Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000065000
3. adaptor related protein…
- 2. AP1G1
  3. adaptor related protein…
  4. 1.000
  5. PPI
- 2. CLTC
  3. clathrin heavy chain
  4. 1.000
  5. PPI
- 2. AP3M1
  3. adaptor related protein…
  4. 1.000
  5. PPI
- 2. AP3S2
  3. adaptor related protein…
  4. 1.000
  5. PPI
- 2. VPS33A
  3. VPS33A core subunit of …
  4. 1.000
  5. PPI
- 2. AP3B1
  3. adaptor related protein…
  4. 1.000
  5. PPI
- 2. VPS41
  3. VPS41 subunit of HOPS c…
  4. 1.000
  5. PPI
- 2. AP3B2
  3. adaptor related protein…
  4. 1.000
  5. PPI
- 2. AP3S1
  3. adaptor related protein…
  4. 1.000
  5. PPI
- 2. VPS39
  3. VPS39 subunit of HOPS c…
  4. 1.000
  5. PPI
- 2. LAMP1
  3. lysosomal associated me…
  4. 1.000
  5. PPI
- 2. VPS33B
  3. VPS33B late endosome an…
  4. 1.000
  5. PPI
- 2. SNX21
  3. sorting nexin family me…
  4. 1.000
  5. PPI
- 2. VPS18
  3. VPS18 core subunit of C…
  4. 1.000
  5. PPI
- 2. HSP90AA1
  3. heat shock protein 90 a…
  4. 1.000
  5. PPI
- 2. TMEM63A
  3. transmembrane protein 6…
  4. 1.000
  5. PPI
- 2. AP2A2
  3. adaptor related protein…
  4. 1.000
  5. PPI
- 2. KIF5B
  3. kinesin family member 5B
  4. 1.000
  5. Complex
- 2. XPO1
  3. exportin 1
  4. 1.000
  5. PPI
- 2. CLINT1
  3. clathrin interactor 1
  4. 1.000
  5. PPI
- 2. VPS16
  3. VPS16 core subunit of C…
  4. 1.000
  5. PPI
- 2. NSF
  3. N-ethylmaleimide sensit…
  4. 1.000
  5. Metabolic
- 2. PSMD2
  3. proteasome 26S subunit,…
  4. 1.000
  5. PPI
- 2. SH3GL1
  3. SH3 domain containing G…
  4. 0.999
  5. Metabolic
- 2. RNF13
  3. ring finger protein 13
  4. 0.999
  5. PPI
- 2. SOD1
  3. superoxide dismutase 1
  4. 0.999
  5. PPI
- 2. VAMP7
  3. vesicle associated memb…
  4. 0.999
  5. PPI
- 2. CLTA
  3. clathrin light chain A
  4. 0.999
  5. PPI
- 2. VPS45
  3. vacuolar protein sortin…
  4. 0.999
  5. Complex
- 2. VPS11
  3. VPS11 core subunit of C…
  4. 0.999
  5. PPI

