Found 1 of 1 query genes

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Query interactions

Interaction partners
Confidence
Network
MEX
PIN
SCL
PHP
MIR
TFB
PEX
GIN
DOM
QMS
GRG
Evidence types
HSA
MMU
RNO
CFA
GGA
DRE
CIN
DME
CEL
BTA
SCE
ATH
SPO
BSU
ECO
PFA
DDI
SSO
SSC
MJA
OSA
Species
In Gold st.

ID Query gene
ID Query ortholog

Log-likelihood ratio (LLR)
	Highly positive
	Positive
	Zero
	Negative
	Highly negative
Known coupling
	This network
	Other network

2. ENSG00000064651
3. solute carrier family 1…
- 2. ILK
  3. integrin linked kinase
  4. 0.997
  5. PPI
- 2. RAB11FIP2
  3. RAB11 family interactin…
  4. 0.993
  5. Complex
- 2. STK39
  3. serine/threonine kinase…
  4. 0.989
  5. PPI
- 2. PCF11
  3. PCF11 cleavage and poly…
  4. 0.986
  5. Complex
- 2. EGFR
  3. epidermal growth factor…
  4. 0.980
  5. PPI
- 2. KDM3B
  3. lysine demethylase 3B
  4. 0.978
  5. Complex
- 2. SUCLG2
  3. succinate-CoA ligase GD…
  4. 0.977
  5. Complex
- 2. NRAS
  3. NRAS proto-oncogene, GT…
  4. 0.975
  5. PPI
- 2. OXSR1
  3. oxidative stress respon…
  4. 0.960
  5. PPI
- 2. LGALS3
  3. galectin 3
  4. 0.958
  5. PPI
- 2. COBLL1
  3. cordon-bleu WH2 repeat …
  4. 0.929
  5. Complex
- 2. UTP4
  3. UTP4 small subunit proc…
  4. 0.926
  5. Complex
- 2. TCTN3
  3. tectonic family member 3
  4. 0.925
  5. PPI
- 2. LRIG2
  3. leucine rich repeats an…
  4. 0.872
  5. Metabolic
- 2. VPS35
  3. VPS35 retromer complex …
  4. 0.861
  5. Complex
- 2. B3GLCT
  3. beta 3-glucosyltransfer…
  4. 0.847
  5. Complex
- 2. SYPL1
  3. synaptophysin like 1
  4. 0.826
  5. PPI
- 2. LGALS8
  3. galectin 8
  4. 0.826
  5. PPI
- 2. ATP1A1
  3. ATPase Na+/K+ transport…
  4. 0.813
  5. Metabolic
- 2. GLUL
  3. glutamate-ammonia ligase
  4. 0.802
  5. Metabolic
- 2. MAPK14
  3. mitogen-activated prote…
  4. 0.787
  5. PPI
- 2. ATP6V0D1
  3. ATPase H+ transporting …
  4. 0.785
  5. Complex
- 2. MRE11
  3. MRE11 homolog, double s…
  4. 0.782
  5. Complex
- 2. APLP2
  3. amyloid beta precursor …
  4. 0.781
  5. Metabolic
- 2. ASS1
  3. argininosuccinate synth…
  4. 0.776
  5. Metabolic
- 2. PACSIN2
  3. protein kinase C and ca…
  4. 0.774
  5. Complex
- 2. ATP1B3
  3. ATPase Na+/K+ transport…
  4. 0.746
  5. Metabolic
- 2. IQGAP1
  3. IQ motif containing GTP…
  4. 0.740
  5. Metabolic
- 2. CANX
  3. calnexin
  4. 0.739
  5. Metabolic
- 2. AHCYL1
  3. adenosylhomocysteinase …
  4. 0.729
  5. Complex

