sapiens_subnetwork.tsv	48.66 KB

Species:

Network information:

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Network appearance:

ENSG00000069535

OTC

SORD

IVD

ACADM

FECH

AIFM1

CRAT

BPHL

TRAP1

ASS1

MGST1

ETFDH

PGRMC1

CYB5A

HADHB

MAPK3

MTARC2

ALDH2

MAOA

LPIN1

CAT

BDH1

ULK1

VAT1

DDC

NNT

KMO

FAM210B

HEXA

ATP2B2

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