Subnetwork gene interactions

ENSG00000065000

adaptor related protein complex 3 subunit delta 1

FunCoup

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Ensembl

ENSG00000065000

UniProt

NCBI

8943

VPS18

VPS18 core subunit of CORVET and HOPS complexes

FunCoup

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Ensembl

ENSG00000104142

UniProt

NCBI

57617

CLTC

clathrin heavy chain

FunCoup

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Ensembl

ENSG00000141367

UniProt

NCBI

1213

NSF

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

FunCoup

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Ensembl

ENSG00000073969

UniProt

NCBI

4905

AP2A2

adaptor related protein complex 2 subunit alpha 2

FunCoup

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Ensembl

ENSG00000183020

UniProt

NCBI

SH3GL1

SH3 domain containing GRB2 like 1, endophilin A2

FunCoup

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Ensembl

ENSG00000141985

UniProt

NCBI

6455

AP3B2

adaptor related protein complex 3 subunit beta 2

FunCoup

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Ensembl

ENSG00000103723

UniProt

NCBI

8120

VPS39

VPS39 subunit of HOPS complex

FunCoup

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Ensembl

ENSG00000166887

UniProt

NCBI

23339

VPS45

vacuolar protein sorting 45 homolog

FunCoup

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Ensembl

ENSG00000136631

UniProt

NCBI

11311

RNF13

ring finger protein 13

FunCoup

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Ensembl

ENSG00000082996

UniProt

NCBI

11342

VAMP7

vesicle associated membrane protein 7

FunCoup

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Ensembl

ENSG00000124333

UniProt

NCBI

6845

CLTA

clathrin light chain A

FunCoup

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Ensembl

ENSG00000122705

UniProt

NCBI

1211

XPO1

exportin 1

FunCoup

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Ensembl

ENSG00000082898

UniProt

NCBI

7514

AP1G1

adaptor related protein complex 1 subunit gamma 1

FunCoup

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Ensembl

ENSG00000166747

UniProt

NCBI

PSMD2

proteasome 26S subunit, non-ATPase 2

FunCoup

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Ensembl

ENSG00000175166

UniProt

NCBI

5708

VPS11

VPS11 core subunit of CORVET and HOPS complexes

FunCoup

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Ensembl

ENSG00000160695

UniProt

NCBI

55823

AP3B1

adaptor related protein complex 3 subunit beta 1

FunCoup

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Ensembl

ENSG00000132842

UniProt

NCBI

8546

AP3S1

adaptor related protein complex 3 subunit sigma 1

FunCoup

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Ensembl

ENSG00000177879

UniProt

NCBI

1176

CLINT1

clathrin interactor 1

FunCoup

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Ensembl

ENSG00000113282

UniProt

NCBI

9685

HSP90AA1

heat shock protein 90 alpha family class A member 1

FunCoup

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Ensembl

ENSG00000080824

UniProt

NCBI

3320

SOD1

superoxide dismutase 1

FunCoup

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Ensembl

ENSG00000142168

UniProt

NCBI

6647

KIF5B

kinesin family member 5B

FunCoup

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Ensembl

ENSG00000170759

UniProt

P33176

NCBI

3799

AP3M1

adaptor related protein complex 3 subunit mu 1

FunCoup

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Ensembl

ENSG00000185009

UniProt

Q9Y2T2

NCBI

26985

VPS33A

VPS33A core subunit of CORVET and HOPS complexes

FunCoup

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Ensembl

ENSG00000139719

UniProt

NCBI

65082

LAMP1

lysosomal associated membrane protein 1

FunCoup

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Ensembl

ENSG00000185896

UniProt

P11279

NCBI

3916

VPS33B

VPS33B late endosome and lysosome associated

FunCoup

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Ensembl

ENSG00000184056

UniProt

NCBI

26276

VPS41

VPS41 subunit of HOPS complex

FunCoup

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Ensembl

ENSG00000006715

UniProt

NCBI

27072

VPS16

VPS16 core subunit of CORVET and HOPS complexes

FunCoup

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Ensembl

ENSG00000215305

UniProt

NCBI

64601

TMEM63A

transmembrane protein 63A

FunCoup

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Ensembl

ENSG00000196187

UniProt

NCBI

9725

AP3S2

adaptor related protein complex 3 subunit sigma 2

FunCoup

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Ensembl

ENSG00000157823

UniProt

NCBI

10239

SNX21

sorting nexin family member 21

FunCoup

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Ensembl

ENSG00000124104

UniProt

NCBI

90203

Query genes

		Identifier	Description
30	ENSG00000065000	ENSG00000065000	adaptor related protein complex 3 subunit delta 1
		UniProt	A0A087WYN6 A0A2R8Y4J3 A0A2R8Y611 A0A2R8YCY8 K7ELX8 K7ERW8 O14617
		NCBI	8943
		KEGG metabolic	Lysosome