Subnetwork gene interactions

ENSG00000064651

solute carrier family 12 member 2

FunCoup

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Ensembl

ENSG00000064651

UniProt

NCBI

6558

ILK

integrin linked kinase

FunCoup

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Ensembl

ENSG00000166333

UniProt

NCBI

3611

PACSIN2

protein kinase C and casein kinase substrate in neurons 2

FunCoup

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Ensembl

ENSG00000100266

UniProt

NCBI

11252

SUCLG2

succinate-CoA ligase GDP-forming subunit beta

FunCoup

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Ensembl

ENSG00000172340

UniProt

NCBI

8801

MAPK14

mitogen-activated protein kinase 14

FunCoup

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Ensembl

ENSG00000112062

UniProt

NCBI

1432

MRE11

MRE11 homolog, double strand break repair nuclease

FunCoup

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Ensembl

ENSG00000020922

UniProt

NCBI

4361

KDM3B

lysine demethylase 3B

FunCoup

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Ensembl

ENSG00000120733

UniProt

NCBI

51780

TCTN3

tectonic family member 3

FunCoup

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Ensembl

ENSG00000119977

UniProt

NCBI

26123

ATP1A1

ATPase Na+/K+ transporting subunit alpha 1

FunCoup

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Ensembl

ENSG00000163399

UniProt

NCBI

CANX

calnexin

FunCoup

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Ensembl

ENSG00000127022

UniProt

NCBI

IQGAP1

IQ motif containing GTPase activating protein 1

FunCoup

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Ensembl

ENSG00000140575

UniProt

NCBI

8826

OXSR1

oxidative stress responsive kinase 1

FunCoup

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Ensembl

ENSG00000172939

UniProt

NCBI

9943

ATP6V0D1

ATPase H+ transporting V0 subunit d1

FunCoup

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Ensembl

ENSG00000159720

UniProt

NCBI

9114

UTP4

UTP4 small subunit processome component

FunCoup

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Ensembl

ENSG00000141076

UniProt

NCBI

84916

GLUL

glutamate-ammonia ligase

FunCoup

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Ensembl

ENSG00000135821

UniProt

NCBI

2752

SYPL1

synaptophysin like 1

FunCoup

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Ensembl

ENSG00000008282

UniProt

NCBI

6856

ATP1B3

ATPase Na+/K+ transporting subunit beta 3

FunCoup

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Ensembl

ENSG00000069849

UniProt

NCBI

PCF11

PCF11 cleavage and polyadenylation factor subunit

FunCoup

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Ensembl

ENSG00000165494

UniProt

NCBI

51585

RAB11FIP2

RAB11 family interacting protein 2

FunCoup

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Ensembl

ENSG00000107560

UniProt

Q7L804

NCBI

22841

VPS35

VPS35 retromer complex component

FunCoup

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Ensembl

ENSG00000069329

UniProt

NCBI

55737

ASS1

argininosuccinate synthase 1

FunCoup

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Ensembl

ENSG00000130707

UniProt

NCBI

LGALS3

galectin 3

FunCoup

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Ensembl

ENSG00000131981

UniProt

NCBI

3958

APLP2

amyloid beta precursor like protein 2

FunCoup

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Ensembl

ENSG00000084234

UniProt

NCBI

B3GLCT

beta 3-glucosyltransferase

FunCoup

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Ensembl

ENSG00000187676

UniProt

Q6Y288

NCBI

145173

NRAS

NRAS proto-oncogene, GTPase

FunCoup

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Ensembl

ENSG00000213281

UniProt

P01111

NCBI

4893

EGFR

epidermal growth factor receptor

FunCoup

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Ensembl

ENSG00000146648

UniProt

NCBI

1956

LRIG2

leucine rich repeats and immunoglobulin like domains 2

FunCoup

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Ensembl

ENSG00000198799

UniProt

O94898

NCBI

9860

AHCYL1

adenosylhomocysteinase like 1

FunCoup

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Ensembl

ENSG00000168710

UniProt

O43865

NCBI

10768

STK39

serine/threonine kinase 39

FunCoup

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Ensembl

ENSG00000198648

UniProt

Q9UEW8

NCBI

27347

COBLL1

cordon-bleu WH2 repeat protein like 1

FunCoup

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Ensembl

ENSG00000082438

UniProt

NCBI

22837

LGALS8

galectin 8

FunCoup

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Ensembl

ENSG00000116977

UniProt

NCBI

3964

Query genes

		Identifier	Description
30	ENSG00000064651	ENSG00000064651	solute carrier family 12 member 2
		UniProt	G3XAL9 P55011
		NCBI	6558