Subnetwork genes

		Identifier	Description
23	VPS18	ENSG00000104142	VPS18 core subunit of CORVET and HOPS complexes
		UniProt	H0YLM6 H0YMC9 Q9P253
		NCBI	57617
29	CLTC	ENSG00000141367	clathrin heavy chain
		UniProt	A0A087WVQ6 J3KRF5 J3KS13 J3KSQ2 J3KTN1 J3QL20 K7EJJ5 Q00610
		NCBI	1213
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Endocytosis Lysosome
27	NSF	ENSG00000073969	N-ethylmaleimide sensitive factor, vesicle fusing ATPase
		UniProt	I3L0L3 I3L0N3 I3L2G1 I3L338 I3L4Q9 K7EQD6 P46459
		NCBI	4905
		KEGG signaling	Synaptic vesicle cycle GABAergic synapse
29	AP2A2	ENSG00000183020	adaptor related protein complex 2 subunit alpha 2
		UniProt	E9PNC4 E9PPY8 E9PPZ3 E9PQP4 E9PR62 E9PS94 H0YDE9 H0YEG0 O94973
		NCBI	161
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Endocytosis
14	SH3GL1	ENSG00000141985	SH3 domain containing GRB2 like 1, endophilin A2
		UniProt	M0QYE0 M0R0I3 M0R2K6 Q99961
		NCBI	6455
		KEGG metabolic	Endocytosis
17	AP3B2	ENSG00000103723	adaptor related protein complex 3 subunit beta 2
		UniProt	A0A2R8Y2A8 A0A590UJ44 A0A590UJ60 A0A590UJ88 A0A590UJE5 A0A590UJS5 A0A590UJU0 A0A590UJU7 A0A590UJW5 A0A590UK04 A0A590UK30 A0A590UK64 A0A590UK69 A0A590UKC4 A0A590UKD3 A0A5F9UJV3 F5GWU4 F5GYB0 Q13367
		NCBI	8120
		KEGG metabolic	Lysosome
25	VPS39	ENSG00000166887	VPS39 subunit of HOPS complex
		UniProt	H3BTU0 Q96JC1
		NCBI	23339
23	VPS45	ENSG00000136631	vacuolar protein sorting 45 homolog
		UniProt	A0A087WU65 A0A1B0GXI6 A0A2R8Y7W9 A0A2R8YD95 A0A2R8YDP1 A0A2R8YE10 A0A2R8YEX8 A0A2R8YF01 B7Z7G7 Q9NRW7
		NCBI	11311
		KEGG metabolic	Endocytosis
18	RNF13	ENSG00000082996	ring finger protein 13
		UniProt	C9IY58 C9J383 C9J7B4 C9J8T4 C9JCY0 C9JRV0 C9JU37 C9JYN7 C9JYY4 F8WDJ5 F8WEX6 H7C5Q6 O43567
		NCBI	11342
26	VAMP7	ENSG00000124333	vesicle associated membrane protein 7
		UniProt	E5RH06 P51809
		NCBI	6845
		KEGG signaling	SNARE interactions in vesicular transport
		KEGG metabolic	SNARE interactions in vesicular transport
24	CLTA	ENSG00000122705	clathrin light chain A
		UniProt	C9J8P9 F8WF69 P09496 S4R3F6
		NCBI	1211
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Endocytosis Lysosome
24	XPO1	ENSG00000082898	exportin 1
		UniProt	C9IYM2 C9IZS4 C9J673 C9JF49 C9JKM9 C9JQ02 C9JV99 F8WF71 H7BZC5 O14980
		NCBI	7514
		KEGG metabolic	Ribosome biogenesis in eukaryotes RNA transport
28	AP1G1	ENSG00000166747	adaptor related protein complex 1 subunit gamma 1
		UniProt	B3KNW1 B4DGE1 H3BN71 H3BN75 H3BNN2 H3BNR4 H3BPN9 H3BR36 H3BRM7 H3BS13 H3BUN9 H3BV30 O43747
		NCBI	164
		KEGG metabolic	Lysosome
23	PSMD2	ENSG00000175166	proteasome 26S subunit, non-ATPase 2
		UniProt	C9JPC0 F8WBS8 H7C1H2 H7C2Q3 Q13200
		NCBI	5708
		KEGG metabolic	Proteasome
25	VPS11	ENSG00000160695	VPS11 core subunit of CORVET and HOPS complexes
		UniProt	A0A087WXL6 A0A087X2J4 B7Z879 Q9H270
		NCBI	55823
28	AP3B1	ENSG00000132842	adaptor related protein complex 3 subunit beta 1
		UniProt	H0YBD0 O00203
		NCBI	8546
		KEGG metabolic	Lysosome
14	AP3S1	ENSG00000177879	adaptor related protein complex 3 subunit sigma 1
		UniProt	F5H459 Q92572
		NCBI	1176
		KEGG metabolic	Lysosome
19	CLINT1	ENSG00000113282	clathrin interactor 1
		UniProt	H0YCL3 H0YD52 H0YDU9 Q14677
		NCBI	9685
20	HSP90AA1	ENSG00000080824	heat shock protein 90 alpha family class A member 1
		UniProt	A0A0U1RR69 G3V2J8 G3V592 H0YJF5 P07900
		NCBI	3320
		KEGG signaling	Antigen processing and presentation NOD-like receptor signaling pathway PI3K-Akt signaling pathway Estrogen signaling pathway Progesterone-mediated oocyte maturation IL-17 signaling pathway
		KEGG metabolic	Protein processing in endoplasmic reticulum
18	SOD1	ENSG00000142168	superoxide dismutase 1
		UniProt	H7BYH4 P00441
		NCBI	6647
		KEGG metabolic	Peroxisome
19	KIF5B	ENSG00000170759	kinesin family member 5B
		UniProt	P33176
		NCBI	3799
		KEGG signaling	Dopaminergic synapse
		KEGG metabolic	Endocytosis
23	AP3M1	ENSG00000185009	adaptor related protein complex 3 subunit mu 1
		UniProt	Q9Y2T2
		NCBI	26985
		KEGG metabolic	Lysosome
25	VPS33A	ENSG00000139719	VPS33A core subunit of CORVET and HOPS complexes
		UniProt	A0A2R8Y5F6 A0A2R8Y5U3 A0A2R8YF87 F5H2X5 F5H6Y0 F5H7N5 Q96AX1
		NCBI	65082
16	LAMP1	ENSG00000185896	lysosomal associated membrane protein 1
		UniProt	P11279
		NCBI	3916
		KEGG metabolic	Phagosome Lysosome Autophagy - animal
15	VPS33B	ENSG00000184056	VPS33B late endosome and lysosome associated
		UniProt	F5H008 G3V3F9 Q9H267
		NCBI	26276
20	VPS41	ENSG00000006715	VPS41 subunit of HOPS complex
		UniProt	C9J2U9 C9J3F8 C9JU58 C9JZ11 H7BXH3 H7BZX6 H7C0K2 P49754
		NCBI	27072
26	VPS16	ENSG00000215305	VPS16 core subunit of CORVET and HOPS complexes
		UniProt	Q5JUA9 Q5JUB0 Q9H269
		NCBI	64601
19	TMEM63A	ENSG00000196187	transmembrane protein 63A
		UniProt	O94886 Q2HIZ8 X6RI56
		NCBI	9725
17	AP3S2	ENSG00000157823	adaptor related protein complex 3 subunit sigma 2
		UniProt	A0A087WY05 H0YKM3 H0YLI7 H0YLX6 H0YN38 H0YNI6 P59780
		NCBI	10239
		KEGG metabolic	Lysosome
2	SNX21	ENSG00000124104	sorting nexin family member 21
		UniProt	Q05DJ0 Q5JZH3 Q5JZH4 Q969T3
		NCBI	90203

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	302.21 KB
	H.sapiens_subnetwork.tsv	62.37 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000065000

VPS18

CLTC

NSF

AP2A2

SH3GL1

AP3B2

VPS39

VPS45

RNF13

VAMP7

CLTA

XPO1

AP1G1

PSMD2

VPS11

AP3B1

AP3S1

CLINT1

HSP90AA1

SOD1

KIF5B

AP3M1

VPS33A

LAMP1

VPS33B

VPS41

VPS16

TMEM63A

AP3S2

SNX21

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