Subnetwork genes

		Identifier	Description
10	ILK	ENSG00000166333	integrin linked kinase
		UniProt	A0A087WW45 A0A087WWY6 A0A0A0MTH3 E9PQ52 Q13418
		NCBI	3611
		KEGG signaling	Focal adhesion PPAR signaling pathway
17	PACSIN2	ENSG00000100266	protein kinase C and casein kinase substrate in neurons 2
		UniProt	A0A0U1RR22 B0QYG7 B0QYG8 B0QYG9 H0Y923 Q9UNF0
		NCBI	11252
8	SUCLG2	ENSG00000172340	succinate-CoA ligase GDP-forming subunit beta
		UniProt	E9PDQ8 H0Y852 Q96I99
		NCBI	8801
		KEGG metabolic	Citrate cycle (TCA cycle) Carbon metabolism Propanoate metabolism
9	MAPK14	ENSG00000112062	mitogen-activated protein kinase 14
		UniProt	B4E0K5 B5TY33 E7EX54 H7C4E2 Q16539
		NCBI	1432
		KEGG signaling	MAPK signaling pathway Leukocyte transendothelial migration Adrenergic signaling in cardiomyocytes VEGF signaling pathway Sphingolipid signaling pathway Neurotrophin signaling pathway RIG-I-like receptor signaling pathway NOD-like receptor signaling pathway Fc epsilon RI signaling pathway Oocyte meiosis Rap1 signaling pathway Toll-like receptor signaling pathway FoxO signaling pathway T cell receptor signaling pathway Prolactin signaling pathway Dopaminergic synapse Relaxin signaling pathway Progesterone-mediated oocyte maturation GnRH signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway IL-17 signaling pathway Retrograde endocannabinoid signaling
8	MRE11	ENSG00000020922	MRE11 homolog, double strand break repair nuclease
		UniProt	F5GXT0 F5H256 F5H742 F8W7U8 P49959
		NCBI	4361
		KEGG metabolic	Non-homologous end-joining Homologous recombination
7	KDM3B	ENSG00000120733	lysine demethylase 3B
		UniProt	H0Y946 H0Y9V5 Q7LBC6
		NCBI	51780
2	TCTN3	ENSG00000119977	tectonic family member 3
		UniProt	A0A0C4DFN5 Q6NUS6
		NCBI	26123
15	ATP1A1	ENSG00000163399	ATPase Na+/K+ transporting subunit alpha 1
		UniProt	P05023 Q5TC01 Q5TC02 Q5TC05
		NCBI	476
		KEGG signaling	cAMP signaling pathway Thyroid hormone signaling pathway cGMP-PKG signaling pathway Adrenergic signaling in cardiomyocytes Cardiac muscle contraction
		KEGG metabolic	Protein digestion and absorption Carbohydrate digestion and absorption
14	CANX	ENSG00000127022	calnexin
		UniProt	D6RAQ8 D6RAU8 D6RB85 D6RD16 D6RDP7 D6RFL1 D6RFW4 D6RG29 D6RGY2 D6RHJ3 H0Y9H1 H0Y9Q7 P27824
		NCBI	821
		KEGG signaling	Antigen processing and presentation
		KEGG metabolic	Phagosome Protein processing in endoplasmic reticulum
17	IQGAP1	ENSG00000140575	IQ motif containing GTPase activating protein 1
		UniProt	A0A087WWP1 A0A087X225 A0A0J9YXZ5 H0YKA5 H0YLE8 P46940
		NCBI	8826
		KEGG signaling	Adherens junction
7	OXSR1	ENSG00000172939	oxidative stress responsive kinase 1
		UniProt	C9JIG9 F8WBK9 O95747
		NCBI	9943
17	ATP6V0D1	ENSG00000159720	ATPase H+ transporting V0 subunit d1
		UniProt	F5GYQ1 F8WEN9 H3BPS0 H3BQB4 H3BQJ1 H3BSG7 H3BTB4 H3BTB5 H3BUQ0 J3QL14 P61421 R4GN72
		NCBI	9114
		KEGG signaling	Synaptic vesicle cycle
		KEGG metabolic	Oxidative phosphorylation Phagosome Lysosome
8	UTP4	ENSG00000141076	UTP4 small subunit processome component
		UniProt	H3BPD7 H3BRM8 H3BSH7 I3L4T9 J3KSE6 J3KSI1 J3KTR0 Q969X6
		NCBI	84916
		KEGG metabolic	Ribosome biogenesis in eukaryotes
12	GLUL	ENSG00000135821	glutamate-ammonia ligase
		UniProt	A0A2R8YDT1 P15104
		NCBI	2752
		KEGG signaling	GABAergic synapse Glutamatergic synapse
		KEGG metabolic	Nitrogen metabolism Alanine, aspartate and glutamate metabolism Biosynthesis of amino acids Arginine biosynthesis Glyoxylate and dicarboxylate metabolism
9	SYPL1	ENSG00000008282	synaptophysin like 1
		UniProt	A0A0U1RQT9 C9JYN0 H7C4J8 Q16563
		NCBI	6856
12	ATP1B3	ENSG00000069849	ATPase Na+/K+ transporting subunit beta 3
		UniProt	C9J6S2 C9JA36 C9JXZ1 F8WBY4 H7C4L9 H7C547 P54709
		NCBI	483
		KEGG signaling	cAMP signaling pathway Thyroid hormone signaling pathway cGMP-PKG signaling pathway Adrenergic signaling in cardiomyocytes Cardiac muscle contraction
		KEGG metabolic	Protein digestion and absorption Carbohydrate digestion and absorption
8	PCF11	ENSG00000165494	PCF11 cleavage and polyadenylation factor subunit
		UniProt	E9PKN0 E9PNY7 E9PQ01 E9PQF9 O94913
		NCBI	51585
		KEGG metabolic	mRNA surveillance pathway
8	RAB11FIP2	ENSG00000107560	RAB11 family interacting protein 2
		UniProt	Q7L804
		NCBI	22841
		KEGG metabolic	Endocytosis
19	VPS35	ENSG00000069329	VPS35 retromer complex component
		UniProt	A0A1W2PP10 A0A3B3ITD4 H3BRJ7 I3L4S0 Q96QK1
		NCBI	55737
		KEGG metabolic	Endocytosis
13	ASS1	ENSG00000130707	argininosuccinate synthase 1
		UniProt	P00966 Q5T6L5 Q5T6L6
		NCBI	445
		KEGG metabolic	Alanine, aspartate and glutamate metabolism Biosynthesis of amino acids Arginine biosynthesis
6	LGALS3	ENSG00000131981	galectin 3
		UniProt	G3V3R6 G3V407 P17931
		NCBI	3958
10	APLP2	ENSG00000084234	amyloid beta precursor like protein 2
		UniProt	E9PK76 E9PPD0 E9PQS3 E9PSC7 Q06481 Q9UED0
		NCBI	334
8	B3GLCT	ENSG00000187676	beta 3-glucosyltransferase
		UniProt	Q6Y288
		NCBI	145173
		KEGG metabolic	Other types of O-glycan biosynthesis
6	NRAS	ENSG00000213281	NRAS proto-oncogene, GTPase
		UniProt	P01111
		NCBI	4893
		KEGG signaling	Thyroid hormone signaling pathway Chemokine signaling pathway Neurotrophin signaling pathway Long-term potentiation Fc epsilon RI signaling pathway B cell receptor signaling pathway FoxO signaling pathway Gap junction T cell receptor signaling pathway Relaxin signaling pathway Serotonergic synapse Cholinergic synapse C-type lectin receptor signaling pathway Oxytocin signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway Apelin signaling pathway VEGF signaling pathway mTOR signaling pathway Phospholipase D signaling pathway Sphingolipid signaling pathway Rap1 signaling pathway Long-term depression Ras signaling pathway ErbB signaling pathway Natural killer cell mediated cytotoxicity Apoptosis Prolactin signaling pathway Melanogenesis Estrogen signaling pathway GnRH signaling pathway Insulin signaling pathway
		KEGG metabolic	Autophagy - animal
4	EGFR	ENSG00000146648	epidermal growth factor receptor
		UniProt	A0A1W2PRR9 C9JYS6 E9PFD7 P00533 Q504U8
		NCBI	1956
		KEGG signaling	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Phospholipase D signaling pathway Rap1 signaling pathway Focal adhesion Adherens junction JAK-STAT signaling pathway Ras signaling pathway FoxO signaling pathway Gap junction ErbB signaling pathway HIF-1 signaling pathway Estrogen signaling pathway Relaxin signaling pathway GnRH signaling pathway Oxytocin signaling pathway
		KEGG metabolic	Endocytosis
3	LRIG2	ENSG00000198799	leucine rich repeats and immunoglobulin like domains 2
		UniProt	O94898
		NCBI	9860
8	AHCYL1	ENSG00000168710	adenosylhomocysteinase like 1
		UniProt	O43865
		NCBI	10768
		KEGG metabolic	Cysteine and methionine metabolism
2	STK39	ENSG00000198648	serine/threonine kinase 39
		UniProt	Q9UEW8
		NCBI	27347
6	COBLL1	ENSG00000082438	cordon-bleu WH2 repeat protein like 1
		UniProt	A0A0B4J1Z0 A0A0D9SG04 A0A0X1KG75 A0A590PXD8 C9J5Y6 C9J8C4 C9JAU3 C9JK90 C9JWZ0 F8WEK0 H7C1G2 Q53SF7
		NCBI	22837
1	LGALS8	ENSG00000116977	galectin 8
		UniProt	B1ANM0 E9PJ77 E9PN19 E9PNC2 E9PPL1 E9PPM4 E9PRN3 F6V2D4 H7BXD8 O00214 Q5T3P9
		NCBI	3964

Enrichment analysis

Search for enrichment of pathways or functional gene sets for your subnetwork genes

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	jSquid_subnetworks.xml	267.58 KB
	H.sapiens_subnetwork.tsv	26.63 KB

Species:

Network information:

Filter Results:

Network appearance:

ENSG00000064651

ILK

PACSIN2

SUCLG2

MAPK14

MRE11

KDM3B

TCTN3

ATP1A1

CANX

IQGAP1

OXSR1

ATP6V0D1

UTP4

GLUL

SYPL1

ATP1B3

PCF11

RAB11FIP2

VPS35

ASS1

LGALS3

APLP2

B3GLCT

NRAS

EGFR

LRIG2

AHCYL1

STK39

COBLL1

LGALS8

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